刘春明


职务/职称： 研究员
联系电话： (86)-
电子邮件： cmliu@ibcas.ac.cn
个人网页： http://www.klpmp.net/ktz_display.asp?ktid=39&ktclass=7
课题组： 胚胎胚乳发育研究组


刘春明，男，博士，研究员，博士生导师。
1984年山东师范学院生物系获学士学位；1987年在中国科学院上海植物生理研究所获硕士学位；1996年英国John Innes Centre/UEA获博士学位。1990-1992年在新加坡国立大学做访问研究；1996-1999年在美国OSU从事博士后研究；1999-2005年在荷兰国际植物研究中心担任实验室主任/高级研究员。2006年获得"国家****基金"。现任国家重大研究计划首席科学家、中国科学院植物研究所植物分子生理学重点实验室主任、中国细胞学会副监事长、中国作物学会常务理事、Journal of Integrative Plant Biology (JIPB)主编、Plant Molecular Biology Reporter副主编。迄今为止已发表论文70余篇，总引用 3200余次。Plant Cell、Plant Physiology和Plant Journal等杂志先后6次将其研究工作作为封面刊登。
研究方向：
本研究组致力于探索植物种子（胚胎和胚乳）的发育生物学基础，研究合子胚受精激活的分子机理以及小分子多肽在植物干细胞调控过程中的作用。主要学术贡献包括提出了生长素的极性运输控制植物器官原基形成的理论；建立了植物界第一个细胞质分裂的突变体模型；阐明了控制胚乳细胞分裂所必需的一系列基因；发现AMP脱氨酶在受精卵激活过程中的关键作用；证实了控制干细胞分化的CLV3和CLE19基因是以小分子多肽激素形式参与信号传递。研究内容包括：1）受精后合子激活的分子机理；2）胚乳糊粉层和淀粉胚乳分化；3）多肽激素与植物的信号转导；4）水稻TILLING技术平台建设。
主持和参加的科研项目：
1．重大研究计划：植物胚胎及种子发育的机理研究（2014CB943400），首席科学家；2014.1至2018.8；资助强度：300万/5年
2．国家****科学基金：植物早期胚胎发育及多肽信号转导，2007.1-2010.12；课题负责人：资助强度：200万元；项目批准号：**；
3．重大研究计划：蛋白质功能的代谢与多肽组学研究，首席科学家; 2006年12月-2011.8，资助强度331万/五年；项目批准号：2006CB910600
4．欧盟第六框架研究计划：development of drought resistant cereals to support efficient water use in the Mediterranean area, 项目负责人; 2006.1-2008.12.31；资助强度：200，000 EURO；项目批准号：015468
研究论文（注*为通讯作者,§为共同第一作者）：
2020
Liu CM. 2020. The war between wheat and Fusarum: fighting with an alien weapon. SCIENCE CHINA Life Sciences, doi: 10.1007/s11427-020-1724-y
Zhang XF, Tong JH, Bai AN, Liu CM, Xiao LT, Xue HW*. 2020. Phytohormone dynamics in developing endosperm influence rice grain shape and quality. Journal of Integrative Plant Biology, doi:10.1111/jipb.12927.
Yao XF, Wu SY, Guo L,Liu CM*.2020. Efficient CELI endonuclease production inNicotiana benthamianathrough transient expression and applications in detections of mutation and gene editing events.Plant Science, 296: 110469.
Song ZB, Sui XY, Li MY, Gao YL, Li WZ, Zhao L, Li F, Yao XF,Liu CM, Wang BW*.2020. Development of a nornicotine-reduced flue-cured tobacco line via EMS mutagenesis of nicotine N-demethylase genes.Plant Signaling and Behavior,15(2): e**.
2019
Zhang DJ^§, GuoXY^§, Xu YY, Li H, Ma L, Yao XF, Weng YX, Guo Y,Liu CM, Chong K*.2019. OsCIPK7 point‐mutation leads to conformation and kinase‐activity change for sensing cold response.Journal of Integrative Plant Biology, 61: 1194-1200.
Wu MW, Zhao H, Zhang JD, Guo L,Liu CM*.2019. RADICLELESS 1 (RL1)-mediated nad4 intron 1 splicing is crucial for embryo and endosperm development in rice (Oryza sativaL.).Biochemical and Biophysical Research Communications, https://doi.org/10.1016/j.bbrc.2019.11.084.
Mao C, He J, Liu L, Deng Q, Yao XF,Liu CM, Ming F*.2019. OsNAC2 integrates auxin and cytokinin pathways to modulate rice root development.Plant Biotechnology Journal, 18(2): 429-442.
刘春明*.2019.防范学术不端的实践与思考.中国科技期刊研究. doi:CNKI:SUN:JYKQ.0.2019-01-019.
Zhao T, Huan Q, Sun J, Liu C, Hou X, Yu X, Silverman IM, Zhang Y, Gregory BD,Liu CM, Qian WF, Cao XF*.2019. Impact of poly (A)-tail G-content onArabidopsisPAB binding and their role in enhancing translational efficiency.Genome Biology, doi:10.1186/s13059-019-1799-8.
Yu K^§, Liu D^§, Chen Y, Wang D, Yang W, Yang W,Liu CM*, Zhang AM*.2019. Unraveling the genetic architecture of grain size in einkorn wheat through linkage and homology mapping, and transcriptomic profiling.Journal of Experimental Botany, 70: 4671-4688.
Ren SC^§, Song XF^§, Chen WQ, Lu R, Lucas WJ,Liu CM*.2019. CLE25 peptide regulates phloem initiation inArabidopsisthrough a CLERK‐CLV2 receptor complex.Journal of Integrative Plant Biology, 61: 1043-1061.
Gao YL^§, Yao XF^§, Li WZ, Song ZB, Wang BW, Wu YP, Shi JL, Liu GS, Li YP,Liu CM*.2019. An efficient TILLING platform for cultivated tobacco.Journal of Integrative Plant Biology, 62: 165-180.
He Y, Yan L, Ge C, Yao XF, Han X, Wang R, Xiong LZ, Jiang LW,Liu CM, Zhao YD*.2019. PINOID is required for formation of the stigma and style in rice.Plant Physiology, 180: 926-936.
2018
Zhang LM^§, Leng CY^§, Luo H^§, Wu XY^§, Liu ZQ^§, Zhang YM, Zhang H, Xia Y, Shang L,Liu CM, Hao DY, Zhou YH, Chu CC, Cai H, Jing HC*.2018. Sweet sorghum originated through selection of dry, a plant-specific NAC transcription factor gene.Plant Cell, 30: 2286-2307.
Liu JX^§, Wu XB^§, Yao XF, Yu R, Larkin P,Liu CM*.2018. Mutations in the DNA demethylase OsROS1 result in a thickened aleurone and improved nutritional value in rice grains.PNAS. 115: 11327-11332.
2017
Song XG, Lu ZF, Yu H, Shao GN, Xiong JS, Meng XB, Jing YH, Liu GF, Xiong GS, Duan JB, Yao XF,Liu CM, Li HQ, Wang YH, Li JY.2017. IPA1 functions as a downstream transcription factor repressed by D53 in strigolactone signaling in rice.Cell Research, 27: 1128-1141.
2016
Wu XB^§, Liu JX^§, Li DQ,Liu CM*.2016. Rice caryopsis development II: Dynamic changes in the endosperm.Journal of Integrative Plant Biology, 58: 786-798.
Wu XB, Liu JX, Li DQ,Liu CM.2016. Rice caryopsis development I: Dynamic changes in different cell layers.Journal of Integrative Plant Biology, 58: 772-785.
Guo L^§, Jiang L^§, Zhang Y, Lu XL, Xie Q, Weijers D,Liu CM.2016. The anaphase promoting complex initiates zygote division in Arabidopsis through degradation of cyclin B1.Plant Journal,86: 161-174.(*Co-first author)
Bai AN, Lu XD, Li DQ, Liu JX,Liu CM*.2016. NF-YB1-regulated expression of sucrose transporters in aleurone facilitates sugar loading to rice endosperm.Cell Research, 26: 384-388.
2015
Guo L,Liu CM*.2015. A single-nucleotide exon found in Arabidopsis.Scientific Reports, 5: 18087.
Wu X, Liu J, Li D,Liu CM*.2015. Rice caryopsis development: Dynamic changes in different cell layers.Journal of Integrative Plant Biology, doi: 10.1111/jipb.12440.
Xu TT, Ren SC, Song XF,Liu CM*.2015. CLE19 expressed in the embryo regulates both cotyledon establishment and endosperm development in Arabidopsis.Journal of Experimental Botany, 66: 5217-5227.
Liu CM*.2015. Auxin binding protein 1 (ABP1): A matter of fact.Journal of Integrative Plant Biology, 57: 234-235.
2014
Yan SJ, Liang YT, Zhang JD, Chen Z,Liu CM*.2014. Autoxidated linolenic acid inhibits aflatoxin biosynthesis in Aspergillus flavus via oxylipin species.Fungal Genetics and Biology, 81: 229-237.
Lu X, Zhang D, Li S, Su Y, Liang Q, Meng H, Shen S, Fan Y,Liu CM, Zhang C*.2014. FtsHi4 is essential for embryogenesis due to its influence on chloroplast development in Arabidopsis.PLoS ONE, 9: e99741.
Zhang Z, Song Y,Liu CM, Thomma B*.2014. Mutational analysis of the Ve1 immune receptor that mediates verticillium resistance in tomato.PloS ONE, 9: e99511.
Zhang JD, Han LD, Yan SJ,Liu CM*.2014. The non-metabolizable glucose analog D-glucal inhibits aflatoxin biosynthesis and promotes kojic acid production in Aspergillus flavus.BMC Microbiology, 14: 95-104.
2013
Xu TT, Song XF, Ren SC,Liu CM*. 2013. The sequence flanking the N-terminus of the CLV3 peptide is critical for its cleavage and activity in stem cell regulation in Arabidopsis.BMC Plant Biology, 13:225, doi:10.1186/1471-2229-13-225.
Song XF, Xu TT, Ren SC, Liu CM*. 2013. Individual amino acid residues in CLV3 peptide contribute to its stability in vitro.Plant Signal Behavior, 8: e25344.
Li S, Chen M. Yu D, Ren S, Sun S, Liu L, Ketelaar, T, Emons AM andLiu CM*. 2013. EXO70A1-mediated vesicle trafficking is critical for tracheary element development in Arabidopsis.Plant Cell, 25: 1774-1786.
Song XF, Guo P, Ren SC, Xu TT,Liu CM*.2013. Antagonistic peptide technology for functional dissection of CLE genes in Arabidopsis.Plant Physiology, 161, 1076-1085
Jiang GQ, Yao XF andLiu CM*.2013. A simple CELI endonuclease-based protocol for genotyping both SNPs and InDels.Plant Molecular Biology Reporter, 1325-1335.
Zhang Z, van Esse HP, van Damme M, Fradin EF,Liu CM, Thomma BPHJ*.2013. Ve1-mediated resistance against Verticillium does not involve a hypersensitive response in Arabidopsis.Molecular Plant Pathology,14: 719–727.
Zhang Y, Immink R,Liu CM, Emons A and Ketelaar T*.2013. The Arabidopsis exocyst subunit SEC3A is essential for embryo development and accumulates in transient puncta at the plasma membrane.New Physiologist, 199:74-88.
Chu H, Liang W, Li J, Hong F, Wu Y, Wang L, Wang J, Wu P,Liu CM, Zhang Q, Xu J, Zhang D*.2013. A CLE-WOX signalling module regulates root meristem maintenance and vascular tissue development in rice.Journal of Experimental Botany, 64: 5359-5369.
Brandt R, Xie Y, Musielak T, Graeff M, Stierhof YD, Huang H,Liu CM, Wenkel S*.2013. Control of stem cell homeostasis via interlocking microRNA and microProtein feedback loops,Mech. Dev. 130: 25-33.
Zhang Z, Fradin E, Jonge R, Esse H.P, Smit P,Liu CMand Thomma B*.2013. Optimized agroinfiltration and virus-induced gene silencing to study ve1-mediated Verticillium resistance in tobacco.Molecular Plant-Microbe Interactions, 26(2): 182-191.
2012
SongXF, Yu DL, XuTT, Ren SC, GuoP,LiuCM*. 2012, Contributions of individual amino acid residues to the endogenous CLV3 function in shoot apical meristem maintenance in Arabidopsis.Molecular Plant, 5(2): 515-523.
Zhang S, Haider I, Kohlen W, Jiang L, Bouwmeester H, Meijer AH, Schluepmann H,Liu CM*, Ouwerkerk PB*.2012. Function of the HD-Zip I gene Oshox22 in ABA-mediated drought and salt tolerances in rice.Plant Molecular Biology, 80: 571–585.
Yu DL, Jiang L, Gong HQ,Liu CM*. 2012.EMBRYONIC FACTOR 19encodes a PPR protein that is essential for the initiation of zygotic embryogenesis in Arabidopsis. Journal of Integrative Plant Biology,54(1): 55-64.
Yan SJ, Liang YT, Zhang JD and Liu CM*. 2012. Aspergillus flavus grown in peptone as the carbon source exhibits spore density- and peptone concentration-dependent aflatoxin biosynthesis.BMC Microbiology, 12:106.
Wang ZZ, Yan SJ,Liu CM, Chen F and Wang T*. 2012. Proteomic Analysis reveals an aflatoxin-triggered immune response in cotyledons ofArachis hypogaeainfected with Aspergillus flavus. Journal of Proteome Research, 11: 2739-2753.
Zheng Y, Xin H, Lin J,Liu CMand Huang SJ*. 2012. An Arabidopsis class II Formin, AtFH19, nucleates actin assembly, binds to the barbed end of actin filaments and antagonizes the effect of AtFH1 on actin dynamics.Journal of Integrative Plant Biology, 54(10): 800-813.
2011
Zheng LY, Guo XS, He B, Sun LJ, Peng Y, Dong SS, Liu TF, Jiang S, Ramachandran S,Liu CM, Jing HC*.2011. Genome-wide patterns of genetic variation in sweet and grain sorghum (Sorghum bicolor).Genome Biology. 12(11): R114.
Ma J, Hanssen M, Lundgren K, Hernandez H, Delatte T, Ehlert A,Liu CM, Schluepmann H, Droge-Laser H, Moritz T, Smeekens S and Hanson J*.2011. The sucrose-regulated Arabidopsis transcription factor bZIP11 reprograms metabolism and regulates trehalose metabolism.New Phytologist,191(3): 733-745.
2010
Li S, Os G van, Ren S, Yu D, Ketelaar T, Emons A andLiu CM*.2010. Expression and functional analyses of EXO70 genes in Arabidopsis implicate their roles in regulating cell type-specific exocytosis.Plant Physiology, 154: 1819-1830.
Liu CM*, Hu Y .2010. Plant stem cells and their regulations in shoot apical meristems. Frontier Biology, 5: 417-423.
Song XF, Guo P, Li C,Liu CM*. 2010. The cysteine pairs in CLV2 are not necessary for sensing the CLV3 peptide in shoot and root meristems.Journal of Integrative Plant Biology, 52: 774-781
Zhou W, Wei L, Xu J, Zhai QZ, Jiang HL, Chen R, Chen Q, Sun JQ, Chu JF, Zhu LH,Liu CMand Li CY*.2010. Arabidopsis tyrosylprotein sulfotransferase acts in the Auxin/PLETHORA pathway in regulating postembryonic maintenance of the root stem cell niche.Plant Cell, 22: 3692-3709.
Zhu YF, Wang YQ, Li RL, Song XF, Wang QL, Huang HJ, Jin JB,LiuCM and Lin JX*. 2010. Analysis of interactions among the CLAVATA3 receptors reveals a direct interaction between CLAVATA2 and CORY in Arabidopsis.Plant Journal, 61: 223-233.
2009
Wang QL, Chen B, Liu P, Zheng MZ, Wang YQ, Cui SJ, Sun DY, Fang XH,Liu CM, Lucas WJ, and Lin JX*. 2009. Calmodulin Binds to Extracellular Sites on the Plasma Membrane of Plant Cells and Elicits a Rise in Intracellular Calcium Concentration.Journal of Biological Chemistry, 284: 12000-12007.
Fradin EM, Zhang Z, Juarez Ayala JC, Castroverde CDM, Nazar RN, Robb J,Liu CM, and Thomma B.P.H.J.*. 2009. Genetic Dissection of Verticillium Wilt Resistance Mediated by TomatoVe11.Plant Physiology, 150: 320–332.
2008
Fan YF, Jiang L, Gong HQ andLiu CM*. 2008. Sexual Reproduction in Higher Plants I: Fertilization and the Initiation of Zygotic Program.Journal of Integrative Plant Biology, 50: 860-867.
Wang G, Ellendorff U, Kemp B, Mansfield JW, Forsyth A, Mitchell K, Bastas K,Liu CM, Woods-Tor A, Zipfel C, de Wit PJGM, Jones JDG, Tor M, and Thomma BPHJ*.2008. A genome-wide functional investigation into the roles s of receptor-like proteins in Arabidopsis.Plant Physiology, 147: 503-517.
2007
Fiers M, Ku KL, Liu CM*. 2007. CLE peptide ligands and their roles in establishing meristems.Current Opinion of Plant Biology, 10: 39-43.
Ribarits A, Mamun ANK, Li S, Resch T, Fiers M., Heberle-Bors E,Liu CMand Touraev A*.2007. Combination of reversible male sterility and doubled haploid production by targeted inactivation of cytoplasmic glutamine synthetase in developing anthers and pollen.Plant Biotechnology Journal, 5: 483–494.
2006
Fiers M, Golemiec E, van der Schors R, van der Geest L, Li KW, Stiekema WJ,Liu CM*. 2006. The CLV3/ESR motif of CLV3 is functionally independent from the non-conserved flanking sequences.Plant Physiology, 141, 1284-1294.
2005
Fiers M, Golemiec E, Xu J, Geest L. van der, Heidstra R, Stiekema W, and Liu CM*. 2005. The 14-Amino Acid CLV3, CLE19 and CLE40 Peptides Trigger Consumption of the Root Meristem in Arabidopsis through a CLAVATA2-Dependent Pathway.Plant Cell,17: 2542-2553 (cover story).
Xu J, Zhang HY, Xie CH, Xue HW, Dijkhuis P, andLiu CM*. 2005. EMBRYONIC FACTOR 1 encodes an AMP deaminase and is essential for the zygote to embryo transition in Arabidopsis.Plant Journal, 42: 743-756.
2004
Fiers M, Hause G, Boutilier K, Casamitjana-Marinez E., Weijers D, Offringa R, Geest L. van der, Lookeren Campagne M. van,Liu CM*. 2004. Mis-expression of the CLV3/ESR-like gene CLE19 in Arabidopsis leads to a consumption of root meristem.Gene, 327: 37-49.
2003
Casamitjana-Martínez E, Hofhuis H. F, Xu J,Liu CM, Heidstra R and Scheres B*. 2003. Root-Specific CLE19 Overexpression and the sol1/2: Suppressors Implicate a CLV-like Pathway in the Control of Arabidopsis Root Meristem.Current Biology, 13: 1435-1441.
2002
Liu CM, McElver J, Tzafrir I, Joosen R, Wittich P, Patton D, van Lammeren A.A.M. and Meinke D*. 2002. Condensin and cohesin knockouts in Arabidopsis exhibit a titan seed phenotype.Plant Journal, 29: 405-415.
Boutilier* K, Offringa R, Sharma V.K, Kieft H, Ouellet T, Zhang L, Hattori J,Liu CM, van Lammeren A.A, Miki B.L, Custers J.B., van Lookeren Campagne M.M. 2002. Ectopic expression of BABY BOOM triggers a conversion from vegetative to embryonic growth.Plant Cell, 14: 1737-1749.
Tzafrir I, McElver JA,Liu CM, Yang LJ, Wu JQ, Martinez A, Patton DA, and Meinke DW*. 2002. Diversity of TITAN Functions in Arabidopsis Seed Development.Plant Physiology, 128: 32-51.
2000
McElver J, Patton D, Rambaugh M,Liu CM,Yang LJ and Meinke D*. 2000. The TITAN5 gene of Arabidopsis encodes a protein related to the ADP ribosylation factor family of GTP binding proteins. Plant Cell, 12: 1379-1302.
Cordewener J*, Bergervoet J andLiu CM. 2000. Changes in protein systhesis and phosphorylation during microspore embryogenesis inBrassica napus.Journal of Plant Physiology, 156: 156-163.
1999
Liu CM, Johnson S. Di Gregorio, S. and Wang TL*. 1999. single cotyledon (sic) mutants of pea and their relevance to the pattern formation and the evolution of monocots.Developmental Genetics, 25: 11-22.
1998
Liu CM and Meinke DW*. 1998. The titan mutants of Arabidopsis are disrupted in mitosis and cell cycle control during seed development.Plant Journal,16: 21-31.
1996
Hong Y, Takano M,Liu CM, Gasch A, Chye M.L and Chua N-H*. 1996. Expression of the three members of the calcium-dependent protein kinase gene family in Arabidopsis thaliana.Plant Molecular Biology, 30: 1259-1275.
1995
Liu CM, Johnson S. and Wang TL*. 1995. cyd, a mutant of pea that alters embryo morphology is defective in cytokinesis.Developmental Genetics, 16: 312-331.
1994
Liu CM,Xu ZH and Chua N-H*. 1994. In vitro culture ofBrassica junceazygotic embryo, in "Plant Tissue Culture Manual: Fundamentals and Applications" K. Lindsey,Ed. Kluwar Academic Publishers, E5, pp1-19.
1993
Liu CM, Xu ZH, and Chua N-H*. 1993. Proembryo culture: in vitro development of early globular-staged zygotic embryos ofBrassica juncea.Plant Journal, 3: 291-300.
Liu CM, Xu ZH and Chua N-H*. 1993. Auxin polar transport is essential for the establishment of bilateral symmetry during early plant embryogenesis.Plant Cell,5: 621-630.
著作专著：
许智宏，刘春明主编，1998. 植物发育的分子机理. 北京：科学出版社