基本信息
赵允男博导中国科学院分子细胞科学卓越创新中心（生物化学与细胞生物学研究所）
电子邮件： yunzhao@sibcb.ac.cn
通信地址： 上海岳阳路320号
邮政编码： 200031
部门/实验室：生物化学与细胞生物学研究所
研究领域

招生信息
招生专业071008-发育生物学
071009-细胞生物学

招生方向细胞内信号传导通路的异常与疾病发生的分子基础
干细胞自我更新及维持的调控机理


教育背景2004-03--2008-09美国西南医学中心博士后
2001-08--2004-02哈佛大学医学院博士后
1996-09--2001-07北京大学博士

学历
学位

工作经历
工作简历2008-10~现在,中科院上海生化细胞所,研究员
2004-03~2008-09,美国西南医学中心,博士后
2001-08~2004-02,哈佛大学医学院,博士后
1996-09~2001-07,北京大学,博士

社会兼职2016-01-01-2021-12-31,第三届发育生物学专业委员会委员,
2015-01-01-2020-12-31,中国细胞生物学学会第十一届理事会理事,


教授课程

专利与奖励
奖励信息（1） 细胞凋亡与NF-kappaB激活的信号传导研究, 一等奖, 部委级, 2006
（2） 全国优秀博士学位论文, 一等奖, 部委级, 2003
（3） 非细胞体系核重建（装配）的系统研究, 一等奖, 部委级, 2001

专利成果（ 1 ） VGLL4基因治疗肿瘤的用途及其相关药物, 2013, 第 4 作者, 专利号: 3.4


出版信息
发表论文（1）Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis,Scientific Reports,2017,第11作者
（2）Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-β2 nuclear import system,PLoS Biology,2017,第11作者
（3）UbcD1 regulates the Hedgehog signaling by directly controlling Ci ubiquitination and processing,EMBO Reports,2017,第11作者
（4）SUMO regulates somatic cyst stem cells maintenance and directly targets Hedgehog pathway in adult Drosophila testis,Development,2016,第11作者
（5）A positive role for polycomb in transcriptional regulation via H4K20me1,Cell Research,2016,第11作者
（6）Set7 mediated Gli3 methylation plays a positive role in the activation of Sonic Hedgehog pathway,eLIFE,2016,第11作者
（7）Chi and dLMO function antagonistically on Notch signaling through directly regulation of fng transcription,Scientific Reports.,2016,第11作者
（8）Deubiquitination of Ci/Gli by Usp7/HAUSP regulates Hedgehog signaling,Developmental Cell.,2015,第11作者
（9）Decoding Ci: From partial degradation to inhibition,Development, Growth & Differentiation,2015,第11作者
（10）Gut-neuron interaction via Hh signaling regulates intestinal progenitor cell differentiation in Drosophila,Cell Discovery,2015,第11作者
（11）Investigation of protein-protein interactions and conformational changes in Hedgehog signaling pathway by FRET,Methods in Molecular Biology, Hedgehog Signaling Protocols (Second Edition, Springer Science), Chapter 6.,2015,第11作者
（12）Sqh is involved in the regulation of Ci stability in Hh signaling pathway.,Journal of Molecular Cell Biology,2015,第11作者
（13）Haiquan Chen# and Hongbin Ji#. Two co-existing germline mutations P53 V157D and PMS2 R20Q promote tumorigenesis in a familial cancer syndrome,Cancer Letters.,2014,第11作者
（14）Bantam is essential for Drosophila intestinal stem cell proliferation in response to Hippo signaling,Developmental Biology.,2014,第11作者
（15）The Kto-Skd complex can regulate ptc expression by interacting with Cubitus interruptus (Ci) in the Hedgehog signaling pathway.,Journal of Biological Chemistry.,2014,第11作者
（16）Structure of the MST4 in Complex with MO25 Provides Insights into Its Activation Mechanism,Structure.,2013,第11作者
（17）Dual roles of Hh signaling in the regulation of somatic stem cell self-renewal and germline stem cell maintenance in Drosophila testis.,Cell Research,2013,第11作者
（18）Hedgehog in the Drosophila testis niche: what does it do there?,Protein and Cell,2013,第11作者
（19）Smoothened Oligomerization/Higher Order Clustering in Lipid Rafts Is Essential for High Hedgehog Activity Transduction,Journal of Biological Chemistry.,2013,第11作者
（20）Par-1 Regulates Tissue Growth by Influencing Hippo Phosphorylation Status and Hippo-Salvador Association.,PLoS Biology,2013,第11作者
（21）A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity.,Cell Research,2013,第11作者
（22）Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling.,Journal of Cell Science,2013,第11作者
（23）Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling,eLIFE.,2013,第11作者
（24）Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci.,Nature Communications.,2013,第11作者
（25）ctivation of Smurf E3 ligase promoted by Smoothened regulates Hedgehog signaling through targeting Patched turnover.,PLoS Biology,2013,第11作者
（26）Ter94 ATPase Complex Targets K11-linked Ubiquitinated Ci to Proteasomes for Partial Degradation. .,Developmental Cell,2013,第11作者
（27）Atrophin/Rpd3 complex represses Hedgehog signaling by acting as a co-repressor of CiR,Journal of Cell Biology,2013,第11作者
（28）aPKC ι/λ: a potential target for the therapy of Hh-dependent and Smo-inhibitor-resistant advanced BCC,Acta Biochimica et Biophysica Sinica.,2013,第11作者
（29）aPKC ι/λ: a potential target for the therapy of Hh-dependent and Smo-inhibitor-resistant advanced BCC,Acta Biochimica et Biophysica Sinica.,2013,第11作者
（30）Dimerization and cytoplasmic localization regulate Hippo kinase signaling activity in organ size control,Journal of Biological Chemistry.,2012,第11作者
（31）Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus (Ci),Cell Research,2011,第11作者
（32）G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila.,Gene and Development,2010,第4作者
（33）Ablation of whirlin long isoform disrupts the USH2 protein complex and causes vision and hearing loss.,PLoS Genet,2010,第3作者
（34）Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade.,PNAS,2009,第11作者
（35）Transducing the Hedgehog Signal Across the plasma Membrane.,Fly,2007,第1作者
（36）Hedgehog regulates Smoothened activity by inducing a conformational switch,Nature,2007,第1作者
（37）Failure of Elastic Fiber Homeostasis Leads to Pelvic Floor Disorders,Am J Pathol.,2006,第2作者
（38）Hedgehog-regulated Costal2/kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus,Developmental Cell,2005,第2作者
（39）Elastic fiber homeostasis requires lysyl oxidase-like 1 protein.,Nature Genetics,2004,第2作者
（40）The retinitis pigmentosa GTPase Regulator (RPGR)-interacting protein: Subserving RPGR function and participating in disk morphogenesis,PNAS,2003,第1作者
（41）Effect of phosphocreatine on apoptosis induced in Xenopus cell-free system,JBC,2001,第1作者
（42）Analysis of nuclear apoptotic process in a cell-free system,Cellular and Molecular Life Science,2001,第1作者
（43）In vitro nuclear reconstitution could be induced in a plant cell-free system,FEBS letters,2000,第1作者
（44）Apoptosis of mouse liver nuclei induced in the cytosol of carrot cells,FEBS letters,1999,第1作者

发表著作

科研活动
科研项目（ 1 ） Hh 信号通路中Ci SUMO 化修饰的作用机制及功能研究, 主持,国家级,2014-01--2017-12
（ 2 ） 发育中PRC1调控H h信号通路Ci/Gli转录的分子机制及功能研究, 主持,国家级,2017-01--2021-12
（ 3 ） 着丝粒蛋白质机器调控细胞命运抉择的效应机制, 参与,国家级,2017-07--2022-06

参与会议（1）Mechanism of the graded Hh signal transduction厦门举办的第三届“模式生物与人类健康”发育遗传学全国学术研讨会。2014-07-18
（2）Mechanism of the graded Hh signal transduction。台北举办的2014 国际癌症新知研讨会/第十一届前瞻生物医学科学新知研讨会暨第十三届海峡两岸生物医学研讨会2014-06-28
（3）Decoding Ci: from partial degradation to inhibition第47 届亚太地区发育生物学年会2014-05-30
（4）Ter94 is involved the selective degradation of Ci新加坡参加会议2013-10-08


合作情况
项目协作单位

指导学生