基本信息
章张男博导中国科学院北京基因组研究所
电子邮件： zhangzhang@big.ac.cn
通信地址： 北京市朝阳区北辰西路1号院中国科学院北京基因组研究所
邮政编码： 100101

研究领域生物信息学/计算生物学


招生信息欢迎生物信息学、计算机科学、数学、物理等专业背景学生报考。




招生专业071021-生物信息学

招生方向生命与健康大数据整合挖掘分析
计算健康基因组学


教育背景2004-09--2007-07中国科学院计算技术研究所计算机科学博士
2002-09--2004-07南京理工大学计算机科学硕士
1998-09--2002-07宁夏大学计算机科学学士


教授课程生命组学
生物信息学前沿讲座
基因组学前沿


科研活动
副主编（Asian Associate Editor）: Briefings in Bioinformatics (2017-)
副主编（Associate Editor-in-Chief）: Genomics, Proteomics & Bioinformatics (2012-)
编委成员：Biology Direct (2013—)
学术编辑（Academic Editor）: PLoS ONE (2012—)




科研项目（ 1 ） 生物信息技术共享、转化研究平台建设, 参与,国家级,2012-01--2016-12
（ 2 ） ****（择优）, 主持,部委级,2014-01--2017-12
（ 3 ） 动物复杂性状的进化解析与调控—动物复杂性状多组学数据的存储与访问平台建设, 主持,部委级,2014-01--2019-12
（ 4 ） 分子模块组学数据整合与辞海系统建设, 主持,部委级,2016-01--2017-12
（ 5 ） 中国人群全基因组测序与系统分析, 主持,国家级,2017-07--2020-12

参与会议（1）RiceWiki: a wiki-based database for community curation of rice genes.Zhang Zhang2014-04-06
（2）Big biological data integration and curation2014中国科学数据大会—科研大数据和数据科学Zhang Zhang2014-02-24
（3）Biocuration in the era of big data.Zhang Zhang2014-02-09
（4）Biological databases: wikify or die.Zhang Zhang2013-10-28
（5）Community curation in biological knowledge wikisZhang Zhang2013-04-07
（6）Next-Generation Bioinformatics: harnessing collective resources for large-scale data manipulationZhang Zhang2012-03-19
（7）Estimating codon usage bias and its statistical significance by accounting for background nucleotide compositionZhang Zhang2011-10-22


指导学生已指导学生
孙世翔博士研究生0710J3-生物信息学
殷红彦博士研究生0710J3-生物信息学
于春蕾硕士研究生0710J3-生物信息学
徐行健博士研究生0710J3-生物信息学
王光煜博士研究生0710J3-生物信息学
现指导学生
夏琳博士研究生0710J3-生物信息学
李漫硕士研究生0710J3-生物信息学
曹佳宝硕士研究生085238-生物工程
桑健博士研究生0710J3-生物信息学
王善正硕士研究生0710J3-生物信息学
王佩硕士研究生0710J3-生物信息学
张阳硕士研究生085211-计算机技术
刘琳博士研究生0710J3-生物信息学
刘晓楠博士研究生0710J3-生物信息学
张亚伟博士研究生0710J3-生物信息学
李昭硕士研究生0710J3-生物信息学
牛广艺博士研究生0710J3-生物信息学
高纯纯博士研究生0710J3-生物信息学
张源笙硕士研究生085238-生物工程

工作经历2016至今 中国科学院北京基因组研究所 “生命与健康大数据中心” 常务副主任
2011至今 中国科学院北京基因组研究所 “****”研究员
2009—2011 沙特阿卜杜拉国王理工大学（King Abdullah University of Science and Technology） 研究科学家
2007—2009 美国耶鲁大学（Yale University） 博士后



发表论著Xia L, Zou D, Sang J, Xu XJ, Yin HY, Li MW, Wu SY, Hu SN, Hao LL, Zhang Z: Rice Expression Database (RED): an integrated RNA-Seq-derived gene expression database for rice. Journal of Genetics and Genomics, 2017, accepted and in press.

Salhi A, Essack M, Alam T,..., Zhang Z, Bajic V: DES-ncRNA: A knowledgebase for exploring information about human micro and long noncoding RNAs based on literature-mining. RNA Biology 2017, accepted and in press.[PMID=**]
Wang YQ, ..., Zhang Z, Zhao WM: GSA: Genome Sequence Archive. Genomics, Proteomics & Bioinformatics 2017, 15(1):14-18.[PMID=**] [Cover Story; Preview]

Xu XJ, Ji ZH,Zhang Z:CloudPhylo: a fast and scalable tool for phylogeny reconstruction. Bioinformatics 2017, 33 (3):438-440. [PMID=**]
Zhang Z authored in The RNAcentral Consortium: RNAcentral: a comprehensive database of non-coding RNA sequences. Nucleic Acids Res 2017, 45(D1):D128-D134.[PMID=**]
Zhang Z as corresponding author in BIG Data Center Members: The BIG Data Center: from deposition to integration to translation. Nucleic Acids Res 2017, 45(D1):D18-D24.[PMID=**]
Zhao W, Zhang S, Tang B, Chen T, Hao L, Sang J, Li R, Xiao J, Zhang Z: Constructing the international database management system for omics big data. BigDataResearch2016,2(6):43-52.(InChinese)
Xue Y, ..., Zhang Z., Huang K, Yu J: Precision Medicine: What Challenges Are We Facing? Genomics Proteomics Bioinformatics 2016, 14(5):253-261. [PMID=**]

Yin HY, Wang GY, Ma LN, Yi SV,Zhang Z:What signatures dominantly associate with gene age?Genome Biology and Evolution 2016, 8(10):3083-9.[PMID=**]
Sun SX, Xiao JF, Zhang HY*,Zhang Z: Pangenome evidence for higher codon usage bias and stronger translational selection in core genes of Escherichia coli. Frontiers in Microbiology 2016, 7:1180.[PMID=**]
Yin HY, Ma LN, Wang GY, Li MW,Zhang Z: Old genes experience stronger translational selection than young genes. Gene2016, 590(1):29-34.[PMID=**]
Tian X, Zhang Z, Yang T, Chen M, Li J, Chen F, Yang J, Li W, Zhang B, Zhang Z, Wu J, Zhang C, Long L, Xiao J: Comparative genomics analysis of Streptomyces species reveals their adaptation to the marine environment and their diversity at the genomic level. Frontiers in Microbiology 2016, 7:998. [PMID=**]

Wang GY, Sun SX,Zhang Z: Randomness in sequence evolution increases over time. PLoS One 2016,11(5): e**. [PMID=**]
Zhang Z as corresponding author in IC4R Project Consortium:Information Commons for Rice (IC4R).Nucleic Acids Res2016, 44(D1):D1172-1180.[PMID=**]

Zhang Y, Chen LL, Zhang Z: The Curation and Analysis of Rice Stress-Resistance Genes Based on RiceWiki. Hans Journal of Computational Biology 2015, 5(3):29-40. (in Chinese)

Zou D, Sun S, Li R, Liu J, Zhang J, Zhang Z:MethBank: a database integrating next-generation sequencing single-base-resolution DNA methylation programming data. Nucleic Acids Res2015, 43(Database issue):D54-58.[PMID=**]
Zou D, Ma L, Yu J, Zhang Z:Biological databases for human research.Genomics Proteomics Bioinformatics2015, 13(1):55-63.[PMID=**]
Ma L, Li A, Zou D, Xu X, Xia L, Yu J, Bajic VB, Zhang Z:LncRNAWiki: harnessing community knowledge in collaborative curation of human long non-coding RNAs.Nucleic Acids Res2015, 43(Database issue):D187-192.[PMID=**]
Bai B, Zhao WM, Tang BX, Wang YQ, Wang L, Zhang Z, Yang HC, Liu YH, Zhu JW, Irwin DM, Wang GD, Zhang YP:DoGSD: the dog and wolf genome SNP database.Nucleic Acids Res2015, 43(Database issue):D777-783.[PMID=**]
Zhao Y, Jia X, Yang J, Ling Y, Zhang Z, Yu J, Wu J, Xiao J:PanGP: a tool for quickly analyzing bacterial pan-genome profile.Bioinformatics2014, 30(9):1297-1299.[PMID=**]
Zhang Z, Zhu W, Luo J:Bringing biocuration to China.Genomics Proteomics Bioinformatics2014, 12(4):153-155.[PMID=**]
Zhang Z, Sang J, Ma L, Wu G, Wu H, Huang D, Zou D, Liu S, Li A, Hao L, Tian M, Xu C, Wang X, Wu J, Xiao J, Dai L, Chen LL, Hu S, Yu J:RiceWiki: a wiki-based database for community curation of rice genes.Nucleic Acids Res2014, 42(Database issue):D1222-1228.[PMID=**]
Xu P, Zhang X, Wang X, Li J, Liu G, Kuang Y, Xu J, Zheng X, Ren L, Wang G, Zhang Y, Huo L, Zhao Z, Cao D, Lu C, Li C, Zhou Y, Liu Z, Fan Z, Shan G, Li X, Wu S, Song L, Hou G, Jiang Y, Jeney Z, Yu D, Wang L, Shao C, Song L, Sun J, Ji P, Wang J, Li Q, Xu L, Sun F, Feng J, Wang C, Wang S, Wang B, Li Y, Zhu Y, Xue W, Zhao L, Wang J, Gu Y, Lv W, Wu K, Xiao J, Wu J, Zhang Z, Yu J, Sun X:Genome sequence and genetic diversity of the common carp, Cyprinus carpio.Nat Genet2014, 46(11):1212-1219.[PMID=**]
Wu J, Xiao J, Zhang Z, Wang X, Hu S, Yu J:Ribogenomics: the science and knowledge of RNA.Genomics Proteomics Bioinformatics2014, 12(2):57-63.[PMID=**]
Wu H, Fang Y, Yu J, Zhang Z:The quest for a unified view of bacterial land colonization.The ISME journal2014, 8(7):1358-1369.[PMID=**]
Wu G, Zhu J, Yu J, Zhou L, Huang JZ, Zhang Z:Evaluation of five methods for genome-wide circadian gene identification.Journal of biological rhythms2014, 29(4):231-242.[PMID=**]
Ma L, Cui P, Zhu J, Zhang Z, Zhang Z:Translational selection in human: more pronounced in housekeeping genes.Biol Direct2014, 9:17.[PMID=**]
Kang Y, Gu C, Yuan L, Wang Y, Zhu Y, Li X, Luo Q, Xiao J, Jiang D, Qian M, Ahmed Khan A, Chen F, Zhang Z, Yu J:Flexibility and symmetry of prokaryotic genome rearrangement reveal lineage-associated core-gene-defined genome organizational frameworks.mBio2014, 5(6):e01867.[PMID=**]
Zhang Z, Yu J:Does the genetic code have a eukaryotic origin?.Genomics Proteomics Bioinformatics2013, 11(1):41-55.[PMID=**]
Zhang Z, Wong GK, Yu J:Protein coding.Encyclopedia of Life Sciences (eLS)2013.[Link]
Wu J, Xiao J, Wang L, Zhong J, Yin H, Wu S, Zhang Z, Yu J:Systematic analysis of intron size and abundance parameters in diverse lineages.Sci China Life Sci2013, 56(10):968-974.[PMID=**]
Tong X, Yang Y, Wang W, Bai Z, Ma L, Zheng X, Sun H, Zhang Z, Zhao M, Yu J, Ge RL:Expression profiling of abundant genes in pulmonary and cardiac muscle tissues of Tibetan Antelope (Pantholops hodgsonii).Gene2013, 523(2):187-191.[PMID=**]
Ma L, Bajic VB, Zhang Z:On the classification of long non-coding RNAs.RNA Biol2013, 10(6):925-933.[PMID=**]
Dai L, Xu C, Tian M, Sang J, Zou D, Li A, Liu G, Chen F, Wu J, Xiao J, Wang X, Yu J, Zhang Z:Community intelligence in knowledge curation: an application to managing scientific nomenclature.PLoS One2013, 8(2):e56961.[PMID=**]
Dai L, Tian M, Wu J, Xiao J, Wang X, Townsend JP, Zhang Z:AuthorReward: increasing community curation in biological knowledge wikis through automated authorship quantification.Bioinformatics2013, 29(14):1837-1839.[PMID=**]
Chen M, Xiao J, Zhang Z, Liu J, Wu J, Yu J:Identification of human HK genes and gene expression regulation study in cancer from transcriptomics data analysis.PLoS One 2013, 8(1):e54082.[PMID=**]
Zhang Z, Yu J:The pendulum model for genome compositional dynamics: from the four nucleotides to the twenty amino acids.Genomics Proteomics Bioinformatics2012, 10(4):175-180.[PMID=**]
Zhang Z, Xiao J, Wu J, Zhang H, Liu G, Wang X, Dai L:ParaAT: a parallel tool for constructing multiple protein-coding DNA alignments.Biochem Biophys Res Commun2012, 419(4):779-781.[PMID=**]
Wu H, Zhang Z, Hu S, Yu J:On the molecular mechanism of GC content variation among eubacterial genomes.Biol Direct2012, 7(1):2.[PMID=**]
Wu H, Qu H, Wan N, Zhang Z, Hu S, Yu J:Strand-biased gene distribution in bacteria is related to both horizontal gene transfer and strand-biased nucleotide composition.Genomics Proteomics Bioinformatics2012, 10(4):186-196.[PMID=**]
Dai L, Gao X, Guo Y, Xiao J, Zhang Z:Bioinformatics clouds for big data manipulation.Biol Direct2012, 7:43; discussion 43.[PMID=**]
Cui P, Ding F, Lin Q, Zhang L, Li A, Zhang Z, Hu S, Yu J:Distinct contributions of replication and transcription to mutation rate variation of human genomes.Genomics Proteomics Bioinformatics2012, 10(1):4-10.[PMID=**]
Zhang Z, Li J, Cui P, Ding F, Li A, Townsend JP, Yu J:Codon Deviation Coefficient: a novel measure for estimating codon usage bias and its statistical significance.BMC Bioinformatics2012, 13(1):43.[PMID=**]
Cui P, Liu W, Zhao Y, Lin Q, Zhang D, Ding F, Xin C, Zhang Z, Song S, Sun F, Yu J, Hu S:Comparative analyses of H3K4 and H3K27 trimethylations between the mouse cerebrum and testis.Genomics Proteomics Bioinformatics2012, 10(2):82-93.[PMID=**]
Zhang Z, Bajic VB, Yu J, Cheung K-H, Townsend JP: Data Integration in Bioinformatics: Current Efforts and Challenges. In: Bioinformatics - Trends and Methodologies. Edited by Mahdavi MA, vol. 1. Rijeka, Croatia: InTech; 2011: 41-56.[Link]
Zhang Z, Yu J:On the organizational dynamics of the genetic code.Genomics Proteomics Bioinformatics 2011, 9(1-2):21-29.[PMID=**]

Zhang Z, Yu J:Modeling compositional dynamics based on GC and purine contents of protein-coding sequences.Biol Direct2010, 5(1):63.[PMID=**]
Zhang Z, Townsend JP:The filamentous fungal gene expression database (FFGED).Fungal Genet Biol2010, 47(3):199-204.[PMID=**]
Zhang Z, Lopez-Giraldez F, Townsend JP:LOX: inferring Level Of eXpression from diverse methods of census sequencing.Bioinformatics2010, 26(15):1918-1919.[PMID=**]
Wang D, Zhang Y, Zhang Z, Zhu J, Yu J:KaKs_Calculator 2.0: a toolkit incorporating gamma-series methods and sliding window strategies.Genomics Proteomics Bioinformatics2010, 8(1):77-80.[PMID=**]
Qu H, Wu H, Zhang T, Zhang Z, Hu S, Yu J:Nucleotide compositional asymmetry between the leading and lagging strands of eubacterial genomes.Res Microbiol2010, 161(10):838-846.[PMID=**]
Zhang Z, Townsend JP:Maximum-likelihood model averaging to profile clustering of site types across discrete linear sequences.PLoS Comput Biol2009, 5(6):e**.[PMID=**]
Zhang Z, Cheung KH, Townsend JP:Bringing Web 2.0 to bioinformatics.Briefings in Bioinformatics2009, 10(1):1-10.[PMID=**]
Li J, Zhang Z, Vang S, Yu J, Wong GK, Wang J:Correlation between Ka/Ks and Ks is related to substitution model and evolutionary lineage.J Mol Evol2009, 68(4):414-423.[PMID=**]
Zheng H, Shi J, Fang X, Li Y, Vang S, Fan W, Wang J, Zhang Z, Wang W, Kristiansen K, Wang J:FGF: a web tool for Fishing Gene Family in a whole genome database.Nucleic Acids Res2007, 35(Web Server issue):W121-125.[PMID=**]
Zhao X, Zhang Z, Yan J, Yu J:GC content variability of eubacteria is governed by the pol III alpha subunit.Biochem Biophys Res Commun2007, 356(1):20-25.[PMID=**]
Hu J, Zhao X, Zhang Z, Yu J:Compositional dynamics of guanine and cytosine content in prokaryotic genomes.Res Microbiol2007, 158(4):363-370.[PMID=**]
Zhang Z, Yu J:Evaluation of six methods for estimating synonymous and nonsynonymous substitution rates.Genomics Proteomics Bioinformatics2006, 4(3):173-181.[PMID=**]
Zhang Z, Li J, Zhao XQ, Wang J, Wong GK, Yu J:KaKs_Calculator: calculating Ka and Ks through model selection and model averaging.Genomics Proteomics Bioinformatics2006, 4(4):259-263.[PMID=**]
Zhang Z, Li J, Yu J:Computing Ka and Ks with a consideration of unequal transitional substitutions.BMC Evol Biol2006, 6:44.[PMID=**]
Li H, Coghlan A, Ruan J, Coin LJ, Heriche JK, Osmotherly L, Li R, Liu T, Zhang Z, Bolund L, Wong GK, Zheng W, Dehal P, Wang J, Durbin R:TreeFam: a curated database of phylogenetic trees of animal gene families.Nucleic Acids Res2006, 34(Database issue):D572-580.[PMID=**]