基本信息
张利民男博导中国科学院武汉物理与数学研究所
电子邮件： zhanglm@wipm.ac.cn
通信地址： 武汉市武昌区小洪山西30号
邮政编码： 430071
部门/实验室：磁共振应用部
研究领域

招生信息
招生专业070302-分析化学

招生方向色谱质谱分析、核磁共振分析
环境化学
代谢组学


教育背景2002-09--2007-06中科院武汉物理与数学研究所理学博士学位
1995-09--1999-07华中师范大学学士学位

学历
学位

工作经历
工作简历2016-10~现在,中科院武汉物理与数学研究所,研究员，磁共振应用部副主任，生物医学代谢组学研究组组长
2012-02~2016-02,美国宾夕法尼亚州州立大学,Research associate
2010-10~2016-10,中科院武汉物理与数学研究所,副研究员
2007-07~2010-10,中科院武汉物理与数学研究所,助理研究员
2002-09~2007-06,中科院武汉物理与数学研究所,理学博士学位
1999-07~2002-09,湖北省宜昌市第一中学,中级化学教师
1995-09~1999-07,华中师范大学,学士学位

社会兼职2018-12-31-2021-11-30,华中科技大学兼职教授, 教授
2018-01-01-2019-12-31,《波谱学杂志》青年编委,


教授课程磁共振前沿讲座


专利与奖励
奖励信息（1） 武汉市“3551”创新人才, 市地级, 2017
（2） 年度考核优秀, 研究所（学校）, 2016
（3） 年度考核优秀, , 研究所（学校）, 2011
（4） 年度考核优秀, , 研究所（学校）, 2010
（5） 年度考核优秀, , 研究所（学校）, 2009
（6） 优秀青年教师, 一等奖, 市地级, 2002
（7） 优秀青年教师, 一等奖, 市地级, 2001

专利成果（ 1 ） 纳米技术 纳米生物效应代谢组学方法 核磁共振波谱法, 2017, 第 1 作者, 专利号: GB/T-34059-2017


出版信息
发表论文（1）Metabolomics Reveals that Dietary Ferulic Acid and Quercetin Modulate Metabolic Homeostasis in Rats,J. Agric. Food. Chem.,2018,第11作者
（2）Colon Ascendens Stent Peritonitis (CASP) Induces Excessive Inflammation and Systemic Metabolic Dysfunction in a Septic Rat Model,J. Proteome Res.,2018,第11作者
（3）Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer,Cell,2018,第8作者
（4）Metabolomics Reveals Aryl Hydrocarbon Receptor Activation Induces Liver and Mammary Gland Metabolic Dysfunction in Lactating Mice,J. Proteome Res.,2018,第3作者
（5）Multiplatform Physiologic and Metabolic Phenotyping Reveals Microbial Toxicity,mSystem,2018,第5作者
（6）Metabolomic Approaches Reveal the Role of CAR in Energy Metabolism,J. Proteome Res.,2018,第4作者
（7）The aryl hydrocarbon receptor as a moderator of host-microbiota communication,Current Opinion in Toxicology,2017,第1作者
（8）A prenatal interruption of DISC1 function in the brain exhibits a lasting impact on adult behaviors, brain metabolism, and interneuron development,Oncotarget,2017,第11作者
（9）Biological effects of amphiphilic copolymer nanoparticle-encapsulated multi-target chemotherapeutic drugs on MCF-7 human breast cancer cells,Metabolomics,2017,第2作者
（10）Orthogonal Comparison of GC-MS and 1H NMR Spectroscopy for Short Chain Fatty Acid Quantitation,Analytical Chemistry,2017,第4作者
（11）Fusarium oxysporum mediates systems metabolicreprogramming of chickpea roots as revealed by acombination of proteomics and metabolomics,Plant Biotechnology Journal,2016,第1作者
（12）Antioxidant Drug Tempol Promotes Functional Metabolic Changes inthe Gut Microbiota,J. Proteome Res.,2016,第2作者
（13）Perfluorooctane Sulfonate-Choline Ion Pair Formation:A Potential Mechanism Modulating Hepatic Steatosisand Oxidative Stress in Mice,Toxiciology Sciences,2016,第1作者
（14）Expression of the aryl hydrocarbonreceptor contributes to theestablishment of intestinalmicrobial community structure inmice,Scitific Reports,2016,第3作者
（15）Farnesoid X Receptor Signaling Shapesthe Gut Microbiota and Controls HepaticLipid Metabolism,mSystems,2016,第1作者
（16）NMR-Based Metabolomics and Its Application in DrugMetabolism and Cancer Research,Curr Pharmacol Rep,2016,第1作者
（17）The Aryl Hydrocarbon Receptor as a Modulator of Host-MicrobiotaInteraction,Current Opinion Toxicology,2016,第1作者
（18）Reversing methanogenesis to capturemethane for liquid biofuel precursors,Microb Cell Fact,2016,第4作者
（19）Microbiota-Dependent Hepatic Lipogenesis Mediatedby Stearoyl CoA Desaturase 1 (SCD1)Promotes Metabolic Syndrome in TLR5-Deficient Mice,Cell Metabolism,2015,第3作者
（20）Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation byEnvironmental Chemicals Induces Systemic Metabolic Dysfunction inMice,Environmental Sciences & Technology.,2015,第1作者
（21）Quantitative Analysis of Purine Nucleotides Reveals Purinosomes Increase de Novo Purine Biosynthesis,Journal of Biological Chemistry,2015,第3作者
（22）Persistent Organic Pollutants Modify Gut Microbiota–Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation,Environmental Health Perspective,2015,第1作者
（23）Intestinal farnesoid X receptor signaling promotes non-alcoholic fatty liver disease,Journal of Clinical Investigation,2015,第4作者
（24）Combined NMR and GC？MS Analyses Revealed Dynamic Metabolic Changes Associated with the Carrageenan-Induced Rat Pleurisy,J. Proteome Res. ,2015,第2作者
（25）Metabonomic Analysis Reveals Efficient Ameliorating Effects of Acupoint Stimulations on the Menopause-caused Alterations in Mammalian Metabolism,Scitific Reports ,2014,第1作者
（26）Dynamic metabolomic responses of Escherichia coli to nicotine stress,Canadian Journal of Microbiolo,2014,第11作者
（27）Selective metabolic effects of gold nanorods on normal and cancer cells and their application in anticancer drug screening,Biomaterials,2013,第1作者
（28）Rapid Diagnosis and Prognosis of de novo Acute Myeloid Leukemia by Serum Metabonomic Analysis,J. Proteome Res. ,2013,第1作者
（29）Metabolic Phenotypes Associated with High-Temperature Tolerance of Porphyra haitanensis Strains,J. Agric. Food Chem. ,2013,第2作者
（30）, High-Fat Diet Induces Dynamic Metabolic Alterations in Multiple Biological Matrices of Rats,J. Proteome Res. ,2013,第11作者
（31）Combined NMR and GC？MS Analyses Revealed Dynamic Metabolic Changes Associated with the Carrageenan-Induced Rat Pleurisy,J. Proteome Res. ,2013,第11作者
（32）Nano-cellulose 3D-networks as controlled-release drug carriers,J. Mater. Chem. B,2013,第11作者
（33）Global metabolomic responses of E. coli HB101 to heat stress,J. Proteome Res.,2012,第2作者
（34）Age-Related Topographical Metabolic Signatures for the Rat Gastrointestinal Contents,J. Proteome Res.,2012,第2作者
（35）Unraveling the concentration-dependent metabolic response of Pseudomonas sp. HF-1 to nicotine stress by 1H NMR-based metabolomics,Ecotoxicology,2012,第3作者
（36）Comprehensive Solid-State NMR Analysis Reveals the Effects of N-methylation on the Molecular Dynamics of Glycine,J. Phys. Chem. B,2012,第3作者
（37）Systems Biological Responses of Rats to Aflatoxin B1 Exposure Revealed by Metabonomic NMR Analysis,J. Proteome Res.,2011,第1作者
（38）Understanding the Molecular Dynamics Associated with Polymorphic Transitions of dl-Norvaline with Solid-State NMR Methods,J. Phys. Chem. B,2011,第4作者
（39）A solid-state NMR study of structure and segmental dynamics of poly(propylmethacrylheptaisobutyl-pss)-co-styrene nanocomposites,J Colloid and Interface Sci .,2011,第2作者
（40）Beyond the T1 limit: Quantitative measure- ment in solid state NMR, Journal of the American Chemical Society,2010,第3作者
（41）An insight into the metabolic responses of ultra-small superparamagnetic particles of iron oxide using metabonomic analysis of biofluids,Nanotechnology ,2010,第3作者
（42）NMR analysis of metabolite composition of Escherichia coli,Chinese Analytical Chemistry,2010,第2作者
（43）Solid State NMR Studies of the Structure and Mobility of Semi-crystalline Poly(3-hydroxybutyrate) and Poly(3-hydroxybutyrate-co-3-hydroxyvalerate),polymer,2007,第1作者
（44）Interactions between Nafion Resin and Protonated Dodecylamine Modified Montmorillonite: A Solid State NMR Study,J Colloid and Interface Sci,2007,第1作者

发表著作

科研活动
科研项目（ 1 ） 典型代谢物分子动力学与结构依赖性的固体NMR研究, 主持,国家级,2010-01--2013-06
（ 2 ） 黄曲霉毒素毒性和致病机理及药物的预防作用, 主持,部委级,2008-01--2010-01
（ 3 ） 有害物质引发动物应答的代谢组变化研究, 参与,国家级,2009-01--2013-12
（ 4 ） 转基因小麦快速甄别与检测技术, 参与,国家级,2009-06--2011-12
（ 5 ） 花生四烯酸及代谢组学研究, 参与,国家级,2010-01--2014-12
（ 6 ） 基于宿主代谢和肠道菌群变化研究四氯二苯并呋喃诱导肥胖发生的分子机理, 主持,国家级,2016-01--2019-12
（ 7 ） 基于质谱探针技术的模型鼠粪便代谢物全分析方法学研究, 参与,国家级,2017-01--2021-12
（ 8 ） 基于宿主代谢和肠道菌群调节研究多环芳烃核受体AHR抑制改善肥胖的分子机理, 主持,省级,2017-01--2018-12
（ 9 ） 特定位点同位素的食品真实性鉴定 核磁共振技术及应用, 主持,省级,2017-01--2019-12

参与会议（1）Application of Metabolomics in Environmental HealthLimin Zhang2018-08-24
（2）肠道菌群与四氯二苯并呋喃(TCDF)诱导的脂肪肝第九届全国环境化学大会2017-10-19
（3）In Vitro Biological Effects of Different Surface Modified Gold Nanorods: An NMR -based Metabolomics Study2017-09-16
（4）Applications of Metabolomics in Environmental Health,2017-04-20
（5）Gut microbiota contributes to TCDF-induced lipogenesis in mice2016-07-01
（6）Metabolomics and its application in biological effects of gold nano-rods2016-04-12
（7）The role of gut microbiota in the liver metabolic disorders induced by mild hepatic injury in miceLimin Zhang, Emmanuel Hatzakis, Ruixin Hao, Robert G. Nichols, Jingwei Cai, Philip B. Smith, Gary H. Perdew, Frank J. Gonzalez, Andrew D. Patterson, 2015-03-23
（8）Aryl Hydrocarbon Receptor Activation by Persistent Organic Pollutants Impacts Gut Microbiota-Host Metabolic Homeostasis in Mice3.Limin Zhang, Robert G. Nichols, Jared Correll, Iain A. Murray, Naoki Tanaka, Philip Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, A2014-03-22
（9）Systems Biological Responses of Rats to Aflatoxin B1 Exposure Revealed by Metabonomic NMR AnalysisL. M. Zhang, Y. Ye, Y. P. An, Y. L. Wang, H. R. Tang2010-04-22
（10）Metabonomics methods developmentLimin Zhang2009-11-30
（11）Molecular Dynamics in the Semi-crystalline Poly(3-hydroxybutyrate) and Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) as Studied by Solid State NMR SpectroscopyL. Zhang, H. Tang, G. Hou, Y. Shen, F. Deng,2005-07-19


合作情况
项目协作单位

指导学生