基本信息
徐明男硕导中国科学院生态环境研究中心
电子邮件： mingxu@rcees.ac.cn
通信地址： 北京市海淀区双清路18号，中国科学院生态环境研究中心
邮政编码： 100085
部门/实验室：人事教育处
研究领域

招生信息
招生专业083001-环境科学
070302-分析化学
0703J1-纳米科学与技术

招生方向典型环境污染物的靶蛋白识别与毒性机理
环境污染物与人体健康


教育背景2006-09--2011-06厦门大学，化学化工学院理学博士
2002-09--2006-06厦门大学，化学化工学院理学学士

学历
学位

工作经历
工作简历2016-01~现在,中国科学院生态环境研究中心，环境化学与生态毒理学国家重点实验室,副研究员
2014-02~2015-12,中国科学院生态环境研究中心，环境化学与生态毒理学国家重点实验室,助理研究员
2011-09~2013-12,法国国家科学研究院（CNRS）,博士后
2006-09~2011-06,厦门大学，化学化工学院,理学博士
2002-09~2006-06,厦门大学，化学化工学院,理学学士

社会兼职

教授课程现代生物学技术在环境健康研究中的应用


专利与奖励
奖励信息
专利成果

出版信息
发表论文（1）LncRNA PU.1 AS regulates arsenic-induced lipid metabolism through EZH2/Sirt6/SREBP-1c pathway,Journal of Environmental Sciences-China,2019-11,第4作者
（2）Protein target identification and toxicological mechanism investigation of silver nanoparticles-induced hepatotoxicity by integrating proteomic and metallomic strategies,Particle and Fibre Toxicology,2019-09,第1作者
（3）Desferrioxamine-caffeine shows improved efficacy in chelating iron and depleting cancer stem cells,Journal of Trace Elements in Medicine and Biology,2019-03,第5作者
（4）How Entanglement of Different Physicochemical Properties Complicates the Prediction of in Vitro and in Vivo Interactions of Gold Nanoparticles,ACS Nano,2018-09,第1作者
（5）大气细颗粒物导致呼吸系统疾病及相关生物机制的研究进展,中国科学：化学,2018,第11作者
（6）Computational Investigations of the Interaction between the Cell Membrane and Nanoparticles Coated with Pulmonary Surfactant,ACS Applied Materials & Interfaces,2018,第2作者
（7）Reduction of Graphene Oxide Alters Its Cyto-Compatibility Towards Primary and Immortalized Macrophages,Nanoscale,2018,第5作者
（8）Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles,Journal of Environmental Sciences-China,2018,第11作者
（9）Low-dose exposure of graphene oxide significantly increases metal toxicity to macrophages by altering their cellular priming state,Nano Research,2018,第1作者
（10）Molybdenum disulfide (MoS2)/graphene oxide (GO) nanocomposites show favorable lung targeting and enhanced drug loading/tumor-killing efficacy with improved biocompatibility,NPG Asia Materials,2018,第4作者
（11）LncRNA UCA1 attenuates autophagy-dependent cell death through blocking autophagic flux under arsenic stress,Toxicology Letters,2018,第3作者
（12）Graphene oxide regulates cox2 in human embryonic kidney 293T cells via epigenetic mechanisms: dynamic chromosomal interactions,Nanotoxicology,2018,第4作者
（13）Long non-coding RNA MT1DP shunts the cellular defense to cytotoxicity through crosstalk with MT1H and RhoC in cadmium stress,Cell Discovery,2018,第4作者
（14）LncRNA MT1DP Aggravates Cadmium‐Induced Oxidative Stress by Repressing the Function of Nrf2 and is Dependent on Interaction with miR‐365,Advanced Science,2018,第3作者
（15）Graphene Oxide Induced Perturbation to Plasma Membrane and Cytoskeletal Meshwork Sensitize Cancer Cells to Chemotherapeutic Agents,ACS Nano,2017,第11作者
（16）A protective role of Heme-regulated eIF2a kinase in cadmium-induced liver and kidney injuries,Chemosphere,2017,第4作者
（17）Genome-Wide DNA Methylation Variations upon Exposure to Engineered Nanomaterials and Their Implications in Nanosafety Assessment,Advanced Materials,2017,第2作者
（18）Nrf-2-driven long noncoding RNA ODRUL contributes to modulating silver nanoparticle-induced effects on erythroid cells,Biomaterials,2017,第5作者
（19）纳米银生物过程及影响的研究进展,中国材料进展,2016,第1作者
（20）Improved In Vitro and In Vivo Biocompatibility of Graphene Oxide through Surface Modification: Poly(Acrylic Acid)-Functionalization is Superior to PEGylation,ACS Nano,2016,第1作者
（21）Se-Hg Dual-element Labeling Strategy for Selectively Recognizing Selenoprotein and Selenopeptide,Chinese Journal of Analytical Chemistry,2015,第1作者
（22）Disruption of iron homeostasis and resultant health effects upon exposure to various environmental pollutants: A critical review,Journal of Environmental Sciences-China,2015,第11作者
（23）Silver nanoparticle-induced hemoglobin decrease involves alteration of histone 3 methylation status,Biomaterials,2015,第4作者
（24）Development of a non-denaturing 2D gel electrophoresis protocol for screening in vivo uranium-protein targets in Procambarus clarkii with laser ablation ICP MS followed by protein identification by HPLC–Orbitrap MS,Talanta,2014,第1作者
（25）Non-denaturating isoelectric focusing gel electrophoresis for uranium–protein complexes quantitative analysis with LA-ICP MS,Analytical and Bioanalytical Chemistry,2014,第1作者
（26）Investigating the response of cuproproteins from oysters (Crassostrea gigas) after waterborne copper exposure by metallomic and proteomic,Metallomics,2014,第1作者
（27）Nanosilver incurs an adaptive shunt of energy metabolism mode to glycolysis in tumor and nontumor cells,ACS Nano,2014,第3作者
（28）Chemical interactions of mercury species and some transition and noble metals towards metallothionein (Zn7MT-2) evaluated using SEC/ICP-MS, RP-HPLC/ESI-MS and MALDI-TOF-MS,Metallomics,2013,第1作者
（29）A way to probe the microenvironment of free sulfhydryls in intact proteins with a series of monofunctional organic mercurials,Chemistry - A European Journal,2012,第1作者
（30）A dual-labelling strategy for integrated ICPMS and LIF for the determination of peptides,Journal of Analytical Atomic Spectrometry,2011,第3作者
（31）Strategies for Protein Quantification by Integrated Elemental and Molecular Mass Spectrometry,Clinical Chemistry and Laboratory Medicine,2011,第2作者
（32）Dynamic labeling strategy with 204Hg-isotopic methylmercurithiosalicylate for absolute peptide and protein quantification,Analytical Chemistry,2010,第1作者
（33）Free cadmium ions released from CdTe-based nanoparticles and their cytotoxicity on Phaeodactylum tricornutum,Metallomics,2010,第1作者
（34）Absolute quantification of intact proteins via 1,4,7,10-tetraazacyclododecane-1,4,7-trisacetic acid-10-maleimidoethylacetamide-europium labeling and HPLC coupled with species-unspecific isotope dilution ICPMS,Analytical Chemistry,2010,第2作者
（35）Strategy for absolute quantification of proteins: CH3Hg+ labeling integrated molecular and elemental mass spectrometry,Journal of Analytical Atomic Spectrometry,2009,第2作者
（36）Quantification of selenium-tagged proteins in human plasma using species-unspecific isotope dilution ICP-DRC-qMS coupled on-line with anion exchange chromatography,Journal of Analytical Atomic Spectrometry,2008,第1作者

发表著作

科研活动
科研项目（ 1 ） 基于金属组学揭示纳米银肝细胞毒性的分子机制, 主持,国家级,2015-01--2017-12
（ 2 ） 探索纳米银与重要蛋白相互作用的分子机制, 主持,市地级,2015-01--2015-12
（ 3 ） 耐极端条件的有机含氟纳米材料的研究, 主持,国家级,2015-01--2019-08
（ 4 ） 典型人工纳米材料的水环境过程、生物效应及其调控研究, 主持,国家级,2014-01--2018-12
（ 5 ） 环境污染物的毒性效应与机制, 主持,国家级,2020-01--2022-12
（ 6 ） 2019年度中国科学院青年创新促进会, 主持,部委级,2019-01--2022-12

参与会议（1）纳米银的转化与肝脏毒性机理第六届青年地学论坛2019-10-12
（2）纳米银的靶蛋白识别与肝脏毒性机理第十届全国环境化学大会2019-08-15
（3）纳米银杀伤肿瘤细胞的毒理机制中国毒理学会分析毒理专业委员会—青年委员会成立大会暨2018年学术研讨会2018-12-08
（4）Molecular mechanism of silver nanoparticles-induced hepatotoxicityMing Xu, Lining Xu, Sijin Liu2018-10-18
（5）基于元素质谱技术揭示金纳米颗粒的理化特性与生物作用规律第五届全国原子光谱及相关技术学术会议徐明，刘思金2018-09-20
（6）基于MoS2/GO纳米复合物良好生物相容性的肺部靶向载药抗肿瘤研究中国化学会第31届学术年会2018-05-05
（7）利用组学方法揭示纳米银生物毒性的蛋白分子作用机制第一届全国环境化学青年论坛2018-04-20
（8）纳米银的肝细胞毒性及分子作用机理第二届全国环境纳米技术及生物效应学术研讨会2018-04-18
（9）纳米材料在体内的转化、归趋和排泄第四届青年环境纳米效应研讨会2017-09-01
（10）Investigation of Graphene Oxide-Induced Biological Effects and Underlying Molecular Mechanisms2017-08-19
（11）利用组学研究策略揭示纳米银生物毒性的分子机制第四届全国原子光谱及相关技术学术会2016-09-23
（12）氧化石墨烯与细胞膜作用机制研究全国环境纳米技术及生物效应学术研讨会2016-04-08
（13）氧化石墨烯的生物安全性研究第八届全国环境化学大会2015-11-05


合作情况
项目协作单位

指导学生