基本信息
徐卉芳女硕导中国科学院青岛生物能源与过程研究所
电子邮件： xu_hf@qibebt.ac.cn
通信地址： 山东省青岛市崂山区松岭路189号
邮政编码： 266101

研究领域

招生信息
招生专业071010-生物化学与分子生物学
071005-微生物学

招生方向蛋白质工程，分子酶学，合成生物学
合成生物学，生物工程


教育背景1999-09--2002-07中国科学院微生物研究所博士

学历
学位

工作经历
工作简历2015-07~现在,中国科学院青岛生物能源与过程研究所,副研究员
2008-08~2015-03,Imperial College London, UK,Senior Research Associate
2004-10~2007-12,Imperial College London, UK,Research Associate
2002-08~2004-10,纽英伦生物技术（北京）有限公司,研发部主任兼生产部经理
1999-09~2002-07,中国科学院微生物研究所,博士

社会兼职2018-04-16-今,EDITORIAL BOARD MEMBER of American Journal of Bioscience and Bioengineering (BIO), EDITORIAL BOARD MEMBER


教授课程

专利与奖励
奖励信息（1） 最佳展板奖, 其他, 2018
（2） Best poster prize, The 18th CLSS-UK Annual Meeting. London UK, 其他, 2012
（3） Best poste prize, The XXIInd FECTS Meeting. Davos, Swiss, 其他, 2010
（4） Conference Attendance Award, ICGEB (International Centre for Genetic Engineering and Biotechnology), 其他, 2007

专利成果（ 1 ） Production of Alpha-Olefins, 2016, 第 5 作者, 专利号: WO A1
（ 2 ） Method for detecting hydrogen peroxide conversion activity of an enzyme, 2017, 第 2 作者, 专利号: EP**.9
（ 3 ） 3.IMPROVED CYTOCHROME P450 FATTY ACID DECARBOXYLASES, 2018, 第 2 作者, 专利号: EP**.4


出版信息
发表论文（1）Biochemical characterization of three new α-olefin-producing P450 fatty acid decarboxylases with a halophilic property,Biotechnology for Biofuels,2019,第11作者
（2）Mutagenesis and redox partners analysis of the P450 fatty acid decarboxylase OleTJE,Scientific Reports,2017,第1作者
（3）In vitro oxidative decarboxylation of free fatty acids to terminal alkenes by two new P450 peroxygenases,Biotechnology for Biofuels,2017,第1作者
（4）Complete Elucidation of the Late Steps Bafilomycin Biosynthesis in Streptomyces lohii,Journal of Biological Chemistry,2017,第8作者
（5）Recombinant Collagen Engineered to Bind to Discoidin Domain Receptors Functions as a Receptor Inhibition,Journal of Biological Chemistry,2016,第3作者
（6）Molecular and cellular analysis of a novel mutation in DDR2 causing Spondylo-meta-epiphyseal dysplasia with short limbs and abnormal calcifications (SMED-SL),BMC Medical Genetics,2014,第3作者
（7）Normal activation of discoidin domain receptor 1 mutants with disulfide cross-links, insertions, or deletions in the extracellular juxtamembrane region: mechanistic implications,Journal of Biological Chemistry,2014,第1作者
（8）Discoidin domain receptors promote alpha1beta1- and alpha2beta1-integrin mediated cell adhesion to collagen by enhancing integrin activation,PLos One,2012,第1作者
（9）Collagen binding specificity of the discoidin domain receptors: binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1,Matrix Biology,2011,第1作者
（10）Trafficking defects and loss of ligand binding are the underlying causes of all reported DDR2 missense mutations found in SMED-SL patients,Human Molecular Genetics,2010,第1作者
（11）Directed Evolution of E. coli Alkaline Phosphatase Towards Higher Catalytic Activity,Biocatalysis and Biotransformation,2003,第1作者
（12）Engineering E. coli Alkaline Phosphatase Yields Changes of Catalytic Activity, Thermal Stability and Phosphate Inhibition,Biocatalysis and Biotransformation,2002,第4作者

发表著作

科研活动
科研项目（ 1 ） Improving C12 Activity of New P450 Decarboxylase Encoding Sequences, 主持,院级,2015-07--2017-02
（ 2 ） 基于P450催化元件的高值天然产物生物合成途径重构, 参与,省级,2017-08--2019-07
（ 3 ） Proof of Concept of Pathway Integration for α-Olefin Biosynthesis in Photosynthetic Microorganisms, 主持,院级,2017-07--2019-07
（ 4 ） P450 脂肪酸脱羧酶的定向进化及催化机理研究, 主持,国家级,2018-01--2021-12
（ 5 ） 耦合非天然辅酶的P450脂肪酸衍生细胞工厂, 主持,市地级,2018-03--2020-02

参与会议（1）催化脂肪酸脱羧生成末端烯烃的新型P450过氧化物酶的鉴定和酶学表征2018年中国微生物学会学术年会2018-10-19
（2）Characterization of novel P450 fatty acids decarboxylases for 1-alkene production第三届合成微生物学与生物制造暨第八届生物催化与生物合成工程国际学术研讨会2018-10-12
（3）Characterization of novel P450 peroxygenases for oxidative decarboxylation of free fatty acids to terminal alkenes2018-06-30
（4）学术交流全国首届生物传感、生物芯片高端论坛2017-10-20
（5）学术交流国际化学生物学年会2017-10-17
（6）学术交流2016-10-16
（7）Understanding the molecular mechanism for discoidin domain receptor activation2013-09-01
（8）Discoidin Domain Receptors Promote β1-integrin Mediated Cell Adhesion to Collagen2012-09-07
（9）The role of discoidin domain receptors in cell adhesion2012-04-02
（10）The role of DDR Receptors in cell adhesion2011-09-05
（11）Trafficking defects and loss of ligand binding are the underlying causes of all reported DDR2 missense mutations found in SMED-SL patients2010-07-03
（12）Determining the collagen binding specificity of the discoidin domain receptors (DDRs)2010-03-29
（13）Characterization of polyomavirus middle T antigen complexes using affinity purification and MS2007-07-22


合作情况
项目协作单位

指导学生