基本信息
向志明男硕导中国科学院南海海洋研究所
电子邮件： zhimingxiang@scsio.ac.cn
通信地址： 广州市海珠区新港西路164号
邮政编码： 510301

研究领域 主要研究无脊椎动物在病理胁迫下的先天性免疫、细胞凋亡、以及个体胚胎发育以及器官再生等生理现象，并揭示在此过程中相关分子的调控功能；在国内、外刊物上发表学术论文50余篇，其中在国际知名SCI 论文40余篇；申请并公开专利多项；先后主持国家自然基金青年项目1 项，省部属基金2项，国家自然基金面上项目1 项；参加973 研究项目、广东-国家联合基金和海洋先导专项等课题多项；担任国家自然科学基金委评审委员，以及Cellular & Molecular Biology Letters, Fish & Shellfish Immunology 等国际学术期刊审稿人；同时在生态调查研究方面也做了一些相关的工作，在国南海沙群岛的多个岛屿进行了长期的生物学资源的调查，为国家生物资源的可持续性发展提供了材料。











招生信息2018年度招硕士研究生一名，主要从事细胞凋亡，先天性免疫，贝类器官的再生等方面研究，希望有志此方向的学生申报。






招生专业085238-生物工程
070703-海洋生物学

招生方向细胞凋亡与免疫学，发育生物学，再生生物学，发酵工程


教育背景2006-09--2010-06中山大学博士
2003-09--2006-06湖南师范大学硕士
1998-09--2002-06湖南农业大学学士


教授课程

指导学生现指导学生
赵泽慧硕士研究生085238-生物工程
许多硕士研究生085238-生物工程

论文发表
1. XiangZM, Qi L, Chen W, Dong C, LiuZ, Liu D, He JG*. Characterization of a TnMAVS protein from Tetraodonnigroviridis. Dev Comp Immunol. 2011 35:1103-15.
2. XiangZM, Dong C, Qi L, Chen W,Huang L, Li Z, He JG*. Characteristics of the interferon regulatory factorpairs zfIRF5/7 and their stimulation expression by ISKNV Infection in zebrafish(Danio rerio). Dev Comp Immunol. 2010 34:1263-73.
3. XiangZM, Yuan W, Luo N, Wang Y,Tan K, Deng Y,Liu MY,Wu XS*. A novel human zinc finger protein ZNF540 interactswith MVP and inhibits transcriptional activities of the ERK signal pathway.Biochem Biophys Res Commun. 2006 347:288-96.
4. XiangZM, Qu F, Qi L, Zhang Y, XiaoS, Yu ZN*. A novel ortholog of serum response factor (SRF) with immune defensefunction identified in Crassostrea hongkongensis. Fish Shellfish Immunol. 201436:75-82.
5. XiangZM, Qu F, Li J, Qi L, Yang Z,Kong X, Yu ZN*. Activator protein-1 (AP-1) and response to pathogen infectionin the Hong Kong oyster (Crassostrea hongkongensis). Fish Shellfish Immunol.2014 36:83-9.
6. XiangZM, Qu F, Qi L, Zhang Y, TongY, Yu ZN*. Cloning, characterization and expression analysis of a caspase-8like gene from the Hong Kong oyster, Crassostrea hongkongensis. Fish ShellfishImmunol. 2013 35:1797-803.
7. XiangZM, Qu F, Qi L, Ying T, Li J,Shu X, Yu ZN*. Cloning and characterization of an apoptosis-related DNA fragmentationfactor (DFF) from oyster, Crassostrea hongkongensis. Fish Shellfish Immunol. 2014,38:119-126.
8. XiangZM, Weng S, Qi H, He JG*,Dong C*. Identification and characterization of a novel FstK-like protein fromspotted knifejaw iridovirus (genus Megalocytivirus). Gene. 2014 545:233-40.
9. XiangZM, Qu F, Wang F, Li J, ZhangY, Yu Z*. Characteristic and functional analysis of a ficolin-like protein fromthe oyster Crassostrea hongkongensis. Fish Shellfish Immunol. 2014 40:514-23.
10. XiangZM, Qu FF, Wang FF, Shu X, LiJ , Zhang Y, Yu ZN*. ChBax/Bak as key regulators of the mitochondrial 1apoptotic pathway:cloned and characterized in Crassostrea hongkongensis. FishShellfish Immunol. 2014, 42: 225-232.
11. XiangZM, Xiao S, Wang F, Qin Y, WuJ, Ma H, Yu ZN*. Cloning, characterization and comparative analysis of fourdeath receptorTNFRs from the oyster Crassostrea hongkongensis. Fish ShellfishImmunol. 2016 59:288-97.
12. Qi L, XiangZM*. Molecular cloning andexpression analysis of an apoptosis-associated gene Daxx from zebrafish, Daniorerio. Fish Shellfish Immunol. 2015, 45, 59-66.
13. Wang F, Xiao S, Zhang Y, Liu Y, Yan Y, Xiang ZM*, Yu ZN*. ChAkt1 involvement in orchestrating the immuneand heat shock responses in Crassostrea hongkongensis: Molecular cloning andfunctional characterization. Fish Shellfish Immunol. 2015 47:1015-23.
14. Qu F, XiangZM*, Zhang Y, Li J, Xiao S,Mao F, Yu ZN*. A novel p38 MAPK indentified from Crassostrea hongkongensis andits involvement in host response to immune challenges. Mol Immunol. 201679:113-24.
15. Fufa Qu, XiangZM*, Xiao S, Wang FF, Li J,Zhang Y, , Zhang YH, Qin YP, Ziniu Yu*. c-Jun N-terminal kinase (JNK) isinvolved in immune defense against bacterial infection in Crassostreahongkongensis. Developmental and Comparative Immunology. 2016 32 1-9.
16. Fufa Qu, XiangZM*, Li J, Xiao S, Mao F, QinYP, Zho u YL, Ma HT, Yu ZN*. A molluscan extracellular signal-regulated kinaseis involved in host response to immune challenges in vivo and in vitro. Fishand Shellfish Immunology. 2017.
17. Fufa Qu, XiangZM*, Zhang Y, Li J, Xiao S,Zhang YH, Qin YP, Zhou YL, Yu ZN*. Molecular identification and functionalcharacterization of a tumor necrosis factor (TNF) gene in Crassostreahongkongensis. Immunobiology.2017.
18. Qu F, XiangZM^#, Yu ZN*. Thefirst molluscan acute phase serum amyloid A (A-SAA) identified from oyster Crassostreahongkongensis: Molecular cloning and functional characterization. FishShellfish Immunol. 2014 39:145-51.
19. Qu F, XiangZM^#, Zhang Y, LiJ, Yu ZN*. The identification of the first molluscan Akirin2 with immunedefense function in the Hong Kong oyster Crassostrea hongkongensis. FishShellfish Immunol. 2014, 41:455-465.
20. Fufa Qu,Xiang ZM^#,Wang FF, Yu ZN*. A novel prostaglandin E receptor 4 (PTGER4) gene involved inhost protection against immune challenges in Crassostrea hongkongensis. FishShellfish Immunol. 2014, 42: 316-324.
21. Qu F, XiangZM^#, Wang F, ZhangY, Li J, Xiao S, Yu ZN*. Identification and function of an evolutionarilyconserved signaling intermediate in Toll pathways (ECSIT) from Crassostreahongkongensis. Dev Comp Immunol. 2015,53(1):244-252.
22. Liu F, Zhu C, Xiao J, Wang Y, Tang W, Yuan W, Xiang ZM et al. A novel human KRAB-containing zinc-finger geneZNF446 inhibits transcriptional activities of SRE and AP-1. Biochem Biophys ResCommun. 2005 333:5-13.
23. Zhang DF, Jiang B, Xiang ZM,Wang SY*. Functional characterisation of altered outer membrane proteins fortetracycline resistance in Escherichia coli. Int J Antimicrob Agents. 200832:315-9.
24. Li Z, Xu X, Huang L, Wu J, Lu Q, Xiang ZM, Weng SP, He JG*. Administration of recombinant IFN1protects zebrafish (Danio rerio) from ISKNV infection. Fish Shellfish Immunol.2010 29:399-406.
25. Chen WJ, Guo CJ, Zhou ZC, Yuan LQ, Xiang ZM, Weng SP, He JG*. Molecular cloning of IKKbeta from themandarin fish Siniperca chuatsi and its up-regulation in cells by ISKNVinfection. Vet Immunol Immunopathol. 2011 139:61-6.
26. Li J, ZY, XiangZM, Xiao S, Yu F, Yu ZN*.High mobility group box 1 can enhance NF-kappaB activation and act as apro-inflammatory molecule in the Pacific oyster, Crassostrea gigas. FishShellfish Immunol. 2013 35:63-70. Fish Shellfish Immunol. 2008 35:63-70.
27. Li J, Zhang Y, Xiang ZM,Tong Y, Qu F, Yu Z*. Genomic characterization and expression analysis of fivenovel IL-17 genes in the Pacific oyster, Crassostrea gigas. Fish ShellfishImmunol. 2014,40 455-465.
28. Li J, Zhang Y, Liu Y, Xiang ZM,Qu F, Yu Z*. Cloning and characterization of three suppressors of cytokinesignaling (SOCS) genes from the Pacific oyster, Crassostrea gigas. FishShellfish Immunol. 2015,44(2):525-32.
29. Li J, Zhang Y, Liu Y, Xiang ZM,Qu F, Yu ZN*. A thymosin beta-4 is involved in production of hemocytes andimmune defense of Hong Kong oyster, Crassostrea hongkongensis. Dev CompImmunol. 2016, 57, 1-9.
30. Zhang Y, Li J, Yu F, Tong Y, Xiang ZM, Yu ZN*. Identification and functional characterizationof SIMPL in Crassostrea gigas reveals its ancient origin and involvement in theregulation of Rel/NF-kappaB transcription activity. Fish ShellfishImmunol. 2014 40(1):239-44..
31. Zhang Y, He X, Yu F, Xiang ZM,Li J, Thorpe KL, Yu ZN*. Characteristic and functional analysis of toll-likereceptors (TLRs) in the lophotrocozoan, Crassostrea gigas, reveals ancientorigin of TLR-mediated innate immunity. PLoS One. 2013 8:e76464.
32. Zhang Y, Sun J, Mu H, Li J, Xu F, Xiang ZM, Yu ZN*. Proteomic basis of stress responses in thegills of the Pacific oyster Crassostrea gigas. J Proteome Res. 2015;14(1):304-17.
33. Qu F, XiangZM, Wang F, Zhang Y, Tong Y,Li J, Yu ZN*. A novel molluscan Fos gene with immune defensefunction identified in the Hong Kong oyster, Crassostrea hongkongensis.Dev Comp Immunol. 2015;51(1):194-201.
34. Xu F, Zhang Y, Li J, Xiang ZM,Yu ZN*. Expression and Function analysis of two Naturally Truncated MyD88variants in the Pacific oyster Crassostrea gigas. Fish ShellfishImmunol. 2015 45(2):510-6.
35. Xu F, Li J, Zhang Y, Li X, Xiang ZM, Yu ZN*. CgIkappaB3, the third novel inhibitor ofNF-kappa B (IkappaB) protein, is involved in the immune defense of thePacific oyster, Crassostrea gigas. Fish Shellfish Immunol. 2015 46(2):648-55.
36. Zhang YH, Zhang Y, Li J, Xiao S, Xiang ZM, Wang ZP, Yan XW, Yu ZN*. Artificial interspecificbackcrosses between the hybrid of female Crassostreahongkongensis× male C.gigas and the two parental species. Aquaculture. 2016:450: 95–101.


专利申报
1、向志明，瞿符发，肖述，喻子牛。一种血清淀粉样蛋白A及其编码基因和应用，国家发明专利, 专利号: ZL 3.2
2、向志明，瞿符发，喻子牛。一种纤维胶凝蛋白及其编码基因和应用，国家发明专利, 专利号: 8.2


项目基金
1. 主持科研项目：
1、国家自然科学青年基金：香港巨牡蛎Fas 信号通路在诱导细胞凋亡和免疫防御中的功能研究，（No.**，2013-2015），24万，结题。
2、广东省海洋渔业科技推广专项： 海洋生物抗菌肽制备的关键技术攻关，（A201301B08，2013-2015），30万，结题。
3、国家自然科学面上基金：逆境胁迫下香港牡蛎DNA损伤与线粒体凋亡途径的活化机制, （No. **，2016-2019），71.3万，在研。
4、广州市自然科学基金：香港巨牡蛎凋亡标志性基因Caspase-3 的功能分析与应用，（ 2017-2020），20万，在研。
2. 参与部分科研项目：
1、国家农业领域973项目：贝类抗病和抗逆的关键基因及其网络调控机制（2010CB126404）2010-14，487万；
2、国家-广东联合基金项目：近江牡蛎广盐高温耐受/适应性及高效生物矿化的基因资源发掘与分子调控研究（U** 2013-16，218万；
3、科技部863项目子课题：牡蛎全基因组选育技术及 新品种培育（2012AA10A405）2012-15，83万；
4、中国科学院科技服务网络计划（STS计划）海产品精深加工相关技术与对虾种业技术研发与产业化示范，2016-18，240万；
5、中国科学院A类战略性先导科技专项，生物种群的恢复与重建技术研发2016-19，1000万。