基本信息
吴凌云男博导中国科学院数学与系统科学研究院
电子邮件： lywu@amss.ac.cn
通信地址： 北京市海淀区中关村东路55号
邮政编码： 100190
部门/实验室：应用数学研究所
招生信息
招生专业070105-运筹学与控制论
1201Z1-管理运筹学
081203-计算机应用技术

招生方向运筹学及其应用
优化与决策
数据挖掘与生物信息学


教育背景1997-09--2002-07中国科学院数学与系统科学研究院博士
1993-09--1997-07武汉大学数学系本科


工作经历
工作简历2015-04~现在,中国科学院数学与系统科学研究院,研究员
2007-04~2015-04,中国科学院数学与系统科学研究院,副研究员
2005-06~2007-04,中国科学院数学与系统科学研究院,助理研究员
2003-09~2005-06,中国科学院数学与系统科学研究院,博士后
2002-08~2003-08,香港科技大学工业工程与工程管理系,博士后

社会兼职2016-10-16-今,中国运筹学会, 常务理事
2016-10-16-今,中国运筹学会, 青年工作委员会副主任
2012-10-18-今,中国运筹学会, 科普工作委员会副主任
2012-10-18-今,中国运筹学会, 理事
2011-09-01-今,中国运筹学会计算系统生物学分会, 副理事长
2010-10-01-今,运筹与管理, 编委


出版信息
发表论文（1）基于“货到人”拣选模式的储位分配问题研究,运筹与管理,2019,通讯作者
（2）基于机器学习的 RNA 编辑位点预测方法综述,生物信息学,2019,通讯作者
（3）Discovering cooperative biomarkers for heterogeneous complex disease diagnoses,Briefings in Bioinformatics,2019,通讯作者
（4）基于AGV的智能仓库系统订单分批问题研究,运筹与管理,2019,通讯作者
（5）区块链性能的量化分析研究,计算机工程与应用,2019,通讯作者
（6）CEA: Combination-based gene set functional enrichment analysis,Scientific Reports,2018,通讯作者
（7）Structure alignment-based classification of RNA-binding pockets reveals regional RNA recognition motifs on protein surfaces,BMC Bioinformatics,2017,通讯作者
（8）NetGen: a novel network-based probabilistic generative model for gene set functional enrichment analysis,BMC Systems Biology,2017,通讯作者
（9）Gly-PseAAC: Identifying protein lysine glycation through sequences,Gene,2017,第4作者
（10）iSulf-Cys: prediction of S-sulfenylation sites in proteins with physicochemical properties of amino acids,PLoS ONE,2016,第3作者
（11）Mal-Lys: prediction of lysine malonylation sites in proteins integrated sequence-based features with mRMR feature selection,Scientific Reports,2016,第4作者
（12）Cancer stem cells display extremely large evolvability: alternating plastic and rigid networks as a potential mechanism,Seminars in Cancer Biology,2015,第4作者
（13）iSuc-PseAAC: predicting lysine succinylation in proteins by incorporating peptide position-specific propensity,Scientific Reports,2015,第4作者
（14）Enrichment set cover problem,The Proceedings of 12th International Symposium on Operations Research and Its Applications,2015,通讯作者
（15）Phogly-PseAAC: Prediction of lysine phosphoglycerylation in proteins incorporating with position-specific propensity,Journal of Theoretical Biology,2015,第4作者
（16）iNitro-Tyr: Prediction of nitrotyrosine sites in proteins with general pseudo amino acid composition,PLOS ONE,2014,第4作者
（17）Discovery of co-occurring driver pathways in cancer,BMC Bioinformatics,2014,第2作者
（18）iSNO-PseAAC: Predict Cysteine S-Nitrosylation Sites in Proteins by Incorporating Position Specific Amino Acid Propensity into Pseudo Amino Acid Composition,PLOS ONE,2013,第3作者
（19）GOMA: Functional enrichment analysis tool based on GO modules,Chinese Journal of Cancer,2013,通讯作者
（20）Corbi: A new R package for biological network alignment and querying,BMC Systems Biology,2013,通讯作者
（21）Efficient methods for identifying mutated driver pathways in cancer,Bioinformatics,2012,第3作者
（22）Potts model based on a Markov process computation solves the community structure problem effectively,Physical Review,2012,第3作者
（23）Revealing metabolite biomarkers for acupuncture treatment by linear programming based feature selection,BMC Systems Biology,2012,第4作者
（24）CNetA: Network alignment by combining biological and topological features,Proceedings of the 6th IEEE International Conference on Systems Biology (ISB),2012,通讯作者
（25）Community structure detection based on Potts model and network’s spectral characterization,Europhysics Letters,2012,第3作者
（26）NOA: a novel network ontology analysis method,Nucleic Acids Research,2011,通讯作者
（27）An efficient network querying method based on conditional random fields,Bioinformatics,2011,通讯作者
（28）Analyzing time-course gene expression data using profile-state hidden Markov model,Proceedings of the 5th IEEE International Conference on Systems Biology (ISB),2011,通讯作者
（29）Detecting coherent local patterns from time series gene expression data by a temporal biclustering method,Proceedings of the 5th IEEE International Conference on Systems Biology (ISB) ,2011,第3作者
（30）Prediction of protein-RNA binding sites by a random forest method with combined features,Prediction of protein-RNA binding sites by a random forest method with combined features,Bioinformatics,2010,第2作者
（31）An information-flowbased model with dissipation, saturation and direction for active pathway inference,An information-flowbased model with dissipation, saturation and direction for active pathway inference,BMC Systems Biology,2010,第3作者
（32）Semi-supervised drug-protein interaction prediction from heterogeneous biological spaces,Semi-supervised drug-protein interaction prediction from heterogeneous biological spaces,BMC Systems Biology,2010,第2作者
（33）SANA: an algorithm for sequential and non-sequential protein structure alignment,SANA: an algorithm for sequential and non-sequential protein structure alignment,Amino Acids,2010,第2作者
（34）多阶段多目标多部门应急决策模型,Emergency decision model with multiple stages, multiple objectives, and multidivisional cooperation,系统工程理论与实践,2010,第3作者
（35）Lysine acetylation sites prediction using an ensemble of support vector machine classifiers,Lysine acetylation sites prediction using an ensemble of support vector machine classifiers,Journal of Theoretical Biology,2010,第4作者
（36）DEA with weight constraints for evaluation of work safety supervision,DEA with weight constraints for evaluation of work safety supervision,Lecture Notes in Operations Research,2010,第2作者
（37）Conditional random pattern algorithm for LOH inference and segmentation,Conditional random pattern algorithm for LOH inference and segmentation,Bioinformatics,2009,第1作者
（38）Prediction of palmitoylation sites using the composition of K-spaced amino acid pairs,Prediction of palmitoylation sites using the composition of K-spaced amino acid pairs,Protein Engineering, Design, and Selection,2009,第2作者
（39）Evaluating protein similarity from coarse structures,Evaluating protein similarity from coarse structures,IEEE/ACM Transactions on Computational Biology and Bioinformatics,2009,第2作者
（40）Self-organizing map approaches for the haplotype assembly problem,Self-organizing map approaches for the haplotype assembly problem,Mathematics and Computers in Simulation,2009,第1作者
（41）Predicting DNA and RNA-binding proteins from sequences with kernel methods,Predicting DNA and RNA-binding proteins from sequences with kernel methods,Journal of Theoretical Biology,2009,第3作者
（42）Pattern-selection based power analysis and discrimination of low- and high-grade myelodysplastic syndromes study using SNP arrays,Pattern-selection based power analysis and discrimination of low- and high-grade myelodysplastic syndromes study using SNP arrays,PLoS ONE,2009,第4作者

发表著作（1）Proceedings of 12th International Symposium on Operations Research and Its Applications,IET,2015-08,第3作者