基本信息
吴惠丰男博导中国科学院烟台海岸带研究所
电子邮件： hfwu@yic.ac.cn
通信地址： 山东省烟台市莱山区春晖路17号
邮政编码： 264003

研究领域海洋生态毒理

招生信息
招生专业083001-环境科学
085238-生物工程
070703-海洋生物学

招生方向海岸带生态毒理学、环境生物学
海岸带生态毒理与环境基准
海岸带生态毒理与环境基准


教育背景2000-09--2005-06中国科学院长春应用化学研究所理学博士
1996-09--2000-06南京大学理学学士

学历
学位

工作经历
工作简历2009-03~现在,中国科学院烟台海岸带研究所,研究员
2008-08~现在,香港科技大学,博士后
2005-08~2008-07,英国伯明翰大学,博士后

社会兼职

教授课程

专利与奖励
奖励信息（1） 中国科学院优秀研究生指导教师奖, 院级, 2014
（2） 中国科学院优秀导师奖, 院级, 2013
（3） 黄河三角洲滨海湿地退化机制、植被修复原理与优化对策, 二等奖, 市地级, 2013
（4） 中国科学院大学-澳大利亚必和必拓导师科研奖, 其他, 2012

专利成果

出版信息
发表论文（1）Impact of metal pollution on shrimp Crangon affinis by NMR-based metabolomics,Mar. Pollut. Bullet.,2016,通讯作者
（2）A metabolomic study on the biological effects of metal pollutions in oysters Crassostrea sikamea,Mar. Pollut. Bullet.,2016,通讯作者
（3）roteomic and metabolomic analysis on the toxicological effects of As (III) and As (V) in juvenile mussel Mytilus galloprovincialis,Chemosphere,2016,通讯作者
（4）An integrated proteomic and metabolomic study on the gender-specific responses of mussels Mytilus galloprovincialis to tetrabromobisphenol A (TBBPA),Chemosphere,2016,通讯作者
（5）Both released silver ions and particulate Ag contribute to the toxicity of AgNPs to earthworm Eisenia fetida,Nanotoxicology,2015,通讯作者
（6）Comparative investigations on the biological effects of As (III) and As (V) in clam Ruditapes philippinarum using multiple biomarkers,Fish & Shellfish Immunol.,2015,通讯作者
（7）典型持久性有机污染物与抑癌基因相互作用的分子模拟与验证.,科学通报,2015,第1作者
（8）BDE-47对人胚肾细胞HEK293的毒理效应及作用机制,生态毒理学报,2015,第3作者
（9）不同形态磷源对具槽帕拉藻(Paralia sulcata)生长和磷酸酶活性的影响,海洋与湖沼,2015,第4作者
（10）A metabolomic study on the responses of daphnia magna exposed to silver nitrate and coated silver nanoparticles,Ecotoxicol. Environ. Saf.,2015,通讯作者
（11）Glutathione S-transferase (GST) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms,Chin. J. Oceanol. Limnol.,2015,通讯作者
（12）Multiple biomarkers of biological effects induced by cadmium in clam Ruditapes philippinarum,Fish & Shellfish Immunol.,2015,通讯作者
（13）A defensin from clam Venerupis philippinarum: Molecular characterization, localization, antibacterial activity, and mechanism of action,Dev. Comp. Immunol.,2015,通讯作者
（14）Multiple biomarkers of the cytotoxicity induced by BDE-47 in human embryonic kidney cells,Chemosphere,2015,第1作者
（15）Combined metabolome and proteome analysis of the mantle tissue from Pacific oyster Crassostrea gigas exposed to elevated pCO2,Comp. Biochem. Physiol. Part D,2015,通讯作者
（16）Combined metabolome and proteome analysis of the mantle tissue from Pacific oyster Crassostrea gigas exposed to elevated pCO2,Comp. Biochem. Physiol. Part D,2015,通讯作者
（17）A metabolomic investigation of the effects of metal pollution in oysters Crassostrea hongkongensis,Mar. Pollut. Bullet.,2015,通讯作者
（18）Affinities of organophosphate flame retardants to tumor suppressor gene p53: An integrated in vitro and in silico study,Toxicol. Lett.,2015,通讯作者
（19）Proteomic and metabolomic responses of Pacific oyster Crassostrea gigas to elevated pCO2 exposure,J. Proteomics,2015,通讯作者
（20）Determination and prediction of the binding interaction between organophosphate flame retardants and p53,Chem. Res. Toxicol.,2014,通讯作者
（21）iTRAQ-based quantitative proteomic analyses on the gender-specific responses in mussel Mytilus galloprovincialis to tetrabromobisphenol A,Aquat. Toxicol,2014,通讯作者
（22）The interaction between organic phosphate ester and p53: An integrated experimental and in silico approach,Mar. Pollut. Bull.,2014,通讯作者
（23）Molecular responses of European flounder (Platichthys flesus) chronically exposed to contaminated estuarine sediments,Chemosphere,2014,第3作者
（24）Molecular characterization of two glutathione peroxidase genes in Mytilus galloprovincialis and their transcriptional responses to sub-chronic arsenate and cadmium exposure,Invertebrate Surviv. J.,2014,通讯作者
（25）Identification and mRNA expression of two 17β-hydroxysteroid dehydrogenase genes in the marine mussel Mytilus galloprovincialis following exposure to endocrine disrupting chemicals.,Environ. Toxicol. Pharmacol.,2014,通讯作者
（26）Gender-specific metabolic responses in gonad of mussel Mytilus galloprovincialis to 2,2′,4,4′-tetrabromodiphenyl ether,Environ. Toxicol. Pharmacol.,2014,通讯作者
（27）Metabolomic analysis revealed that female mussel Mytilus galloprovincialis was sensitive to bisphenol A exposures.,Environ. Toxicol. Pharmacol.,2014,通讯作者
（28）Expression profiles of two small heat shock proteins and antioxidant enzyme activity in Mytilus galloprovincialis exposed to cadmium at environmentally relevant concentrations.,Chin. J. Oceanol. Limnol.,2014,通讯作者
（29）Soil acidification increases metal extractability and bioavailability in old orchard soils of Northeast Jiaodong Peninsula in China.,Environ. Pollut.,2014,通讯作者
（30）Evaluation of protein extraction protocols for 2DE in marine ecotoxicoproteomics.,Proteomics,2014,通讯作者
（31）Proteomic and metabolomic responses in hepatopancreas of Mytilus galloprovincialis challenged by Micrococcus luteus and Vibrio anguillarum.,J. Proteomics,2013,第1作者
（32）Effect of cadmium on the defense response of Pacific oyster Crassostrea gigas to Listonella anguillarum challenge.,Chin. J. Oceanol. Limnol.,2013,通讯作者
（33）Proteomic and metabolomic analysis of earthworm Eisenia fetida exposed to different concentrations of 2,2’,4,4’-tetrabromodiphenyl ether.,J. Proteomics,2013,通讯作者
（34）Proteomic and metabolomic analysis reveal gender-specific responses of mussel Mytilus galloprovincialis to 2,2’,4,4’-tetrabromodiphenyl ether (BDE 47).,Aquat. Toxicol.,2013,通讯作者
（35）Responses of Mytilus galloprovincialis to bacterial challenges by metabolomics and proteomics.,Fish Shellfish Immunol.,2013,通讯作者
（36）The response profiles of HSPA12A and TCTP from Mytilus galloprovincialis to pathogen and cadmium challenge.,Fish Shellfish Immunol.,2013,通讯作者
（37）A novel C-type lysozyme from Mytilus galloprovincialis: Insight into innate immunity and molecular evolution of invertebrate C-type lysozymes.,PLOS One,2013,通讯作者
（38）Regulation of metabolites, gene expression, and antioxidant enzymes to environmentally relevant lead and zinc in the halophyte Suaeda salsa.,J. Plant Growth Regul.,2013,第1作者
（39）Molecular cloning, characterization and expression profiles of thioredoxin 1 and thioredoxin 2 genes in Mytilus galloprovincialis.,Chin. J. Oceanol. Limnol.,2013,通讯作者
（40）An integrated proteomic and metabolomic study on the chronic effects of mercury in Suaeda salsa under an environmentally relevant salinity.,PLOS One,2013,通讯作者
（41）Proteomic and metabolomic responses of clam Ruditapes philippinarum to arsenic exposure under different salinities.,Aquat. Toxicol.,2013,第1作者
（42）Proteomic and metabolomic responses of clam Ruditapes philippinarum to arsenic exposure under different salinities.,Aquat. Toxicol.,2013,第1作者
（43）Molecular characterization of a manganese superoxide dismutase and copper/zinc superoxide dismutase from the mussel Mytilus galloprovincialis,Fish Shellfish Immunol.,2013,通讯作者
（44）Molecular characterization of a manganese superoxide dismutase and copper/zinc superoxide dismutase from the mussel Mytilus galloprovincialis,Fish Shellfish Immunol.,2013,通讯作者
（45）Molecular characterization of a manganese superoxide dismutase and copper/zinc superoxide dismutase from the mussel Mytilus galloprovincialis,Fish Shellfish Immunol.,2013,通讯作者
（46）The influence of salinity on toxicological effects of arsenic in digestive gland of clam Ruditapes philippinarum using metabolomics.,Chin. J. Oceanol. Limnol,2013,通讯作者
（47）A metabolomics investigation on arsenic-induced toxicological effects in the clam Ruditapes philippinarum under different salinities.,Ecotoxicol. Environ. Saf.,2013,第1作者
（48）Manila clam Venerupis philippinarum as a biomonitor to metal pollution.,Chin. J. Oceanol. Limnol.,2013,第1作者
（49）Effects of heavy metals on the expression of a zinc-inducible metallothionein-III gene and antioxidant enzyme activities in Crassostrea gigas.,Ecotoxicology,2012,通讯作者
（50）Two goose-type lysozymes in Mytilus galloprovincialis: possible function diversification and adaptive evolution.,PLoS one,2012,通讯作者
（51）Toxicological responses in halophyte Suaeda salsa to mercury under environmentally relevant salinity.,Ecotoxicol. Environ. Saf.,2012,第1作者
（52）Toxicological effects of environmentally relevant lead and zinc in halophyte Suaeda salsa by NMR-based metabolomics.,Ecotoxicology,2012,第1作者
（53）Effects of salinity on metabolic profiles, gene expressions, and antioxidant enzymes in halophyte Suaeda salsa.,J. Plant Growth Regul.,2012,第1作者
（54）Salinity-induced effects in the halophyte Suaeda salsa using NMR-based metabolomics,Plant Mol. Biol. Rep.,2012,第1作者
（55）Identification and expression profile of a new cytochrome P450 isoform (CYP414A1) in the hepatopancreas of Venerupis philippinarum exposed to benzo[a]pyrene, cadmium and copper.,Environ. Toxicol. Pharmacol.,2012,通讯作者
（56）Molecular cloning and differential expression patterns of sigma and omega glutathione S-transferases from Venerupis philippinarum to heavy metals and benzo[a]pyrene exposure.,Chin. J. Oceanol. Limnol.,,2012,通讯作者
（57）Docking and QSAR study on the binding interactions between polycyclic aromatic hydrocarbons and estrogen receptor.,Ecotoxicol. Environ. Saf.,2012,通讯作者
（58）Expression profiles of seven glutathione S-transferase (GST) genes from Venerupis philippinarum exposed to heavy metals and benzo[a]pyrene. Comp.,Biochem. Physiol. Part C,2012,通讯作者
（59）Uptake pathways and subcellular fractionation of Cd in the polychaete Nereis diversicolor.,Ecotoxicology,2012,通讯作者
（60）Pathways of cadmium fluxes in the root of the halophyte Suaeda salsa.,Ecotoxicol. Environ. Saf.,2012,通讯作者
（61）Differential toxicological effects induced by mercury in gills from three pedigrees of Manila clam Ruditapes philippinarum by NMR-based metabolomics,Ecotoxicology,2011,通讯作者
（62）Toxicological responses to acute mercury exposure for three species of Manila clam Ruditapes philippinarum by NMR-based metabolomics,Environ. Toxicol. Pharmacol.,2011,通讯作者
（63）Tissue-specific toxicological effects of cadmium in green mussel (Perna viridis): Nuclear magnetic resonance-based metabolomics study,Environ. Toxicol. Chem.,2011,第1作者
（64）Benzo(a)pyrene-induced metabolic responses in Manila clam Ruditapes philippinarum by proton nuclear magnetic resonance (1H NMR) based metabolomics,Environ. Toxicol. Pharmacol.,2011,通讯作者
（65）Metabolic responses in gills of Manila clam Ruditapes philippinarum exposed to copper using NMR-based metabolomics,Mar. Environ. Res.,2011,通讯作者
（66）Metabolomic study on the halophyte Suaeda salsa in the Yellow River Delta,Clean Soil, Air, Water,2011,通讯作者
（67）Metabolic profiling of cadmium-induced effects in one pioneer intertidal halophyte Suaeda salsa by NMR-based metabolomics,Ecotoxicology,2011,通讯作者
（68）Responses of thioredoxin 1 and thioredoxin-related protein 14 mRNAs to cadmium and copper stresses in Venerupis philippinarum,Comp. Biochem. Physiol. Part C,2011,通讯作者
（69）QSAR studies on the depuration rates of polycyclic aromatic hydrocarbons, polybrominated diphenyl ethers and polychlorinated biphenyls in mussels (Elliptio complanata),Sar QSAR Environ. Res.,2011,通讯作者
（70）Assessment of three pedigrees of clam Ruditapes philippinarum as bioindicator for heavy metal monitoring using NMR-based metabolomics,Clean Soil, Air, Water,2011,通讯作者
（71）NMR-Based metabolomic investigations on the differential responses in adductor muscles from two pedigrees of Manila clam Ruditapes philippinarum to cadmium and zinc.,Mar. Drugs,2011,第1作者
（72）Towards a system level understanding of non-model organisms sampled from the environment: A network biology approach.,PLoS Comput. Biol.,2011,第4作者
（73）Towards a system level understanding of non-model organisms sampled from the environment: A network biology approach.,PLoS Comput. Biol.,2011,第4作者
（74）Metabolic profiling of cadmium-induced effects in one pioneer intertidal halophyte Suaeda salsa by NMR-based metabolomics.,Ecotoxicology,2011,通讯作者
（75）Responses of thioredoxin 1 and thioredoxin-related protein 14 mRNAs to cadmium and copper stresses in Venerupis philippinarum.,Comp. Biochem. Physiol. Part C,2011,通讯作者
（76）Benzo(a)pyrene-induced metabolic responses in Manila clam Ruditapes philippinarum by proton nuclear magnetic resonance (1H NMR) based metabolomics.,Environ. Toxicol. Pharmacol.,2011,通讯作者
（77）QSAR studies on the depuration rates of polycyclic aromatic hydrocarbons, polybrominated diphenyl ethers and polychlorinated biphenyls in mussels (Elliptio complanata).,SAR QSAR Environ. Res.,2011,通讯作者
（78）Metabolomic study on the halophyte Suaeda salsa in the Yellow River Delta.,Clean-Soil, Air, Water,2011,通讯作者
（79）Metabolomic study on the halophyte Suaeda salsa in the Yellow River Delta.,Clean-Soil, Air, Water,2011,通讯作者
（80）Metabolic responses in gills of Manila clam Ruditapes philippinarum exposed to copper using NMR-based metabolomics.,Mar. Environ. Res.,2011,通讯作者
（81）Noncovalent interactions between hydroxylated polycyclic aromatic hydrocarbon and DNA: Molecular Docking and QSAR Study.,Environ. Toxicol. Pharmacol.,2011,通讯作者
（82）Assessment of Clam Ruditapes philippinarum as heavy metal bioindicators using NMR-based metabolomics.,Clean - Soil, Air, Water,2011,通讯作者
（83）Docking and 3D-QSAR studies on the Ah receptor binding affinities of polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs).,Environ. Toxicol. Pharmacol.,2011,通讯作者
（84）Transcriptional regulation of selenium-dependent glutathione peroxidase from Venerupis philippinarum in response to pathogen and contaminants challenge,Fish Shellfish Immunol.,2011,通讯作者
（85）Toxicological effects induced by cadmium in gills of Manila clam Ruditapes philippinarum using NMR-based metabolomics.,Clean-Soil, Air, Water,2011,通讯作者
（86）Differential toxicological effects induced by mercury in gills from three pedigrees of Manila clam Ruditapes philippinarum by NMR-based metabolomics.,Ecotoxicology,2011,通讯作者
（87）Toxicological responses to acute mercury exposure for three species of Manila clam Ruditapes philippinarum by NMR-based metabolomics.,Environ. Toxicol. Pharmacol.,2011,通讯作者
（88）Tissue-specific toxicological effects of cadmium in green mussel (Perna viridis): Nuclear magnetic resonance-based metabolomics study.,Environ. Toxicol. Chem.,2011,第1作者
（89）Molecular phylogenies and evolutionary behavior of AhR (aryl hydrocarbon receptor) pathway genes in aquatic animals: Implications for the toxicology mechanism of some persistent organic pollutants (POPs),Chemosphere,2010,第3作者
（90）Identifying health impacts of exposure to copper using transcriptomics and metabolomics in a fish model,Environ. Sci. Technol.,2010,第4作者
（91）NMR-based metabolomic studies on the toxicological effects of cadmium and copper on green mussels Perna viridis,Aquat. Toxicol.,2010,第1作者
（92）Hepatic transcriptomic and metabolomic responses in the stickleback (Gasterosteus aculeatus) exposed to environmentally relevant concentrations of dibenzanthracene,Environ. Sci. Technol.,2009,第2作者
（93）Metabolic profiling studies on the toxicological effects of Realgar in rats by 1H NMR spectroscopy,Toxicol. Appl. Pharmacol.,2009,第3作者
（94）Toxicological effects of Cinnabar in rats by NMR-based metabolic profiling of urine and serum,Toxicol. Appl. Pharmacol.,2008,第3作者
（95）High throughput tissue extraction protocol for NMR and Mass spectrometry based metabolomics,Anal. Biochem.,2008,第1作者
（96）Evaluation of metabolite extraction strategies from tissue samples using NMR metabolomics,Metabolomics,2007,第1作者
（97）Investigation on the acute biochemical effects of Ce(NO3)3 on liver and kidney Tissues by MAS 1H NMR spectroscopic-based metabonomic approach,J. Rare Earths,2006,第1作者
（98）Studies on acute toxicity of model toxins by proton magnetic resonance spectroscopy of urine combined with two-step cluster analysis, Chin. J. Anal. Chem.,2006,第1作者
（99）Comparison of biochemical effects induced by Changle between male and female rats using NMR and ICP-MS techniques,J. Rare Earths,2006,第1作者
（100）NMR-Based metabonomic study on the sub-acute biochemical effects of (Aristolochic acid),Food Chem. Toxicol.,2006,第2作者
（101）Studies of the acute toxicities of Lu(NO3)3 by NMR and pattern recognition techniques,Chem. J. Chin. Univ.,2005,第1作者
（102）Bioeffects of rare earth complex on rats studied by NMR and ICP-MS spectroscopy,J. Rare Earths,2005,第1作者
（103）Studies on the acute biochemical effects of La(NO3)3 using 1H NMR spectroscopy of urine combined with pattern recognition,J. Inorg. Biochem.,2005,第1作者
（104）Acute biochemical effects of La(NO3)3 on liver and kidney tissues by MAS 1H NMR and pattern recognition,Anal. Biochem.,2005,第1作者
（105）Comparison of metabolic profiles from serum for the hepatotoxin-treated rats by NMR spectroscopic-based metabonomic analysis,Anal. Biochem.,2005,第1作者
（106）NMR spectroscopic-based metabonomic investigation on the acute biochemical effects induced by Ce(NO3)3 in rats,J. Inorg. Biochem.,2005,第1作者
（107）NMR and pattern recognition studies on the acute biochemical effects of Lu(NO3)3,Chin. J. Chem.,2004,第1作者
（108）1H NMR spectroscopic studies on the acute toxicities of Lu(NO3)3 by biological fluids,Chin. J. Anal. Chem.,2004,第1作者
（109）

发表著作

科研活动
科研项目（ 1 ） 典型海洋污染物毒性生物标记物及其机理研究, 主持,部委级,2009-06--2012-06
（ 2 ） 海岸带典型污染物生态毒理效应研究, 主持,部委级,2010-09--2013-09
（ 3 ） 痕量重金属在菲律宾蛤仔体内毒理的系统生物学研究, 主持,省级,2010-05--2012-05
（ 4 ） 特征污染物对重要渔业生物的毒性效应, 主持,国家级,2015-01--2019-12
（ 5 ） 典型湿地生态系统恢复与重建关键技术研究与示范, 主持,国家级,2010-10--2014-12
（ 6 ） 海岸带生态毒理学, 主持,省级,2013-10--2016-10
（ 7 ） 中国南方典型河口生物的重金属生物动力学与毒理, 主持,国家级,2013-01--2017-12
（ 8 ） 渤海典型重金属污染物对菲律宾蛤仔毒理效应的代谢组学研究, 主持,国家级,2012-01--2014-12

参与会议

合作情况
项目协作单位

指导学生已指导学生
张林宝**
张杏艳**
刘小莉**
章盈盈**
吉成龙**
由丽萍**
曹璐璐**
魏磊**
陈丽竹**
现指导学生
刘佳琳**
于德良**
张明兴**
钟鸣宇**
徐兰兰**
王爽**
路珍**