基本信息
魏刚男博导中国科学院上海营养与健康研究所
电子邮件： weigang@picb.ac.cn
通信地址： 岳阳路320号
邮政编码：
部门/实验室：计算生物学伙伴研究所
研究领域

招生信息
招生专业0710Z2-计算生物学

招生方向表观遗传组学


教育背景2000-09--2005-07北京大学博士
1996-09--2000-07北京大学学士

学历
学位

工作经历
工作简历2012-01~现在,中科院上海生命科学研究院计算生物学研究所,研究员
2005-09~2011-12,美国国立健康研究院,博士后研究助理
2000-09~2005-07,北京大学,博士
1996-09~2000-07,北京大学,学士

社会兼职

教授课程

专利与奖励
奖励信息
专利成果

出版信息
发表论文（1）Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model,Clinicla Epigenetics,2016,第11作者
（2）A positive role for polycomb in transcriptional regulation via H4K20me1,Cell Research,2016,第11作者
（3）Retinoid signaling controls spermatogonial differentiation by regulating expression of replication-dependent core histone genes,Development,2016,第4作者
（4）Comparison of REST cistromes across human cell types reveals common and context-specific functions,PLoS Computational Biology,2014,第4作者
（5）Understanding human diseases with high-throughput quantitative measurement and analysis of molecular signatures,Science of China,2013,第2作者
（6）The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responses,Immunity,2012,第4作者
（7）c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells.,Cell,2012,第3作者
（8）Genome-wide mapping of nucleosome occupancy, histone modifications, and gene expression using next-generation sequencing technology,Methods of Enzymology,2012,第1作者
（9）Characterization of genome-wide enhancer-promoter interactions reveals co-expression of interacting genes and modes of higher order chromatin organization,Cell Research,2012,第2作者
（10）Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types,Immunity,2011,第1作者
（11）Mapping of INS promoter interactions reveals its role in long-range regulation of SYT8 transcription,Nature Structural and Molecular Biology,2011,第2作者
（12）The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma,Immunity,2010,第3作者
（13）Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq,Cell Research,2010,第3作者
（14）IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells,Proc Natl Acad Sci USA,2009,第2作者
（15）H3.3/H2A.Z double variant-containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions,Nature Genetics,2009,第3作者
（16）Detection of single nucleotide variations in expressed exons of the human genome using RNA-Seq,Nucleic Acids Research,2009,第2作者
（17）Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103+ inducible regulatory T cells,Journal of Experimental Medicine,2009,第3作者
（18）Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells,Immunity,2009,第1作者

发表著作

科研活动
科研项目（ 1 ） Th2 细胞分化过程中染色质长距离相互作用的调控功能, 主持,国家级,2013-01--2016-12
（ 2 ） 干细胞衰老的细胞分子机理及转化应用研究, 参与,国家级,2015-05--2019-08
（ 3 ） 细胞转分化过程中染色质高级结构的动态变化及其调控机制, 主持,国家级,2018-01--2021-12
（ 4 ） 非编码RNA介导的染色质高级结构动态变化对骨骼肌细胞谱系命运决定的调控功能及分子机制（中胚层）, 参与,国家级,2016-07--2020-12

参与会议

合作情况
项目协作单位

指导学生