基本信息
卫涛涛男博导中国科学院生物物理研究所
电子邮件： weitt@ibp.ac.cn
通信地址： 中科院生物物理所3505房间
邮政编码： 100101

研究领域

招生信息
招生专业071010-生物化学与分子生物学

招生方向生物膜动态变化、稳态维持的分子机制与重大疾病


教育背景1996-09--1999-06中国科学院生物物理研究所博士
1993-09--1996-07湖北省化学研究所硕士
1989-09--1993-06华中理工大学（现华中科技大学）学士

学历
学位

工作经历
工作简历2008-03~现在,中国科学院生物物理研究所,研究员
2001-02~2008-03,中国科学院生物物理研究所,副研究员
1999-07~2001-02,中国科学院生物物理研究所,助理研究员
1996-09~1999-06,中国科学院生物物理研究所,博士
1993-09~1996-07,湖北省化学研究所,硕士
1989-09~1993-06,华中理工大学（现华中科技大学）,学士

社会兼职2018-01-01-今,生物化学与生物物理进展, 编委会委员
2017-11-01-今,中国生物物理学会, 理事
2015-12-31-今,中国生物物理学会膜生物学分会, 理事、秘书长
2015-01-01-今,中国抗癌协会纳米肿瘤学专业委员会, 委员
2012-10-30-今,中国生物物理学会自由基生物学分会, 理事
2004-12-01-今,中华预防医学会自由基预防医学专业委员会, 常务委员


教授课程细胞生物学


专利与奖励
奖励信息（1） 中国科学院大学生命科学学院精品课程, 研究所（学校）, 2019

专利成果

出版信息
发表论文（1）Transforming growth factor (TGF)-β1-induced miR-133a inhibits myofibroblast differentiation and pulmonary fibrosis.,Cell Death & Disease,2019-09,第11作者
（2）Detection of tBid oligomerization and membrane permeabilization by graphene-based single-molecule surface-induced fluorescence attenuation,Nano Letters,2019-09,第11作者
（3）Genetically Encoded FapR-NLuc as a Biosensor to Determine Malonyl-CoA in Situ at Subcellular Scales,Bioconjugate Chemistry,2019-01,第11作者
（4）14-3-3 proteins recognize phosphorylated TFEB by a non-canonical mode for controlling TFEB cytoplasmic localization,Autophagy,2019-01,第11作者
（5）Tissue distribution, subcellular localization, and enzymatic activity analysis of human SIRT5 isoforms.,Biochemical and Biophysical Research Communications,2018,第11作者
（6）Human Elongation Factor 4 regulates cancer bioenergetics by acting as a mitochondrial translation switch.,Cancer Research,2018,第11作者
（7）SIRT5 deacylates metabolism-related proteins and attenuates hepatic steatosis in ob/ob mice,EBioMedicine,2018,第11作者
（8）Prediction of protein lysine acylation by integrating primary sequence information with multiple functional features.,Journal of Proteome Research,2016,第11作者
（9）Interactions of graphene with mammalian cells: Molecular mechanisms and biomedical insights.,Advanced Drug Delivery Reviews,2016,第11作者
（10）ESeroS-GS protects neuronal cells from oxidative stress by stabilizing lysosomes.,Molecules,2016,第11作者
（11）Phorbol myristate acetate suppresses breast cancer cell growth via down-regulation of P-Rex1 expression.,Protein & Cell,2016,第11作者
（12）Xanthohumol induces generation of reactive oxygen species and triggers apoptosis through inhibition of mitochondrial electron transfer chain complex I.,Free Radical Biology & Medicine,2015,第11作者
（13）Lysine malonylation is elevated in type 2 diabetic mouse models and enriched in metabolic associated proteins.,Molecular & Cellular Proteomics,2015,第11作者
（14）Inhibition of cancer cell migration by gold nanorods: molecular mechanisms and implications for cancer therapy.,Advanced Functional Materials,2014,第11作者
（15）The α-tocopherol derivative ESeroS-GS induces cell death and inhibits cell motility of breast cancer cells through the regulation of energy metabolism.,European Journal of Pharmacology,2014,第11作者
（16）Energy metabolism analysis reveals the mechanism of inhibition of breast cancer cell metastasis by PEG-modified graphene oxide nanosheets.,Biomaterials,2014,第11作者
（17）Lysosomal chymotrypsin induces mitochondrial fission in apoptotic cells by proteolytic activation of calcineurin.,Protein & Cell,2014,第11作者
（18）Inputs and outputs of insulin receptor.,Protein & Cell,2014,第11作者
（19）The inhibition of migration and invasion of cancer cells by graphene via the impairment of mitochondrial respiration.,Biomaterials,2014,第11作者
（20）Hydrogen peroxide impairs autophagic flux in a cell model of nonalcoholic fatty liver disease.,Biochemical and Biophysical Research Communications,2013,第11作者
（21）Plasma membrane calcium ATPase 4b inhibits nitric oxide generation through calcium-induced dynamic interaction with neuronal nitric oxide synthase.,Protein Cell,2013,第11作者
（22）Phosphatidic acid mediates the targeting of tBid to induce lysosomal membrane permeabilization and apoptosis.,Journal of Lipid Research,2012,第11作者
（23）The interactions between pristine graphene and macrophages and the production of cytokines/chemokines via TLR- and NF-κB-related signaling pathways.,Biomaterials,2012,第11作者
（24）TrxR1 and GPx2 are potently induced by isothiocyanates and selenium, and mutually cooperate to protect Caco-2 cells against free radical-mediated cell death.,Biochimica et Biophysica Acta Molecular Cell Research,2012,第4作者
（25）The triggering of apoptosis in macrophages by pristine graphene through the MAPK and TGF-beta signaling pathways.,Biomaterials,2012,第4作者
（26）质膜钙离子ATP酶,Plasma membrane calcium ATPase.,生物物理学报,2012,第11作者
（27）神经型一氧化氮合酶的活性调控,The regulation of neuronal nitric oxide synthase activity.,生物物理学报,2012,第11作者
（28）溶酶体与细胞凋亡,Lysosomes and apoptosis.,生命科学,2011,第11作者
（29）The inhibition of death receptor mediated apoptosis through lysosome stabilization following internalization of carboxyfullerene nanoparticles.,Biomaterials ,2011,第11作者
（30）ESeroS-GS modulates lipopolysaccharide-induced macrophage activation by impairing the assembly of TLR-4 complexes in lipid rafts.,Biochimica et Biophysica Acta Molecular Cell Research ,2011,第11作者
（31）Lysosomal chymotrypsin B potentiates apoptosis via cleavage of Bid.,Cellular and Molecular Life Sciences ,2010,第11作者
（32）Induction of inducible nitric oxide synthase increases the production of reactive oxygen species in RAW264.7 macrophages.,Bioscience Reports,2010,第11作者
（33）Breast Cancer Migration and Invasion Depend on Proteasome Degradation of Regulator of G-Protein Signaling 4.,Cancer Research,2009,第3作者
（34）Chymotrypsin B Cached in Rat Liver Lysosomes and Involved in Apoptotic Regulation through a Mitochondrial Pathway., The Journal of Biological Chemistry,2008,第3作者
（35）Melatonin impairs NADPH oxidase assembly and decreases superoxide anion production in microglia exposed to amyloid-b1–42.,Journal of Pineal Research,2008,第11作者
（36）The translocation of fullerenic nanoparticles into lysosome via the pathway of clathrin-mediated endocytosis.,Nanotechnology ,2008,第11作者

发表著作

科研活动
科研项目（ 1 ） 功能纳米材料与肿瘤间质细胞的相互作用, 主持,国家级,2012-01--2016-12
（ 2 ） 生物膜转运及其调控机制的研究, 参与,国家级,2010-01--2014-12
（ 3 ） 溶酶体胰凝乳蛋白酶的新功能探索, 主持,国家级,2011-01--2013-12
（ 4 ） 线粒体丙酮酸转运复合物作为抗糖尿病药物新靶标的发现与确证, 主持,部委级,2018-01--2019-12
（ 5 ） 铁基纳米材料类酶效应与急性髓系白血病诊疗技术, 参与,国家级,2017-07--2022-06
（ 6 ） 蛋白质丙二酰化修饰调控肿瘤细胞糖酵解的机制研究, 主持,国家级,2017-01--2020-12
（ 7 ） 膜脂-蛋白质相互作用介导溶酶体膜通透的机制研究, 主持,国家级,2015-01--2018-12
（ 8 ） 溶酶体参与能量与物质代谢稳态调控的蛋白质机器, 主持,国家级,2019-11--2024-10

参与会议

合作情况
项目协作单位

指导学生