基本信息
王斌贵男博导中国科学院海洋研究所
电子邮件： wangbg@ms.qdio.ac.cn
通信地址： 青岛市南海路7号
邮政编码： 266071
部门/实验室：实验海洋生物学重点实验室
研究领域

招生信息
招生专业070703-海洋生物学

招生方向海洋生物天然产物及生物制品
海洋药物及制品


教育背景1994-09--1997-06兰州大学博士

学历
学位

工作经历
工作简历2002-12~2018-06,中国科学院海洋研究所,研究员
2000-04~2002-12,德国杜塞尔多夫大学,博士后
1999-10~2000-03,日本京都大学,海外研究员
1997-07~1999-09,中国科学院昆明植物研究所,博士后，副研
1994-09~1997-06,兰州大学,博士
1986-07~1994-08,西安油脂科学研究院,助理研究员

社会兼职2017-03-01-2020-02-29,Chemistry & Biodiversity国际编委, 国际编委
2013-12-31-2018-12-31,中国海洋湖沼学会药物学分会, 理事长
2013-01-01-2018-12-31,Marine Drugs国际编委, 国际编委
2012-02-29-2021-12-31,青岛市政协, 政协委员、常委
2007-07-01-今,地（市、州、盟）侨联委员,


教授课程海洋天然产物
海洋天然产物结构解析原理与方法


专利与奖励
奖励信息（1） 海藻内生真菌代谢产物分子多样性与活性研究, 一等奖, 省级, 2016
（2） 海洋红藻中卤代化合物的快速识别、精准鉴定与生物活性研究, 二等奖, 省级, 2016
（3） 海洋红藻卤代活性成分的发现及关键技术研究, 二等奖, 部委级, 2016
（4） 青岛市技术发明奖, 二等奖, 市地级, 2014
（5） 青岛市自然科学优秀论文奖, 三等奖, 市地级, 2005
（6） 云南省自然科学一等奖, 一等奖, 省级, 2003

专利成果（ 1 ） 聚醚三萜类化合物及其制备方法和应用, 2008, 第 1 作者, 专利号: ZL 1.9
（ 2 ） 一种四降二萜双内酯类衍生物在制备抗肿瘤药物中的应用, 2011, 第 1 作者, 专利号: 9.9
（ 3 ） 一种Azaphilone类衍生物及其制备和应用, 2010, 第 1 作者, 专利号: 6.0
（ 4 ） 细胞松驰素类化合物及其制备方法和用途, 2009, 第 1 作者, 专利号: 5.9
（ 5 ） 海藻溴酚类化合物及其制备方法和应用, 2007, 第 1 作者, 专利号: ZL 0.6
（ 6 ） 多管藻中溴酚类化合物及其制备方法和应用, 2007, 第 1 作者, 专利号: ZL 0.5
（ 7 ） 一种弯孢霉菌素类衍生物及其制备方法和应用, 2013, 第 1 作者, 专利号: 8.8
（ 8 ） 一种抗海洋弧菌单萜衍生物及其制备方法和应用, 2014, 第 1 作者, 专利号: 20**
（ 9 ） 硫代二酮哌嗪类化合物及其制备方法和用途, 2014, 第 1 作者, 专利号: 20**
（ 10 ） 一种多羟基甾醇衍生物及其制备和应用, 2012, 第 1 作者, 专利号: ZL 2010 1 **.0
（ 11 ） 一种吲哚二酮哌嗪类衍生物及其制备方法和应用, 2012, 第 1 作者, 专利号: 3.5
（ 12 ） 抗细菌单萜化合物及其制备方法和用途, 2016, 第 1 作者, 专利号: ZL6.5
（ 13 ） 硫代二酮哌嗪类化合物及其制备方法和用途, 2017, 第 1 作者, 专利号: ZL0.2
（ 14 ） 一种三环系倍半萜类化合物及其制备方法和用途, 2017, 第 1 作者, 专利号: ZL6.4
（ 15 ） 一种抗海洋弧菌单萜衍生物及其制备方法和应用, 2017, 第 1 作者, 专利号: ZL2.8
（ 16 ） 一种缩酚酸肽类化合物及其制备方法和应用, 2018, 第 1 作者, 专利号: ZL20**
（ 17 ） 硫代二酮哌嗪类化合物及其应用, 2018, 第 1 作者, 专利号: ZL7.2


出版信息
发表论文（1）Isolation, Synthesis, and Radical-Scavenging Activity of Rhodomelin A, a Ureidobromophenol from the Marine Red Alga Rhodomela confervoides,Organic Letters,2018,第11作者
（2）Simpterpenoid A, a Meroterpenoid with a Highly Functionalized Cyclohexadiene Moiety Featuring gem-Propane-1,2-dione and Methylformate Groups, from the Mangrove-derived Penicillium simplicissimum MA-332,Organic Letters,2018,第11作者
（3）Two New Diketomorpholine Derivatives and a New Highly Conjugated Ergostane-Type Steroid from the Marine Algal-Derived Endophytic Fungus Aspergillus alabamensis EN-547,Marine Drugs,2018,第11作者
（4）New Citrinin Analogues Produced by Coculture of the Marine Algal-derived Endophytic Fungal Strains Aspergillus sydowii EN-534 and Penicillium citrinum EN-535,Phytochemistry Letters,2018,第11作者
（5）Antibacterial Anthraquinone Derivatives Isolated from a Mangrove-derived Endophytic Fungus Aspergillus nidulans by Ethanol Stress Strategy,The Journal of Antibiotics,2018,第11作者
（6）Characterization of Cladosporols from the Marine Algal-Derived Endophytic fungus Cladosporium cladosporioides EN-399 and Configurational Revision of the Previously Reported Cladosporol Derivatives,Journal of Organic Chemistry,2017,第11作者
（7）Antioxidant Hydroanthraquinones from the Marine Algal-Derived Endophytic Fungus Talaromyces islandicus EN-501,Journal of Natural Products,2017,第11作者
（8）Indolediketopiperazine Alkaloids from Eurotium cristatum EN-220, an Endophytic Fungus Isolated from the Marine Alga Sargassum thunbergii,Marine Drugs,2017,第11作者
（9）Three New Indole Diterpenoids from the Sea-Anemone-Derived Fungus Penicillium sp. AS-79,Marine Drugs,2017,第11作者
（10）Wentinoids A–F, Six New Isopimarane Diterpenoids from Aspergillus wentii SD-310, a Deep-sea Sediment Derived Fungus,RSC Advances,2017,第11作者
（11）Antimicrobial Polyketides from Trichoderma koningiopsis QA-3, an Endophytic Fungus Obtained from the Medicinal Plant Artemisia argyi,RSC Advances,2017,第11作者
（12）Antimicrobial Alkaloids Produced by the Mangrove Endophyte Penicillium brocae MA-231 Using the OSMAC Approach,RSC Advances,2017,第11作者
（13）Enhanced Production of Asperolide A, a Potential Anti-tumor Tetranorditerpenoid Originally Produced by the Algal-derived Endophytic Fungus Aspergillus wentii EN-48,Chinese Journal of Oceanology and Limnology,2017,第11作者
（14）Two New Diphenylketones and a New Xanthone from Talaromyces islandicus EN-501, an Endophytic Fungus Derived from the Marine Red Alga Laurencia okamurai,Marine Drugs,2016,第11作者
（15）Three Diketopiperazine Alkaloids with Spirocyclic Skeletons and One Bisthiodiketopiperazine Derivative from the Mangrove-derived Endophytic Fungus Penicillium brocae MA-231,Organic Letters,2016,第11作者
（16）Rhizovarins A?F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189,Journal of Natural Products,2016,第11作者
（17）Chermesins A?D: Meroterpenoids with a Drimane-Type Spirosesquiterpene Skeleton from the Marine Algal-Derived Endophytic Fungus Penicillium chermesinum EN-480,Journal of Natural Products,2016,第11作者
（18）Aspewentins D?H, 20-Nor-isopimarane Derivatives from the Deep Sea Sediment-Derived Fungus Aspergillus wentii SD-310,Journal of Natural Products,2016,第11作者
（19）Mycochemistry of Marine Algicolous Fungi,Fungal Diversity,2016,第11作者
（20）Secondary Metabolites from the Marine Algal-Derived Endophytic Fungi: Chemical Diversity and Biological Activity,Planta Medica,2016,第11作者
（21）20-Nor-isopimarane cycloethers from the deep-sea sediment-derived fungus Aspergillus wentii SD-310,RSC Advances,2016,第11作者
（22）Citrifelins A and B, Citrinin Adducts with a Tetracyclic Framework from Cocultures of Marine-derived Isolates of Penicillium citrinum and Beauveria felina,Journal of Natural Products,2015,第11作者
（23）Structure, Absolute Configuration, and Conformational Study of Resorcylic acid Derivatives and Related congeners from the fungus Penicillium brocae,RSC Advances,2015,第11作者
（24）Rubrumazines A–C, Indolediketopiperazines of the Isoechinulin Class from Eurotium rubrum MA-150, a Fungus Obtained from Marine Mangrove-derived Rhizospheric Soil,Journal of Natural Products,2015,第11作者
（25）Antimicrobial Phenolic Bisabolanes and Related Derivatives from Penicillium aculeatum SD-321, a Deep Sea Sediment-Derived Fungus,Journal of Natural Products,2015,第11作者
（26）Bisthiodiketopiperazines and Acorane Sesquiterpenes Produced by the Marine-Derived Fungus Penicillium adametzioides AS-53 on Different Culture Media,Journal of Natural Products,2015,第11作者
（27）Penicibrocazines A–E, Five New Sulfide Diketopiperazines from the Marine-Derived Endophytic Fungus Penicillium brocae,Marine Drugs,2015,第11作者
（28）Peniciadametizine A, a Dithiodiketopiperazine with a Unique Spiro[furan-2,7’-pyrazino[1,2-b][1,2]oxazine] Skeleton, and a Related Analogue, Peniciadametizine B, from the Marine Sponge-derived Fungus Penicillium adametzioides,Marine Drugs,2015,第11作者
（29）New Butenolide Derivatives from the Marine-derived Fungus Paecilomyces variotii with DPPH radical scavenging activity,Phytochemistry Letters,2015,第11作者
（30）New Indole-diterpenoids from the Algal-associated Fungus Aspergillus nidulans,Phytochemistry Letters,2015,第11作者
（31）Polyketides from the marine mangrove-derived fungus Aspergillus ochraceus MA-15 and their activity against aquatic pathogenic bacteria,Phytochemistry Letters,2015,第11作者
（32）Two new alkaloids from Penicillium oxalicum EN-201, an endophytic fungus derived from the marine mangrove plant Rhizophora stylosa,Phytochemistry Letters,2015,第11作者
（33）Oxepine-Containing Diketopiperazine Alkaloids from the Algal-Derived Endophytic Fungus Paecilomyces variotii EN-291,Helvetica Chimica Acta,2015,第11作者
（34）Diphenyl Ether and Benzophenone Derivatives from the Marine Mangrove-derived Fungus Penicillium sp. MA-37,Phytochemistry Letters,2014,第11作者
（35）Prenylated Indolediketopiperazine Peroxides and Related Homologues from the Marine Sediment-derived Fungus Penicillium brefeldianum SD-273,Marine Drugs,2014,第11作者
（36）Cyclodepsipeptides and Other O-Containing Heterocyclic Metabolites from Beauveria felina EN-135, a Marine-Derived Entomopathogenic Fungus,Marine Drugs,2014,第11作者
（37）Cyclohexadepsipeptides of the Isaridin Class from the Marine-Derived Fungus Beauveria felina EN-135,Journal of Natural Products,2014,第11作者
（38）Penicibilaenes A and B, Sesquiterpenes with a Tricyclo[6.3.1.01,5]dodecane Skeleton from the Marine Isolate of Penicillium bilaiae MA-267,Organic Letters,2014,第11作者
（39）Varioxepine A, a 3H-Oxepine-Containing Alkaloid with a New Oxa-Cage from the Marine Algal-Derived Endophytic Fungus Paecilomyces variotii,Organic Letters,2014,第11作者
（40）Brocazines A-F, Cytotoxic Bisthiodiketopiperazine Derivatives from Penicillium brocae MA-231, an Endophytic Fungus Derived from the Marine Mangrove Plant Avicennia marina,Journal of Natural Products,2014,第11作者
（41）Brocaeloids A–C, 4-Oxoquinoline and Indole Alkaloids with C-2 Reversed Prenylation from the Mangrove-Derived Endophytic Fungus Penicillium brocae,European Journal of Organic Chemistry,2014,第11作者
（42）Nigerasterols A and B, Antiproliferative Sterols from the Mangrove-Derived Endophytic Fungus Aspergillus niger MA-132,Helvetica Chimica Acta,2013,第11作者
（43）Sesterterpenes and 2H-Pyran-2-ones (=α-Pyrones) from the Mangrove-Derived Endophytic Fungus Fusarium proliferatum MA-84,Helvetica Chimica Acta,2013,第11作者
（44）Two New Secoanthraquinone Derivatives from the Marine-Derived Endophytic Fungus Aspergillus wentii EN-48,Helvetica Chimica Acta,2013,第11作者
（45）Triazoles and Other N-Containing Metabolites from the Marine-Derived Endophytic Fungus Penicillium chrysogenum EN-118,Helvetica Chimica Acta ,2013,第11作者
（46）Halogenated Molecules of Rhodomelaceae Origin: Chemistry and Biology,Chemical Reviews,2013,第11作者
（47）Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamurai,Marine Drugs,2012,第11作者
（48）Cristatumins A-D, new indole alkaloids from the marine-derived endophytic fungus Eurotium cristatum EN-220,Bioorganic and Medicinal Chemistry Letters,2012,第11作者
（49）New nitrogen-containing bromophenols from the marine red alga Rhodomela confervoides and their radical scavenging activity,Food Chemistry,2012,第11作者
（50）Asperolides A？C, Tetranorlabdane Diterpenoids from the Marine Alga-Derived Endophytic Fungus Aspergillus wentii EN-48,Journal of Natural Products,2012,第11作者
（51）Meroterpenoid and Diphenyl Ether Derivatives from Penicillium sp. MA-37, a Fungus Isolated from Marine Mangrove Rhizospheric Soil,Journal of Natural Products,2012,第11作者
（52）Diverse secondary metabolites produced by marine-derived fungus Nigrospora sp. MA75 on various culture media,Chemistry and Biodiversity,2012,第11作者
（53）Penicisteroids A and B, antifungal and cytotoxic polyoxygenated steroids from the marine alga-derived endophytic fungus Penicillium chrysogenum QEN-24S,Bioorganic and Medicinal Chemistry Letters,2011,第11作者
（54）Comazaphilones A–F, Azaphilone Derivatives from the Marine Sediment-derived Fungus Penicillium commune QSD-17,Journal of Natural Products,2011,第11作者
（55）Secondary Metabolites from a Marine-Derived Endophytic Fungus Penicillium chrysogenum QEN-24S,Marine Drugs,2011,第11作者
（56）Chemical constituents of marine algal-derived endophytic fungus Exophiala oligosperma EN-21,Chinese Journal of Oceanology and Limnology,2011,第11作者
（57）Aza-Alkaloids from the Marine Sediment-Derived Fungus Penicillium paneum SD-44,Journal of Natural Products ,2011,第11作者
（58）Bromophenols from Marine Red Alga Symphyocladia latiuscula and the PTP1B Inhibitory Activity,Chinese Journal of Oceanology and Limnology ,2011,第11作者

发表著作

科研活动
科研项目（ 1 ） 海洋红树林植物内生真菌的多样性与活性成分, 主持,国家级,2010-01--2012-12
（ 2 ） 973项目子课题, 主持,国家级,2010-01--2014-12
（ 3 ） 海洋微生物药物成药性研究, 主持,国家级,2011-07--2014-06
（ 4 ） 海洋动物寄生白僵菌Beauveria felina EN-135代谢产物分子多样性与活性研究, 主持,国家级,2013-01--2016-12
（ 5 ） 基于内共生的松节藻科若干关键海藻次生代谢的藻-菌互作研究, 主持,国家级,2014-01--2018-12
（ 6 ） 含硫、氮等杂原子的海洋真菌代谢产物分子多样性及其抗肿瘤活性研究, 主持,国家级,2017-01--2020-12
（ 7 ） 海洋来源小分子化合物温替莱克酮抗癌成药性研究, 主持,省级,2017-07--2020-06
（ 8 ） 深海天然化合产物抗肿瘤药物, 主持,研究所（学校）,2017-01--2018-12
（ 9 ） 深海冷泉生物多样性、环境适应性与应用潜力评估, 主持,国家级,2018-08--2021-12
（ 10 ） 深海极端环境微生物培养技术体系建立及资源挖掘, 参与,部委级,2019-01--2023-12

参与会议（1）Chemical diversity and bioactivity of metabolites from marine derived fungi2018-09-28
（2）深海微生物代谢产物分子多样性挖掘及其功能评价研究第11 届全国海洋生物技术与创新药物暨海洋生化学术会议王斌贵2018-08-26
（3）Diversified bioactive natural products from marine-derived endophytic fungi第十三届海洋药物学术年会暨2017国际海洋药物研讨会2017-11-05
（4）海洋真菌代谢产物分子多样性挖掘及其生物活性研究第二届澳门海洋论坛王斌贵2017-03-31
（5）Bioactive secondary metabolites from alga-derived endophytic fungi王斌贵2010-09-20


合作情况
项目协作单位

指导学生