基本信息
田宇清男硕导中国科学院微生物研究所
电子邮件： tianyq@im.ac.cn
通信地址： 北京市朝阳区北辰西路1号院3号，中国科学院微生物研究所A618室
邮政编码： 100101

研究领域微生物次级代谢的合成与调控

招生信息
招生专业071007-遗传学

招生方向微生物次级代谢的合成与调控


教育背景1994-09--1997-05中国科学院微生物研究所硕士研究生
1987-09--1991-07北京大学分校学士

学历
学位

工作经历
工作简历2007-05~现在,中国科学院微生物研究所，微生物资源前期开发国家重点实验室,副研究员
2001-07~2003-12,Department of Molecular Microbiology, John Innes Centre, UK,访问
1999-05~2001-02,北京华大基因研究中心,合作研究
1996-11~2007-04,中国科学院微生物研究所，微生物代谢工程研究中心,助理研究员
1991-08~1996-10,中国科学院微生物研究所，遗传与育种研究室,实习研究员

社会兼职

教授课程微生物遗传与分子生物学


专利与奖励
奖励信息
专利成果

出版信息
发表论文（1）Reconstruction of a hybrid nucleoside antibiotic gene cluster based on scarless modification of large DNA fragment,Sci China Life Sciences,2017,通讯作者
（2）Activation and molecular mechanism of a cryptic oviedomycin biosynthetic gene cluster via the disruption of a global regulatory gene--adpA in Streptomyces ansochromogenes,Journal of Biological Chemistry,2017,通讯作者
（3）Specialised metabolites regulating antibiotic biosynthesis in Streptomyces spp,FEMS Microbiol Rev,2016,第3作者
（4）Genome engineering and direct cloning gene cluster via phage phiBT1 integrase-mediated site-specific recombination in Streptomyces,Sci Rep,2015,第3作者
（5）GouR, a TetR-family t ranscriptional regulator, coordinates the biosynthesis and export of gougerotin in Streptomyces graminearus,Appl Environ Microb,2014,第2作者
（6）Assembly and features of secondary metabolite biosynthetic gene clusters in Streptomyces ansochromogenes,Sci China Life Sciences,2013,通讯作者
（7）Improvement of gougerotin and nikkomycin production by engineering their biosynthetic gene clusters,Appl Microbiol Biotechnol,2013,第4作者
（8）Importance and regulation of inositol biosynthesis during growth and differentiation of Streptomyces coelicolor,Mol Microbiol,2012,第1作者
（9）Hybrid antibiotics with the nikkomycin nucleoside and polyoxin peptidyl moieties,Metab Eng,2011,第3作者
（10）SabR enhances nikkomycin production via regulating the transcriptional level of sanG, a pathway-specific regulatory gene in Streptomyces ansochromogenes,BMC Microbiol,2011,第4作者
（11）Hybrid antibiotics with the nikkomycin nucleoside and polyoxin peptidyl moieties,Metab Eng,2011,第3作者
（12）Characterization of EndoTT, a novel single-stranded DNA specific endonuclease from Thermoanaerobacter tengcongensis,Nucleic Acids Res,2010,第4作者
（13）Cloning, reassembling and integration of the entire nikkomycin biosynthetic gene cluster into Streptomyces ansochromogenes lead to an improved nikkomycin production,Microb Cell Fact,2010,第5作者
（14）SCO3900, co-transcripted with three downstream genes, is involved in the differentiation of Streptomyces coelicolor,Current Microbiology,2010,第2作者
（15）The pleiotropic regulator AdpA-L directly controls the pathway-specific activator of nikkomycin biosynthesis in Streptomyces ansochromogenes,Mol Microbiol,2009,第4作者
（16）The pleiotropic regulator AdpA-L directly controls the pathway-specific activator of nikkomycin biosynthesis in Streptomyces ansochromogenes,Mol Microbiol,2009,第4作者
（17）Selectively improving nikkomycin Z production by blocking the imidazolone biosynthetic pathway of nikkomycin X and uracil feeding in Streptomyces ansochromogenes,Microb Cell Fact,2009,第5作者
（18）polR, a pathway-specific transcriptional regulatory gene, positively controls polyoxin biosynthesis in Streptomyces cacaoi subsp. asoensis,Microbiology-SGM,2009,第3作者
（19）The tyrosine degradation gene hppD is transcriptionally activated by HpdA and repressed by HpdR in Streptomyces coelicolor, while hpdA is negatively autoregulated and repressed by HpdR,Molecular Microbiology,2007,第4作者
（20）An unusual response regulator influences sporulation at early and late stages in Streptomyces coelicolor,JOURNAL OF BACTERIOLOGY,2007,第1作者
（21）SanM catalyzes the formation of 4-pyridyl-2-oxo-4-hydroxyisovalerate in nikkomycin biosynthesis by interacting with SanN,Biochemical and Biophysical Research Communications,2007,第3作者
（22）SanT, a bidomain protein, is essential for nikkomycin biosynthesis of Streptomyces ansochromogenes,Biochemical and Biophysical Research Communications,2007,第2作者
（23）Identification and characterization of sawC, a whiA-like gene, essential for sporulation in Streptomyces ansochromogenes,Arch Microbiol,2007,第3作者
（24）SanJ, an ATP-dependent picolinate-CoA ligase, catalyzes the conversion of picolinate to picolinate-CoA during nikkomycin biosynthesis in S. ansochromogenes,Metabolic Engineering,2006,第3作者
（25）A pathway-specific transcriptional regulatory gene for nikkomycin biosynthesis in Streptomyces ansochromogenes that also influences colony development,Molecular Microbiology,2005,第2作者
（26）Lambda red-mediated genetic manipulation of antibiotic producing Streptomyces,Adv Appl Microbiol,2004,第4作者
（27）A novel Streptomyces gene, samR, with different effects on differentiation of Streptomyces ansochromogenes and Streptomyces coelicolor,Arch Microbiol,2002,第2作者
（28）A Complete Sequence of the T. tengcongensis Genome,Genome Research,2002,第1作者
（29）The Streptomyces coelicolor sporulation-specific Sigma-WhiG form of RNA polymerase transcribes a gene encoding a ProX-like protein that is dispensable for sporulation,Gene,1998,第3作者

发表著作

科研活动
科研项目（ 1 ） 圈卷产色链霉菌隐性次级代谢基因簇的调控机制, 主持,国家级,2014-01--2017-12
（ 2 ） 合成微生物体系的适配性研究, 参与,国家级,2013-01--2017-08
（ 3 ） 尼可霉素生物合成中信号分子介导的SabR调控的分子机制, 参与,国家级,2016-01--2019-12

参与会议

合作情况
项目协作单位

指导学生已指导学生
朱宇硕士研究生071007-遗传学
卓继明硕士研究生071007-遗传学
徐晶晶博士研究生071007-遗传学