基本信息
孙飞男博导中国科学院生物物理研究所
电子邮件： feisun@ibp.ac.cn
通信地址： 北京朝阳区大屯路15号8212室
邮政编码： 100101

研究领域综合运用冷冻电镜三维重构、X射线晶体学以及其他生物物理等研究技术和手段，开展生物大分子复合体和膜蛋白的结构与功能研究，研究内容主要集中在冷冻电镜三维重构技术方法学、重要生物超大分子复合体和膜蛋白的结构功能研究以及生物膜（如线粒体膜）动态的分子机制研究三个方向。同时，瞄准冷冻电镜三维重构技术的前沿，深入开展新技术、新方法的研究。

招生信息
招生专业071010-生物化学与分子生物学


招生方向线粒体动态的分子机制；生物超大分子复合体结构功能；
膜蛋白、蛋白质复合体、细胞/细胞器的结构与功能研究；
生物成像方法学研究。

教育背景2001-09--2006-07清华大学博士
1997-09--2001-07南京大学学士

学历 清华大学 -- 研究生

学位 清华大学 -- 博士


工作经历
工作简历2006/7 - 至今，中国科学院生物物理研究所，研究员
2012/7 - 至今，中国科学院生物物理研究所，研究平台生物成像中心，主任
社会兼职2009年至今，中国生物物理学会理事，生物超微结构显微成像专业委员会副主任，青年工作委员会主任
2010年至今，中国电子显微镜学会低温电子显微学专业委员会委员
2012年至今，北京电镜学会理事
2010 - 2014，《生物物理学报》常务编委
2015年至今，Biophysics Reports, Associate Editor

教授课程细胞成像技术
生物大分子电子显微三维重构
结构生物学导论
生物物理学系列讲座
生物大分子电子显微分析
国家税收

中国科学院大学研究生课程《生物大分子电子显微三维重构》（专业选修课）
《细胞成像原理和技术》
华中科技大学-生物物理所贝时璋英才班课程《生物成像原理和技术》
中国科学院大学本科生课程《生物物理学概论》

专利与奖励
奖励信息（1） 贝时璋青年生物物理学家奖, , 其他, 2009
（2） 全国优秀博士论文奖, , 国家级, 2008
（3） 中央国家机关优秀青年, , 国家级, 2008

专利成果（1） 季刚，李硕果，孙飞；专利名称：光镜电镜关联成像用光学真空冷台，专利授权号：2014 2 **.X
（2）季刚，李硕果，孙飞；专利名称：一种光镜电镜关联成像用光学真空冷台；专利申请号：4.8
（3）孙飞，庞效云，翟宇佳，王刚刚，谢天；专利名称：用于在细菌表面呈递目的蛋白的DNA分子及其应用；专利申请号：6.6
（4）黄小俊，季刚，孙飞；专利名称：透射电子显微镜载网制备方法；专利申请号：9.8

发表论文在电镜图像处理方法学研究、生物膜变形分子机制研究、生物超大分子复合体和膜蛋白/膜结合蛋白的结构功能研究领域均取得突出成果，在国际国内重要学术刊物上发表成果性研究论文96篇，包括以第一作者或通讯作者在Cell，Developmental Cell，Nature Communications，Nat. Struct. Mol. Biol.，PLoS Pathogens，STRUCTURE等国际知名学术刊物上发表的论文。
论文目录如下：


1. Wang S., Li S., JiG., Huang X. and Sun F.* (2017), Using integrated correlativecryo-light and electron microscopy to directly observe syntaphilin-immobilizedneuronal mitochondria in situ. Biophysics Reports (online). doi: 10.1007/s41048-017-0035-x
2. Chen Y., Wang Z.,Zhang J., Li L., Wan X., Sun F.*, and Zhang F.* (2017),Accelerating electron tomography reconstruction algorithm ICON with GPU. BiophysicsReports (in press).
3. Zhou Y., Lou H.,Liu Z., Yang M., Pang X., Sun F. and Wang G.* (2017), Structuralinsight into the specific DNA template binding to DnaG primase in Bacteria. ScientificReport, 7(1): 659. doi: 10.1038/s41598-017-00767-8.
4. Chan K.C., Lu L., SunF., Fan J. (2017), Molecular details of the PH domain of ACAP1BAR-PHprotein binding to PIP-containing membrane. JPhys Chem B. doi:10.1021/acs.jpcb.6b09563. [Epub ahead of print]
5. Chen R., Gao B.,Liu, X., Ruan F., Zhang Y., Lou J., Feng K., Wunsch C., Li S.M., Dai J.* and SunF.* (2017), Molecular insights into the enzyme promiscuity of anaromatic prenyltransferase. Nature Chemical Biology (Advancedonline at Dec. 19, 2016), 13(2): 226-234. doi: 10.1038/nchembio.2263.
6.Wei R., Wang X., Zhang Y., Mukherjee S., Zhang L., ChenQ., Huang X., Jing S., Liu C., Li S., Wang G., Xu Y., Zhu S., Williams A., SunF.* and Yin C.C.* (2016), Structural insights into Ca2+ -activatedlong-range allosteric channel gating of RyR1. Cell Research 26:977-994 (Cover story). doi: 10.1038/cr.2016.99
7. Wang S., Zhai Y.,Pang X., Niu T., Ding Y.H., Dong, M.Q., Hsu W.V. Sun Z.* and Sun F.*(2016), Structural characterization of coatomer in its cytosolic state. ProtenCell 7(8): 586-600.doi: 10.1007/s13238-016-0296-z.[This researchhas been recommended In F1000Prime, 12 Dec 2016; DOI:10.3410/f... F1000Prime.com/#eval]
8. Chen Y., Zhang Y.,Zhang K.*, Deng Y., Zhang F.* and Sun F.* (2016), FIRT: filterediterative reconstruction technique with information restoration. Journalof Structural Biology 195(1) : 49-61. doi: 10.1016/j.jsb.2016.04.015.
9. Deng Y., Chen Y.,Zhang Y., Wang S., Zhang F.* and Sun F.* (2016), ICON: 3Dreconstruction with ‘missing-information’ restoration in biological electrontomography. Journal of Structural Biology 195(1) : 100-112. doi: 10.1016/j.jsb.2016.04.004.
10. Zhang J., Ji G.,Huang X., Xu W.* and Sun F.* (2016), An improved cryo-FIB methodfor fabrication of frozen hydrated lamella. Journal of Structural Biology194(2): 218-223. doi: 10.1016/j.jsb.2016.02.013.
11. Li W., Ding W., JiG., Zhang J. and Sun F.* (2016), Three-dimensional visualizationof arsenic stimulated mouse liver sinusoidal by FIB-SEM approach. ProtenCell 7(3) : 227-232.doi: 1007/s13238-016-0246-9.
12. Shan H., Wang Z.,Zhang F., Xiong Y., Yin C.C.* and Sun F.* (2016), Alocal-optimization refinement algorithm in single particle analysis formacromolecular complex with multiple rigid modules. Proten Cell 7(1): 46-62. doi:10.1007/s13238-015-0229-2.
13. Mao G., Zhao Y.,Kang X., Li Z., Zhang Y., Wang X., Sun F., Sankaran, K., andZhang, X.C. (2016), Crystal structure of E. coli lipoprotein diacylglyceryltransferase. Nature communications 7, 10198.
14. Cui Y., Zhao S.,Wang J., Gao B., Fan Q., Sun F. and Zhou B. (2015), A novelmitochondrial carrier protein Mme1 acts as a yeast mitochondrial magnesiumexporter. Biochim Biophys Acta. 1854(3): 724-32. doi:10.1016/j.bbamcr.2014.12.029.
15. Ma D.K., Li Z., LuA.Y., Sun F., Chen S., Rothe M., Menzel R., Sun F. and HorvitzHR.* (2015), Acyl-CoA Dehydrogenase Drives Heat Adaptation by SequesteringFatty Acids. Cell, 161(5) : 1152-63. doi:10.1016/j.cell.2015.04.026.
16. Gao B., Chen R.,Liu X., Dai J. and Sun F.* (2015), Expression, purification,crystallization and crystallographic study of the Aspergillus terreus acromaticprenyltransferase AtaPT. Acta Crystallogr F Struct Biol Commun.F71: 889-894. doi: 10.1107/S**X**.
17. Sun F. (Sun Fang),Pang X., Xie T., Zhai Y., Wang G.G.* and Sun F.* (2015),BrkAutoDisplay: functional display of multiple exogenous proteins on thesurface of Escherichia coli by using BrkA autotransporter. MicrobialCell Factories. 14: 129. doi: 10.1186/s12934-015-0316-3.
18. Liu B., Xue Y.,Zhao W., Chen Y., Fan C., Gu L., Zhang Y., Sun L., Huang X., Ding W., SunF., Ji W.* and Xu T.* (2015), Three-dimensional super-resolutionprotein localization correlated with vitrified cellular context. Sci Rep5, 13017. doi: 10.1038/srep13017.
19. Han R., Wang L.,Liu Z., Sun F.* and Zhang F.* (2015), A novel fully automaticscheme for fiducial marker-based alignment in electron tomography. Journalof Structural Biology 192: 403-17. doi: 10.1016/j.jsb.2015.09.022.(The program markerauto can be downloaded from http://ear.ict.ac.cn/)
20. Pang X., Fan J.,Zhang Y., Zhang K., Gao B., Ma J., Li J., Deng Y., Zhou Q., Egelman E.H., HsuV.W.* and Sun F.* (2014), A PH Domain in ACAP1 PossessesKey Features of the BAR Domain in Promoting Membrane Curvature. DevelopmentalCell, 31(1) : 73-86. doi: 10.1016/j.devcel.2014.08.020. [CAS News]This paper was commented and previewed in the same issue by Haucke andcolleagues (Dev. Cell. 31(1): 3-4.). [This research has been recommended In F1000Prime, 17 Nov 2014; DOI:10.3410/f... F1000Prime.com/#eval]
21. Xu Y., Li H., JinYH., Fan J.* and Sun F.* (2014), Dimerization interface of3-hydroxyacyl-CoA dehydrogenase tunes the formation of its catalyticintermediate. PLOS one. 9(4): e95965. doi:10.1371/journal.pone.**.
22. Ma J. and SunF.* (2014), Expression, purification, crystallization and preliminary crystallographicstudy of the cytoplasmic domain of the mitochondrial dynamics protein MiD51. ActaCrystallographica Section F. F70: 596-599.doi:10.1107/S**X**.
23. Sun F., Li J. and ChenC.* (2014), Puzzle out the regulation mechanism of PI4KIIα activity. SciChina Life Sci. doi: 10.1007/s11427-014-4656-8.
24. Zhou Q., Li J., YuH., Zhai Y., Gao Z., Liu Y., Pang X., Zhang L., Schulten K., Sun F.*and Chen C.* (2014), Molecular insights into the membrane-associatedphosphatidylinositol 4-kinase IIα. Nature Communications, 5:3552.doi:10.1038/ncomms4552. [CAS News][This researchhas been recommended In F1000Prime, 18 Jul 2014;DOI: 10.3410/f... F1000Prime.com/#eval]
25. Qiu B., Zhang K.,Wang S., Sun F.* (2014). C-terminal motif within Sec7 domainregulates guanine nucleotide exchange activity via tuning protein conformation.Biochem Biophys Res Commun, 446(1) : 380-386. doi: 10.1016/j.bbrc.2014.02.125.
26. Han R., Zhang F.,Wan X., Fernandez J.J., Sun F. and Liu Z. (2014). A marker-freeautomatic alignment method based scale-invariant features. Journal ofStructural Biology, 186 : 167-180. doi: 10.1016/j.jsb.2014.02.011.
27. Cheng, L., Huang,X., Li, X., Xiong, W., Sun, W., Yang, C., Zhang, K., Wang, Y., Liu, H., Huang,X., Ji, G., Sun F., Zheng, C.* and Zhu, P.* (2014).Cryo-EM structures of two bovine adenovirus type 3 intermediates. Virology,450-451 : 174-181.
28. Zhang, Y., and SunF.* (2013). Electron Microscopy Reconstruction of Helical Assemblies. ActaBiophys Sin, 29: 879-898.
29. Sun F.*, Zhou Q., PangX., Xu Y. and Rao Z. (2013), Revealing various coupling of electron transferand proton pumping in mitochondrial respiratory chain. Current Opinion inStructural Biology, 23: 526-538. doi: 10.1016/j.sbi.2013.06.013.
30. Zhang K., Wang L.,Liu Y., Chan K.Y., Pang X., Schulten K., Dong Z. and Sun F.*(2013), Flexible interweaved termini determine the thermal stability ofthermosomes. Protein Cell, 4(6): 432-444. doi:10.1007/s13238-013-3026-9.
31. Zhang Y., Wang W., ChenJ., Zhang K., Gao F., Gao B., Zhang S., Dong M., Besenbacher F., GongW., Zhang M., Sun F.* and Feng W.* (2013), Structural insightsinto the intrinsic self-assembly of Par-3 N-terminal domain. Structure,21(6):997-1006. doi: 10.1016/j.str.2013.04.004.
32. Lu J., Zhai Y. andSun F.* (2013), Research of Mitochondrial Calcium Transportation.ACTA BIOPHYSICA SINICA, 29(3): 167-180.
33. Xu Y. and SunF.* (2013), Purification, crystallization and preliminarycrystallographic analysis of 3-hydroxyacyl-CoA dehydrogenase from Caenorhabditiselegans. Acta Crystallographica Section F, F69: 515-519.doi:10.1107/S**07045.
34. Wu L., Zhai Y., LuJ., Wang Q. and Sun F.* (2013), Expression, purification andpreliminary characterization of glucagon receptor extracellular domain. ProteinExpression and Purification, 89: 232-240. doi:10.1016/j.pep.2013.04.004.
35. Quinlan R., ZhangY., Lansbury A., Williamson I., Pohl E.* and Sun F.* (2013),Changes in the quaternary structure and function of MjHSP16.5 attributable todeletion of the I-X-I motif and introduction of the substitution, R107G in thealpha-crystallin domain. Philosophical Transactions of The Royal SocietyB, 368. doi:10.1098/rstb.2012.0327.
36. Wang X., Xu F., Liu J.,Gao B., Liu Y., Zhai Y., Ma J., Zhang K., Baker T.S., Schulten K., Zheng D.*,Pang H.* and Sun F.* (2013), Atomic model of rabbit hemorrhagic diseasevirus by cryo-electron microscopy and crystallography. PLoS Pathogens,9(1): e**. doi: 10.1371/journal.ppat.**. [NSFC News][China ScienceDaily News][NCSA of UIUC News]
37. Zhang S.,Andreasen M., Nielsen J.T., Liu L., Nielsen E.H., Song J., Ji G., SunF., Skrydstrup T., Besenbacher F., Nielsen N.C., Otzen D.E andDong M.* (2013), Coexistence of ribbon and helical fibrils originating fromhIAPP20-29 revealed by quantitative nanomechanical atomic force microscopy. PNAS,doi:10.1073/pnas..
38. Wang L., Li Q., WuL., Liu S., Zhang Y., Yang X., Zhu P., Zhang H., Zhang K., Lou J., Liu P., TongL.*, Sun F.* and Fan Z.* (2013), Identification of SERPINB1 as aphysiological inhibitor of human granzyme H. The Journal of Immunology,190(3):1319-30. doi:10.4049/jimmunol.**.
39. Yang S., Liu X.,Li, X., Sun S.F., Sun F., Fan B., and Zhao S.* (2013),MicroRNA-124 reduces caveolar density by targeting caveolin-1 in porcine kidneyepithelial PK15 cells. Molecular and cellular biochemistry 384,213-219.
40. Wang G., Zhang F.,Fan L., Sun F. and Liu, Z. (2013) Contrast TransferFunction Correction Model Based on Sine and Gaussian Modulation and SplineInterpolation. Journal of Computer Research and Development 50,808-814.
41. Wang G., Zhang F.,Fan L., Sun F. and Liu, Z. (2013) A fast calculationstrategy of density function in ISAF reconstruction algorithm. ScientiaSinica Informationis 43, 584-598.
42. Zhao Y., Zhao H.,Miao L., Wang L., Sun F. and Zhang H. (2012), The p53-inducedgene Ei24 is an essential component of the basal autophagy pathway. Journalof Biological Chemistry, 287(50):42053-63.
43. Wang S. and SunF.* (2012), Dynactin is an indispensable helper for dynein’s function inintracellular motility. ACTA BIOPHYSICA SINICA, 28(10):785-793.
44. Bai M., Pang X.,Lou J., Zhou Q., Zhang K., Ma J., Li J., Sun F.* Hsu V.* (2012),Mechanistic insights into regulated cargo binding by ACAP1. Journalof Biological Chemistry, 287: 28675-28685.
45. Hu J., Sun L.,Shen F., Chen Y., Hua Y., Liu Y., Zhang M., Hu Y., Wang Q., Xu W., Sun F.,Ji J., Murray J., Carr A., Kong D.* (2012), The Intra-S phase checkpointtargets Dna2 to prevent stalled replication forks from reversing. Cell,149: 1221-1232.
46. Yang C., Ji G.,Liu H., Zhang K., Liu G., Sun F., Zhu P.*, Cheng L*. (2012),Cryo-EM structure of a transcribing cypovirus. PNAS, 109(16):6118-6123.
47. Wang G., Zhang F.,Sun F., Liu Z. (2012), An accelerated ISAF algorithm with thefast mapping strategy. Journal of Computers, 7(2): 528-533.
48. Guo H., Yuan X.,Liu J., Shan G., Chi X., Sun F. (2012), Interference microscopyvolume illustration for biomedical data. Pacific Visualization Symposium(PacificVis), 2012 IEEE. 177-184. doi: 10.1109/PacificVis.2012.**.
49. Wang L., Zhang K.,Wu L., Liu S., Zhang H., Zhou Q., Tong L., Sun F.* and Fan Z.*.(2012), Structural Insights into the substrate specificity of human granzyme H- the functial roles of a novel RKR motif. The Journal of Immunology,188(2): 765-73.
50. Wang X., Wang L.,Wang Xi., Sun F.* and Wang C.C.*.(2012), Structural insights intothe peroxidase activity and inactivation of human peroxiredoxin 4. Biochem.J.,441: 113-118.
51. Cheng L., Sun J.,Zhang K., Mou Z., Huang X., Ji G., Sun F., Zhang J.*, Zhu P.*(2011), Atomic model of a cypovirus built from cryo-EM structure providesinsight into the mechanism of mRNA capping. PNAS,108(4):1373-1378.
52. Wang L., Zhang K.,Fan Z., Dong Z., Sun F.* (2011), Substrate binding properties ofthermosome ATcpn-beta from Acidianus Tengchongensis. Progress inBiochemistry and Biophysics, 38(2):151-158.
53. Zhai Y., Zhang K.,Huo Y., Zhu Y., Zhou Q., Lu J., Black I., Pang X., Roszk A.W., Zhang X., IsaacsN.W., Sun F.* (2011), Autotransporter passenger domain secretionrequires a hydrophobic cavity at the extracellular entrance of the beta-domainpore. Biochem. J. , 435:577-587. (This paper was featured as akey scientific article by Global MedialDiscovery.))
54. Chu Q., Zhang K.,Wan X., Zhang C., Zhang Y., Zhang G., Shen B., Lu X., Zhao K.,Chu X., ZhangF.*, Sun F.* (2011), ATOM1.0 : A GPU Powered Package for ElectronTomography Reconstruction. ACTA BIOPHYSICA SINICA, 27(3):231-241.(The software ATOM1.0 could be found here.)
55. Zheng X., Guo J.,Xu L., Li H., Zhang D., Zhang K.,Sun F., Wen T., Liu S., Pang H.*(2011), Crystal Structure of a Novel Esterase Rv0045c from Mycobacteriumtuberculosis. PLoS ONE, 6(5): e20506.doi:10.1371/journal.pone.**
56. Wan X., Zhang F., Chu Q.,Zhang K., Sun F., Yuan B., Liu Z.* (2011), Three-dimensionalreconstruction using an adaptive simultaneous algebraic reconstructiontechnique in electron tomography. Journal of Structural Biology ,175(3):277-87. doi:10.1016/j.jsb.2011.06.002
57. Zhou Q., Zhai Y.,Lou J., Liu M., Pang X. and Sun F.* (2011), Thiabendazoleinhibits ubiquinone reduction activity of mitochondrial respiratory complex IIvia a water molecule mediated binding feature. Protein & Cell,2(7):531-542, doi:10.1007/s13238-011-1079-1 (cover story).
58. Li M., Xu G.*,Sorzano, O.S.C., Sun F. and Bajaj L.C. (2011), Single-particlereconstruction using L2-gradient flow. Journal of Structural Biology,176:259-267.doi:10.1016/j.jsb.2011.08.005.
59. Sun Fei* and Wang Xue.(2011), Application and aspect of cryo-electron microscopy for the structuralstudy of membrane proteins. Chinese Bulletin of Life Sciences,23(11):1130-1139.
60. Chen Shaohong,Pang Xiaoyun and Sun Fei*. (2011), Mitochondrial movement and itsrelated cytoskeletons and proteins. ACTA BIOPHYSICA SINICA,27(12):1019-1029.
61. Wang G., Zhang F.,Fan L., Sun F., Liu Y. (2011), Analysis and solution ofcomplexity of basis function in ISAF reconstruction algorithm. Journal ofComputer-Aided Design & Computer Graphics. 23 (7) : 1148-1158.
62. Li Z., Zhai Y.,Fang J., Zhou Q., Geng Y., Sun F.* (2010), Purification,crystallization and preliminary crystallographic analysis of very long chainAcyl-CoA dehydrogenase from Caenorhadbitis elegans. ActaCrystallographica Section F, F66: 426-430.
63. Wang L., Hu Z.,Luo Y., Huo Y., Ma Q., He Y., Zhang Y., Sun F.*, Dong Z.* (2010),Distinct symmetry and limited peptide refolding activity of the thermosomesfrom the acidothermophilic archaea Acidianus tengchongensis S5T, BiochemBiophys Res Commun, 393: 228-234.
64. Li Z., Zhang K., Zhai Y., ZhouQ., Geng Y., Sun F.* (2010), Cloning, Expression, Purificationand Preliminary Crystallographic Analysis of Caenorhabditis elegnas Enoyl-CoAHydratase. Acta Biophysica Sinica, 26(1):37-48.
66. Hu Z., Tian X.,Zhai Y., Xu W., Zheng D., Sun F.* (2010), Cryo-ElectronMicroscopy Reconstructions of Two Types of Wild Rabbit Hemorrhagic DiseaseViruses Characterized the Structural Features of Lagovirus. Protein &Cell, 1(1):48-58. (Cover story).
67. Zhou Q., Sun J.,Zhai Y., Sun F.* (2010). Prokaryotic Expression of ActiveMitochondrial Uncoupling Protein 1. Progress in Biochemistry andBiophysics, 37(1): 56~62.
68. Li S., Zhao Q.,Zhou Q., Unno H., Zhai Y., Sun F.*(2010). The Role and Structureof Carboxyl-terminal Domain of the Human Voltage-gated Proton Channel HV1. Journalof Biological Chemistry, 285 (16): 12047-12054.
69. hang S., Zhang K.,Chen X., Chu X., Sun F.*, Dong Z. (2010), Five mutations inN-terminus confer thermostability on mesophilic xylanase, BBRC,395: 200-206.
70. Lu B., Zhai Y., Wu C., PangX., Xu Z. and Sun F.* (2010), Expression, purification andpreliminary biochemical studies of the N-terminal domain of leucine-rich repeatkinase 2, Biochimica et Biophysica Acta, 1804: 1780-1784.
71. Zhang K., ZhangY., Hu Z., Gang J. and Sun F.* (2010), Development and Frontierof Electron Microscopy 3D Reconstruction. ACTA BIOPHYSICA SINICA,26(7): 533-559. (cover story)
72. 71.Zhang Y, Liu D, Chen X, LiJ, Li L, Bian Z, Sun F., Lu J, Yin Y, Cai X, Sun Q, Wang K, Ba Y,Wang Q, Wang D, Yang J, Liu P, Xu T, Yan Q, Zhang J, Zen K, Zhang CY. (2010).Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol.Cell, 39(1):133-44.
73. Hu YW, Hu ZJ,Zhang K, Wang L, Zhai Y, Zhou QJ, Lander G, Zhu J, He YZ, Pang XY, Xu W,Bartlam M, Dong ZY, Sun F.*. (2010). Crystal structure of groupII chaperonin in the open state. Structure, 18(10): 1270-1279.(cover story)
74. Ma J, Sun F.*(2010). Translocation of Mitochondrial Proteins. ACTA BIOPHYSICA SINICA,26(10): 880-893.
75. Xu L., Guo J.,Zheng X., Wen T., Sun F., Liu, S., and Pang, H.* (2010).Crystallization and preliminary X-ray analysis of a novel esterase Rv0045c fromMycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol CrystCommun 66, 1579-1582.
76. Zhang K,, ZhangC,, Sun F*. (2009) Disclosing the Structure and Function ofTranslation Machine - Introduction of the Noble Prize in Chemistry 2009. ActaBiophysica Sinica, 25(5):325-334.
77. Wu L., Wang L.,Hua G., Liu K., Yang X., Zhai Y., Bartlam M., Sun F*. and Fan Z.*(2009) Structural Basis for Proteolytic Specificity of the HumanApoptosis-Inducing Granzyme M, The Journal of Immunology, 183,421-9.
78. Sun S.，Zhang K., Xu W.，Wang G.，Chen J. and Sun F*. (2009) 3DStructural Investigation of Caveolae From Porcine Aorta Endothelial Cell byElectron Tomography, Progress in Biochemistry and Biophysis,36(6), 729-35.
79. Sun, F.*#, Zhou, Q. J.,Sun, J., Zhai, Y. J. & Rao, Z. H. (2008) Structure of mitochondrialrespiratory membrane protein complexes, Chinese Bulletin of Life Sciences.20.
80. Wang, L., Wang,L., Vavassori, S., Li, S., Ke, H., Anelli, T., Degano, M., Ronzoni, R., Sitia,R., Sun, F.* & Wang, C. C.* (2008) Crystal structure of humanERp44 shows a dynamic functional modulation by its carboxy-terminal tail, EMBORep. 9, 642-7.
81. Chen, J., Li, W.,Wang, M., Zhu, G., Liu, D., Sun, F., Hao, N., Li, X., Rao, Z.& Zhang, X. C. (2008) Crystal structure and mutagenic analysis of GDOsp, agentisate 1,2-dioxygenase from Silicibacter pomeroyi, Protein Sci. 17,1362-73.
82. Huo X, Su D, WangA, Zhai Y, Xu J, Li X, Bartlam M, Sun F*, Rao Z. 2007.Preliminary molecular characterization and crystallization of mitochondrialrespiratory complex II from porcine heart , FEBS JOURNAL, 274(6):1524-1529
83. Zheng, W., Sun,F., Bartlam, M., Li, X., Li, R. & Rao, Z. (2007) The crystalstructure of human isopentenyl diphosphate isomerase at 1.7 a resolutionreveals its catalytic mechanism in isoprenoid biosynthesis, J Mol Biol.366, 1447-58.
84. Su D, Lou Z, SunF, Zhai Y, Yang H, Zhang R, Joachimiak A, Zhang XC, Bartlam M, Rao Z.2006. Dodecamer Structure of Severe Acute Respiratory Syndrome CoronavirusNonstructural Protein nsp10. J Virol. 80(16):7902-8.
85. Xu X, Zhai Y, SunF, Lou Z, Su D, Xu Y, Zhang R, Joachimiak A, Zhang XC, Bartlam M, RaoZ. 2006. New Antiviral Target Revealed by the Hexameric Structure of MouseHepatitis Virus Nonstructural Protein nsp15. J Virol.80(16):7909-17.
86. Li X, Liu X, SunF, Gao J, Zhou H, Gao GF, Bartlam M, Rao Z. 2006. Crystal structure of theN-terminal SH3 domain of mouse betaPIX, p21-activated kinase-interactingexchange factor. Biochem Biophys Res Commun. 339(1):407-14.
87. 孙飞#，徐建兴，饶子和.2005.膜蛋白三维结构研究的新突破－线粒体呼吸链膜蛋白复合物II结构解析.中国科学院院刊. 2005（5）：381－384
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科研活动
科研项目（按时间倒序排列）1. 国家973计划“蛋白质机器及分子机制”（2006CB806500），2006/09-2010/08，已结题，子课题负责人。
2. 国家863计划“富亮氨酸重复激酶2(LRRK2)突变的致病机制及其作为帕金森氏病药物靶标的可行性研究”（2006AA02Z173），2006/12-2008/12，已结题，参加。
3. 国家重大研究计划“蛋白质研究计划”“膜蛋白和蛋白质复合体的功能与结构研究”（2006CB911000），2006/12-2010/12，已结题，参加。
4. 国家重点实验室优秀基金（基金委重点项目）“通过基因敲除和三维结构来揭示重要蛋白复活物的体内功能”（** ），2007/01-2010/12，已结题，参加。
5.自然科学基金委面上项目“应用低温电镜和晶体学方法对古菌II类分子伴侣的结构解析”（**），2008/01-2010/12，已结题，主持。
6. 中国科学院知识创新工程重要方向项目“冷冻电子断层三维成像技术建立及其应用”（KSCX2-YW-R-126），2007/10-2010/09，已结题，主持。
7. 中国科学院知识创新工程重大项目“面向蛋白质科学的高性能计算研究”（KGGX1-YW-13），2007/12-2010/12，已结题，子课题负责人。
8. 自然科学基金委创新群体“膜蛋白与蛋白质复合体的结构生物学研究”（**），2008/01-2010/12，已结题，参加。
9. 自然科学基金委创新群体“膜蛋白与蛋白质复合体的结构生物学研究”（**），2011/01-2013/12，已结题，参加。
10. 国家973计划“重要生命活动中关键膜蛋白及蛋白质复合物结构与功能研究”（2011CB910300），2011/01-2015/12，在研（2015年结题），参加（学术骨干）。
11. 自然科学基金委面上项目“二型分子伴侣素的动态结构与协同性”（**），2012/01-2015/12，在研（2015年结题），主持。
12. 中组部“”青年拔尖人才，2013/01-2015/12，在研，主持。
13. 国家973计划“青年科学家项目”“复杂生物大分子复合体的低温电镜高分辨三维重构及功能研究”（2014CB910700），2014/01-2018/12，在研，项目首席科学家。
14. 中国科学院战略性先导科技专项（B类）“超大分子复合体前沿技术”（XDB**），2014/01-2018/12，在研，项目首席科学家。

合作情况
项目协作单位

指导学生已指导学生
欧阳珠清**
胡仲军**
霍艳武**
周强军**
徐颖之**
马军**
邱彪**
张凯**
庞效云**
高丙全**
陆久维**
王圣柳**
陈文博**
邓雨辰**
王雪**
现指导学生
牛彤欣**
朱春梅**
师扬**
玉蕾叶**
张丹阳**
台林华**
杨静媛 **
张双博 **
孙芳**