基本信息
宋林生男博导中国科学院海洋研究所
电子邮件： lshsong@ms.qdio.ac.cn
通信地址： 青岛市南海路7号生物楼115室
邮政编码： 266000
部门/实验室：实验海洋生物学重点实验室
研究领域

招生信息
招生专业070703-海洋生物学
090801-水产养殖
070703-海洋生物学

招生方向免疫学基础及应用
水产动物病害防治
基因组学，海洋生物技术


教育背景1991-09--1994-08南开大学博士
1987-09--1990-08南开大学硕士
1983-09--1987-08南开大学学士

学历
学位

工作经历
工作简历1998-07~现在,中国科学院海洋研究所,研究员
1996-07~1998-07,中国科学院海洋研究所,博士后
1991-09~1994-08,南开大学,博士
1990-09~1996-09,南开大学,讲师、副教授
1987-09~1990-08,南开大学,硕士
1983-09~1987-08,南开大学,学士

社会兼职2013-01-01-今,SCI期刊Peer J 编委,
2013-01-01-今,SCI期刊PLoS One 编委,
2012-02-01-今,SCI 期刊Developmental and Comparative Immunology编委 ,
2009-12-01-今,天津市水产养殖与生态重点实验室学术委员会主任,
2009-01-01-今,国际期刊《Fish and shellfish immunology》编委, 编委
2008-01-01-今,国家贝类产业技术体系岗位科学家,
2007-10-01-今,中国海洋与湖沼学会贝类学分会理事,
2006-10-01-今,《微生物通报》编委,
2004-01-01-今,《动物学杂志》编委,


教授课程

专利与奖励
奖励信息（1） 扇贝凝集素功能多样性的分子基础, 三等奖, 省级, 2013
（2） 我国重要经济虾蟹类的免疫与内分泌学基础研究, 三等奖, 省级, 2011
（3） 重要水产养殖无脊椎动物免疫防御的分子机制, 二等奖, 省级, 2011
（4） 扇贝模式识别受体结构与功能的研究, 二等奖, 部委级, 2010

专利成果（ 1 ） 一种对水产动物有免疫增强活性的CpG寡聚核苷酸及其制备和应用, 2010, 第 2 作者, 专利号: 1.0
（ 2 ） 中华绒螯蟹半胱氨酸蛋白酶抑制剂EsCystatin基因编码蛋白及应用, 2010, 第 1 作者, 专利号: 8.1
（ 3 ） 中华绒鳌蟹Crustin-2基因及其重组蛋白的应用, 2010, 第 1 作者, 专利号: ZL 2009 1 **.8
（ 4 ） 一种具有抑菌活性的抗脂多糖因子的制备及应用, 2010, 第 1 作者, 专利号: 6.4
（ 5 ） 一种具抑菌活性的中华绒螯蟹乳清酸蛋白的制备和应用, 2010, 第 1 作者, 专利号: .8
（ 6 ） 病原相关分子模式免疫检测芯片及其制备方法与应用, 2010, 第 1 作者, 专利号: 2.X


出版信息
发表论文（1）A conserved zinc finger transcription factor GATA involving in the hemocyte production of scallop Chlamys farreri,Fish Shellfish Immunol ,2014,第11作者
（2）The immunomodulation of a novel tumor necrosis factor (CgTNF-1) in oyster Crassostrea gigas,Dev Comp Immunol ,2014,第11作者
（3）Maternal immune transfer in mollusc,Dev Comp Immunol ,2014,第11作者
（4）The promotion of cytoskeleton integration and redox in the haemocyte of shrimp Litopenaeus vannamei after the successive stimulation of recombinant VP28,Dev Comp Immunol ,2014,第11作者
（5）A new fibrinogen-related protein from Argopecten irradians (AiFREP-2) with broad recognition spectrum and bacteria agglutination activity,Fish Shellfish Immunol ,2014,第11作者
（6）The modulation of catecholamines on immune response of scallop Chlamys farreri under heat stress,Gener Comp Endocrino,2014,第11作者
（7）The essential roles of core binding factors CfRunt and CfCBFβ in hemocyte production of scallop Chlamys farreri,Dev Comp Immunol ,2014,第11作者
（8）The specifically enhanced cellular immune responses in Pacific oyster (Crassostrea gigas) against secondary challenge with Vibrio splendidus,Dev Comp Immunol ,2014,第11作者
（9）Acetylcholine modulates the immune response in Zhikong scallop Chlamys farreri,Fish Shellfish Immunol ,2014,第11作者
（10）A low-density lipoprotein receptor-related protein (LRP)-like molecule identified from Chlamys farreri participated in immune response against bacterial infection,Fish Shellfish Immunol ,2014,第11作者
（11）The immune responses triggered by CpG ODNs in shrimp Litopenaeus vannamei are associated with LvTolls,Dev Comp Immunol ,2014,第11作者
（12）The protein expression profile in hepatopancreas of scallop Chlamys farreri under heat stress and Vibrio anguillarum challenge,Fish Shellfish Immunol ,2014,第11作者
（13）The immunomodulation of inducible hydrogen sulfide in Pacific oyster Crassostrea gigas,Dev Comp Immunol ,2014,第11作者
（14）A high mobility group box 1 (HMGB1) gene from Chlamys farreri and the DNA-binding ability and pro-inflammatory activity of its recombinant protein,Fish Shellfish Immunol ,2014,第11作者
（15）A double WAP domain-containing protein from Chinese mitten crab Eriocheir sinensis with antimicrobial activities against Gram-negative bacteria and yeast,Dev Comp Immunol,2012,第11作者
（16）A novel C1qDC protein acting as pattern recognition receptor in scallop Argopecten irradians,Fish Shellfish Immunol,2012,第11作者
（17）The phenoloxidase activity and antibacterial function of a tyrosinase from scallop Chlamys farreri,Fish Shellfish Immunol,2012,第11作者
（18）An iodothyronine deiodinase from Chlamys farreri and its induced mRNA expression after LPS stimulation,Fish Shellfish Immunol,2012,第11作者
（19）The expression of dopa decarboxylase and dopamine beta hydroxylase and their responding to bacterial challenge during the ontogenesis of scallop Chlamys farreri,Fish Shellfish Immunol,2012,第11作者
（20）The arginine kinase in Zhikong scallop Chlamys farreri is involved in immunomodulation,Dev Comp Immunol,2012,第11作者
（21）Association of CfLGBP gene polymorphism with disease susceptibility/resistance of Zhikong scallop (Chlamys farreri) to Listonella anguillarum,Fish Shellfish Immunol,2012,第11作者
（22）A novel cold-regulated cold shock domain containing protein from scallop Chlamys farreri with nucleic acid-binding activity,PLoS One,2012,第11作者
（23）Alternation of immune parameters and cellular energy allocation of Chlamys farreri under ammonia-N exposure and Vibrio anguillarum challenge,Fish Shellfish Immunol,2012,第11作者
（24）The immunomodulation of acetylcholinesterase in zhikong scallop Chlamys farreri,PLoS One,2012,第11作者
（25）A multi-CRD C-type lectin with broad recognition spectrum and cellular adhesion from Argopectenirradians,Dev Comp Immunol,2012,第11作者
（26）A gamma-aminobutyrate type A receptor-associated protein involved in the immune response of Eriocheir sinensis,Int J Immunogenet,2012,第11作者
（27）A macrophage migration inhibitory factor like gene from scallop Chlamys farreri: Involvement in immune response and wound healing., Dev Comp Immunol,2011,第11作者
（28）A dopamine beta hydroxylase from Chlamys farreri and its induced mRNA expression in the haemocytes after LPS stimulation.,Fish Shellfish Immunol,2011,第11作者
（29）A novel type III crustin (CrusEs2) identified from Chinese mitten crab Eriocheir sinensis.,Fish Shellfish Immunol,2011,第11作者
（30）A dopa decarboxylase modulating the immune response of scallop Chlamys farreri.,PLoS One,2011,第11作者
（31）A TRAF and TNF receptor-associated protein (TTRAP) in mollusk with endonuclease activity.,Dev Comp Immunol,2011,第11作者
（32）An interleukin-2 enhancer binding factor 2 homolog involved in immune response from Chinese mitten crab Eriocheir sinensis.,Fish Shellfish Immunol.,2011,第11作者
（33）A monoamine oxidase from scallop Chlamys farreri serving as an immunomodulator in response against bacterial challenge.,Dev Comp Immunol,2011,第11作者
（34）C-type lectin in Chlamys farreri (CfLec-1) mediating immune recognition and opsonization.,PLoS One,2011,第11作者
（35）A novel C-type lectin from bay scallop Argopecten irradians (AiCTL-7) agglutinating fungi with mannose specificity.,Fish Shellfish Immunol,2011,第11作者
（36）A galectin with quadruple-domain from bay scallop Argopecten irradians is involved in innate immune response.,Dev Comp Immunol,2011,第11作者
（37）A primitive Toll-like receptor signaling pathway in mollusk Zhikong scallop Chlamys farreri.,Dev Comp Immunol,2011,第11作者
（38）A novel scavenger receptor-cysteine-rich (SRCR) domain containing scavenger receptor identified from mollusk mediated PAMP recognition and binding.,Dev Comp Immunol,2011,第11作者
（39）A macrophage migration inhibitory factor like gene from scallop Chlamys farreri: Involvement in immune response and wound healing.,Dev Comp Immunol,2011,第11作者
（40）AiCTL-6, a novel C-type lectin from bay scallop Argopecten irradians with a long C-type lectin-like domain.,Fish Shellfish Immunol,2011,第11作者
（41）Identification and characterization of a Cystatin gene from Chinese mitten crab Eriocheir sinensis.,Fish Shellfish Immunol,2010,第11作者
（42） Peptidoglycan recognition protein of Chlamys farreri (CfPGRP-S1) mediates immune defenses against bacterial infection.,Dev Comp Immunol.,2010,第11作者
（43）CfLGBP, a pattern recognition receptor in Chlamys farreri involved in the immune response against various bacteria.,Fish Shellfish Immunol,2010,第11作者
（44）An ancient C-type lectin in Chlamys farreri (CfLec-2) that mediate pathogen recognition and cellular adhesion.,Dev Comp Immunol,2010,第11作者
（45）cDNA cloning and mRNA expression of a selenium-dependent glutathione peroxidase from Zhikong scallop Chlamys farreri.,Comp Biochem Physiol B Biochem Mol Biol,2010,第11作者
（46）A Dicer-1 gene from white shrimp Litopenaeus vannamei: expression pattern in the processes of immune response and larval development.,Fish Shellfish Immunol.,2010,第11作者
（47）The second anti-lipopolysaccharide factor (EsALF-2) with antimicrobial activity from Eriocheir sinensis.,Dev Comp Immunol,2010,第11作者
（48）AiC1qDC-1, a novel gC1q-domain-containing protein from bay scallop Argopecten irradians with fungi agglutinating activity., Dev Comp Immunol,2010,第11作者
（49）Cflec-5, a pattern recognition receptor in scallop Chlamys farreri agglutinating yeast Pichia pastoris.,Fish Shellfish Immunol.,2010,第11作者
（50） Molecular characterization and expression of a crustin-like gene from Chinese mitten crab, Eriocheir sinensis.,Dev Comp Immunol,2010,第11作者
（51） An inhibitor kappaB homologue from bay scallop Argopecten irradians., Fish Shellfish Immunol,2010,第11作者
（52）Two novel secreted ferritins involved in immune defense of Chinese mitten crab Eriocheir sinensis.,Fish Shellfish Immunol,2010,第11作者
（53）Two novel secreted ferritins involved in immune defense of Chinese mitten crab Eriocheir sinensis.,Fish Shellfish Immunol,2010,第11作者
（54）Protective immunity induced by CpG ODNs against white spot syndrome virus (WSSV) via intermediation of virus replication indirectly in Litopenaeus vannamei.,Dev Comp Immunol.,2010,第11作者
（55）An immune responsive multidomain galectin from bay scallop Argopectens irradians., Fish Shellfish Immunol,2010,第11作者
（56）A putative endocrine factor SIBD (single insulin binding domain protein) involved in immune response of Chinese mitten crab Eriocheir sinensis., Fish Shellfish Immunol,2010,第11作者
（57）AiCTL-6, a novel C-type lectin from bay scallop Argopecten irradians with a long C-type lectin-like domain.,Fish Shellfish Immunol,2010,第11作者
（58）The involvement of HSP22 from bay scallop Argopecten irradians in response to heavy metal stress,Mol Biol Rep.,2010,第11作者
（59）The involvement of suppressors of cytokine signaling 2 (SOCS2) in immune defense responses of Chinese mitten crab Eriocheir sinensis.,Dev Comp Immunol,2010,第11作者
（60）The first molluscan TCTP in Venerupis philippinarum: molecular cloning and expression analysis., Fish Shellfish Immunol.,2010,第11作者
（61）Identification of two small heat shock proteins with different response profile to cadmium and pathogen stresses in Venerupis philippinarum., Cell Stress Chaperones,2010,第11作者
（62） Molecular cloning and expression of a Relish gene in Chinese mitten crab Eriocheir sinensis.,International Journal of Immunogenetics,2010,第11作者

发表著作（ 1 ） 双壳贝类免疫,Bivalve immunity. Invertebrate immunity.,Landes Bioscience and Springer Science,2010-06,第1作者
（ 2 ） 无脊椎动物免疫, Bivalve immunity. Invertebrate immunity,Landes Bioscience and Springer Science,2010-06,第1作者


科研活动
科研项目（ 1 ） 对虾的抗病及免疫物质应用原理与途径, 主持,国家级,2006-10--2010-10
（ 2 ） 重要生产性状关键基因的发掘与应用技术, 主持,国家级,2006-10--2010-11
（ 3 ） 农业部贝类产业技术体系病害防控岗位专家, 主持,国家级,2008-11--2015-10
（ 4 ） 扇贝免疫识别的分子机制, 主持,国家级,2008-01--2011-12
（ 5 ） 扇贝免疫防御的分子机制, 主持,国家级,2009-12--2012-12
（ 6 ） 海水养殖动物主要病毒性疫病爆发机理与免疫防治的基础研究, 主持,国家级,2012-01--2016-12

参与会议（1）第10届海峡两岸细胞生物学学术研讨会第10届海峡两岸细胞生物学学术研讨会宋林生2014-04-23
（2）The Preliminary Study on the Molecular Mechanism of Immune Defense in ScallopLinsheng Song, Lingling Wang, Limei Qiu, Huan Zhang2011-04-20
（3）Identification and characterization of genes involved in immune system of scallopsLinsheng Song2010-11-18
（4）The immunity system of scallop.Linsheng Song2010-10-12
（5）The catecholaminergic modulation of the immune response in scallops Chlamys farreri.Zhi Zhou2010-10-08
（6） C-type lectin in Chlamys farreri (CfLec-3) mediates immune recognition and opsonizationJialong Yang2010-10-08
（7）The complement-like molecules identified from scallopsLingling Wang2010-10-08
（8）Protective immunity induced by CpG ODNs against white spot syndrome virus (WSSV) via intermediation of virus replication indirectly in Litopenaeus vannameiYing Zhang2010-06-20


合作情况
项目协作单位

指导学生