基本信息
裴端卿 男 汉族 博导 广州生物医药与健康研究院
电子邮件：pei_duanqing@gibh.ac.cn
联系电话：
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通信地址：广州市萝岗区开源大道190号
邮政编码：510530

研究领域干细胞的全能性调控机制，体细胞重编程技术与机制，蛋白质在正常与癌细胞里的运送机制，EGFR 的信号传导机制与肺癌

招生信息
招生专业071009-细胞生物学

招生方向癌细胞与干细胞
癌细胞与干细胞


教授课程

出版信息
发表论文1. Pei, D., C. Shih. Transcriptional repression and activation by cellular DNA-binding protein C/EBP. J. Virol. 64 1990.: 1517-1522
2. Pei, D., C. Shih. An attenuator is sandwiched by two transactivation domains in the transcriptional factor C/EBP. Mol. Cell. Biol. 11: 1991. 1480-1487
3. Pei, D., Majmudar, G., Weiss, S.J. Hydrolytic inactivation of a breast carcinoma cell-derived serpin by human stromelysin-3. J Biol. Chem; 269: 1994. 25849-25855.
4 Pei, D., Weiss, S.J.. Furin-dependent Intracellular Activation of the Human Stromelysin-3 Zymogen. Nature. 375: 1995 244-247.
5 Pei, D., Weiss, S.J., Transmembrane-deletion Mutants of the Membrane-type Matrix Metalloproteinase-1 Process Progelatinase A and Express Intrinsic Matrix-degrading Activity. J. Biol. Chem. 271 (15): 1996. 9135-9140.
6 Pei, D., Yi, J. A High Level Mammalian Expression System Based on the Madin-Darby canine kidney (MDCK) cell line. Prot. Exp.& Puri. 13: 1998. 277-281.
7 Lei, J., Jiang, A., and Pei, D. Identification and Characterization of a New Splicing Variant of Vascular Endothelial Growth Factor: VEGF183. Biochim. Biophys. Acta 1443 (3): 1998. 400-406.
8 Pei, D. Identification and characterization of the fifth member of the membrane-type matrix metalloproteinase MT5-MMP. J. Biol. Chem. 274: 1999. 8925-8932.
9 Pei, D. CA-MMP: a matrix metalloproteinase with a novel cysteine-array, but without the classic cysteine switch. FEBS Lett. 457: 1999. 262-270.
10 Wang, X., Lei, L., Yi, J. and Pei, D. Expression, Purification and Charaterization of Recombinant Mouse MT5-MMP Protein Products. FEBS Lett. 462: 1999. 261-266.
11 Pei, D.. MMP25/MT6-MMP/Leukolysin: a novel matrix metalloproteinase specifically expressed in the leukocyte lineage, Cell Res. 9: 1999 291-303.
12 Pei, D., Kang, T., and Qi, H. CA-MMP/MMP-23 is a Type II Transmembrane Matrix Metalloproteinase Regulated by a Single Cleavage for Both Secretion and Activation. J. Biol. Chem. 275: 2000. 33988-33997.
13 Kang, T., Yi, J., Yang, W., Wang, X., Jiang, A., and Pei, D.. Functional characterization of MT3-MMP in transfected MDCK cells: progelatinase A activation and tubulogenesis in 3-D collagen lattice. FASEB J. 14: **-2568.
14 Damjanovski, S., Amano, T., Li, Q., Pei, D., and Shi, Y.-B. Overexpression of Matrix Metalloproteinases Leads to Lethality in Transgenic Xenopus Laevis: Implications for Tissue-Dependent Functions of Matrix Metalloproteinases during Late Embryonic development. Dev. Dynamics 221: 2001. 37-47.
15 Iida, J., Pei, D., Kang, T., Simpson, M.A., Herlyn, M., Furcht, L. T., and McCarthy, J. B. Melanoma Chondroitin Sulfate Proteoglycan Regulates Matrix Metalloproteinase -Dependent Human Melanoma Invasion into Type I Collagen. J. Biol. Chem. 276: 2001. 18786-18794.
16 Kang, T., Yi, J., Guo, A., Wang, X., Overall, C.M., Jiang, W., Elde, R., Borregaard, N., and Pei, D. Subcellular Distribution, Cytokine- and Chemokine- Regulated Secretion of Leukolysin / MT6-MMP /MMP-25 in Neutrophils. J. Biol. Chem. 276: 2001. 21960-21968.
17 Wang, X., Pei, D. Shedding of MT5-MMP by a Furin-Type Convertase: A Potential Mechanism of Down-Regulation. J. Biol. Chem. 276: 2001. 35953-60.
18 Jiang, A., Lehti, K., Wang, X., Weiss, S.J., Keski-Oja, J., and Pei, D. Regulation of Membrane-Type Matrix Metalloproteinase 1 Activity by Dynamin-Mediated Endocytosis. Proc. Natl. Acad. Sci. 98: 2001. 13693-8.
19 Pei, D. 2001. Matrix Metalloproteinases: An Introduction. Chinese J. of Biochem. & Mol. Biol. 17：1-6.
20 Kang, T., Nagase, H., and Pei, D. Activation of ProMT3-MMP by Proprotein-Convertase Furin in Trans-Golgi Network. Cancer Res. 62: 2002. 675-681.
21 Lehti,K.., Lohi, J., Juntunen, M. M., Pei, D., Keski-Oja, J. Oligomerization through hemopexin and cytoplasmic domains regulate the activity and turnover of membrane-type-1 matrix metalloproteinase (MT1-MMP). J. Biol. Chem. 277: 2002.8440-8448.
22 Wilson, MJ, RG Sellars, C Wiehr, O Melamud, Pei, D and DM Peehl. Expression of matrix metalloprotease-2 and ¬9 and their inhibitors, tissue inhibitors of metalloprotease-1 and ¬2, in primary cultures of human prostatic stromal and epithelial cells. J. Cell. Physiol. 191: 2002. 208-216.
23 Kang, T., Zhao, Y.G., Pei, D., Sucic, F. J., Sang, Q-X. A. Intracellular Activation of Human Adamalysin 19/Disintegrin and Metalloproteinase 19 by Furin Occurs via one of the two Consecutive Recognition Sites. J. Biol. Chem. 277: 2002. 25583-91.
24 Doherty, T.M., Asotra, K., Pei, D., Uzui, H., Wilkin, D.J., Shah, P.K., Rajavashisth, T.B. Therapeutic developments in matrix metalloproteinase inhibition. Expert Opinion on Therapeutic Patents. 12: 2002. 665-707.
25 Pan, GJ, Chang ZY, Scholer HR, Pei D. Stem cell pluripotency and transcription factor Oct4. Cell Res 12: 2002.321-9.
26 Jiang, A., Pei, D. Distinct Roles of Catalytic and Pexin-like Domains in MT-MMP Mediated proMMP-2 Activation and Collagenolysis. J. Biol. Chem. 278: 2003. 38765-38771.
27 Nie, J., Pei, D.. Direct Activation of proMMP-2 by Leukolysin / MT6-MMP at the Asn109-Tyr bond. Cancer Res. 63: 2003 6758-6762.
28 Pan, G., Pei, D. Identification of Two Distinct Transactivation Domains in the Pluripotency Sustaining Factor Nanog. Cell Res., 13: 2003. 499-502.
29 Zucker, S., Pei, D., Cao, J., Lopez-Otin. Membrane-type Matrix Metalloproteinases (MT1-MMP). Cell Surface Proteases Current Topics in Developmental Biology. 541: 2003. -74.
30 Cui, P., Qin, B., Pan, G., Liu, N., and Pei, D. Nuclear Localization of the Phosphatidylserine Receptor Protein Via Multiple Nuclear Localization Signals. Exp. Cell Res., 293: 2004, 154-163.
31 Iida, J., Whilhelmson, K. L., Price, M A., Wilson, C. M., Pei, D., Furcht, L T. , and McCarthy, J.B. Memrane-type-1-matrix metalloproteinase (MT1-MMP) promotes human melanoma invasion and growth. J. Inv. Derm. 122: 2004. 167-176.
32 Wilson, M.J., Jiang, A., Wiehr, C., Wang, X., Sinha, A.A., And Pei. D. Limited Processing of Pro-Matrix Metalloprotease-2 (Gelatinase A) Overexpressed by Transfection in PC-3 Human Prostate Tumor Cells: Association With Restricted Cell Surface Localization of Membrane-Type Matrix Metalloproteinase-1. J. Andrology, 25: 2004,274-285.
33 Wang, X., Ma, D., Keski-Oja, J., and Pei, D. Co-recycling of MT1-MMP and MT3-MMP Through the trans-Golgi Network: Identification of DKV582 as a Recycling Signal. J. Biol. Chem., 279: 2004.9331-6.
34 Zhao, H., Bernardo, M. M., Osenkowski, P., Pei, D., Nagase, H., Kashiwagi, M., Soloway, P. D., DeClerck, Y. A., Fridman, R. Differential Inhibition of MT3-MMP And MT1-MMP By TIMP-2 and TIMP-3 Regulates Pro-MMP-2 Activation. J. Biol. Chem. 279: 2004. 8592-8601.
35 Wang, P., Tortorella, M., England, K., Malfait, A.M., Thomas, G., Arner, E., Pei, D. Proprotein Convertase Furin interacts with and cleaves pro-ADAMTS4 (aggrecanase-1) in the trans-Golgi Network. J. Biol. Chem. 279: 2004. 15434-15440.
36 Wang, P., Wang, X., and Pei, D. Mint-3 regulates the retrieval of internalized MT5-MMP to plasma membrane by binding to its carboxyl end motif EWV. J. Biol. Chem. 279: 2004. 20461-20470.
37 Nie, J., Pei, D. Rapid Inactivation of Alpha-1-Proteinase Inhibitor by Neutrophil Specific Leukolysin / Membrane-Type Matrix Metalloproteinase 6. Exp.Cell Res. 296: 2004. 145-150.
38 Cha, T., Guo, A., Jun, Y., Pei, D., and Zhu, X. Y.. Immobilization of oriented protein molecules on poly(ethylene glycol)-coated Si(111) (p NA). Proteomics, 4: **-76.
39 Ma, D., Xie, WQ., Zou, B., Lei, Q., and Pei, D. An efficient and tunable route to AG7088, a rhinovirus protease inhibitor. Tetrahedron Letters 45: 2004 8103-5.
40 Pan, G., Qin, B., Liu, N., Scholer, H.R., Pei, D. Identification of a nuclear localization signal in Oct4 and generation of a dominant negative mutant by its ablation. J. Biol. Chem. 279: 2004. 37013–37020.
41 Wang, P., Nie, J., and Pei, D. The hemopexin domain of MT1-MMP is not required for its activation of proMMP2 on cell surface, but essential for MT1-MMP mediated invasion in 3-D type I collagen. J. Biol. Chem. 279: 2004. 51148 - 51155.
42 Pan. G., Pei. D. The Stem Cell Pluripotency Factor Nanog Activates Transcription With Two Unusually Potent Subdomains at its C-terminus. J. Biol. Chem. 280: 2005.1401-1407.
43 Pei, D. Matrix Metalloproteases Target Protease-activated Receptors During Tumor Progression. Cancer Cell, 7: 2005. 207-8.
44 Qin, B., Chen, X., Zhu, J., and Pei, D. Identification of EGFR kinase domain mutations among lung cancer patients in China: implication for targeted cancer therapy. Cell Res., 15(3): 2005.212-7.
45 Liu, B, Wang J, Chan KM, Tjia WM, Deng W, Guan X, Huang J, Li KM, Chau PY, Chen DJ, Pei D, Pendas AM, Cadinanos J, Lopez-Otin C, Tse HF, Hutchinson C, Chen J, Cao Y, Cheah KSE, Tryggvason K, Zhou Z. Genomic instability in laminopathy-based premature aging Nat. Med. 11, 2005. 780 - 785.
46 Yang, H., Xie W, Xue X, Yang K, Ma J, Liang W, Zhao Q, Zhou Z, Pei D, Ziebuhr J, Hilgenfeld R, Yuen K.Y., Wong L, Gao G, Chen S, Chen Z, Ma D, Bartlam M & Rao Z. Design of wide-spectrum inhibitors targeting coronavirus main proteases. PLoS Biology. 3(10): 2005. e324.
47 Xie, W., Zou, B., Pei, D., and Ma, D. Total Synthesis of Cyclic Tetrapeptide FR235222, a Potent Immunosuppressant that Inhibits Mammalian Histone Deacetylases. Org. Lett.; 7: 2005. 2775 – 2777.
48 Shi, W., Wang,H., Pan, G., Geng, Y., Guo Y., and Pei, D. Regulation of the pluripotency marker Rex-1 by Nanog and Sox 2. J. Biol. Chem. ,281: 2006. 33 23319-23325
49 Pan,G., Li, J., Zhou, Y., Zheng, H., and Pei, D. A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal. FASEB J. 20: 10 2006.1730- +
50 Pei, D. Metalloproteinases as Therapeutical Targets for Cancer Therapy. IDrugs 9(9): 2006.598-9
51 Qin B, He M, Chen X, Pei D. Sorting nexin 10 induces giant vacuoles in mammalian cells. J Biol Chem. 281: 2006. 36891 – 36896.
52 Minond, D., Lauer-Fields, JL., Cudic, M., Overall, CM., Pei, D., Brew, K., Visse, R., Nagase, H., and Fields, GB. The Roles of Substrate Thermal Stability and P2 and P1' Subsite Identity on Matrix Metalloproteinase Triple-helical Peptidase Activity and Collagen Specificity. J. Biol. Chem. 281: 2006. 38302 – 38313.
53 Nie, J., Pei, J., Blumenthal, M., and Pei, D. Complete restoration of cell surface activity of transmembrane-truncated MT1-MMP by a GPI anchor: Implications for MT1-MMP mediated proMMP2 activation and collagenolysis in 3D. J. Biol. Chem. 282: 2007. 6438-43.
54 Li, J., Pan, G., Cui, K., Liu, Y., Xu, S., and Pei, D. A Dominant-negative Form of Mouse SOX2 Induces Trophectoderm Differentiation and Progressive Polyploidy in Mouse Embryonic Stem Cells. J. Biol. Chem. 282: 2007. 19481 - 19492
55 Qin, D., Li, W., Zhang, J., and Pei D. Direct generation of ES-like cells from unmodified mouse embryonic fibroblasts by Oct4/Sox2/Myc/Klf4. Cell Res. 17: 2007.959-62.
56 Qi, H., and Pei, D.. The magic of four: induction of pluripotent stem cells from somatic cells by Oct4, Sox2, Myc and Klf4. Cell Res 17: 2007 578-580
57 Duanqing Pei .The magic continues for the iPS strategy. Cell Res. 18: 2008,221–223
58 Wang, Z., Ma, T., Chi, X., and Pei, D. Aromatic residues in the C-terminal domain 2 is required for nanog to mediate lif-independent self renewal of mouse embryonic stem cells. J. Biol. Chem., Feb,283: 8 2008 4480-4489
59 Dajiang Qin, Yi Gan, Kaifeng Shao, Hao Wang, Wen Li, Tao Wang, Wenzhi He, Jianyong Xu, Yu Zhang, Zhaohui Kou, Lingwen Zeng, Guoqing Sheng, Miguel A. Esteban, Shaorong Gao, Duanqing Pei Mouse meningiocytes express Sox2 and yield high efficiency of chimeras after nuclear reprogramming with exogenous factors. J. Biol. Chem., Vol. 283, 2008 pp. 33730-33735
60 Xiaofei Zhang, Juan Zhang, Tao Wang, Miguel A. Esteban, and Duanqing Pei, Esrrb activates oct4 transcription and sustains self renewal and pluripotency in embryonic stem cells. J. Biol. Chem., Dec; 283: 2008 35825 - 35833 ;
61 Tianhua Ma, Zhe Wang, Yunqian Guo, and Duanqing Pei, The C-terminal Pentapeptide of Nanog Tryptophan Repeat Domain Interacts with NaC1 and Regulates Stem Cell Proliferation but Not Pluripotency; JBC 284: 2009, 16071-16081
62 Miguel Angel Esteban1, Jianyong Xu1, Jiayin Yang1, Meixiu Peng1, Dajiang Qin1, Wen Li1, Zhuoxin Jiang1, Jiekai Chen1, Kang Deng2, Mei Zhong2, Jinglei Cai1, Liangxue Lai1, and Duanqing Pei, Generation Of Induced Pluripotent Stem Cell Lines From Tibetan Miniature Pig , J. Biol. Chem. 284: 2009, 17634-17640
63 Juan Zhang, Xiaofei Zhang, Yunqian Guo, Liangliang Xu, and Duanqing Pei, Sorting Nexin 33 Induces Mammalian Cell-micronucleated Phenotype and Actin Polymerization by Interacting with Wiskott-Aldrich Syndrome Protein, JBC 284: 2009, 21659-21669
64 Duanqing Pei .Regulation of Pluripotency and Reprogramming by Transcription Factors. J. Biol. Chem., 284: Feb 2009;3365 - 3369 Feb 2009;
65 Miguel Angel Esteban, Tao Wang, Baoming Qin, Jiayin Yang, Dajiang Qin, Jinglei Cai, Wen Li, Zhihui Weng, Jiekai Chen, Su Ni, Keshi Chen, Yuan Li, Xiaopeng Liu, Jianyong Xu, Shiqiang Zhang, Feng Li, Wenzhi He, Krystyna Labuda, Yancheng Song, Anja Peterbauer, Susanne Wolbank, Heinz Redl, Daozhang Cai, Lingwen Zeng, and Duanqing Pei, Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells, Cell Stem Cell 6, 2010 1–9
66 Jinglei Cai, Wen Li, Huanxing Su, Dajiang Qin, Jiayin Yang, Fan Zhu, Jianyong Xu, Wenzhi He, Hengpeng Guo, Krystyna Labuda, Anja Peterbauer, Susanne Wolbank, Mei Zhong, Zhiyuan Li, Wutian Wu, Kwok-Fai So, Heinz Redl, Lingwen Zeng, Miguel Angel Esteban, and Duanqing Pei Generation of human induced pluripotent stem cells from umbilical cord matrix and amniotic membrane mesenchymal cells J. Biol. Chem. VOL. 285, NO. 15, 2010 pp. 11227–11234
67 Ronghui Li, Jialiang Liang, Su Ni, Ting Zhou, Xiaobing Qing, Huapeng Li, Wenzhi He, Jiekai Chen,1 Feng Li, Qiang Zhuang, Baoming Qin, Jianyong Xu, Wen Li, Jiayin Yang, Yi Gan, Dajiang Qin, Shipeng Feng, Hong Song, Dongshan Yang, Biliang Zhang, Lingwen Zeng, Liangxue Lai, Miguel Angel Esteban, and Duanqing Pei A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts Cell Stem Cell 7, July 2, 2010, 1–13
68 Chen J, Liu J, Han Q, Qin D, Xu J, Chen Y, Yang J, Song H, Yang D, Peng M, He W, Li R, Wang H, Gan Y, Ding K, Zeng L, Lai L, Esteban MA, Pei D.Towards an optimized culture medium for the generation of mouse induced pluripotent stem cells. J Biol Chem. 285(40): 2010 Jul 1. 31066–31072
69 Yang, JY; Cai, J; Zhang, Y; Wang, XM; Li, W; Xu, JY; Li, F; Guo, XP; Deng, K; Zhong, M; Chen, YL; Lai, LX; Pei, DQ; Esteban, MA; Induced Pluripotent Stem Cells Can Be Used to Model the Genomic Imprinting Disorder Prader-Willi Syndrome J Biol Chem. 285 (51): 2010 40303-40311
70 Xu, Jianyong; Li, Huapeng; Wang, Bo; Xu, Yan; Yang, Jiayin; Zhang, Xiaofei; Harten, Sarah K; Shukla, Deepa; Maxwell, Patrick H; Pei, Duanqing; Esteban, Miguel A; VHL Inactivation Induces HEF1 and Aurora Kinase A. J Am Soc Nephrol 21 (12): 2010 2041-6
71 Duanqing Pei, Jianyong Xu, Qiang Zhuang, Hung-Fat Tse and Miguel A. Esteban. Induced pluripotent stem cell technology in regenerative medicine and biology.Adv Biochem Eng Biotechnol. 2010;123:127-41.
72 Pei, Duanqing; The mighty mice prove pluripotency for iPSCs. J Mol Cell Biol 2 (4): 2010 171-2
73 Chen, JK; Liu, J; Yang, JQ; Chen, Y; Chen, J; Ni, S; Song, H; Zeng, LW; Ding, K; Pei, DQ; BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone; CELL RESEARCH 21 (1): 2011 205-212

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