基本信息
刘畅女博导中国科学院深圳先进技术研究院
电子邮件： chang.liu3@siat.ac.cn
通信地址： 广东省深圳市南山区学苑大道1068号
邮政编码：
部门/实验室：脑所
研究领域


主要研究方向是本能行为与习得性行为间相互调控的神经机制，着重于睡眠和学习记忆的神经环路以及分子机制的跨物种解析，以及睡眠障碍和认知衰退的神经环路致病机制和干预策略。




招生信息欢迎对神经生物学具有浓厚兴趣的同学报考硕士和博士研究生！




招生专业071006-神经生物学

招生方向睡眠调控的分子和细胞机制
睡眠和学习记忆的神经整合机制


教育背景2009-11--2012-02德国马克斯普朗克神经生物学研究所联合培养博士研究生
2007-09--2012-07中国科学院昆明动物研究所研究生学历/博士学位
1999-09--2003-06河北师范大学本科学历/理学学士学位


工作经历
工作经历2019-01~现在,中国科学院深圳先进技术研究院,研究员
2012-07~2019-01,美国布兰迪斯大学,博士后
2004-06~2007-08,中国科学院昆明动物研究所,实习研究员
2003-07~2004-06,河北石家庄二中,高中生物教师


专利与奖励

专利成果（ 1 ） 固定蜜蜂嗅觉条件化训练装置, 发明, 2011, 第 2 作者, 专利号: ZL 2009 1 **.8
（ 2 ） 蜜蜂电击振翅反应气味学习训练方法, 发明, 2011, 第 2 作者, 专利号: ZL 2009 1 **.7


出版信息




发表论文



（1）Timothy D. Wiggin, Patricia R. Goodwin, Nathan C. Donelson, Chang Liu, Kien Trinh, Subhabrata Sanyal, Leslie C. Griffith*. Covert sleep-related biological processes are revealed by probabilistic analysis in Drosophila. PNAS, 2020 (accepted)

（2）Chang Liu*, Zhiqiang Meng, Timothy D. Wiggin, Junwei Yu, Fang Guo, Martha Reed, Yunpeng Zhang, Michael Rosbash, Leslie C. Griffith*. A serotonin-modulated circuit controls sleep architecture to regulate cognitive function independent of total sleep in Drosophila. Current Biology, 2019, 29(21):3635-3646
（3） Peter Bronk, Elena A. Kuklin, Srinivas Corur-Shandilya, Chang Liu, Timothy D. Wiggin, Martha L. Reed, Eve Marder, Leslie C. Griffith*. Regulation of Eag by calcium/calmodulin controls presynaptic excitability in Drosophila. Journal of Neurophysiology. 2018;119(5):1665-1680. Doi:10.1152/jn.00820.2017
（4）Chang Liu, Paula R. Haynes, Nathan C. Donelson, Shani Aharon, Leslie C. Griffith*. Sleep in populations of Drosophila melanogaster. eNeuro, 2015, 2 (4) e0071-15.2015
（5） Zhiqiang Meng*, Chang Liu, Chengyang Yu, Yuanye Ma*. Transcranial direct current stimulation of the frontal-pariental-temporal area attenuates smoking behavior. Journal of Psychiatric Research, 2014 Jul; 54:19-25
（6） Chang Liu, Pierre-Yves Pla?ais, Nobuhiro Yamagata, Barret D. Pfeiffer, Yoshinori Aso,Anja B. Friedrich, Igor Siwanowicz, Gerald M. Rubin, Thomas Préat, Hiromu Tanimoto*. A subset of dopamine neurons signals reward for odour memory in Drosophila. Nature, 2012, 488(7412):512-6
（7） Yu Mao, Shangchuan Yang, Chang Liu, Xintian Hu*. Effects of propranolol on acquisition and retrieval of morphine-induced conditioned place preference memories in ICR mice. Zoology Research. 2011, 32(6):670-4 (中文）
（8）Zhiqiang Meng, Chang Liu, Xintian Hu*, Yuanye Ma*. Irregular morphine administration affects the retention but not acquisition of conditioned place preference in rats. Brain Research, 2010, 1311: 86-92
（9） Zhiqiang Meng#, Chang Liu#, Xintian Hu*, Yuanye Ma*. Somatosensory cortices are required for morphine-induced conditioned place preference in rats. PLoS ONE, 2009, 4(11):e7742 (#co-first author)














科研活动
科研项目?广东省自然科学基金
中国科学院深圳先进技术研究院“优秀青年创新基金”
深港脑科学创新研究院基金

参加会议


Monoamines in regulation of sleep and learning in Drosohila. 中国神经科学学会神经科学研究技术分会2019年学术会议，2019.10.29-11.01，深圳 （大会报告）

A serotonin-modulated circuit controls sleep architecture in Drosophila. 第五届中国果蝇生物学大会，2019.08.15-08.17，大连（大会报告）
Serotonergic modulation of an ellipsoid body circuit controls sleep architecture in Drosophila.The 2018 Janelia Farm Campus Conference on Structure and Function of the Insect Central Complex. 2018.10.28-31 (poster)

Experience modifies transient neuronal activity of MB extrinsic neurons.The 2017 Janelia Farm Campus Conference on Structure and Function of the Insect Mushroom Body. 2017.03.05-08 (poster)

Serotonergic activity controls sleep architecture in Drosophila.2016 Invited talk at University of Mississippi Medical Center. 2016.09.23.(invited talk)

Serotonergic activity controls sleep architecture in Drosophila. The 2015 Cold Srping Harbor Laboratory Meeting on Neurobiology of Drosophila. 2015.09.29-10.02 (poster)

Neural circuits underlying sleep and learning.The 2014 Janelia Farm Campus Conference on Structure and Function of the Insect Mushroom Body. 2014.04.27-30 (poster)
Characterizing sleep in populations of flies. The 2013 Volen Center for Complex Systems Annual Retreat. Boston. (Poster)
A subset of dopaminergic neurons signal reward in Drosophila melanogaster.The 2012 53^rd Annual Drosophila Research Conference. 2012.03.07-11, Chicago, IL. (poster)

Identification of dopaminergic neurons in reward signaling.The 2011 Champalimaud Neuroscience Symposium. 2011.09.18-21, Champalimaud Centre, Lisbon, Portugal. (Poster)

Dopamine signals appetitive and aversive reinforcement in Drosophila.The 2011 Ninth G?ttingen Meeting of the German Neuroscience Society. 2011.03.23-26. Gottingen, Germany. (Poster)