李启寨，博士、研究员
通讯地址：中国科学院数学与系统科学研究院，北京市中关村东路55号,100190.
E-mail:liqz@amss.ac.cn
研究方向：生物医学统计、分组检测、统计遗传学

















教育背景






博士，概率论与数理统计，2006，中国科学院数学与系统科学研究院
学士，统计学，2001，中国科学技术大学








工作经历













所长助理, 2018-至今，中国科学院数学与系统科学研究院 系统科学研究所
研究员, 2015-至今，中国科学院数学与系统科学研究院
副研究员, 2010-2015，中国科学院数学与系统科学研究院
助理研究员, 2006-2010，中国科学院数学与系统科学研究院
博士后，2006-2009，National Cancer Institute, National Institutes of Health, USA

















奖励荣誉








Fellow of American Statistical Association
Elected Member of International Statistical Institute
农业部神农中华农业科技奖科学研究类成果一等奖
中国工业与应用数学学会优秀青年奖
中国科学院卢嘉锡青年人才奖












本科生教学





(2016年至今)
概率论与数理统计，秋季, 80学时
应用数学研讨课(统计学)，春季，60学时









学术活动


中国数学会：常务理事，2020-至今
? 全国工业统计学教学研究会：常务理事，2018-至今
全国工业统计学教学研究会 青年统计学家协会：副会长，2019-至今
中国现场统计研究会 数据科学与人工智能分会：副会长，2019-至今
北京应用统计学会：常务理事，2019-至今
北京大数据协会：常务理事，2019-至今
北京生物统计与数据管理研究会：副会长，2018-至今




发表论文英文期刊论文
Manuscripts
1.Zhang W, Liu A,Li Q, Albert PS (2019) Nonparametric estimation of distributions and diagnostic accuracy based on group testing results with differential misclassification.
Biometrics(Accepted)
2.Zhang W, Tang LL,Li Q, Liu A, Lee MT (2019) Order-restricted inference for correlated and clustered ROC data with application to fingerprint data.
Biometrics(Accepted)
3.Wang L, Zhang W,Li Q(2019) AssocTests: an R package for genetic association studies.
Journal of Statistical Software(Accepted)
2020
4.Zhang W, Liu A,Li Q, Albert PS (2020) Incorporating retesting outcomes for estimation of disease prevalence.
Statistics in Medicine39:687–697.
2019
5.Zhang W, Liu A, Tang LL,Li Q(2019) A cluster-adjusted rank-based test for a clinical trial concerning multiple endpoints with application to dietary intervention assessment.
Biometrics75:821–830.
6.Xiong WJ, Ding J,He YZ,Li Q(2019) Improved matrix pooling.
Statistical Methods in Medical Research28(1):211-222.
7.Hu JY, Zhang W, Li XM, Pan DD,Li Q(2019) Efficient estimation of disease odds ratios for the follow-up genetic association studies.
Statistical Methods in Medical Research28(7):1927-1941.
8.Li JL, Zhang W, Zhang SG,Li Q(2019) A theoretic study of distance-based regression model.
Science in China Series A Mathematics62:979-998.
9.Wang JJ, Ding J, Huang SY,Li Q, Pan DD (2019)A powerful method to test associations between ordinal traits and genotypes.
G3: Genes,Genomes & Genetics9:2573-2579.
10.Xue Y, Wang JJ, Ding J, Zhang SG,Li Q(2019) A powerful test for ordinal trait genetic association analysis.
Statistical Applications in Genetics and Molecular Biology18(2):**.
2018
11.Liang F,Li Q, Zhou, L (2018) Bayesian neural networks for selection of drug sensitive Genes.
Journal of the American Statistical Association113(523): 955-972.
12.Liang F, Jia B, Xue J,Li Q, Luo Y (2018) An imputation-consistency algorithm for high-dimensional missing data problems and beyond.
Journal of the Royal Statistical Society: Series B80(5):899-926.
13.Zheng G, Xiong JH,Li Q, Xu, J, Yuan A, Gastwirth JL. (2018). Evaluating the accuracy of small p-values in genetic association studies using Edgeworth expansions.
Scandinavian Journal of Statistics45: 1-33.
14.Li P, Zhao J, Kothapalli KSD, Li X, Li H, Han Y, Mi S, Zhao W,Li Q, Zhang H, Song Y, Brenna JT, Gao Y (2018) A regulatory insertion-deletion polymorphism in the FADS gene cluster influences PUFA and lipid profiles among Chinese adults: a population-based study.
American Journal of Clinical Nutrition107(6):867-875.
15.Wu J, Wei Y,Li Q, Yuan F (2018) Economic transition and changing location of manufacturing industry in China: a study of the Yangtze river delta.
Sustainability10:2624.
16.Yuan A, Fan RZ, Xu JF, Xue Y,Li Q(2018) Asymptotic relative efficiencies of the score and robust tests in genetic association studies.
Open Statistics and Probability Journal9:18-25.
2017
17.Li Q, Liu A, Xiong W (2017) D-optimality of group testing for joint prevalence estimation of correlated rare diseases in the presence of misclassification.
Statistica Sinica27:823-838.
18.Zhang W, Yang L, Tang LL, Liu A, Mills JL, Sun YC,Li Q(2017) GATE: an efficient procedure in study of pleiotropic genetic associations.
BMC Genomics18(1):552.
19.Huang T,Li Q, Yin Y, Wang J, Sun S, Yang F, Li L, Wang J, Wang Q, Li Y (2017) Composition of intestinal microflora associated with Yang-deficiency.
Journal of Traditional Chinese Medical Sciences4:254-260.
20.Zhu JY, Zhang W,Li Q, Li ZB (2017) Testing association between mixed type outcomes and covariates jointly by the use of a latent variable.
Scientific Reports7(1):8006.
21.Wang L, Liu H, Liu L, Wang Q, Li S,Li Q(2017) Prediction of peanut protein solubility based on the evaluation model established by supervised principal component regress.
FoodChemistry218:553-560.
22.Hu XN, Duan XG, Pan DD, Zhang SG,Li Q(2017) A model-embedded trend test with incorporating Hary-Weinberg equilibrium information.
Journal of Systems Science & Complexity30: 101–110.
2016
23.Hu XN, Zhang W, Zhang SG, Ma SS,Li Q(2016) Group-combined p-values with applications to genetic association studies.
Bioinformatics32(18):2737-2743.
24.Zhang W,Li Q(2016) Incorporating Hardy-Weinberg equilibrium law to enhance the association strength for ordinal trait genetic study.
Annals of Human Genetics80(2):102-112.
25.Zang YG, Zhang SG, Zhang QZ,Li Q(2016) Jackknife empirical likelihood test for high-dimensional regression coefficients.
Computational Statistics and Data Analysis94:302-316.
26.Yuan A,Li Q, Xiong M, Tan MT (2016) Adaptive design for staggered-start clinical trial.
The International Journal of Biostatistics12(2):**.
27.Tang LL, Zhang W,Li Q, Ye X, Chan L. (2016) Parametric and semi-parametric least square regression methods for clustered ROC Data.
Biometrical Journal58,747-765.
28.Zheng G, Zhang W, Xu J, Yuan A,Li Q, Gastwirth JL (2016) Genetic risks and genetic model specification.
Journal of Theoretic Biology403:68-74.
29.Pan DD, Li ZB,Li Q, Fung WK (2015) A novel powerful joint analysis with data fusion in two-stage case-control genome-wide association studies.
Communications in Statistics-Simulation and Computation45(7):2362-2376.
30.Li ZB, Zhang W, Pan DD,Li Q(2016) Power calculation of multi-step combined principal components with applications to genetic association studies.
Scientific Reports6:26243.
31.Lei Y, Li J, Wang N, Yang X, Hamada Y,Li Q, Zheng WF, Jiang XY. (2016) An on-chip model for investigating the interaction between neurons and cancer cells.
Integrative Biology8(3):359-367.
32.Zhang W, Li HY, Li Z,Li Q(2016) A two-phase procedure for non-normal quantitative trait genetic association study.
BMC Bioinformatics17(1):52.
2015
33.Zheng G, Zhang W,Li Q,Xu J, Yuan A, Gastwirth JL (2015) Analysis of genetic association studies incorporating prior information of genetic models.
Journal of Agricultural, Biological, and Environmental Statistics20(2):173-191.
34.Zhang W, Zhang ZH Li XM,Li Q(2015) Fitting proportional odds model to case-control data with incorporating Hardy-Weinberg equilibrium.
Scientific Reports5:17286.
35.Zhang W,Li Q(2015) Nonparametric risk and nonparametric odds in quantitative genetic association Studies.
Scientific Reports5:12105.
2014
36.Chen W,Li Q, Zheng W, Hu F, Zhang G, Wang Z, Zhang D, Jiang X (2014) Identification of Bacteria in Water by a Fluorescent Array.
Angewandte Chemie-International Edition53:13734-13739.
37.Li Q, Hu J, Ding J, Zheng G (2014) Fisher's method of combining dependent statistics using generalizations of the gamma distribution: with applications to genetic pleiotropic associations.
Biostatistics15(2):284-295.
38.Li Q, Xiong WJ, Chen J, Zheng G, Li Z, Mills JL, Liu A (2014) A robust test for quantitative trait analysis with model uncertainty in genetic association studies.
Statistics and Its Interface7:61-68.
39.Zheng G,Li Q, Yuan A (2014) Some statistical properties of robust tests for genetic studies.
Scandinavian Journal of Statistics41:762-774.
40.Li ZB, Liu A, Li Z,Li Q(2014) Rank-based tests for comparison of multiple endpoints among several populations.
Statistics and Its Interface7:9-18.
41.Li ZB, Yuan A, Han G, Gao G,Li Q(2014) Rank-based tests for identifying multiple genetic variants associated with quantitative traits.
Annals of Human Genetics78:306-310.
42.Wang L, Meng J, Cao W,Li Q, Qiu Y, Sun B, Li LM. (2014) Induction of apoptosis through ER stress and TP53 in MCF-7 cells by the nanoparticle [Gd@C82(OH)22]n: A systems biology study.
Methods67:394-406.
43.Yuan A,Li Q, Qin J, Zheng G (2014) Estimation of genetic effects incorporating prior information.
Statistics and Its Interface7:43-50.
44.Wang L, Liu H, Liu L, Wang Q,Li Q, Du Y, Zhang J (2014) Protein contents in different peanut varieties and their relationship to gel property.
International Journal of Food Properties17:1560-1576.
45.Li ZB,Li Q, Han CP, Li B (2014) A hybrid approach for regression analysis with block missing data.
Computational Statistics and Data Analysis75:239-247.
46.Yuan A, Qin G, He W,Li Q(2014) On coalescence analysis using genealogy rooted trees.
Computational and Mathematical Methods in MedicineVolume 2014, Article ID 194202.
2013
47.Li Q, Li ZB, Zheng G, Gao G, Yu K (2013) Rank-based robust tests for quantitative-trait genetic association Studies.
Genetic Epidemiology37(4):358-365.
48.Li ZB, Cao F, Zhang J,Li Q(2013) Summation of absolute value test for multiple outcome comparison with moderate effect.
Journal of Systems Science & Complexity26:462-469.
49.Han G, Huang Y,Li Q, Chen L,Zhang X (2013) Hybrid bayesian inference on HIV viral dynamic models.
Journal of Applied Statistics40(11):2516-2532.
50.Yuan A,Li Q(2013) Convolution representation in practice.
Journal of Statistics: Advances in Theory and Application9(2):105-133.
51.Yan T,Li Q, Li Y, Li Z, Zheng G (2013) Genetic association with multiple traits in the presence of population stratification.
Genetic Epidemiology37(6):571-580.
52.Chen W, Chen X, Archer KJ, Liu N,Li Q, Zhao Z, Sun S, Gao G (2013) A rapid association test procedure robust under different genetic models accounting for population stratification.
Human Heredity75(1):23-33.
53.Li J, Liu J, Zhao L, Ma Y, Jia M, Lu T, Ruan Y,Li Q, Yue W, Zhang D, Wang L (2013) Association study between genes in Reelin signaling pathway and autism identifies DAB1 as a susceptibility gene in a Chinese Han population.
Progress in Neuro-Psychopharmacology & Biological Psychiatry44C:226-232.
2012
54.Li Q, Pan D, Yue W, Gao Y, Yu K (2012) Evaluating rare variants under two-stage design.
Journal of Human Genetics57(6):352-357.
55.Wang LL,Li Q, Li Z, Zheng G (2012) Bayes factor based on a maximum statistic for case-control genetic association studies.
Journal of Agricultural, Biological, and Environmental Statistics17:568-582.
56.Gao Y, Killian K, Zhang H,Li Q, Weinstein S, Virtamo J, Tucker M, Taylor P, Albanes D, Meltzer P, Caporaso N (2012) Leukocyte DNA methylation and colorectal cancer among male smokers.
World journal of gastrointestinal oncology4(8):193-201.
57.Safaeian M, Hildersheim A, Gonzalez P, Yu K, Porras C,Li Q, Rodriguez AC, Sherman ME, Schiffman M, Wacholder S, Burk R, Herrero R, Burdete L, Chanock S, Wang S (2012) Single nucleotide polymorphisms in the PRDX3 and RPS19 and risk of HPV persistence and cervical precancer/cancer.
PLoS One7(4):e33619.
58.Guo G, Kang G, Wang J, Qin H, Jiang B,Li Q, Chen W, Liu N, Allison DB. (2012) A sequential Bonferroni procedure using smoothed weights for genome-wide association studies incorporating information on Hardy-Weinberg disequilibrium among cases.
Human Heredity73:1-13.
59.Meyer TE, Chu LW,Li Q, Yu K, Rosenberg PS, Menashe I, Chokkalingam AP, Quraishi SM, Huang WY, Weiss JM, Kaaks R, Hayes RB, Chanock SJ, Hsing AW (2012) The association between inflammation-related genes and serum androgen levels in men: The prostate, lung, colorectal, and ovarian study.
Prostate72(1):65-71.
2011
60.Li Q(2011) An MSE-reduced estimator for the response proportion in a two-stage clinical trial.
Pharmaceutical Statistics10(3):277-279.
61.Li Q, Zheng G, Tiwari R (2011) Analysis of ordered categorical data with score averaging: with applications to case-control genetic associations.
Journal of Applied Statistics38(9):1833-1843.
62.Pan DD,Li Q, Jiang N, Liu A, Yu K (2011) Robust joint analysis allowing for model uncertainty in two-stage genetic association studies.
BMC Bioinformatics12:9.
63.Yue WH, Wang HF, Sun LD, Tang FL, Liu ZH, Zhang HX, Li WQ, Zhang YL, Zhang Y, Ma CC, Du B, Wang LF, Ren YQ, Yang YF, Hu XF, Wang Y, Deng W, Tan LW, Tan YL, Chen Q, Xu GM, Yang GG, Zuo XB, Yan H, Ruan YY, Lu TL, Han X, Ma XH, Wang Y, Cai LW, Jin C, Zhang HY, Yan J, Mi WF, Yin XY, Ma WB, Liu Q, Kang L, Sun W, Pan CY, Shuang M, Yang FD, Wang CY, Yang JL, Li KQ, Ma X, Li LJ, Yu X,Li Q, Huang X, Lv LX, Li T, Zhao GP, Huang W, Zhang XJ, Zhang D (2011) Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2.
Nature Genetics43(12):1228-1284.
64.Wang LL,Li Q, Li Z, Zheng G (2011) Bayes factors in the presence of population stratification.
Statistics & Probability Letters81(7):836-841.
2010
65.Li Q, Zhang H, Yu K (2010) Approaches for evaluating rare polymorphisms in genetic association studies.
Human Heredity69(4):219-228.
66.Li Q, Li G, Xiong S (2010) Assessment of cell number for a multinomial distribution with application to genomic data.
Metrika71(2): 151-164.
67.Li Q, Zheng G, Liu AY, Xiong SF, Li Z, Yu K (2010) The limiting bound of Efron's W-formula for hypothesis testing when a nuisance parameter is present only under the alternative.
Journal of Statistical Planning and Inference140(6):1610-1617.
68.Li Q, Zheng G, Liu AY, Li Z, Yu K (2010) Approximating probabilities of correlated events.
Science in China Series A-Mathematics53(11):2937-2948.
69.Liu A,Li Q, Liu CL, Yu K, Yu KF (2010) A rank-based test for comparison of multidimensional outcomes.
Journal of the American Statistical Association105(490):578-587.
70.Liu A, Liu CL,Li Q, Yu KF, Yuan VW (2010) A threshold sample-enrichment approach in a clinical trial with heterogeneous subpopulations.
Clinical Trials7(5):537-545.
71.Yu K, Wheeler W,Li Q, Bergen AW, Caporaso N, Chatterjee N, Chen JB (2010) A partially linear tree-based regression model for multivariate outcomes.
Biometrics66(1):89-96.
72.Shebl FM , Andreotti G, Rashid A, Gao YT, Yu K, Shen MC, Wang BS,Li Q, Han TQ, Zhang BH, Fraumeni Jr JF, Hsing AW (2010) Diabetes in relation to biliary tract cancer and stones: a population-based study in Shanghai, China.
British Journal of Cancer10:115-119.
73.Chu LW, Meyer TE,Li Q, Menashe I, Yu K, Rosenberg PS, Huang WY, Quraishi SM, Kaaks R, Weiss JM, Hayes RB, Chanock SJ, Hsing AW (2010) Association between genetic variants in the 8q24 cancer risk regions and circulating levels of androgens and sex hormone-binding globulin.
Cancer Epidemiology Biomarkers & Prevention19(7):1848-1854.
74.Koutros S, Freeman LEB, Berndt SI,Andreotti G, Lubin JH, Sandler DP, Hoppin JA, Yu K,Li Q, Burdette LA , Yuenger J, Yeager M, Alavanja MCR (2010) Pesticide use modifies the association between genetic variants on chromosome 8q24 and prostate cancer.
Cancer Research70(22):9224-9233.
75.Ahn J, Yu K, Stolzenberg-Solomon R,Simon KC, McCullough ML, Gallicchio L, Jacobs EJ, Ascherio A, Helzlsouer K, Jacobs KB,Li Q, Weinstein SJ, Purdue M, Virtamo J, Horst R, Wheeler W, Chanock S, Hunter DJ, Hayes RB, Kraft P, Albanes D (2010) Genome-wide association study of circulating vitamin D levels.
Human Molecular Genetics19(13):2739-2745.
76.Yang HP, Bosquet JG,Li Q, Platz EA, Brinton LA, Sherman ME, Lacey JV, Gaudet MM, Burdette LA, Figueroa JD, Ciampa JG, Lissowska J, Peplonska B, Chanock SJ, Garcia-Closas M (2010) Common genetic variation in the sex hormone metabolic pathway and endometrial cancer risk: pathway-based evaluation of candidate genes.
Carcinogenesis31(5):827-833.
77.Meyer TE, O'Brien TG, Andreotti G, Yu K,Li Q, Gao YT, Rashid A, Shen MC, Wang BS, Han TQ, Zhang BH, Niwa S, Fraumeni JF , Hsing AW (2010) Androgen receptor CAG repeat length and risk of biliary tract cancer and stones.
Cancer Epidemiology Biomarkers & Prevention19(3):787-793.
78.Wang SS, Gonzalez P, Yu K, Porras C,Li Q, Safaeian M, Rodriguez AC, Sherman ME, Bratti C,Schiffman M, Wacholder S, Burk RD, Herrero R, Chanock SJ, Hildesheim A (2010) Common genetic variants and risk for HPV persistence and progression to cervical cancer.
PLoS One5(1):e8667.
2009
79.Li Q, Wacholder S, Hunter DJ, Hoover RN, Chanock S, Thomas G, Yu K (2009) Genetic background comparison using distance-based regression, with applications in population stratification evaluation and adjustment.
Genetic Epidemiology33(5):432-441.
80.Li Q, Yu K (2009) Inference of non-centrality parameter of a truncated non-central chi-squared distribution.
Journal of Statistical Planning and Inference139(7):2431-2444.
81.Li Q, Zheng G, Liang XY, Yu K (2009) Robust tests for single-marker analysis in case-control genetic association studies.
Annals of Human Genetics73,245-252.
82.Li Q, Liu AY, Yu K, Yu KF (2009) A weighted rank-sum procedure for comparing samples with multiple endpoints.
Statistics and Its Interface2(2):197-201.
83.Li Q, Zhang JJ, Dai S (2009) On estimating the non-centrality parameter of a chi-squared distribution.
Statistics & Probabilities Letters79(1):98-104.
84.Mendelsohn JB,Li Q, Ji BT, Shu XO, Yang G, Li HL, Lee KM, Yu K, Rothman N, Gao YT, ZhengW, Chow WH (2009) Personal use prospective cohort of Chinese women.
Cancer Science100(6):1088-1091.
85.Yu K,Li Q, Bergen AW, Pfeiffer RM, Rosenberg PS, Caporaso N, Kraft P, Chatterjee N (2009) Pathway analysis by adaptive combination of p-values.
Genetic Epidemiology33(8):700-709.
86.Landi MT, Chatterjee N, Yu K, Goldin LR, Goldstein AM, Rotunno M, Mirabello L, Jacobs K, Wheeler W, Yeager M, Bergen AW,Li Q, Consonni D, Pesatori AC, Wacholder S, Thun M, Diver R, Oken M, Virtamo J, Albanes D, Wang ZM, Burdette L, Doheny KF, Pugh EW, Laurie C, Brennan P, Hung R, Gaborieau V, McKay JD, Lathrop M, McLaughlin J, Wang Y, Tsao MS, Spitz MR, Wang YF, Krokan H, Vatten L, Skorpen F, Arnesen E, Benhamou S, Bouchard C, Metsapalu A, Vooder T, Nelis M, Valk K, Field JK, Chen C, Goodman G, Sulem P, Thorleifsson G, Rafnar T, Eisen T, Sauter W, Rosenberger A, Bickeboller H, Risch A, Chang-Claude J, Wichmann HE, Stefansson K, Houlston R, Amos CI, Fraumeni JF, Savage SA, Bertazzi PA, Tucker MA, Chanock S, Caporaso NE (2009) A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma.
American Journal of Human Genetics85(5):679-691.
87.Liang X, Gao Y, Lam TK,Li Q, Falk C, Yang XR, Goldstein AM, Goldin LR (2009) Identifying rheumatoid arthritis susceptibility genes using high-dimensional methods.
BMC proceedings3 Suppl 7:S79.
2008
88.Li Q, Zheng G, Li Z, Yu K (2008) Efficient approximation of P-value of the maximum of correlated tests, with applications to genome-wide association studies.
Annals of Human Genetics72:397-406.
89.Li Q, Yu K,Li Z, Zheng G (2008) MAX-rank: a simple and robust genome-wide scan for case-control association studies.
Human Genetics123(6):617-623.
90.Li Q, Yu K (2008) Improved correction for population stratification in genome-wide association studies by identifying hidden population structures.
Genetic Epidemiology32(3):215-226.
91.Yu K, Wang ZM,Li Q, Wacholder S, Hunter DJ, Hoover RN, Chanock S, Thomas G (2008) Population substructure and control selection in genome-wide association studies.
PLoS One3(7):e2551.
2007
92.Yu K, Chatterjee N, Wheeler W,Li Q, Wang S, Rothman N, Wacholder S (2007) Flexible design for following up positive findings.
American Journal of Human Genetics81(3):540-551.
93.Liu HY, Lang JH , Zhou QF, Shan D,Li Q(2007)Detection of endometriosis with the use of plasma protein profiling by surf ace-enhanced laser desorption/ionization time-of-flight mass spectrometry.
Fertility and Sterility87(4):988-990.
2006
94.Zhao H,Li Q, Li J, Zeng CQ, Hu SN, Yu J (2006) The study of neighboring nucleotide composition and transition/transversion bias.
Science in China Series C-Lifer Sciences49(4):395-402.
2005
95.Zhao H,Li Q, Zeng CQ, Yang HM, Yu J. (2005) Neighboring-nucleotide effects on the mutation patterns of the rice genome.
Genomics, Proteomics & Bioinformatics3(3):158-168.