基本信息

李莉女博导中国科学院海洋研究所
电子邮件： lili@qdio.ac.cn
电话：
通信地址： 青岛南海路7号实验海洋生物学重点实验室
邮政编码： 266071

部门/实验室：实验海洋生物学重点实验室
个人简介、研究领域及主要学术成绩




中国科学院海洋研究所研究员，海洋科学与技术国家试点实验室研究员、国家贝类产业技术体系环境胁迫性疾病防控岗位科学家。先后在中国科学院海洋研究所任职助理研究员、副研究员以及研究员，曾在美国新泽西州立大学和美国弗吉尼亚州立大学进行博士与博士后研究。
多年来致力于贝类资源的保护与可持续利用。主要围绕贝类抗性等主要经济和适应性状，利用基因组学、生态遗传学与分子生物学等手段，开展牡蛎等贝类重要性状分子解析、适应进化以及分子育种研究。近 5 年，主持 973、国家自然基金、贝类产业技术体系等项目。代表性论文发表在包括 Nature Ecology & Evolution（并列第一作者，第 1 位）、Nature（并列第一作者）、Cell Death & Disease（IF=5.965，通讯作者）、Molecular Ecology Resources（IF=7.332，通讯作者）等杂志。近 5 年发表 SCI 论文 89篇，其中第一或通讯作者 SCI 论文 40 篇(含并列第一和并列通讯）。SCI 论文他引 2000 次余次。获授权发明专利 15 项。获贝类新品种授权 1 项，获山东省自然科学奖 1 项。











招生专业070703-海洋生物学
090801-水产养殖


专利与奖励

出版信息
发表论文（第一和通讯作者含并列第一和并列通讯）（1）Tissue-specific molecular and cellular toxicity of Pb in the oyster (Crassostrea gigas): mRNA expression and physiological studies,Aquatic Toxicology,2018,通讯作者
（2）Inducible variation in anaerobic energy metabolism reflects hypoxia tolerance across the intertidal and subtidal distribution of the Pacific oyster (Crassostrea gigas),Marine Environmental Research,2018,通讯作者
（3）Construction of a high-density genetic map and fine QTL mapping for growth and nutritional traits of Crassostrea gigas,Bmc Genomics,2018,通讯作者
（4）Relationship Among Intron Length, Gene Expression, and Nucleotide Diversity in the Pacific Oyster Crassostrea gigas,Marine Biotechnology,2018,通讯作者
（5）Population resequencing reveals candidate genes associated with salinity adaptation of the Pacific oyster Crassostrea gigas,Scientific Reports,2018,通讯作者
（6）Transcriptomics and Fitness Data Reveal Adaptive Plasticity of Thermal Tolerance in Oysters Inhabiting Different Tidal Zones,Frontiers in Physiology,2018,通讯作者
（7）Divergence and plasticity shape adaptive potential of the Pacific oyster,Nature Ecology & Evolution,2018,第1作者
（8）Genetic and evolutionary patterns of innate immune genes in the Pacific oyster Crassostrea gigas,Developmental and Comparative Immunology,2017,通讯作者
（9）The association between DNA methylation and exon expression in the Pacific oyster Crassostrea gigas,Plos One,2017,通讯作者
（10）Bias and Correction in RNA-seq Data for Marine Species,Marine Biotechnology,2017,通讯作者
（11）Construction and evaluation of a high-density SNP array for the Pacific oyster (Crassostrea gigas),Plos One,2017,通讯作者
（12）Respiration disruption and detoxification at the protein expression levels in the Pacific oyster (&ITCrassostrea gigas&IT) under zinc exposure,Aquatic Toxicology,2017,通讯作者
（13）Cadmium effects on DNA and protein metabolism in oyster (Crassostrea gigas) revealed by proteomic analyses,Scientific Reports,2017,通讯作者
（14）Conservation and divergence of mitochondrial apoptosis pathway in the Pacific oyster, Crassostrea gigas,Cell Death & Disease,2017,通讯作者
（15）Integrated application of transcriptomics and metabolomics provides insights into glycogen content regulation in the Pacific oyster Crassostrea gigas,Bmc Genomics,2017,通讯作者
（16）Identification and Functional Characterization of the Glycogen Synthesis Related Gene Glycogenin in Pacific Oysters (Crassostrea gigas),Journal of Agricultural and Food Chemistry,2017,通讯作者
（17）Temperature, energy metabolism, and adaptive divergence in two oyster subspecies,Ecology and Evolution,2017,通讯作者
（18）Characterization of the Mollusc RIG-I/MAVS Pathway Reveals an Archaic Antiviral Signalling Framework in Invertebrates,Scientific Reports,2017,通讯作者
（19）Characterization of the IRF2 proteins isolated from the deep-sea mussel Bathymodiolus platifrons and the shallow-water mussel Modiolus modiolus,Developmental and Comparative Immunology,2017,通讯作者
（20）Characterization of CgHIF alpha-Like, a novel bHLH-PAS transcription factor family member, and Its role under hypoxia stress in the pacific oyster Crassostrea gigas,Plos One,2016,通讯作者
（21）A high-density snp genetic linkage map and qtl analysis of growth-related traits in a hybrid family of oysters (Crassostrea gigas x Crassostrea angulata) using genotyping-by-sequencing,G3-Genes Genomes Genetics,2016,通讯作者
（22）Genome-Wide Analysis of Alternative Splicing Provides Insights into Stress Adaptation of the Pacific Oyster,Marine Biotechnology,2016,通讯作者
（23）Expression Characterization of Stress Genes Under High and Low Temperature Stresses in the Pacific Oyster, Crassostrea gigas,Marine Biotechnology,2016,通讯作者
（24）RestrictionDigest: A powerful Perl module for simulating genomic restriction digests,Electronic Journal of Biotechnology,2016,通讯作者
（25）Characterization of Oyster Voltage-Dependent Anion Channel 2 (VDAC2) Suggests Its Involvement in Apoptosis and Host Defense,Plos One,2016,通讯作者
（26）Molecular characterization and functional analysis of tumor necrosis factor receptor-associated factor 2 in the Pacific oyster,Fish & Shellfish Immunology,2016,通讯作者
（27）TANK-binding kinase-1 broadly affects oyster immune response to bacteria and viruses,Fish & Shellfish Immunology,2016,通讯作者
（28）Characterization of an inhibitor of apoptosis protein in Crassostrea gigas clarifies its role in apoptosis and immune defense,Developmental and Comparative Immunology,2015,通讯作者
（29）Transcription factor CgMTF-1 regulates CgZnT1 and CgMT expression in Pacific oyster (Crassostrea gigas) under zinc stress,Aquatic Toxicology,2015,通讯作者
（30）Comparative analysis of oyster (Crassostrea gigas) immune responses under challenge by different Vibrio strains and conditions,Molluscan Research,2015,通讯作者
（31）Cloning and characterization of a novel caspase-8-like gene in Crassostrea gigas,Fish & Shellfish Immunology,2015,通讯作者
（32）Highly diverse fibrinogen-related proteins in the Pacific oyster Crassostrea gigas,Fish & Shellfish Immunology,2015,通讯作者
（33）Candidate gene polymorphisms and their association with glycogen content in the pacific oyster Crassostrea gigas,Plos One,2015,通讯作者
（34）Discovery and validation of genic single nucleotide polymorphisms in the Pacific oyster Crassostrea gigas,Molecular Ecology Resources,2015,通讯作者
（35）Phylogeny of forkhead genes in three spiralians and their expression in Pacific oyster Crassostrea gigas,Chinese Journal of Oceanology and Limnology,2014,通讯作者
（36）SNP Identification by Transcriptome Sequencing and Candidate Gene-Based Association Analysis for Heat Tolerance in the Bay Scallop Argopecten irradians,Plos One,2014,通讯作者
（37）Alternative splicing and immune response of Crassostrea gigas tumor necrosis factor receptor-associated factor 3,Molecular Biology Reports,2014,通讯作者
（38）Identification and Functional Characterization of Two Executioner Caspases in Crassostrea gigas,Plos One,2014,通讯作者
（39）Genome and Transcriptome Analyses Provide Insight into the Euryhaline Adaptation Mechanism of Crassostrea gigas,Plos One,2013,通讯作者
（40）Fosmid library construction and end sequences analysis of the Pacific oyster, Crassostrea gigas,Molluscan Research,2013,通讯作者
（41）Evolution and functional analysis of the Pif97 gene of the Pacific oyster Crassostrea gigas,Current Zoology,2013,通讯作者
（42）Oyster Shell Proteins Originate from Multiple Organs and Their Probable Transport Pathway to the Shell Formation Front,Plos One,2013,第1作者
（43）Validation of housekeeping genes as internal controls for studying gene expression during Pacific oyster (Crassostrea gigas) development by quantitative real-time PCR,Fish and Shellfish Immunology,2013,通讯作者
（44）Molecular cloning, characterization, and expression of two myeloid differentiation factor 88 (Myd88) in Pacific oyster, Crassostrea gigas,Journal of the World Aquaculture Society,2013,通讯作者
（45）The oyster genome reveals stress adaptation and complexity of shell formation,Nature,2012,第1作者
（46）Sequence variability of fibrinogen-related proteins (FREPs) in Crassostrea gigas,Chinese Science Bulletin,2012,通讯作者


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