基本信息
李恺男硕导中国科学院上海硅酸盐研究所
电子邮件： likai@mail.sic.ac.cn
通信地址： 上海市定西路1295号
邮政编码： 200050

研究领域
1）病理状态下骨植入体表面生物涂层基础研究。基于骨微量营养元素和生物抗氧化剂在治疗骨质疏松、糖尿病和风湿性关节炎等方面的功能性，对涂层生物学性能进行改性研究。
2）具生物响应能力的功能性骨修复材料研究。通过骨修复材料组分与拓扑结构的调控，实现光电/光热/声电等功能，以满足对骨折微环境下特定骨修复细胞的生物刺激。
3）骨修复与替代材料产品研发。采用等离子喷涂技术和新型合金制备技术研发具有自主知识产权的，兼具优良生物学和力学性能的骨修复与替代材料产品（例如，人工关节、外固定螺钉和脊柱融合器等）。




招生信息
招生专业080502-材料学
080501-材料物理与化学

招生方向生物医用材料
纳米生物材料
无机涂层材料


教育背景2008-09--2013-07中国科学院上海硅酸盐研究所博士学位
2004-09--2008-07北京科技大学学士学位

学历研究生

学位博士


工作经历
工作简历2016-07~现在,中国科学院上海硅酸盐研究所,副研究员
2013-07~2016-06,中国科学院上海硅酸盐研究所,助理研究员

社会兼职

教授课程

专利与奖励
奖励信息
专利成果（ 1 ） 一种抗降解和抗菌性能良好的生物涂层及其制备方法, 发明, 2015, 第 1 作者, 专利号: ZL3.9
（ 2 ） 一种银掺杂的氧化铝陶瓷涂层及其制备方法, 发明, 2015, 第 1 作者, 专利号: CNA
（ 3 ） 一种抗氧化生物涂层及其制备方法, 发明, 2015, 第 1 作者, 专利号: CNA
（ 4 ） 一种抗降解和抗菌性能良好的二氧化铈掺杂硅酸钙涂层及其制备方法和应用, 发明, 2015, 第 1 作者, 专利号: A
（ 5 ） 一种生物抗氧化性能良好的二氧化铈掺杂羟基磷灰石涂层及其应用, 发明, 2016, 第 1 作者, 专利号: 6.4
（ 6 ） 一种掺硼硅酸钙生物活性涂层的制备方法, 发明, 2017, 第 1 作者, 专利号: CNA


出版信息
发表论文（1）Room-temperature facile synthesis of MnO2 on carbon film via UVphotolysis for supercapacitor,Progress in Natural Science: Materials International,2019,通讯作者
（2）The enhanced angiogenic responses to ionic dissolution products from a boron-incorporated calcium silicate coating,Materials Science & Engineering C,2019,第1作者
（3）Improved osteogenesis of boron incorporated calcium silicate coatings via immunomodulatory effects,JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2019,通讯作者
（4）Unveiling the Mechanism of Surface Hydrophilicity- Modulated Macrophage Polarization,Advanced healthcare materials,2018,通讯作者
（5）Adhesion Behavior of Escherichia coli on Plasma-Sprayed Zn and Ag Co-incorporated Calcium Silicate Coatings with Varying Surface Roughness,Journal of thermal spray technology,2018,通讯作者
（6）Sr-doped nanowires modification of Ca-Si based coatings for improved osteogenic activities and reduced inflammatory reactions,Nanotechnology,2018,第1作者
（7）Incorporation of Cerium Oxide into Hydroxyapatite Coating Protects Bone Marrow Stromal Cells Against H2O2-Induced Inhibition of Osteogenic Differentiation,Biological Trace Element Research,2018,第1作者
（8）Improved osteogenesis of boron incorporated calcium silicate coatings via immunomodulatory effects,Journal of Biomedical Materials Research: Part A,2018,通讯作者
（9）Micro/nano structural tantalum coating for enhanced osteogenic differentiation of human bone marrow stem cells,Materials,2018,第3作者
（10）Black plasma-sprayed Ta2O5coatings with photothermal effect for bone tumor therapy,Ceramics International,2018,第3作者
（11）Incorporation of cerium oxide into hydroxyapatite coating regulates osteogenic activity of mesenchymal stem cell and macrophage polarization,Journal of biomaterials applications,2017,第1作者
（12）The effects of cerium oxide incorporation in calcium silicate coating on bone mesenchymal stem cell and macrophage response,Biological Trace Element Research,2017,第1作者
（13）The effects of cerium valence states at cerium oxide coatings on the responses of bone mesenchymal stem cells and macrophages,Biological Trace Element Research,2017,通讯作者
（14）The combined effects of nano-topography and Sr ion for enhanced osteogenic activity of bone marrow mesenchymal stem cells (BMSCs),Journal of biomaterials applications,2017,通讯作者
（15）Enhanced osteogenic activity of anatase TiO2 film: surface hydroxyl groups induce conformational changes in fibronectin,Materials Science & Engineering C-Materials for Biological Applications,2017,第2作者
（16）Hierarchical macropore/nano surface regulates stem cell fate through a ROCK-related signaling pathway,RSC Advances,2017,第4作者
（17）Improved Mechanical Compatibility and Cytocompatibility of Ta/Ti Double-Layered Composite Coating,Journal of Thermal Spray Technology,2017,第3作者
（18）Immunomodulation effect of a hierarchical macropore/nanosurface on osteogenesis and angiogenesis,Biomedical Materials,2017,第4作者
（19）YAP-mediated mechanotransduction regulates osteogenic andadipogenic differentiation of BMSCs on hierarchical structure,Colloids and Surfaces B: Biointerfaces,2017,第4作者
（20）Zinc-modified Calcium Silicate Coatings Promote Osteogenic Differentiation through TGF-β/Smad Pathway and Osseointegration in Osteopenic Rabbits,Scientific reports,2017,第3作者
（21）Optimal Zn-Modified Ca–Si-Based Ceramic Nanocoating with Zn Ion Release for Osteoblast Promotion and Osteoclast Inhibition in Bone Tissue Engineering,Journal of Nanomaterials,2017,第4作者
（22）Plasma sprayed cerium oxide coating inhibits H2O2-induced oxidative stress and supports cell viability,Journal of Materials Science: Materials in Medicine,2016,第1作者
（23）Cerium oxide-incorporated calcium silicate coating protects MC3T3-E1 cells from H2O2-induced oxidative stress,Biological Trace Element Research,2016,第1作者
（24）Chemical stability and osteogenic activity of plasma-sprayed boron-modified calcium silicate-based coatings,Journal of Materials Science: Materials in Medicine,2016,通讯作者
（25）Different response of osteoblastic cells to Mg2+, Zn2+ and Sr2+ doped calcium silicate coatings,Journal of Materials Science: Materials in Medicine,2016,通讯作者
（26）Plasma-sprayed titanium patterns for enhancing early cell responses,Journal of Thermal Spray Technology,2016,第7作者
（27）ROCK-regulated synergistic effect of macrophage/nanowire topography on cytoskeletal distribution and cell differentiation,RSC Advances,2015,第3作者
（28）Effects of graphene plates’ adoption on the microstructure, mechanical properties, and in vivo biocompatibility of calcium silicate coating,International Journal of nanomedicine,2015,第5作者
（29）Preparation and Characterization of Calcium-Magnesium Phosphate Cements,Advanced Materials Research,2014,第1作者
（30）Microstructure and wear behavior of graphene nanosheets-reinforced zirconia coating,Ceramics International,2014,第3作者
（31）Antibacterial mechanism of plasma sprayed Ca2ZnSi2O7 coating against Escherichia coli,Journal of Materials Science: Materials in Medicine,2013,第1作者
（32）Effects of Zn content on crystal structure, cytocompatibility, antibacterial activity and chemical stability in Zn-modified calcium silicate coatings,Journal of Thermal Spray Technology,2013,第1作者
（33）The enhanced bactericidal effect of the zinc-modified calcium silicate coating by the addition of silver,Ceramics International,2013,第1作者

发表著作

科研活动
科研项目（ 1 ） 氧化铈纳米涂层对氧化应激状态下骨修复影响机制研究, 主持,国家级,2016-01--2018-12
（ 2 ） 抗菌型XXX研制, 主持,国家级,2017-08--2018-07
（ 3 ） 适用于骨质疏松症的骨科植入器械研制, 主持,省级,2017-06--2020-09
（ 4 ） 适用于XXX环境的XXX器械技术, 主持,国家级,2018-10--2019-10

参与会议

合作情况
项目协作单位

指导学生