基本信息
李富花女博导中国科学院海洋研究所
电子邮件： fhli@qdio.ac.cn
通信地址： 青岛市南海路7号
邮政编码： 266071
部门/实验室：实验海洋生物学重点实验室
研究领域

招生信息
招生专业070703-海洋生物学

招生方向遗传学与遗传工程；免疫学基础及其应用


教育背景1993-09--1999-07中国科学院海洋研究所博士
1987-09--1990-10厦门大学硕士
1983-09--1987-07厦门大学学士

学历
学位

工作经历
工作简历2009-02~2009-03,澳大利亚CSIRO动物研究所,高访
2005-01~2005-04,法国蒙彼利埃第二大学,高访
2001-10~现在,中国科学院海洋研究所,研究员
1998-01~1999-05,美国康州大学,访问
1996-02~2001-10,中国科学院海洋研究所,副研究员
1993-09~1999-07,中国科学院海洋研究所,博士
1993-02~1996-02,中国科学院海洋研究所,助理研究员
1990-10~1993-02,中国科学院海洋研究所,研究实习员
1987-09~1990-10,厦门大学,硕士
1983-09~1987-07,厦门大学,学士

社会兼职

教授课程

专利与奖励
奖励信息（1） 对虾免疫防御体系的系统解析和应用途径研究, 二等奖, 部委级, 2018
（2） 对虾体液免疫和免疫稳态的分子基础, 二等奖, 市地级, 2015
（3） 对虾抗逆、生长等性状的分子生物学基础及其应用研究, 二等奖, 省级, 2012
（4） 经济虾贝类功能基因组学研究, 二等奖, 部委级, 2007
（5） 海洋水产动物的遗传学基础和免疫学分子机制, 二等奖, 省级, 2007

专利成果（ 1 ） 一种对虾性别探针及其获取方法 , 2012, 第 1 作者, 专利号: ZL 2009 1 **.7
（ 2 ） 不同种类对虾三倍体的制备方法, 2009, 第 2 作者, 专利号: WO2006/042445A1
（ 3 ） 一种中国明对虾抗菌蛋白基因及其表达和应用, 2009, 第 3 作者, 专利号: ZL2005 1 004 7228.7
（ 4 ） 一种累代选育对虾新品种的鉴定方法, 2014, 第 4 作者, 专利号: ZL 2012 1 **.2
（ 5 ） 一种明显提高脊尾白虾人工育苗存活率的方法, 2014, 第 3 作者, 专利号: ZL2012 1 **.7
（ 6 ） 进行凡纳滨对虾家系鉴定的多重微卫星鉴定体系及其应用, 2015, 第 2 作者, 专利号: ZL 2013 1 **.1
（ 7 ） 一种中华绒螯蟹三倍体诱导新方法, 2015, 第 2 作者, 专利号: ZL2013 1 **.7
（ 8 ） 一种稳定提高中华绒螯蟹多倍体诱导效率的便利设施, 2013, 第 2 作者, 专利号: ZL2013 2 **.7
（ 9 ） 一种线性的合成多肽G及其抗病毒应用, 2015, 第 1 作者, 专利号: ZL 2013 1 **.9
（ 10 ） 一种环状的合成多肽A 及其抗菌抗病毒应用, 2015, 第 1 作者, 专利号: ZL2013 1 **.8
（ 11 ） 一种环状的合成多肽B 及其抗菌抗病毒应用, 2015, 第 1 作者, 专利号: ZL2013 1 **.2
（ 12 ） 一种环状的合成多肽E 及其抗菌抗病毒应用, 2016, 第 2 作者, 专利号: ZL2013 1 **.5
（ 13 ） 一种环状的合成多肽F 及其抗菌抗病毒应用, 2016, 第 2 作者, 专利号: ZL2013 1 **.1
（ 14 ） 一种环状的合成多肽D及其抗菌抗病毒应用, 2016, 第 1 作者, 专利号: ZL2013 1 **.4
（ 15 ） 一种脊尾白虾人工选育小群体亲本同步化建系方法, 2017, 第 3 作者, 专利号: ZL 2015 1 **.4
（ 16 ） 一种用于凡纳滨对虾遗传性别鉴定的DNA探针序列及获取方法, 2017, 第 1 作者, 专利号: ZL 2015 1 **.9
（ 17 ） 一种基于一步PCR技术进行凡纳滨对虾性别遗传鉴定的方法, 2018, 第 2 作者, 专利号: ZL 2015 1 **.2
（ 18 ） 用于中国明对虾遗传性别鉴定的DNA序列及其获取和应用, 2018, 第 1 作者, 专利号: ZL 2015 1 **.7
（ 19 ） 一种鉴定中国明对虾遗传性别的DNA序列标签及其应用, 2018, 第 2 作者, 专利号: ZL5.2
（ 20 ） 一种基于高分辨率溶解曲线技术进行对虾性别鉴定的方法, 2018, 第 2 作者, 专利号: ZL 4.5
（ 21 ） 一种脊尾白虾两段式人工育苗方法, 2018, 第 2 作者, 专利号: ZL 2015 1 **.4


出版信息
发表论文（1）Transcriptome analysis reveals the activation of neuroendocrine-immune system in shrimp hemocytes at the early stage of WSSV infection,BMC Genomics,2019,第11作者
（2）An E3 ubiquitin ligase TRIM9 is involved in WSSV infection via interaction with β- TrCP,Developmental and Comparative Immunology,2019,第11作者
（3）Characterization of a lymphoid organ specific anti-lipopolysaccharide factor from shrimp reveals structure-activity relationship of the LPS-binding domains,Frontiers in Immunology,2019,第11作者
（4）Genome-Wide Identification and Expression Profiles of Myosin Genes in the Pacific White Shrimp, Litopenaeus vannamei,Front. Physiol.,2019,第11作者
（5）A novel candidate gene associated with body weight in the Pacific white shrimp Litopenaeus vannamei,Frontiers in Genetics,2019,第11作者
（6）Identification and characterization of two novel vascular endothelial growth factor genes in Litopenaeus vannamei,Fish and Shellfish Immunology,2019,第11作者
（7）Penaeid shrimp genome provides insights into benthic adaptation and frequent molting,Nature Communications,2019,第11作者
（8）Identification of functional gene modules associated with STAT-mediated antiviral responses to white spot syndrome virus in shrimp,Frontiers in Physiology,2019,第11作者
（9）Evaluation on the genomic selection in Litopenaeus vannamei for the resistance against Vibrio parahaemolyticus,Aquaculture,2019,第11作者
（10）Genome Scan for Genomic Regions and Genes Associated with Growth Trait in Pacific White Shrimp Litopeneaus vannamei,Marine Biotechnology,2019,第11作者
（11）A cuticle protein from the Pacific white shrimp Litopenaeus vannamei involved in WSSV infection,Developmental and Comparative Immunology,2018,第11作者
（12）Identification and characterization of a doublesex gene which regulates the expression of insulin-like androgenic gland hormone in Fenneropenaeus chinensis,Gene,2018,第11作者
（13）Multiple Isoforms of Anti-Lipopolysaccharide Factors and Their Antimicrobial Functions in the Ridgetail Prawn Exopalaemon carinicauda,Marine Drugs,2018,第11作者
（14）A Putative Insulin-like Androgenic Gland Hormone Receptor Gene Specifically Expressed in Male Chinese Shrimp,Endocrinology,2018,第11作者
（15）Isolation and identification of the main carotenoid pigment from a new variety of the ridgetail white prawn Exopalaemon carinicauda,Food Chemistry,2018,第11作者
（16）Triosephosphate isomerase (TPI) facilitates the replication of WSSV in Exopalaemon carinicauda,Developmental and Comparative Immunology,2017,第11作者
（17）An eclosion hormone-like gene participates in the molting process of Palaemonid shrimp Exopalaemon carinicauda,Development Genes and Evolution,2017,第11作者
（18）Identification of sex-determining loci in Pacific white shrimp Litopeneaus vannamei using linkage and association analysis,Marine Biotechology,2017,第11作者
（19）Effects of marker density and population structure on the genomic prediction accuracy for growth traits in Pacific white shrimp Litopenaeus vannamei,BMC Genetics,2017,第11作者
（20）Identification and function analysis of an anti-lipopolysaccharide factor from the ridgetail prawn Exopalaemon carinicauda,Developmental and Comparative Immunology,2017,第11作者
（21）Acute toxic effects of zinc and mercury on survival, standard metabolism, and metal accumulation in juvenile ridgetail white prawn, Exopalaemon carinicauda,Ecotoxicology and Environmental Safety,2017,第11作者
（22）Predictive ability of genomic selection models for breeding value estimation on growth traits of Pacific white shrimp Litopenaeus vannamei,Chinese Journal of Oceanology and Limnology,2017,第11作者
（23）A Novel Vascular Endothelial Growth Factor Receptor Participates in White Spot Syndrome Virus Infection in Litopenaeus vannamei,Front. Immunol.,2017,第11作者
（24）The sea cucumber genome provides insights into morphological evolution and visceral regeneration,PLoS Biololy,2017,第11作者
（25）Gene set based association analyses for the WSSV resistance of Pacific white shrimp Litopenaeus vannamei,Scientific Reports,2017,第11作者
（26）Differentially proteomic analysis of the Chinese shrimp atWSSV latent and acute infection stages by iTRAQ approach,Fish & Shellfish Immunology,2016,第11作者
（27）Identification and function analysis of a novel vascular endothelial growth factor, LvVEGF3, in the Pacific whiteleg shrimp Litopenaeus vannamei,Developmental and Comparative Immunology,2016,第11作者
（28）Structure and Bioactivity of a Modified Peptide Derived from the LPS-Binding Domain of an Anti-Lipopolysaccharide Factor (ALF) of Shrimp,Marine Drugs,2016,第11作者
（29）Characterization of two pathogenic Photobacterium strains isolated from Exopalaemon carinicauda causing mortality of shrimp,Aquaculture,2016,第11作者
（30）Recombinant expression of a modified shrimp anti-lipopolysaccharide factor gene in Pichia pastoris GS115 and its characteristic analysis,Marine Drugs,2016,第11作者
（31）Recombinant expression and functional analysis of an isoform of anti-lipopolysaccharide factors (FcALF5) from Chinese shrimp Fenneropenaeus chinensis,Developmental and Comparative Immunology,2015,第11作者
（32）Characterization of two types of vascular endothelial growth factor from Litopenaeus vannamei and their involvements during WSSV infection,Fish & Shellfish Immunology,2015,第11作者
（33）Recombinant expression and functional analysis of an isoform of antilipopolysaccharide factors (FcALF5) from Chinese shrimp. Fenneropenaeus chinensis,Developmental and Comparative Immunology,2015,第11作者
（34）One type of VEGFR is involved in WSSV infection to the Pacific whiteleg shrimp Litopenaeus vannamei,Developmental and Comparative Immunology,2015,第11作者
（35）Molecular markers for identifying a new selected variety of Pacific white shrimp Litopenaeus vannamei,Chinese Journal of Oceanology and Limnology,2015,第11作者
（36） Functional diversity of anti-lipopolysaccharide factor isoforms in shrimp and their characters related to antiviral activity,Marine Drugs,2015,第11作者
（37）Analysis on the expression and function of syndecan in the Pacific white shrimp Litopenaeus vannamei,Developmental and Comparative Immunology,2015,第11作者
（38）Acute effects of cadmium and copper on survival, oxygen consumption, ammonia-N excretion, and metal accumulation in juvenile Exopalaemon carinicauda,Ecotoxicology and Environmental Safety,2014,第2作者
（39）Effect of starvation on survival, growth, and development of Exopalaemon carinicauda larvae,Aquaculture Research,2014,第2作者
（40）Comparison of protein expression profiles of the hepatopancreas in Fenneropenaeus chinensis with heat-inactivated Vibrio anguillarum and white spot syndrome virus,Marine Biotechnology,2014,第2作者
（41）Functional analysis on immune deficiency (IMD) homolog gene in Chinese shrimp Fenneropenaeus chinensis.,Molecular Biology Reports,2014,第11作者
（42）SNP discovery in the transcriptome of White Pacific Shrimp Litopenaeus vannamei by next generation sequencing,PLoS ONE,2014,第11作者
（43）Prediction on the invasion route of WSSV infection to shrimp by bioinformatics analysis,BioMed Research International,2014,第11作者
（44）A new anti-lipopolysaccharide factor (ALF) gene with its SNP polymorphisms related to WSSV resistance of L. vannamei,Fish and shellfish immunology,2014,第11作者
（45）Cloning and expression analysis on a homolog of spermatogonial stem-cell renewal factor in Fenneropenaeus chinensis,Invertebrate Reproduction and Development,2014,第11作者
（46）Function of Shrimp STAT during WSSV Infection,Fish and Shellfish Immunology ,2014,第11作者
（47）Modification of a synthetic LPS-binding domain of anti-lipopolysaccharide factor from shrimp reveals strong structure-activity relationship in their antimicrobial characteristics,Developmental and Comparative Immunology,2014,第11作者
（48）Transcriptome analysis of the initial stage of acute WSSV infection caused by temperature change,PLoS ONE ,2014,第11作者
（49）A new ALF from Litopenaeus vannamei and its SNPs related to WSSV resistance,Chinese Journal of Oceanology and Limnology,2014,第11作者
（50）Characterization and function analysis of an anti-lipopolysaccharide factor (ALF) from the Chinese shrimp Fenneropenaeus chinensis,Developmental and Comparative Immunology,2014,第11作者
（51）A new shrimp peritrophin-like gene from Exopalaemon carinicauda involved in white spot syndrome virus (WSSV) infection,Fish and Shellfish Immunology ,2013,第2作者
（52） Screening of genes regulated by Relish in Chinese shrimp Fenneropenaeus chinensis,Developmental and Comparative Immunology,2013,第11作者
（53） Expression and function analysis of Rac1 homolog in Chinese shrimp Fenneropenaeus chinensis,Fish and Shellfish Immunology,2013,第11作者
（54） Recent advances in researches on the innate immunity of shrimp in China, Developmental and Comparative Immunology,2013,第1作者
（55）Signaling pathways regulating innate immune responses in shrimp,Fish and Shellfish Immunology,2013,第1作者
（56） Analysis on the dynamic changes of the amount of WSSV in Chinese shrimp Fenneropenaeus chinensis,Aquaculture ,2013,第11作者
（57）Shrimp MyD88 Responsive to Bacteria and White Spot Syndrome Virus,Fish and Shellfish Immunology,2013,第11作者
（58）An IκB homologue (FcCactus) in Chinese shrimp Fenneropenaeus chinensis,Developmental and Comparative Immunology ,2013,第11作者
（59）Transcriptome analysis on Chinese shrimp Fenneropenaeus chinensis during WSSV acute infection,PLoS ONE,2013,第11作者
（60）A Homolog of Cell Apoptosis Susceptibility Gene Involved in the Ovary Development of Chinese Shrimp Fenneropenaeus chinensis,Biology of Reproduction,2012,第11作者
（61） Expression profiles of antimicrobial peptides (AMPs) and their regulation by Relish, Chinese Journal of Oceanology and Limnology,2012,第11作者
（62） Functional relationship among the major antioxidant enzymes in eliminating hydrogen peroxide in penaeid shrimp, Cell Stress and Chaperone,2012,第11作者
（63）Two spliced variants of insulin-like androgenic gland hormone gene in the Chinese shrimp, Fenneropenaeus chinensis,General and Comparative Endocrinology ,2012,第11作者
（64）Identification and characterization of the sex-determiner transformer-2 homologue in Chinese shrimp, Fenneropenaeus chinensis,Sexual Development ,2012,第11作者
（65）Structure and partial protein profiles of the peritrophic membrane (PM) from the gut of the shrimp Litopenaeus vannamei,Fish and Shellfish Immunology,2012,第2作者
（66）A Dorsal homolog (FcDorsal) in the Chinese shrimp Fenneropenaeus chinensis is responsive to both bacteria and WSSV challenge,Developmental and Comparative Immunology,2010,第1作者
（67）Cloning and expression profiles of two isoforms of a CHH-like gene specifically expressed in male Chinese shrimp, Fenneropenaeus chinensis,General and Comparative Endocrinology,2010,第11作者
（68）Proteomic analysis of differentially expressed proteins in lymphoid organ of Fenneropenaeus chinensis response to Vibrio anguillarum stimulation,Fish and Shellfish Immunology,2010,第11作者
（69） Screening of genes related to ovary development in Chinese shrimp Fenneropenaeus chinensis by suppression subtractive hybridization,Comparative Biochemistry and Physiology, Part D,2010,第11作者
（70）Three tetraspanins from Chinese shrimp, Fenneropenaeus chinensis, may play important roles in WSSV infection,Journal of Fish Diseases,2010,第1作者
（71）Penaeid shrimp polyploidy: Global status and future direction,aquaculture,2010,第2作者
（72） Identification of a novel inducible cytosolic Hsp70 gene in Chinese shrimp Fenneropenaeus chinensis and comparison of its expression with the cognate Hsc70 under different stresse,Cell Stress and Chaperone ,2010,第11作者
（73） Molecular characterization and effect of RNA interference of retinoid X receptor (RXR) on E75 and chitinase gene expression in Chinese shrimp Fenneropenaeus chinensis,Comparative Biochemistry and Physiology, Part B,2009,第2作者
（74）Molecular cloning and characterisation of a pattern recognition protein, lipopolysaccharide and β-1,3-glucan binding protein (LGBP) from the Chinese shrimp Fenneropenaeus chinensis,Moecular Biology Reprots,2009,第2作者
（75）Molecular cloning and characterisation of prophenoloxidase (ProPO) cDNA from Fenneropenaeus chinensis and its transcription injected by Vibrio anguillarum,Molecular Biology Reportes,2009,第2作者
（76） Identification of a novel relish homolog in Chinese shrimp Fenneropenaeus chinensis and its function in regulating the transcription of antimicrobial peptides,Developmental and Comparative Immunology,2009,第1作者
（77）Cloning of cytoplasmic heat shock protein 90 (FcHSP90) from Fenneropenaeus chinensis and its expression response to heat shock and hypoxia,Cell Stress and Chaperones,2009,第1作者
（78）Comparative proteomic profiles of the hepatopancreas in Fenneropenaeus chinensis response to hypoxic stress, Proteomics,2009,第1作者
（79）A serpin from Chinese shrimp Fenneropenaeus chinensis is responsive to bacteria and WSSV challenge, Fish and Shellfish Immunology ,2009,第1作者
（80）Cloning and expression of glucose regulated protein 78 (GRP78) in Fenneropenaeus chinensis,Molecular Biology Report,2009,第11作者
（81）Comparison of gene expression profiles of Fenneropenaeus chinensis challenged with WSSV and Vibrio,Marine Biotechnology,2008,第1作者
（82）Molecular Cloning and Characterization of Proliferating Cell Nuclear Antigen (PCNA) from Chinese Shrimp Fenneropenaeus chinensis,Comparative Biochemistry and Physiology, Part B,2008,第11作者
（83） cDNA cloning, characterization and expression analysis of the antioxidant enzyme gene, catalase of Chinese shrimp Fenneropenaeus chinensis,Fish and Shellfish Immunology,2008,第2作者
（84）Synaptonemal Complex Analysis in Spermatocytes of Diploid and Triploid Chinese Shrimp Fenneropenaeus chinensis,Tissue and Cell,2008,第11作者
（85）Microsatellite -centromere distances and microsatellite diversity in different ploidy classes of Chinese shrimp (Fenneropenaeus chinensis),Genetica,2008,第2作者
（86）Molecular cloning, characterization and expression analysis of a putative C-type lectin (Fclectin) gene in Chinese shrimp Fenneropenaeus chinensis.,Molecular Immunology,2007,第2作者
（87）Molecular cloning, expression of a peroxiredoxin gene in Chinese shrimp Fenneropenaeus chinensis and the antioxidant activity of its recombinant protein,Molecular Immunology,2007,第2作者
（88）The mitochondrial manganese superoxide dismutase gene in Chinese shrimp Fenneropenaeus chinensis: Molecular cloning, characterization and expression,Developmental and Comparative Immunology,2007,第2作者
（89）A transglutaminase from Chinese shrimp (Fenneropenaeus chinensis), full length cDNA cloning, tissue localization and expression profile after challenge,Fish and Shellfish Immunology,2007,第2作者
（90）Cloning and recombinant expression of a crustin-like gene from Chinese shrimp, Fenneropenaeus chinensis,Journal of Biotechnology,2007,第2作者
（91）Molecular characteristics and expression analysis of calreticulin in Chinese shrimp Fenneropenaeus chinensis.,Comparative Biochemistry and Physiology B,2007,第2作者
（92）Expression, purification, and characterization of recombinant Chinese shrimp crustin-like protein (CruFc) in Pichia pastoris.,Biotechnology Letters,2007,第2作者
（93）Larval metamorphosis and morphological characteristic analysis of triploid shrimp Fenneropenaeus chinensis,Aquaculture Research ,2006,第1作者
（94）Discovery of the genes in response to white spot syndrome virus (WSSV) infection in Fenneropenaeus chinensis through cDNA microarray,Marine Biotechnology,2006,第2作者
（95）Cloning, Expression and Identification of Ferritin from Chinese Shrimp, Fenneropenaeus chinensis,Journal of Biotechnology,2006,第2作者
（96）Evaluation of induced triploid shrimp Penaeus (Fenneropenaeus) chinensis cultured under laboratory conditions,Aquaculture,2006,第2作者

发表著作

科研活动
科研项目（ 1 ） 三倍体对虾卵巢发育调控关键基因的克隆与表达, 主持,国家级,2009-01--2011-12
（ 2 ） 对虾对病原识别应答的核因子NF-κB信号转导通路研究, 主持,国家级,2011-01--2013-12
（ 3 ） 对虾产业体系岗位科学家, 主持,国家级,2016-01--2020-12
（ 4 ） VEGF信号通路在对虾抗病毒免疫中的功能研究, 主持,国家级,2013-01--2016-12
（ 5 ） 甲壳动物神经肽在调控性别特异性的胰岛素样雄激素介导的性别分化中的作用研究, 主持,国家级,2014-10--2017-09
（ 6 ） 对虾良种扩繁及健康养殖产业化, 主持,部委级,2014-04--2016-10
（ 7 ） 对虾良种选育及高效生产体系产业化, 主持,部委级,2017-01--2018-06
（ 8 ） 凡纳滨对虾重组激活基因RAGs的结构与功能, 主持,国家级,2018-01--2021-12
（ 9 ） 比较基因组学揭示对虾独特基因组结构和生理学特征, 主持,研究所（学校）,2017-12--2018-11

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