基本信息
孔祥银男博导中国科学院上海营养与健康研究所
电子邮件： xykong@sibs.ac.cn
通信地址： 上海市岳阳路320号生命科学实验楼A座1515室
邮政编码： 200031
部门/实验室：健康科学研究所
研究领域

招生信息
招生专业071009-细胞生物学
100104-病理学与病理生理学

招生方向人类重大疾病发生的遗传学和表现遗传学基础


教育背景1983-09--1988-07山东医科大学医学系医学学士

学历
学位

工作经历
工作简历2014-06~现在,中科院上海生命科学院上海交通大学医学院健康科学研究所,副所长
2007-01~2007-07,Wellcome Trust/Cancer Research UK Gurdon Institute, Cambridge, UK,访问
2004-01~2004-04,University of Bath, Bath, United Kingdom,访问
2002-04~现在,中科院上海生命科学院上海交通大学医学院健康科学研究所,研究员
2001-01~2001-04,The Forsyth Institute and Harvard School of Dental Medicine,访问
1997-09~2002-06,中科院上海生物工程研究中心,副研究员、研究员
1995-07~1997-09,Max-Planck Institute for Molecular Genetics, Germany,访问
1988-09~1995-06,中国医学科学院血液学研究所,研究实习员、助理研究员
1983-09~1988-07,山东医科大学医学系,医学学士

社会兼职

教授课程

专利与奖励
奖励信息（1） 药明康德生命化学研究奖, 二等奖, 其他, 2010
（2） 谈家桢生命科学奖创新奖, 三等奖, 其他, 2009
（3） 中国青年科技奖, 国家级, 2004
（4） 上海市自然科学牡丹奖, 市地级, 2004
（5） 热休克蛋白转录因子HSF4突变导致白内障, 一等奖, 市地级, 2003
（6） DSPP突变引起遗传性乳光牙本质Ⅰ型伴有或不伴有进行性高频耳聋, 二等奖, 市地级, 2002
（7） 遗传性乳光牙本质致病基因的研究, 二等奖, 国家级, 2002

专利成果（ 1 ） Method of diagnosing and treating dentinogenesis imperfecta type II by using dentin sialophosphoprotein gene and coded product thereof, 2008, 第 1 作者, 专利号: US7,396,644 B2
（ 2 ） Method for diagnosing and treating dentinogenesis imperfecta type II by using dentin sialophosphoprotein (DSPP) gene and its encoding product, 2008, 第 1 作者, 专利号: EP**
（ 3 ） Baldness related gene and the polypeptide encoded thereby, and uses, 2009, 第 1 作者, 专利号: US7,554,485 B2
（ 4 ） ?Method?of?Diagnosing?and?Treating?Baldness?Using?Human?and?Mouse?Rhor?Gene?and?Coded?Product?Thereof, 2009, 第 1 作者, 专利号: **
（ 5 ） 人CYLD基因及其编码产物在制备诊断试剂中的用途, 2008, 第 1 作者, 专利号: ZL**.9
（ 6 ） 体外检测CRYGS基因及其编码产物是否存在突变的方法, 2006, 第 1 作者, 专利号: ZL**.8
（ 7 ） 利用人和鼠Rhor基因及其编码产物诊断和治疗秃发的方法, 2007, 第 1 作者, 专利号: ZL**.9
（ 8 ） 牙本质唾磷蛋白基因及其编码产物在制备治疗牙本质生成不全II型的药物中的用途及检测牙本质生成不全II型的试剂盒, 2007, 第 1 作者, 专利号: ZL**.6


出版信息
发表论文（1）Integrative analysis reveals enhanced regulatory effects of human long intergenic non-coding RNAs in lung adenocarcinoma,J Genet Genomics,2015,第11作者
（2）Genome-Wide Association Studies of HIV-1 Host Control in Ethnically Diverse Chinese Populations,Sci Rep,2015,第11作者
（3）Identifying New Candidate Genes and Chemicals Related to Prostate Cancer Using a Hybrid Network and Shortest Path Approach,Comput Math Methods Med,2015,第11作者
（4）Identifying Novel Candidate Genes Related to Apoptosis from a Protein-Protein Interaction Network,Comput Math Methods Med,2015,第11作者
（5）Alternative splicing at GYNNGY 5' splice sites: more noise, less regulation,Nucleic Acids Res,2014,第11作者
（6）COL4A3 mutations cause focal segmental glomerulosclerosis,J Mol Cell Biol,2014,第11作者
（7）Exome sequencing identifies frequent mutation of MLL2 in non-small cell lung carcinoma from Chinese patients,Sci Rep,2014,第11作者
（8）Genes that escape X-inactivation in humans have high intraspecific variability in expression, are associated with mental impairment but are not slow evolving,Mol Biol Evol,2013,第11作者
（9）Identification of two maternal transmission ratio distortion loci in pedigrees of the Framingham heart study,Sci Rep,2013,第11作者
（10）SKAP2, a novel target of HSF4b, associates with NCK2/F-actin at membrane ruffles and regulates actin reorganization in lens cell,J Cell Mol Med,2011,第11作者
（11）Genome-wide interaction-based association analysis identified multiple new susceptibility Loci for common diseases,PLoS Genet,2011,第11作者
（12）Loss-of-function mutations in the PRPS1 gene cause a type of nonsyndromic X-linked sensorineural deafness, DFN2,Am J Hum Genet,2010,第11作者
（13）Identification of vimentin as a novel target of HSF4 in lens development and cataract by proteomic analysis,Invest Ophthalmol Vis Sci,2010,第11作者
（14）Nonsense-mediated decay targets have multiple sequence-related features that can inhibit translation,Mol Syst Biol,2010,第11作者
（15）Length of the ORF, position of the first AUG and the Kozak motif are important factors in potential dual-coding transcripts,Cell Res,2010,第11作者
（16）Predicting drug-target interaction networks based on functional groups and biological features,PLoS One,2010,第11作者
（17）Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay,BMC Biol,2009,第11作者
（18）Gain-of-function mutation of KIT ligand on melanin synthesis causes familial progressive hyperpigmentation,Am J Hum Genet,2009,第11作者
（19）Removal of Hsf4 leads to cataract development in mice through down-regulation of gamma S-crystallin and Bfsp expression,BMC Mol Biol,2009,第11作者
（20）Divergence of exonic splicing elements after gene duplication and the impact on gene structures,Genome Biol,2009,第11作者
（21）Dosage compensation on the active X chromosome minimizes transcriptional noise of X-linked genes in mammals,Genome Biol,2009,第11作者
（22）Alternative promoters influence alternative splicing at the genomic level,PLoS One,2008,第11作者
（23）Evidence for common short natural trans sense-antisense pairing between transcripts from protein coding genes,Genome Biol,2008,第11作者
（24）Triphalangeal thumb-polysyndactyly syndrome and syndactyly type IV are caused by genomic duplications involving the long range, limb-specific SHH enhancer,J Med Genet,2008,第11作者
（25）Association of IL4R gene polymorphisms with asthma in Chinese populations,Hum Mutat,2007,第11作者
（26）Activation of paternally expressed imprinted genes in newly derived germline-competent mouse parthenogenetic embryonic stem cell lines,Cell Res,2007,第11作者
（27）Temporal and parental-specific expression of imprinted genes in a newly derived Chinese human embryonic stem cell line and embryoid bodies,Hum Mol Genet,2006,第11作者
（28）Simple sequence repeat-based consensus linkage map of Bombyx mori,Proc Natl Acad Sci U S A,2005,第11作者
（29）Epigenetic inactivation of DLC-1 in supratentorial primitive neuroectodermal tumor,Hum Pathol,2005,第11作者
（30）CYLD mutation causes multiple familial trichoepithelioma in three Chinese families,Hum Mutat,2004,第11作者
（31）Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China,Science,2004,第1作者
（32）Embryonic stem cells generated by nuclear transfer of human somatic nuclei into rabbit oocytes,Cell Res,2003,第11作者
（33）Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract,Nat Genet,2002,第11作者
（34）Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP,Nat Genet,2001,第11作者

发表著作

科研活动
科研项目（ 1 ） 无义介导降解机制的新靶标——非编码转录本, 主持,国家级,2015-01--2018-12
（ 2 ） 药物分层的系统生物学研究, 参与,部委级,2015-10--2020-09
（ 3 ） 人类基因组疾病易感变异的系统性研究, 主持,部委级,2016-08--2020-12
（ 4 ） 组织干细胞突变的形成和演化规律研究, 主持,国家级,2017-07--2021-12

参与会议（1）Systematic analysis of GYNNGY donor splicing sites in humans and mice2014-10-08
（2）New insights into the functional diversity of mRNA第三届中英癌症生物学前沿研讨会：暨MRC-中国上海“细胞死亡，干细胞与癌症”国际研讨会2013-05-08


合作情况
项目协作单位

指导学生