基本信息
洪然 男 汉族 博导 上海有机化学研究所
电子邮件：rhong@sioc.ac.cn
联系电话：
手机号码：
通信地址：上海市徐汇区零陵路345号
邮政编码：200032

研究领域
天然产物（仿生）全合成，生物酶催化，不对称合成


招生信息
招生专业070303-有机化学

招生方向天然有机化学
天然有机化学


教育背景
学历 -- 研究生

学位 -- 博士

出国学习工作?2001年8月—2002年6月博士后，UniversityofHouston(JayK.Kochi教授)；
2002年7月—2007年3月博士后，BrandeisUniversity(LiDeng教授)



工作经历2007年3月始 研究员，中国科学院上海有机化学研究所


工作简历
社会兼职

教授课程

专利与奖励
奖励信息（1） ACP Lectureship (Japan), 其他, 2016
（2） ACP Lectureship (Malaysia), 其他, 2016
（3） ACP Lectrueship (Taiwan), 其他, 2015

专利成果

出版信息39.Guoli He, Yan Wang, Calvine Lai, Wenhua Li, and Ran Hong*, "Stereoselective construction of skipped polyol in polyketides enabled by oxonia-Cope rearrangement and iodolactonization: Enantioselective synthesis of (+)-yashabushitriol”Sci. China Chem. 2016, 59, 1197-1204.
http://link.springer.com/article/10.1007/s11426-016-0073-3
38. Lin Yang,Zuming Lin,Sha-Hua Huang*, and Ran Hong*, "Stereodivergent Synthesis of Functionalized Tetrahydropyrans Accelerated by Mechanism-Based Allylboration and Bioinspired oxa-Michael Cyclization" Angew. Chem. Int. Ed. 2016, 55, 6280-6284.
http://onlinelibrary.wiley.com/doi/10.1002/anie./full
37.Lumin Zhang, Lili Zhu, Jun Yang*, Jisheng Luo, and Ran Hong*, "Stereoselective alpha-Hydroxylation of Amides with Oppolzer's Sultam as Chiral Auxiliary" J. Org. Chem. 2016, 81, 3890-3900.
http://pubs.acs.org/doi/abs/10.1021/acs.joc.6b00068
36.Wenhua Li,Zuming Lin, Long Chen, Xuechao Tian, Sha-Hua Huang*, and Ran Hong*, "Highly Stereoselective Kinetic Resolution of alpha-Allenic Alcohols: An Enzymatic Approach" "Tetrahedron Lett. 2016, 57, 603-606. http://www.sciencedirect.com/science/article/pii/S513X
Highlighted as "Hot off the press" (Nat. Prod. Rep. 2016, doi:10.1039/c6np90012g)
35. Sha-Hua Huang*, Xuechao Tian,Xianwei Mi, Yan Wang*, Ran Hong,"Nitroso-ene Cyclization Enabled Access To 1-Azaspiro[4.4]nonane and Its Application In a Modular Synthesis Toward (±)-Cephalotaxine" Tetrahedron Lett. 2015, 56, 6656-6658. DOI:10.1016/j.tetlet.2015.10.002
http://www.sciencedirect.com/science/article/pii/S1994
34. Hao Liu^#, Jing Yu^#,Xinyu Li, Rui Yan, Ji-Chang Xiao, and Ran Hong*, "Stereoselectivity in N-Iminium Ion Cyclization: Development of an Efficient Synthesis of (+/-)-Cephalotaxine" Org. Lett. 2015, 17, 4444-4447. DOI: 10.1021/acs.orglett.5b02106.(^# Theseauthors contributed equally to the work.)
http://pubs.acs.org/doi/abs/10.1021/acs.orglett.5b02106?src=recsys
33. Jie Ouyang^#, Rui Yan^#, Xianwei Mi, and Ran Hong*, "Enantioselective Total Synthesis of (?)-HosieineA" Angew. Chem. Int. Ed. 2015, 54, 10940-10943. DOI: 10.1002/anie.. (^#Theseauthors contributed equally to the work.)
http://onlinelibrary.wiley.com/doi/10.1002/anie./abstract
32. Kuan Zheng, Changmin Xie,and Ran Hong*,"Bioinspired Iterative Synthesis of Polyketides", Front. Chem. 2015, 3,e32. http://journal.frontiersin.org/article/10.3389/fchem.2015.00032/abstract
31. Lili Zhu*, Sha-Hua Huang,Jing Yu, and Ran Hong*, "Constructive Innovation of Approaching Bicyclo[3.2.1]octane in ent-Kauranoids" (Digest paper) Tetrahedron Lett.2015, 56, 23-31. doi:10.1016/j.tetlet.2014.11.035
http://www.sciencedirect.com/science/article/pii/S9170
30. Sha-Hua Huang*, Wenhua Li, Long Chen, Jian-He Xu, and Ran Hong*, "Chemoenzymatic Construction of Chiral Alkenyl Acetylenic Alcohol: A Key Building Block to AccessDiastereoisomersof Polyacetylenes: " Bioresources and Bioprocessing 2015, 2, e10.
http://www.bioresourcesbioprocessing.com/content/2/1/10
29. Sha-Hua Huang*, Meng-Yuan Huang, Xueshun Jia, and Ran Hong,"Chemistry and Biology of Bakuchiol" Chin. J. Org. Chem. 2014, 34, 2412-2423.
http://sioc-journal.cn/Jwk_yjhx/CN/abstract/abstract344619.shtml
28.Lin Yang,^# Guoli He,^# Ruifeng Yin,^# Lili Zhu,Xiaoxia Wang, and Ran Hong*,"Synthesis of Polyketide Stereoarrays Enabled by A Traceless Oxonia–Cope Rearrangement" Angew. Chem. Int. Ed. 2014,53, 11600-116004. (^#Theseauthors contributed equally to the work.) DOI:10.1002/anie..
http://onlinelibrary.wiley.com/doi/10.1002/anie./abstract
27.Meng-Yuan Huang,Long Chen,Ruoxi Li, Xueshun Jia*, andRan Hong*,"Synthesis of rac-Bakuchiol via a Pot-Economy Approach" Chin. J. Chem. 2014, 32, 715-720.(Dedicated to Professors Lixin Dai and Chengye Yuan onthe Occasion of Their 90th Birthdays.)
http://onlinelibrary.wiley.com/doi/10.1002/cjoc./pdf
26. Hua-Xing Huo, Jeremy R. Duvall, Meng-Yuan Huang, and Ran Hong*, "Catalytic Asymmetric Allylation of Carbonyl Compounds and Imines with Allyl Boronates" Org. Chem. Front. 2014, 1, 303-320. doi:10.1039/C3QO00081H.
http://pubs.rsc.org/en/content/articlelanding/2014/qo/c3qo00081h#!divAbstract
25. Lili Zhu,^# Chisheng Loh,^# and Ran Hong*, "Total Synthesis of (±)-Cafestol: A Late-Stage Construction of the Furan Ring Inspired by A Biosynthesis Strategy" Org. Lett.2014, 16, 2162-2165. (^#Theseauthors contributed equally to the work.) (ACS Editor's Choice)
Open Acess: http://pubs.acs.org/doi/full/10.1021/ol500623w
24. Changmin Xie,^# Donghu Bai,^# Sha-Hua Huang, Xueshun Jia*, and Ran Hong*, "Kinetic Resolution of Diols via Etherification Catalyzed by a Chiral Phosphoric Acid: Concise Synthesis of (+)-Sacidumlignan D" Asian J. Org. Chem. 2014, 3,277-280. doi:10.1002/ajoc.. (^#Theseauthors contributed equally to the work.) (Editor's Choice)
http://onlinelibrary.wiley.com/doi/10.1002/ajoc./pdf
23. Huili Liu, Kuan Zheng, Xiang Lu, Xiaoxia Wang*, and Ran Hong*, "Study on Total Synthesis of Velbanamine: Chemoselective Dioxygenation of Alkenes with PIFA via a Stop-and-Flow Strategy" Beilstein J. Org. Chem. 2013,9, 983-990(Invited for the Thematic Issue on Natural Product Synthesis).
http://www.beilstein-journals.org/bjoc/content/pdf/1860-5397-9-113.pdf
22. Donghu Bai, Sha-Hua Huang*,Zuming Lin,Lin Yang, Junzeng Dai, Meng-Yuan Huang, Xueshun Jia*, and Ran Hong*, "Aza-Bellu?-Claisen Rearrangement-Enabled Synthesis of Racemic Tapentadol and Its Stereoisomers" Chin. J. Chem. 2013, 31, 317-320 (selected as the Cover Paper) (Dedicated to Professor Guo-Qiang Lin on the occasion of his 70th Birthday).
21.Lili Zhu and Ran Hong*, "Biomimetic Cationic Cyclization toward ent–Kaurene-type Diterpenoids" Chin. J. Chem. 2013, 31, 111-118 (Special Issue, Dedicated to the Memory of Professor Wei-Shan Zhou).
20. Ran Hong, "Biomimetic Organic Synthesis" in Advances inChemistry(China, 1982-2012), Sciences Press: Beijing;2012, pp. 153-155.
19. Yan Wang, Rob Hoen, and Ran Hong*, "Development of a Non-enzymatic Kinetic Resolution of α-Allenic Alcohols" Synlett 2012, 23, 2729-2734 (doi:10.1055/s-) (Synpacts).
https://www.thieme-connect.com/ejournals/pdf/10.1055/s-.pdf
18. Xianwei Mi, Yan Wang, Lili Zhu, Ren-Xiao Wang, and Ran Hong*, "Enantioselective Synthesis of (-)-Stemoamide" Synthesis 2012,44, 3432-3440 (doi:10.1055/s-) (Feature article).
https://www.thieme-connect.com/ejournals/pdf/10.1055/s-.pdf
17. Sha-Hua Huang*, Huaxin Huo, Wenhua Li, and Ran Hong*, "Research Progress on Nitroso-ene Reaction" Chin. J. Org. Chem. 2012, 32, 1776-1791.
16.Yan Wang, Kuan Zheng,and Ran Hong*,"Chiral Silver Phosphate-catalyzed Cycloisomeric Kinetic Resolution of alpha-Allenic Alcohols"J. Am. Chem. Soc. 2012,134, 4096-4099.
(https://www.thieme-connect.com/ejournals/pdf/synfacts/doi/10.1055/s-.pdf)
15. He Zhang, Chang-Bing Zhou, Qing-Yun Chen, Ji-Chang Xiao*, and Ran Hong*, "Monofluorovinyl Tosylate: A Useful Building Block for the Synthesis of Terminal Vinyl Monofluorides via Suzuki-Miyaura Coupling" Org. Lett. 2011, 13, 560-563.
(https://www.thieme-connect.com/ejournals/pdf/synfacts/doi/10.1055/s-.pdfand http://www.organic-chemistry.org/abstracts/lit3/158.shtm
14. Yan Wang, Lili Zhu, Yuying Zhang, and Ran Hong*, "Bioinspired and Concise Synthesis of (+/-)-Stemoamide" Angew. Chem. 2011, 123, 2839-2842; Angew. Chem., Int. Ed. 2011,50, 2787-2790.
(https://www.thieme-connect.com/ejournals/pdf/synfacts/doi/10.1055/s-.pdf)
13. Zhiyun Zhong, Ran Hong, and Xiaoxia Wang* "Construction of 3-Aryl-1,2,4-benzotriazines via Unprecedented Rearrangement of Bis(benzotrizaol-1-yl)methylarenes"Tetrahedron Lett. 2010,51, 6763-6766.
12. Xinyu Li, Cheng Li, Wenjing Zhang, Shiqing Han, Xiang Lu, and Ran Hong* "Highly Stereoselective 7-Endo-Trig/Ring Contraction Cascade To Construct Pyrrolo[1,2-a]quinoline Derivatives"Org. Lett. 2010, 12, 1696-1699.
11. Cheng Li, Xinyu Li, and Ran Hong* “Synthetic Study on Tetrapetalones: Stereoselective Cyclization of N-acyliminium Ion To Construct Substituted 1-Benzazepines” Org. Lett. 2009, 11, 4036-4039.
Representative publications (PhD and postdoc period):
10. Bingfeng Sun, Ran Hong, Yanbiao Kang, and Li Deng* “Asymmetric Total Synthesis of (-)-Plicatic Acid via a Highly Enantioselective and Diastereoselective Nucleophilic Epoxidation of Acyclic Trisubstitued Olefins” J. Am. Chem. Soc. 2009, 131, 10384-10385.
9.Yongqiang Wang, Jun Song, Ran Hong, Hongmin Li,and Li Deng* “Asymmetric Friedel-Crafts Reaction of Indoles with Imines by an Organic Catalyst” J. Am. Chem. Soc. 2006, 128, 8156-8157.
8. Fanghui Wu, Ran Hong, Jihan Khan, Xiaofeng Liu, and Li Deng* “Asymmetric Synthesis of Chiral Aldehydes by Conjugate Additions with Bifunctional Organocatalysis by Cinchona Alkaloids” Angew. Chem., Int. Ed. 2006, 45, 4301-4305.
7. Fanghui Wu, Hongmin Li, Ran Hong, and Li Deng* “Construction of Quaternary Stereocenters by Efficient and Practical Conjugate Additions to α,β-Unsaturated Ketones with a Chiral Organic Catalyst” Angew. Chem., Int. Ed. 2006, 45, 947-950.
6. Ran Hong, Yonggang Chen, and Li Deng* “Catalytic Enantioselective Total Syntheses of Bisorbicillinolide, Bisorbicillinol and Bisorbibutenolide” Angew. Chem., Int. Ed. 2005, 44, 3478-3481.
5. Shi-Kai Tian, Ran Hong, and Li Deng* “Catalytic Asymmetric Cyanosilylation of Ketones with Chiral Lewis Base” J. Am. Chem. Soc. 2003, 125, 9900-9901.
4.Jian-Guang Lei, Ran Hong, Shen-Gang Yuan, and Guo-Qiang Lin* “Nickel-catalyzed Tandem Reaction To Asymmetric Synthesis of Chiral Phthalides” Synlett 2002, 927-930.
3. Ran Hong, Rob Hoen, Jing Zhang, and Guo-Qiang Lin* “Nickel-catalyzed Ullmann-type Coupling Reaction to Prepare tetra-ortho-substituted Biaryls” Synlett 2001, 1527-1530.
2. Ran Hong, Jun Feng, Rob Hoen, and Guo-Qiang Lin* “Synthesis of (±)-3,3'-Bis(4-hydroxy-2H-benzopyran): A Literature Correction” Tetrahedron 2001, 57, 8685-8689.
1. Guo-Qiang Lin* and Ran Hong “A New Reagent System for Modified Ullmann-Type Coupling Reactions: NiCl₂(PPh₃)₂/PPh₃/Zn/NaH/Toluene” J. Org. Chem. 2001, 66, 2877-2880.



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