基本信息
何毛贤男博导中国科学院南海海洋研究所
电子邮件： hmx@scsio.ac.cn
通信地址： 广州市新港西路164号
邮政编码： 510301

研究领域

招生信息
招生专业070703-海洋生物学

招生方向海洋贝类遗传育种及分子生物学


教育背景1997-09--2000-07中国科学院南海海洋研究所博士学位
1990-09--1993-07武汉大学生物学系硕士学位
1986-09--1990-07西南师范大学学士学位

学历
学位

工作经历
工作简历1997-09~2000-07,中国科学院南海海洋研究所,博士学位
1993-07~现在,中国科学院南海海洋研究所,研究员
1990-09~1993-07,武汉大学生物学系,硕士学位
1986-09~1990-07,西南师范大学,学士学位

社会兼职

教授课程

专利与奖励
奖励信息（1） 马氏珠母贝遗传改良技术, 二等奖, 省级, 2006

专利成果（ 1 ） 人工培育三倍体合浦珠母贝及育珠方法, 2005, 第 1 作者, 专利号: ZL**.3
（ 2 ） 一种红壳色品系马氏珠母贝的制种方法, 2008, 第 1 作者, 专利号: ZL73
（ 3 ） 一种橙黄色华贵栉孔扇贝的制种方法, 2010, 第 1 作者, 专利号: ZL7.4
（ 4 ） 一种华贵栉孔扇贝橙黄壳色分子标记及其鉴定方法和试剂盒, 2012, 第 1 作者, 专利号: ZL4.1
（ 5 ） 一种华贵栉孔扇贝自交系的建立方法, 2013, 第 1 作者, 专利号: ZL4.5
（ 6 ） 一种提高海水珍珠质量的细胞小片处理液及制备方法, 2014, 第 1 作者, 专利号: ZL7.8
（ 7 ） 一种与马氏珠母贝闭壳肌重相关联的SNP标记及鉴别方法, 2015, 第 1 作者, 专利号: ZL5.3
（ 8 ） 一种马氏珠母贝优良育珠贝的培育方法, 2016, 第 1 作者, 专利号: ZL4.7
（ 9 ） 一种与马氏珠母贝软体部重和闭壳肌重显著关联的SNP298299标记的检测引物及其应用, 2017, 第 1 作者, 专利号: ZL1.5
（ 10 ） 一种能被马氏珠母贝MSX基因激活的Pif启动子及其应用, 2016, 第 1 作者, 专利号: ZL7.8
（ 11 ） 一种与马氏珠母贝壳型与重量大小关联的SNP411871标记的检测引物及其应用, 2017, 第 1 作者, 专利号: ZL7.2


出版信息
发表论文（1）Identification and analysis of an MKK4 homologue in response to the nucleus grafting operation and antigens in the pearl oyster, Pinctada fucata,Fish and Shellfish Immunology,2018,第11作者
（2）Proteome and Transcriptome Analysis of Ovary, Intersex Gonads, and Testis Reveals Potential Key Sex Reversal/Differentiation Genes and Mechanism in Scallop Chlamys nobilis,Marine Biotechnology,2018,第11作者
（3）Correlation between Genome Methylation Level and Growth Trait of Pearl Oyster, Pinctada fucata,Pakistan Journal of Zoology,2017,第11作者
（4）马氏珠母贝生长性状QTL鉴定及基因型选择效应分析,热带海洋学报,2017,第11作者
（5）Characterization of the distal-less homologue gene, PfDlx, involved in regulating the expression of Pif in the pearl oyster, Pinctada fucata,Comparative Biochemistry and Physiology, Part B,2017,第11作者
（6）Effect of ocean acidification on growth, calcification, and gene expression in the pearl oyster, Pinctada fucata,Marine Environmental Research,2017,第11作者
（7）A PDGF/VEGF homologue provides new insights into the nucleus grafting operation and immune response in the pearl oyster Pinctada fucata,Gene,2017,第11作者
（8）Insulin growth factor binding protein (IGFBP) is involve in endocrine function regulated by insulin-like peptide system of pearl oyster Pinctada fucata,Comparative Biochemistry and Physiology, Part B,2017,第11作者
（9）Functional Characterization and Molecular Mechanism Exploration of Three Granulin Epithelin Precursor Splice Variants in Biomineralization of the Pearl Oyster Pinctada fucata,Molecular Genetics and Genomics,2016,第11作者
（10）PfIRR Can Interact with HrIGF-I and Activate Both MAP kinase and PI3-kinase Signaling Pathways in Pinctada fucata,Scientific Reports,2016,第11作者
（11）PfSMAD4 plays a role in biomineralization and can transduce bone morphogenetic protein-2 signals in the pearl oyster Pinctada fucata,BMC developmental biology,2016,第11作者
（12）Nuclear factor of activated T cells (NFAT) in pearl oyster Pinctada fucata: Molecular cloning and functional characterization,Fish and Shellfish Immunology,2015,第11作者
（13）DNA methylation is associated with expression level changes of galectin gene in mantle wound healing process of pearl oyster, Pinctada fucata,Fish and Shellfish Immunology,2015,第11作者
（14）Cloning and gene expression of signal transducers and activators of transcription(STAT) homologue provide new insights into the immune response and nucleus graft of the pearl oyster Pinctada fucata,Fish and Shellfish Immunology,2015,第11作者
（15）Comparative and Evolutionary Analysis of the IL17 Gene Family in Invertebrate,Plos One,2015,第11作者
（16）Molecular identification of dmrt2 and dmrt5 and effect of sex steroids on their expressions in Chlamys nobilis,Aquaculture,2014,第11作者
（17）Molecular characterization and analysis of a putative 5-HT receptor involved in reproduction process of the pearl oyster Pinctada fucata,General and Comparative Endocrinology,2014,第11作者
（18）Development of sixteen single nucleotide polymorphism markers in the pearl oyster, Pinctada fucata for population genetic structure analysis, Journal of Genetics,2014,第11作者
（19）Molecular Cloning and Single Nucleotide Polymorphisms (SNPs) Identification of Myostatin cDNA in the Pearl Oyster, Pinctada fucata,Journal of the World Aquaculture Society,2014,第11作者
（20）Differential gene expression identified by RNA-Seq and qPCR in two sizes of pearl oyster (Pinctada fucata),Gene,2014,第11作者
（21）Development of 25 novel microsatellite loci and genetic variation analysis in breeding populations of the pearl oyster Pinctada fucata.,Journal of the World Aquaculture Society,2013,第11作者
（22）Gigabase-Scale Transcriptome Analysis on Four Species of Pearl Oysters,Mar Biotechnol,2013,第11作者
（23）Gene cloning and function analysis of Cytokine-induced suppressor of cytokine signaling (SOCS) from pearl oyster Pinctada fucata,Fish and Shellfish Immunology,2013,第11作者
（24）Interleukin-17 in pearl oyster (Pinctada fucata): Molecular cloning and functional characterization,Fish and Shellfish Immunology,2013,第11作者
（25）Molecular characterization of interferon regulatory factor 2 (IRF-2) homolog in pearl oyster Pinctada fucata,Fish and Shellfish Immunology,2013,第11作者
（26）Molecular identification of insulin-related peptide receptor and its potential role in regulating development in Pinctada fucata,Aquaculture,2013,第11作者
（27）Molecular cloning and characterization of class I NF-κB transcription factor from pearl oyster (Pinctada fucata),Fish and Shellfish Immunology,2012,第11作者
（28）Molecular cloning, characterization and expression analysis of Tumor necrosis factor receptor-associated factor 3 (TRAF3) from pearl oyster,Fish and Shellfish Immunology,2012,第11作者
（29）Effects of ocean acidification on clearance, respiration and excretion rates of three species of bivalve molluscs from southern coast of China,Chinese Journal of Oceanology and Limnology,2012,第11作者
（30）Ocean acidification and elevated temperature affected gene expression patterns of the pearl oyster Pinctada fucata.,PLos One,2012,第11作者
（31）Identification of an Aflp Fragment Linked to Shell Color in the Noble Scallop Chlamys nobilis Reeve,J. Shellfish Res,2012,第11作者
（32）Quantitative expression of shell matrix protein genes and their correlations with shell traits in the pearl oyster Pinctada fucata,Aquaculture,2011,第11作者
（33）Construction of cDNA subtractive library from pearl oyster(Pinctada fucata Gould) with red color shell by SSH,Chinese Journal of Oceanology and Limnology,2011,第11作者
（34）马氏珠母贝9个家系的生长比较,南方水产,2011,第11作者
（35）GH与IGF-I对马氏珠母贝壳生长形成相关基因表达影响的研究,热带海洋学报,2011,第11作者
（36）限食对合浦珠母贝幼虫生长、成活及变态的影响,南方水产,2010,第11作者
（37） Genetic linkage maps of huaguizhikong scallop Chlamys nobilis Reeve based on AFLP and micorsatellite markers. ,J Shellfish Res.,2010,第11作者
（38）马氏珠母贝饥饿补偿生长的初步研究,热带海洋学报,2010,第1作者
（39） Intraspecific genetic variation in mitochondrial 16S rRNA and COI genes in domestic and wild populations of Huaguizhikong scallop Chlamys nobilis Reeve,Aquaculture,2009,第11作者
（40）Realized heritability and response to selection for shell height in the pearl oyster Pinctada fucata (Gould),Aquaculture Research,2008,第1作者
（41）（42）
发表著作

科研活动
科研项目（ 1 ） 马氏珠母贝胰岛素样多肽受体基因的鉴定与生物学功能分析, 主持,国家级,2012-01--2015-12
（ 2 ） 合浦珠母贝良种培育, 主持,国家级,2012-01--2015-12
（ 3 ） 马氏珠母贝同源异型盒基因MSX在壳形成中的功能与调控机制, 主持,国家级,2014-01--2017-12
（ 4 ） 马氏珠母贝优良育珠性能品系培育关键技术与示范, 主持,省级,2015-01--2016-12
（ 5 ） 南海生态环境变化-关键生态种群繁育-螺类繁育, 主持,部委级,2016-01--2020-12
（ 6 ） 贝类体系岗位科学家：海水珍珠贝种质资源与品种改良, 主持,研究所（学校）,2017-08--2020-12

参与会议

合作情况
项目协作单位

指导学生