基本信息
韩业君 男 博导 过程工程研究所
电子邮件：yjhan@ipe.ac.cn
通信地址：北京市海淀区中关村北二条1号
邮政编码：100190
部门/实验室：教育处
研究领域
生物合成工程; 酶制剂工程; 生物过程工程


招生信息

招生专业081703-生物化工

招生方向生物合成工程
酶制剂工程
生物过程工程


教育背景 2010-10--2013-02 美国北卡州立大学 博士后
2008-10--2010-09 美国伊利诺伊大学香槟分校 博士后
2005-09--2008-09 中国科学院过程工程研究所 博士
2001-09--2004-07 南京农业大学 硕士
1997-09--2001-07 青岛农业大学 本科

学历研究生

学位博士

工作经历
社会兼职2018-01-01-今,Applied and Environmental Microbiology编委,


专利与奖励
奖励信息（1） 闵恩泽能源化工奖, 一等奖, 其他, 2017


出版信息[1]. Xiaojing Jia, Yejun Han^*. The extracellular endo-β-1,4-xylanase with multidomain from the extreme thermophile Caldicellulosiruptor lactoaceticus is specific for insoluble xylan degradation. Biotechnology for Biofuels. 2019. 12:143 https://doi.org/10.1186/s13068-019-1480-1
[2]. Xiaojing Jia, Robert Kelly, Yejun Han^*. Simultaneous biosynthesis of (R)-acetoin and ethylene glycol from D-xylose through in vitro metabolic engineering. Metabolic Engineering Communications. MEC_2018_23. 2018. https://doi.org/10.1016/j.mec.2018.e00074
[3]. Xiaowei Peng, Robert M. Kelly, and Yejun Han^*. Sequential processing with fermentative Caldicellulosiruptor kronotskyensis and chemolithoautotrophic Cupriavidus necator for converting rice straw and CO₂ to polyhydroxybutyrate. Biotechnology and Bioengineering. 2018. 10.1002/bit.26578
[4]. Jianjun Ding, Xiaowei Peng^*, Yejun Han^*. Electricity production and microbial community of anaerobic sludge. The Chinese Journal of Process Engineering. 2018. 10.12034/j.issn.1009-606X.218152
[5]. Hong Su, Yejun Han^*. Review on electroautotrophic microorganisms: uptaking extracellular electron and catalyzing CO₂ fixation and biosynthesis. Progress in Chemistry. 2018. 0.7536/PC180623.
[6]. Xiaojing Jia, Xiaowei Peng, Ying Liu, Yejun Han^*. Conversion of cellulose and hemicellulose of biomass simultaneously to acetoin by thermophilic simultaneous saccharification and fermentation. Biotechnology for Biofuels. 2017. https://doi.org/10.1186/s13068-017-0924-8.
[7]. Daniel Wefers,Jia Dong,Ahmed M. Abdel-Hamid, Hans Müller Paul,Gabriel V. Pereira,Yejun Han, Dylan Dodd, Ramiya Baskaran,Beth Mayer, Roderick I. MackieandIsaac Cann*. Enzymatic mechanism for arabinan degradation and transport in the thermophilic bacteriumCaldanaerobius polysaccharolyticus. Applied and Environmental Microbiology. 2017. doi: 10.1128/AEM.00794-17.
[8]. Xiaojing Jia, Ying Liu, Yejun Han^*. A thermophilic cell-free cascade enzymatic reaction for acetoin synthesis from pyruvate. ScientificReports. 2017. 10.1038/s41598-017-04684-8.
[9]. Xiaowei Peng, Chao Li*, Jing Liu, Zili Yi, Yejun Han^*. Changes in composition, cellulose degradability and biochemical methane potential of Miscanthus species during the growing season. Bioresource Technology. 2017 (235): 389–395.
[10]. Andrew J. Loder^#, Yejun Han^#, Aaron B. Hawkins^#, Hong Lian, Gina L. Lipscomb, Gerrit J. Schut, Matthew W. Keller, Michael W.W. Adams, Robert M. Kelly*. Reaction kinetic analysis of the 3-hydroxypropionate/4-hydroxybutyrate CO₂fixation cycle in extremely thermoacidophilic archaea. Metabolic Engineering. 2016. http://dx.doi.org/10.1016/j.ymben.2016.10.009. (^# co-first author)
[11]. Shuofu Mi, Hongqiang Li, Shuying Li,YejunHan*. The synergism of hot water pretreatment and enzymatic hydrolysis in depolymerization of lignocellulosic content of palm kernel cake. Journal of Molecular Catalysis B: Enzymatic.2016. 134: 37-42.
[12]. Hong Lian, Benjamin M. Zeldes, Gina L. Lipscomb, Aaron. B. Hawkins, Yejun Han, Andrew J. Loder, Declan Nishiyama, Michael W.W. Adams, and Robert M. Kelly*. Ancillary contributions of heterologous biotin protein ligase and carbonic anhydrase for CO₂ incorporation into 3-hydroxypropionate by metabolically engineered Pyrococcus furiosus. Biotechnology & Bioengineering. 2016. 9999:1-9.
[13]. XiaoweiPeng,Hong Su,ShuofuMi,YejunHan*.A multifunctional thermophilic glycoside hydrolase from Caldicellulosiruptor owensensis with potential applications in production of biofuels and biochemicals. Biotechnololgy for Biofuels. 2016. doi: 10.1186/s13068-016-0509-y.
[14]. Xiaojing Jia, Weibo Qiao, Wenli Tian, Xiaowei Peng, Yejun Han*. Biochemical characterization of extra- and intracellular endoxylanase from thermophilic bacterium Caldicellulosiruptor kronotskyensis. ScientificReports. 2016. doi: 10.1038/srep21672.
[15]. Xiaowei Peng, Weibo Qiao, Shuofu Mi, Xiaojing Jia, Hong Su, Yejun Han*. Characterization of hemicellulase and cellulase from the extremely thermophilic bacterium Caldicellulosiruptor owensensis and their potential application for bioconversion of lignocellulosic biomass without pretreatment. Biotechnololgy for Biofuels. 2015. doi: 10.1186/s13068-015-0313-0.
[16]. Hong Su, Weihua Qiu, Qing Kong, Shuofu Mi,YejunHan*. Thermostable pectate lyase fromCaldicellulosiruptor kronotskyensisprovides an efficient addition for plant biomass deconstruction. Journal of Molecular Catalysis B: Enzymatic, 2015,121:104-112.
[17]. Xiaojing Jia, Shuofu Mi, Jinzhi Wang, Weibo Qiao, Xiaowei Peng, Yejun Han*. Insight into glycoside hydrolases for debranched xylan degradation from extremely thermophilic bacterium Caldicellulosiruptor lactoaceticus. PLoS One. 2014. doi: 10.1371/journal.pone.**.
[18]. Shuofu Mi, Xiaojing Jia, Jinzhi Wang, Weibo Qiao, Xiaowei Peng, Yejun Han*. Biochemical characterization of two thermostable xylanolytic enzymes encoded by a gene cluster of Caldicellulosiruptor owensensis. PLoS One. 2014. doi: 10.1371/journal.pone.**.
[19]. Weibo Qiao, Shuge Tang, Shuofu Mi, Xiaojing Jia, Xiaowei Peng,YejunHan*. Biochemical characterization of a novel thermostable GH11 xylanase with CBM6 domain fromCaldicellulosiruptor kronotskyensis. Journal of Molecular Catalysis B: Enzymatic. 2014, 107: 8-16.
[20]. Takuji Oyama,George E. Schmitz, Dylan Dodd, Yejun Han, Alanna Burnett, Naoko Nagasawa, Roderick I. Mackie, Haruki Nakamura, Kosuke Morikawa, Isaac Cann*. Mutational and structural analyses of Caldanaerobius polysaccharolyticus Man5B reveal novel active site residues for Family 5 glycoside hydrolases. PLoS One. 2013. DOI: 10.1371/journal.pone.**.
[21]. Aaron S. Hawkins, Yejun Han, and Michael W.W. Adams, Robert M. Kelly*. Novel enzymes for catalysis of 4-hydroxybutyrate-CoA ligation for CO₂ fixaion pathways. The Journal of Biological Chemistry. 2013. 288(6):4012-4022.
[22]. Xiaoyun Su, Yejun Han, Dylan Dodd, Young Hwan Moon, Shosuke Yoshida, Roderick I. Mackie, and Isaac K. O. Cann*. Reconstitution of a thermostable hemicellulase mixture from the bacterium Caldicellulosiruptor bescii. Applied and Environmental Microbiology. 2013. 79(5):1481-1490.
[23]. Yejun Han^#, Vinayak Agarwal^#, Dylan Dodd^#, Jason Kim, Brian Bae, Roderick I. Mackie, Satish K. Nair, and Isaac K.O. Cann*. Biochemical and structural insights into xylan utilization by the thermophilic bacterium Caldanaerobius polysaccharolyticus. The Journal of Biological Chemistry. 2012. 287(42): 34946-34960 (^# co-first author).
[24]. Yejun Han, Aaron S. Hawkins, Michael W.W. Adams and Robert M. Kelly*. Epimerase (Msed_0639) and mutase (Msed_0638, Msed_2055) convert (S)-methylmalonyl-CoA to succinyl-CoA in the Metallosphaera sedula 3-hydroxypropionate/4-hydroxybutyrate cycle. Applied and Environmental Microbiology. 2012. 78(17): 6194-6202.
[25]. Aaron S. Hawkins, Yejun Han, Hong Lian, Andrew J. Loder, Angeli L. Menon, Ifeyinwa J. Iwuchukwu, Matthew Keller, Therese T. Leuko, Michael W.W. Adams, and Robert M. Kelly*. Extremely thermophilic routes to microbial electrofuels. American Chemical Society Catalysis. 2011, 1 (9):1043–1050.
[26]. Yejun Han and Hongzhang Chen*. Improvement of corn stover bioconversion efficiency by using plant glycoside hydrolase. Bioresource Technology. 2011. 102(7): 4787-4792.
[27]. Mirjam A. Kabel, Carl J. Yeoman, Yejun Han, Dylan Dodd, Charles A. Abbas, Jan A. M. de Bont,Mark Morrison, Isaac K.O. Cann, Roderick I. Mackie*. Biochemical characterization and relative expression levels of multiple carbohydrate esterases of the xylanolytic rumen bacterium Prevotella ruminicola 23 grown on an ester-enriched substrate. Applied and Environmental Microbiology. 2011. 77(16): 5671-5681.
[28]. Yejun Han, Dylan Dodd, Charles W. Hespen, Samuel Ohene-Adjei, Charles M. Schroeder, Roderick I. Mackie, and Isaac K.O. Cann*. Comparative analyses of two thermophilic enzymes exhibiting both β-1,4 mannosidic and β-1,4 glucosidic cleavage activities from Caldanaerobius polysaccharolyticus. Journal of Bacteriology. 2010. 192(16): 4111-4121.
[29]. Yejun Han and Hongzhang Chen*. Biochemical characterization of a maize stover β-exoglucanase and its use in lignocellulose conversion. Bioresource Technology. 2010. 101(15): 6111-6117.
[30]. Yejun Han and Hongzhang Chen*. A β-xylosidase from cell wall of maize: purification, properties and its use in hydrolysis of plant cell wall. Journal of Molecular Catalysis B: Enzymatic. 2010. 63: 135-140.
[31]. Yejun Han and Hongzhang Chen*. Synergism between hydrophobic proteins of corn stover and cellulase in lignocellulose hydrolysis. Biochemical Engineering Journal. 2009. 48: 218-224.
[32]. Yejun Han and Hongzhang Chen*. Characterization of β-glucosidase from corn stover and its application in simultaneous saccharification and fermentation. Bioresource Technology. 2008. 99(15): 6081-6087.
[33]. Hongzhang Chen*, Yejun Han, and Jian Xu. Simultaneous saccharification and fermentation of steam exploded wheat straw pretreated with alkaline peroxide. Process Biochemistry. 2008. 43(12): 1462-1466.
[34]. Yejun Han and Hongzhang Chen*. Synergism between corn stover protein and cellulase. Enzyme and Microbial Technology. 2007. 41: 638–645.

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