基本信息
葛高翔男博导中国科学院分子细胞科学卓越创新中心（生物化学与细胞生物学研究所）
电子邮件： gxge@sibs.ac.cn
通信地址： 上海市岳阳路320号新生化大楼1415室
邮政编码： 200031
部门/实验室：生物化学与细胞生物学研究所
研究领域

招生信息
招生专业071010-生物化学与分子生物学

招生方向细胞微环境对肿瘤发生及转移的调控


教育背景1996-09--2001-08中国科学院生物化学研究所博士
1992-08--1996-08南京大学理学学士学位

学历
学位

工作经历
工作简历2007-12~现在,中科院上海生化细胞所,研究员
2002-10~2007-11,美国威斯康星大学麦迪逊分校,Scientist/博士后
2001-12~2002-09,美国田纳西大学健康科学中心,博士后
2001-09~2001-11,中科院上海生化细胞所,助理研究员
1996-09~2001-08,中国科学院生物化学研究所,博士
1992-08~1996-08,南京大学,理学学士学位

社会兼职

教授课程分子肿瘤学


专利与奖励
奖励信息
专利成果

出版信息
发表论文（1）Th-POK regulates mammary gland lactation through mTOR-SREBP pathway,PLOS Genetics,2018,第11作者
（2）细胞外基质与肿瘤相关成纤维细,生物化学与生物物理进展,2017,第11作者
（3）C/EBPβ mediates TNF-α-induced cancer cell migration by inducing MMP expression dependent on p38 MAPK.,J Cell Biochem.,2015,第11作者
（4）Minor type IV collagen ?5 chain promotes cancer progression through discoidin domain receptor-1.,PLOS Genet.,2015,第11作者
（5）Targeting Type Iγ phosphatidylinositol phosphate kinase inhibits breast cancer metastasis,Oncogene,2014,第12作者
（6）Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma,Nat Commun,2014,第12作者
（7）Snail and Slug mediate tamoxifen resistance in breast cancer cells through activation of EGFR-ERK independent of epithelial-mesenchymal transition.,J Mol Cell Biol.,2014,第11作者
（8）Lysyl oxidase promotes bleomycin-induced lung fibrosis through modulating inflammation.,J Mol Cell Biol.,2014,第11作者
（9）Activator protein 1 suppresses antitumor T-cell function via the induction of programmed death 1,Proc Natl Acad Sci U S A,2012,第12作者
（10）Lysyl Oxidase, Extracellular Matrix Remodeling and Cancer Metastasis.,Cancer Microenviron.,2012,第11作者
（11）LKB1 in Lung Cancerigenesis: A Serine/Threonine Kinase as Tumor Suppressor.,Protein and Cell.,2011,第11作者
（12）α3(V) Collagen is critical for glucose homeostasis in mice due to effects in pancreatic islets and peripheral tissues.,J Clin Invest.,2011,第1作者
（13）The CC and DE loops in Ig domains 1 and 2 of MAdCAM-1 play different roles in MAdCAM-1 binding to low- and high-affinity integrin a4b7.,J Biol Chem.,2011,第11作者
（14）LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling.,Proc Natl Acad Sci U S A.,2010,第11作者
（15）Fibronectin binds and enhances the activity of bone morphogenetic protein 1.,J Biol Chem.,2009,第4作者
（16）Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction. ,Nat Cell Biol.,2009,第11作者
（17）ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-beta bioavailability regulation.,Nat Genet.,2008,第11作者
（18）Two domains of the epidermal growth factor receptor are involved in cytoskeletal interactions.,Biochem Biophys Res Commun. ,2008,第3作者
（19）Bone Morphogenetic Protein 1 Processes Prolactin to a 17kDa Anti-Angiogenic Form.,Proc Natl Acad Sci U S A.,2007,第1作者
（20）Bone Morphogenetic Protein 1 Prodomain Specifically Binds, Localizes and Regulates Signaling of Bone Morphogenetic Proteins 2 and 4.,J Biol Chem,2007,第2作者
（21）Inhibition of bone morphogenetic protein 1 by native and altered forms of ？2-macroglobulin.,J Biol Chem,2006,第1作者
（22）.,BMP1 controls TGF？1 activation via cleavage of latent TGF？-binding protein,J Cell Biol.,2006,第1作者
（23）bmp1 and mini fin are functionally redundant in regulating formation of the zebrafish dorsoventral axis.,Mech Dev.,2006,第2作者
（24）TIMP-3 inhibits the procollagen N-proteinase ADAMTS-2.,Biochem J.,2006,第4作者
（25）Developmental roles of the BMP1/TLD metalloproteinases.,Birth Defects Res C Embryo Today,2006,第1作者
（26） Mammalian tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains.,J Biol Chem.,2006,第1作者
（27）GDF11 forms a bone morphogenetic protein 1-activated latent complex that can modulate nerve growth factor-induced differentiation of PC12 cells.,Mol Cell Biol.,2005,第1作者
（28）Bone morphogenetic protein-1/tolloid-related metalloproteinases process osteoglycin and enhance its ability to regulate collagen fibrillogenesis.,J Biol Chem.,2004,第1作者
（29）Activation mechanism of solubilized epidermal growth factor tyrosine kinase.,Biochem Biophys Res Commun,2002,第1作者
（30）Effect of membrane fluidity on tyrosine kinase activity of reconstituted Epidermal Growth Factor Receptor.,Biochem Biophys Res Commun.,2001,第1作者

发表著作

科研活动
科研项目（ 1 ） 细胞生长过程细胞骨架可塑性的调控机制, 参与,国家级,2010-01--2014-12
（ 2 ） Lysyl Oxidase在肿瘤转移中的作用机制研究, 主持,国家级,2010-01--2012-12
（ 3 ） 癌症重大科学问题及防治新策略的研究, 参与,国家级,2009-12--2011-07
（ 4 ） ****, 主持,国家级,2010-01--2012-12
（ 5 ） 赖氨酸氧化酶的调控与功能研究, 主持,国家级,2014-01--2017-12
（ 6 ） IV型胶原蛋白在肿瘤发生发展中的功能与机制研究, 主持,国家级,2015-01--2019-12
（ 7 ） 分子病理表型分析, 主持,部委级,2015-10--2020-12

参与会议（1）Extracellular matrix remodeling in lung fibrosis and cancer第15届海峡两岸生物医学学术研讨会2016-10-17
（2）Minor type IV collagen α5 chain promotes cancer progression through collagen receptor DDR12013-11-29
（3）Minor Type IV Collagen a5 Chain Promotes Cancer Progression through Collagen Receptor DDR12013-11-05
（4）Lysyl Oxidase in Lung Fibrosis and Cancer第一届中-欧个体化肿瘤免疫标志物专家学术论坛2013-09-06
（5）Lysyl Oxidase in Lung Fibrosis and Cancer2013-07-21
（6）Cancer- An Overhealing Wound: Lysyl Oxidase in Lung Fibrosis and Cancer第一届肿瘤新生血管和肿瘤微环境国际研讨会Gaoxiang Ge2011-05-30
（7）LKB1 inhibits lung cancer progression through lysyl oxidase and extracellularGaoxiang Ge2010-11-12
（8）Activation of TGF-？ Family Growth Factors by BMP-1/Tolloid-like MetalloproteinasesGaoxiang Ge2009-10-27
（9）Activation of TGF-β family growth factors by BMP-1/Tolloid-like metalloproteinasesGaoxiang Ge2009-09-12
（10）GDF11 forms a bone morphogenetic protein 1-activated latent complex that can modulate nerve growth factor-induced differentiation of PC12 cellsGaoxiang Ge2004-10-11
（11）Activation mechanism of solubilized epidermal growth factor tyrosine kinase.12000-10-21


合作情况
项目协作单位

指导学生