基本信息
高亮男硕导中国科学院深圳先进技术研究院
电子邮件： liang.gao@siat.ac.cn
通信地址： 深圳市南山区学苑大道1068号中国科学院深圳先进技术研究院
邮政编码： 518055
部门/实验室：脑所
研究领域
We are interested in the molecular and cellular functions of peripheral immune system in CNS injury and degenerative diseases, specially focus on infiltrating monocyte in mediating the immune response post ischemic stroke and inflammaging in the induction of AD. As immune response is a double-edged sword in neuronal death and regeneration post injury, understanding and fine tuning the balance between proinflammatory and anti-inflammatory responses provides new strategies for the relief of neural injury and promotion of regeneration. Aging is the key risking factor for neuronal degenerative diseases, accumulated distortions in the aged immune system lead to the interruption of immune niche in CNS and finally disturb the immune-protective effect of glial cells on neuronal survival. Thus, it is of great importance to find out the mechanism of inflammaging in the induction and progression of CNS degeneration.


Additionally, we will also investigate the role of neural circuitry regulations on immune system in homeostasis and immune disease progression. The innervation of sympathetic and parasympathetic nerves in immune organs provide controlling hubs for CSN in regulating immune activities. However, the detailed neural circuitry and molecular mechanisms of how CNS directing immune system still remains mysteries.




招生信息We are always looking for motivated students who have good trainings in biology，zoology，medicine or other natural science background and willing to join us with great interest on neuroimmunology topics.



招生专业071006-神经生物学

招生方向神经免疫学


教育背景2009-10--2014-12德国海德堡大学博士
2006-09--2009-06第二军医大学硕士
2000-09--2004-06天津科技大学学士

学历博士

学位博士

工作经历
工作简历2015-01~2017-09,德国癌症研究中心,博士后

社会兼职

教授课程神经生物学基础


专利与奖励
奖励信息
专利成果

出版信息
发表论文（1）An Immune-CNS Axis Activates Remote Hippocampal Stem Cells Following Spinal Transection Injury,Frontiers in Molecular Neuroscience,2018,第3作者
（2）Endothelial cell-derived CD95 ligand serves as a chemokine in induction of neutrophil slow rolling and adhesion,eLife,2016,第1作者
（3）Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice,The Journal of Experimental Medicine,2015,第1作者
（4）Blocking P2X receptors can inhibit the injury-induced proliferation of olfactory epithelium progenitor cells in adult mouse,International Journal of Pediatric Otorhinolaryngology,2010,第1作者

发表著作

科研活动
科研项目（ 1 ） 阿尔茨海默症的诊治方法研究, 参与,省级,2018-12--2022-12
（ 2 ） 2019优青基金新引进启动项目, 主持,市地级,2020-01--2021-12
（ 3 ） 深港脑科学创新研究院开放课题, 主持,省级,2019-01--2023-12

参与会议（1）Neutrophil slow rolling involves CD95 activation of integrin signaling2015-11-08


合作情况
项目协作单位

指导学生现指导学生
徐帆硕士研究生071006-神经生物学