基本信息





杜茁
研究员，博士生导师
中国科学院遗传与发育生物学研究所


电子邮件：zdu@genetics.ac.cn
通信地址：北京市朝阳区中科院遗传发育所3-310
邮政编码：100101






研究领域



动物发育功能基因组学
细胞命运决定的分子与系统生物学机制
发育基因表达的多维度调控






招生信息
招生专业071008-发育生物学
071007-遗传学
071021-生物信息学

招生方向发育功能基因组学，细胞命运决定调控机制，发育基因表达调控


教育背景2009-06--2015-01Memorial Sloan Kettering Cancer Center博士后
2008-09--2009-06Albert Einstein College of Medicine博士后
2003-09--2008-06中国农业大学博士
1999-09--2003-06湖南农业大学本科

学历研究生
学位理学博士

工作经历
工作简历 2015-01--今 中国科学院遗传与发育生物学研究所 研究员


教授课程高级分子遗传学


专利与奖励

出版信息



* Corresponding Author


Lineage context switches the function of a C. elegans Pax6 homolog in determining a neuronal fate.
Brandt JP, Rossillo M, Du Z, Ichikawa D, Barnes K, Chen A, Noyes M, Bao Z, Ringstad N*.
Development. 2019 Apr 15;146(8).


Systems Properties and Spatiotemporal Regulation of Cell Position Variability during Embryogenesis.
Li X^#, Zhao Z^#, Xu W, Fan R, Xiao L, Ma X, Du Z*.
Cell Rep. 2019 Jan 8;26(2):313-321.e7.


mTOR Regulates Phase Separation of PGL Granules to Modulate Their Autophagic Degradation.
Zhang G, Wang Z, Du Z, Zhang H*.
Cell. 2018 Sep 6;174(6):1492-1506


Trans-splicing enhances translational efficiency in C. elegans.
Yang YF, Zhang X, Ma X, Zhao T, Sun Q, Huan Q, Wu S, Du Z*, Qian W*.
Genome Res. 2017 Sep;27(9):1525-1535.

Digital Development: A database of C. elegans cell lineage differentiation with lineage phenotypes, cell-specific gene functions and a multiscale model.
Santella A, Kovacevic I, Herndon L Hall D, Du Z*, Bao Z*.
Nucleic Acids Res. 2016 Jan 4;44(D1):D781-5.

The Regulatory Landscape of lineage differentiation in a metazoan embryo.
Du Z*, Santella A, He F, Shah PK, Kamikawa Y, Bao Z*.
Dev Cell. 2015 2015 Sep 14;34(5):592-607. (Free Featured Article)

POS-1 Promotes Endo-mesoderm Development by Inhibiting the Cytoplasmic Polyadenylation of neg-1 mRNA.
Elewa A, Shirayama M, Kaymak E, Harrison PF, Powell DR, Du Z, Chute CD, Woolf H, Yi D, Ishidate T, Srinivasan J, Bao Z, Beilharz TH, Ryder SP, Mello CC*
Dev Cell. 2015 Jul 6;34(1):108-18. Recommend by F1000

E3 ubiquitin ligases promote progression of differentiation during C. elegans embryogenesis.
Du Z, He F, Yu Z, Bowerman B, Bao Z*.
Dev Biol. 2015 Feb 15;398(2):267-79.

De novo inference of systems-level mechanistic models of development from live imaging-based phenotype analysis.
Du Z, Stantella A., He F., Tiongson M, Bao Z*.
Cell. 2014 Jan 16;156(1-2):359-72.

Systematic quantification of developmental phenotypes at single-cell resolution during embryogenesis.
Moore JL, Du Z, Bao Z*.
Development. 2013 Aug;140(15):3266-74.

Inverted selective plane illumination microscopy (iSPIM) enables coupled cell identity lineaging and neurodevelopmental imaging in Caenorhabditis elegans.
Wu Y*, Ghitani A, Christensen R, Santella A, Du Z, Rondeau G, Bao Z, Colón-Ramos D, Shroff H.
Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17708-13. Recommend by F1000

Single-molecule analysis reveals changes in the DNA replication program for the POU5F1 locus upon human embryonic stem cell differentiation.
Schultz SS, Desbordes SC, Du Z, Kosiyatrakul S, Lipchina I, Studer L, Schildkraut CL*.
Mol Cell Biol. 2010 Sep;30(18):4521-34.

Genome-wide colonization of gene regulatory elements by G4 DNA motifs.
Du Z, Zhao Y, Li N*.
Nucleic Acids Res. 2009 Nov;37(20):6784-98.

Genome-wide analysis reveals regulatory role of G4 DNA in gene transcription.
Du Z, Zhao Y, Li N*.
Genome Res. 2008 Feb;18(2):233-41. (Highlighted on Cover)








科研活动
科研项目（ 1 ） ****, 主持,国家级,2015-01--2018-01
（ 2 ） 利用活体成像和单细胞分析研究动物胚胎发育调控规律与机理, 主持,部委级,2015-01--2017-12
（ 3 ） 利用自动化单细胞分析技术解析线虫进化保守基因的发育功能与调控网络, 主持,国家级,2016-01--2019-12
（ 4 ） 全景式解析时空特异性转录因子回路在细胞谱系分化中的功能, 主持,部委级,2017-01--2021-12
（ 5 ） 原肠胚形成过程稳固性维持的分子和细胞生物学机制解析, 主持,国家级,2018-01--2021-12
（ 6 ） 细胞谱系分化, 主持,国家级,2018-01--2020-12