基本信息
刁星星男硕导中国科学院上海药物研究所
电子邮件： xxdiao@simm.ac.cn
通信地址： 上海浦东张江海科路501号1705室
邮政编码： 201203

研究领域

招生信息
招生专业100704-药物分析学
100706-药理学

招生方向药物代谢，药物不良反应机理，新代谢途径，反常药动学，药物代谢新技术
低辐射能量放射性同位素[14C]/[3H]标记技术在新药DMPK中的应用


教育背景2009-09--2014-07中国科学院大学博士
2005-09--2009-06武汉大学学士

学历
学位

工作经历
工作简历2019-02~现在,中国科学院上海药物研究所,课题组长
2018-08~2019-02,美国Celgene公司,科学家II
2016-06~2018-08,美国XenoBiotic Laboratories,科学家I/II
2014-07~2016-06,美国国立卫生研究院（NIH）,博士后
2009-09~2014-07,中国科学院大学,博士
2005-09~2009-06,武汉大学,学士

社会兼职

教授课程

专利与奖励
奖励信息（1） 第4届ISSX/CSSX 联合会议演讲二等奖, 二等奖, 其他, 2013
（2） 第十届全国药物分析优秀论文评选交流会三等奖, 三等奖, 其他, 2011

专利成果

出版信息
发表论文（1）Characterization of TPN171 metabolism in humans via ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry,J Pharm Biomed Anal,2019,第11作者
（2）New Synthetic Cannabinoids Metabolism and Strategies to Best Identify Optimal Marker Metabolites,Frontiers in Chemistry,2019,第1作者
（3）Metabolism of the new synthetic cannabinoid EG-018 in human hepatocytes by high-resolution mass spectrometry,Forensic Toxicol,2018,第1作者
（4）Synthetic cannabinoid BB-22 (QUCHIC): Human hepatocytes metabolism with liquid chromatography-high-resolution mass spectrometry detection,J Pharm Biomed Anal,2018,第1作者
（5）Oxytocin by intranasal and intravenous routes reaches the cerebrospinal fluid in rhesus macaques: determination using a novel oxytocin assay,Mol Psychiatry,2018,第3作者
（6）In vitro and in vivo human metabolism of a new synthetic cannabinoid NM-2201 (CBL-2201),Forensic Toxicol,2017,第1作者
（7）Human hepatocyte metabolism of novel synthetic cannabinoids MN-18 and its 5-fluoro analog 5F-MN-18,Clin Chem,2017,第1作者
（8）In vitro metabolism of new synthetic cannabinoid SDB-006 in human hepatocytes by high-resolution mass spectrometry,Forensic Toxicol,2017,第1作者
（9）Distinguishing intake of new synthetic cannabinoids, ADB-PINACA and 5F-ADB-PINACA, with human hepatocyte metabolites and high resolution mass spectrometry,Clin Chem,2017,第2作者
（10）Approaches, challenges and advances in metabolism of new synthetic cannabinoids and identification of optimal urinary marker metabolites,Clin Pharmacol Ther,2017,第1作者
（11）Identification of new synthetic cannabinoid ADB-CHMINACA (MAB-CHMINACA) metabolites in human hepatocytes,AAPS J,2017,第1作者
（12）25C-NBOMe and 25I-NBOMe metabolite studies in human hepatocytes, in vivo mouse and human urine with high-resolution mass spectrometry,Drug Test Anal,2017,第5作者
（13）In vitro metabolite profiling of ADB-FUBINACA, a new synthetic cannabinoid,Curr Neuropharmacol,2017,第2作者
（14）Effect of N-methyl deuteration on metabolism and pharmacokinetics of enzalutamide,Drug Des Devel Ther,2016,第5作者
（15）First metabolic profile of PV8, a novel synthetic cathinone, in human hepatocytes and urine by high-resolution mass spectrometry,Anal Bioanal Chem,2016,第4作者
（16）Metabolic profiling of new synthetic cannabinoids AMB and 5F-AMB by human hepatocyte and liver microsome incubations and high-resolution mass spectrometry,Rapid Commun Mass Spectrom,2016,第2作者
（17）In vitro and in vivo human metabolism of synthetic cannabinoids FDU-PB-22 and FUB-PB-22,AAPS J,2016,第1作者
（18）In vitro, in vivo and in silico metabolic profiling of α-pyrrolidinopentiothiophenone, a novel thiophene stimulant,Bioanalysis,2016,第5作者
（19）4-Methoxy-a-PVP: in silico prediction, metabolic stability, and metabolite identification by human hepatocyte incubation and high-resolution mass spectrometry,Forensic Toxicol,2016,第4作者
（20）High-resolution mass spectrometry for characterizing the metabolism of synthetic cannabinoids THJ-018 and its 5-fluoro analog THJ-2201 after incubation in human hepatocytes,Clin Chem,2016,第1作者
（21）Metabolic characterization of pyrotinib in humans by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry,J Chromatogr B,2016,第6作者
（22）Strategies to distinguish new synthetic cannabinoid FUBIMINA (BIM-2201) intake from its isomer THJ-2201: metabolism of FUBIMINA in human hepatocytes,Forensic Toxicol,2016,第1作者
（23）Isomer-selective distribution of 3-n-butylphthalide (NBP) hydroxylated metabolites, 3-OH-NBP and 10-OH-NBP, across the rat blood-brain barrier,Acta Pharmacol Sin,2015,第1作者
（24）醛氧化酶在药物代谢中的作用,The role of aldehyde oxidase in drug metabolism,Journal of Baoji University of Arts and Sciences (Natural Science),2014,第1作者
（25）Bioactivation of 3-n-butylphthalide via the sulfation of its major metabolite 3-hydroxy-NBP: mediated mainly by sulfotransferase1A1,Drug Metab Dispos,2014,第1作者
（26）Simultaneous quantitation of 3-n-butylphthalide (NBP) and its four major metabolites in human plasma by LC–MS/MS using deuterated internal standards,J Pharm Biomed Anal,2013,第1作者
（27）Enantioselective determination of 3-n-butylphthalide (NBP) in human plasma by liquid chromatography on a teicoplanin-based chiral column coupled with tandem mass spectrometry,J Chromatogr B,2013,第1作者
（28）Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients,Brit J Pharmacol,2013,第4作者
（29）Metabolism and pharmacokinetics of 3-n-butylphthalide (NBP) in humans: the role of cytochrome P450s and alcohol dehydrogenase in biotransformation,Drug Metab Dispos,2013,第1作者
（30）Metabolism and pharmacokinetics of morinidazole in humans: Identification of diastereoisomeric morpholine N+-glucuronides catalyzed by UDP glucuronosyltransferase,Drug Metab Dispos,2012,第4作者

发表著作

科研活动
科研项目（ 1 ） 川楝素代谢活化和肝脏毒性机理研究, 参与,国家级,2013-01--2015-12
（ 2 ） “****”启动基金, 主持,市地级,2019-02--2024-02

参与会议（1）如何在法医样品中根据特征性代谢物判定吸食某种新型毒品（合成类大麻）？第七届中国生物分析论坛年会2019-06-14
（2）Metabolism of synthetic cannabinoids THJ-018 and its 5-fluoro analog THJ-2201 following human hepatocytes Incubation and high-resolution mass spectrometry美国法医毒理学会2015年会2015-10-22
（3）Simultaneous determination of butylphthalide and four metabolites in human plasma by LC-MS/MS第5届化学与药学结构分析年会2014-04-17
（4）Insight into uncommon metabolic pathways of butylphthalide (NBP) in humans第4届ISSX/CSSX 联合会议2013-05-17
（5）Metabolism of 3-n-butylphthalide (NBP), an anti-celebral ischemia, in vitro and in vivo中国第10届药物与异物代谢暨第3届ISSX/CSSX 联合会议2012-09-23
（6）Metabolism of 3-n-butylphthalide (NBP) in humans中国第10届药物分析会议2011-09-16


合作情况
项目协作单位

指导学生