基本信息
邓菲女博导中国科学院武汉病毒研究所
电子邮件： df@wh.iov.cn
通信地址： 湖北省武汉市小洪山中区44号
邮政编码： 430071

研究领域

招生信息
招生专业071005-微生物学

招生方向病毒学
生物技术


教育背景
学历
学位

工作经历
工作简历2013-08~现在,中国科学院武汉病毒研究所,研究员
2007-09~现在,中国科学院武汉病毒研究所,副研究员
2003-07~现在,中国科学院武汉病毒研究所,助理研究员

社会兼职

教授课程

专利与奖励
奖励信息（1） 湖北省自然科学一等奖, 一等奖, 省级, 2011

专利成果（ 1 ） 一种用于检测乙型肝炎病毒的生物用品。 , 2008, 第 3 作者, 专利号: ZL 2006 1 **.X
（ 2 ） 重组杆状病毒AcBac△cc-GP41及其构建方法 , 2011, 第 4 作者, 专利号: ZL 2007 1 **.0
（ 3 ） 一种用于检测禽流感病毒H5N1亚型的液相芯片。, 2009, 第 4 作者, 专利号: ZL 2006 1 **.X
（ 4 ） 高效表达SARS冠状病毒S蛋白的重组杆状病毒及构建。 , 2010, 第 3 作者, 专利号: ZL 2007 1 **.9
（ 5 ） 用于乙型肝炎病毒共价闭合DNA的检测用品及其应用, 2012, 第 4 作者, 专利号: ZL6.8
（ 6 ） 用液相芯片检测呼吸道传染病病原的引物和探针及方法, 2012, 第 3 作者, 专利号: ZL1.1
（ 7 ） 用于杆状病毒滴度测定的重组细胞系及其测定办法, 2013, 第 1 作者, 专利号: 2.5
（ 8 ） 用液相芯片检测虫媒或接触传播病原的引物和探针及方法, 2013, 第 3 作者, 专利号: ZL5.x
（ 9 ） 一种可进行生物安全操作的冷冻干燥装置, 2017, 第 2 作者, 专利号: ZL4.8


出版信息
发表论文（1）Detection and characterization of a novel hepacivirus in long-tailed ground squirrels (Spermophilus undulatus) in China.,Arch Virol.,2019,第11作者
（2）Improving Baculovirus Transduction of Mammalian Cells by Incorporation of Thogotovirus Glycoproteins,Virol Sin.,2019,第3作者
（3）Interferon-γ-Directed Inhibition of a Novel High-Pathogenic Phlebovirus and Viral Antagonism of the Antiviral Signaling by Targeting STAT1.,Front Immunol.,2019,第9作者
（4）Zika virus circumvents host innate immunity by targeting the adaptor proteins MAVS and MITA,FASEB J.,2019,第9作者
（5）The major hurdle for effective baculovirus transduction into mammalian cells is passing early endosomes.,J Virol.,2019,第4作者
（6）Taxonomy of the order Bunyavirales: update 2019.,Arch Virol.,2019,第12作者
（7）Heartland virus antagonizes type I and III interferon antiviral signaling by inhibiting phosphorylation and nuclear translocation of STAT2 and STAT1.,J Biol Chem.,2019,第2作者
（8）Quantitative Proteomic Analysis Reveals Unfolded-Protein Response Involved in Severe Fever with Thrombocytopenia Syndrome Virus Infection.,J Virol.,2019,第7作者
（9）Single dose of a rVSV-based vaccine elicits complete protection against severe fever with thrombocytopenia syndrome virus.,NPJ Vaccines.,2019,第12作者
（10）Baculovirus Per Os Infectivity Factor Complex: Components and Assembly.,J Virol.,2019,第12作者
（11）Single-Particle Tracking Reveals the Sequential Entry Process of the Bunyavirus Severe Fever with Thrombocytopenia Syndrome Virus.,Small.,2019,第5作者
（12）Identification and genomic sequence analysis of a new Spodoptera exigua multiple nucleopolyhedrovirus, SeMNPV-QD, isolated from Qingdao, China.,J Invertebr Pathol.,2019,第5作者
（13）N6-methyladenosine modification and METTL3 modulate enterovirus 71 replication.,Nucleic Acids Res.,2019,第11作者
（14）The group I alphabaculovirus-specific protein, AC5, is a novel component of the occlusion body but is not associated with ODVs or the PIF complex.,J Gen Virol.,2018,第5作者
（15）Isolation, Characterization, and Phylogenetic Analysis of Two New Crimean-Congo Hemorrhagic Fever Virus Strains from the Northern Region of Xinjiang Province, China.,Virol Sin.,2018,第11作者
（16）Fine mapping epitope on glycoprotein-Gn from Crimean-Congo hemorrhagic fever virus.,Comp Immunol Microbiol Infect Dis.,2018,第11作者
（17）Mapping of B-cell epitopes on the N- terminal and C-terminal segment of nucleocapsid protein from Crimean-Congo hemorrhagic fever virus.,PLoS One.,2018,第11作者
（18）Genome Characteristics of the Cyclophragma Undans Nucleopolyhedrovirus: A Distinct Species in Group I of Alphabaculovirus.,Virol Sin.,2018,第12作者
（19）Establishment of Baculovirus-Expressed VLPs Induced Syncytial Formation Assay for Flavivirus Antiviral Screening.,Viruses.,2018,第11作者
（20）Zika Virus Baculovirus-Expressed Virus-Like Particles Induce Neutralizing Antibodies in Mice.,Virol Sin.,2018,第11作者
（21）Development of Multi-analyte Suspension Assay for Simultaneously Efficient Detection of Avian Influenza Virus A Subtypes.,Virol Sin.,2018,第5作者
（22）The functional oligomeric state of tegument protein GP41 is essential for baculovirus BV and ODV assembly.,J Virol.,2018,第4作者
（23）HearNPV Pseudotyped with PIF1, 2, and 3 from MabrNPV: Infectivity and Complex Stability.,Virol Sin.,2018,第7作者
（24）Prevalence and Phylogenetic Analysis of Crimean-Congo Hemorrhagic Fever Virus in Ticks from Different Ecosystems in Xinjiang, China.,Virol Sin.,2018,第11作者
（25）A novel tick-borne phlebovirus, closely related to severe fever with thrombocytopenia syndrome virus and Heartland virus, is a potential pathogen.,Emerg Microbes Infect.,2018,第11作者
（26）Tick-Borne Viruses.,Virol Sin.,2018,第11作者
（27）Genome analysis of a novel Group I alphabaculovirus obtained from Oxyplax ochracea.,PLoS One.,2018,第8作者
（28）A novel glycoprotein D-specific monoclonal antibody neutralizes herpes simplex virus.,Antiviral Res.,2017,第8作者
（29）A new strain of Crimean-Congo hemorrhagic fever virus isolated from Xinjiang, China.,Virol Sin.,2017,第11作者
（30）Three conserved regions in baculovirus sulfhydryl oxidase, P33, are critical for enzymatic activity and function.,J Virol.,2017,第5作者
（31）Detection, isolation, and characterization of chikungunya viruses associated with the Pakistan outbreak of 2016-2017.,Virol Sin.,2017,第9作者
（32）Antigenicity of severe fever with thrombocytopenia syndrome virus nucleocapsid protein and its potential application in the virus serodiagnosis.,Virol Sin.,2017,第11作者
（33）The roles of ebolavirus glycoproteins in viral pathogenesis.,Virol Sin.,2017,第2作者
（34）Heartland virus NSs protein disrupts host defenses by blocking the TBK1 kinase-IRF3 transcription factor interaction and signaling required for interferon induction.,J Biol Chem.,2017,第4作者
（35）Ebola virus mucin-like glycoprotein (Emuc) induces remarkable acute inflammation and tissue injury: evidence for Emuc pathogenicity in vivo.,Protein Cell.,2017,第8作者
（36）Construction and Rescue of a Functional Synthetic Baculovirus.,ACS Synth Biol.,2017,第11作者
（37）Extensive evolution analysis of the global chikungunya virus strains revealed the origination of CHIKV epidemics in Pakistan in 2016.,Virol Sin.,2017,第11作者
（38）Quantitative Proteomic Analysis of Mosquito C6/36 Cells Reveals Host Proteins Involved in Zika Virus Infection.,J Virol.,2017,第7作者
（39）Isolation, characterization, and phylogenic analysis of three new severe fever with thrombocytopenia syndrome bunyavirus strains derived from Hubei Province, China.,Virol Sin.,2017,第10作者
（40）Characterization of the viral fibroblast growth factor homolog of Helicoverpa armigera single nucleopolyhedrovirus.,Virol Sin.,2016,第6作者
（41）Pathologic Studies of Fatal Encephalomyelitis in Children Caused by Enterovirus 71,Am J Clin Pathol.,2016,第10作者
（42）Spatial Analysis of Severe Fever with Thrombocytopenia Syndrome Virus in China Using a Geographically Weighted Logistic Regression Model.,Int J Environ Res Public Health.,2016,第2作者
（43）Molecular basis for the formation of ribonucleoprotein complex of Crimean-Congo hemorrhagic fever virus.,Journal of Structural Biology.,2016,第11作者
（44）Genome Sequencing and Analysis of Catopsilia pomona nucleopolyhedrovirus: A Distinct Species in Group I Alphabaculovirus.,PLoS One.,2016,第9作者
（45）The Host Specificities of Baculovirus per os Infectivity Factors.,PLoS One.,2016,第6作者
（46）Migration, recombination, and reassortment are involved in the evolution of severe fever with thrombocytopenia syndrome bunyavirus.,Infect Genet Evol.,2016,第9作者
（47）Mutational and functional analysis of N-linked glycosylation of envelope fusion protein F of Helicoverpa armigera nucleopolyhedrovirus.,J Gen Virol.,2016,第11作者
（48）Phylogenetic analysis revealed the central roles of two African countries in the evolution and worldwide spread of Zika virus.,Virol Sin.,2016,第11作者
（49）A 3-year follow-up study of the seroprevalence of antibodies to avian influenza A H5, H6, H7 and H10 viruses among the general population of Wuhan, China.,J Clin Virol.,2016,第11作者
（50）Virus like particle-based vaccines against emerging infectious disease viruses.,Virol Sin.,2016,第11作者
（51）P33 of Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus is a functional homolog of AcP33.,Virol Sin.,2016,第5作者
（52）Characterization of two monoclonal antibodies, 38F10 and 44D11, against the major envelope fusion protein of Helicoverpa armigera nucleopolyhedrovirus.,Virol Sin.,2016,第3作者
（53）Glycoprotein E of the Japanese Encephalitis Virus forms virus-like particles and induces Syncytia when expressed by a baculovirus. ,J Gen Virol. ,2015,第11作者
（54）The FP25K Acts as a Negative Factor for the Infectivity of AcMNPVBudded Virus.,PLoS One.,2015,第11作者
（55）杆状病毒病毒粒子结构与口服感染和系统感染的关系.,Chin Sci Bull.,2015,第3作者
（56）An in vitro recombination-based reverse genetic system for rapid mutagenesis of structural genes of the Japanese encephalitis virus.,Virol Sin.,2015,第11作者
（57）Genomic Sequencing and Analysis of Sucra jujuba Nucleopolyhedrovirus.,Plos One,2014,第11作者
（58）The ha72 Core Gene of Baculovirus Is Essential for Budded Virus Production and Occlusion-Derived Virus Embedding, and Amino Acid K22 Plays an Important Role in Its Function.,J Virol. ,2014,第3作者
（59）Identification and functional analysis of inter-subunit disulfide bonds of F protein of HearNPV. ,J Gen Virol. ,2014,第4作者
（60）Fine epitope mapping of the central immunodominant region of nucleoprotein from Crimean-Congo Hemorrhagic Fever Virus (CCHFV). ,Plos One,2014,第4作者
（61）Unraveling the Entry Mechanism of Baculoviruses and Its Evolutionary Implications., J Virol . ,2014,第11作者
（62）Serological study of antibodies to influenza A viruses among general population in Wuhan city China.,J Clinic Virol. ,2014,第11作者
（63）Characterization and Genomic Analysis of a Plaque Purified Strain of Cyanophage PP.,Virologica Sinica.,2013,第11作者
（64）Freshwater Cyanophages.,Virologica Sinica. ,2013,第3作者
（65）The ha72 core gene of baculovirus is essential for budded virus production and Occlusion-Derived Virus embedding, and amino acid K22 plays an important role in its function. ,J Virol.,2013,第3作者
（66）Reassortment and migration analysis of Crimean–Congo haemorrhagic fever virus.,J Gen Virol. ,2013,第2作者
（67）Comparative Proteomics Reveal Fundamental Structural and Functional Differences between the Two Progeny Phenotypes of a Baculovirus.,J Virol.,2013,第3作者
（68） Betabaculovirus F Proteins Showed Different Efficiency when Rescuing the ,Virology.,2013,第4作者
（69）ORF85 of HearNPV encodes the per os infectivity factor 4 (PIF4) and is essential for the formation of the PIF complex.2012. ,Virology.,2012,第3作者
（70）Functional studies of per os infectivity factor 3 of Helicoverpa armigera nucleopolyhedrovirus.,J Gen Virol. ,2012,第11作者
（71） Incorporation of GP64 into Helicoverpa armigera nucleopolyhedrovirus enhances virus infectivity in vivo and in vitro.,J Gen Virol. ,2012,第11作者
（72）Analysis of the structural proteins from the Musca domestica hytrosavirus with an emphasis on the major envelope protein.,Journal of Invertebrate Pathology.,2012,第2作者
（73）Helicoverpa armigera nucleopolyhedrovirusocclusion-derived virus-associated protein, HA100,affects oral infectivity in vivo but not virus replicationin vitro,Journal of General Virology,2011,第11作者
（74）Partial Functional Rescue of HearNPV Infectivity by Substitution of F Protein with GP64 from AcMNPV. ,Journal of Virology,2010,第11作者
（75）Proteomics of the Autographa californica Nucleopolyhedrovirus Budded Virions., Journal of Virology,2010,第2作者
（76）Identification of protein–protein interactions of the occlusion-derived virus-associated proteins of Helicoverpa armigera nucleopolyhedrovirus. ,Journal of General Virology,2010,第3作者
（77）AcMNPV efficiently infects Sf9 cells and transduces mammalian cells via direct fusion with the plasma membrane at low pH.,Journal of Virology,2010,第4作者
（78）The F protein of Helicoverpa armigera single nucleopolyhedrovirus can be substituted functionally with its homologue from Spodoptera exigua multiple nuclopolyhedrovirus. ,Journal of General Virology,2009,第4作者
（79）Angiotensin-converting enzyme 2 (ACE2) from raccoon dog can serve as an efficient receptor for the spike protein of severe acute respiratory syndrome coronavirus.,Journal of General Virology,2009,第11作者

发表著作

科研活动
科研项目（ 1 ） 昆虫病毒感染关键步骤的分子机理研究； , 参与,国家级,2009-01--2013-12
（ 2 ） Ⅱ型包膜病毒的入侵机制 , 参与,国家级,2010-01--2014-12
（ 3 ） 棉铃虫病毒的结构蛋白HA44的结构与功能及真核定位机理研究, 主持,国家级,2007-11--2010-12
（ 4 ） 中国境内重要生物安全Ⅲ-Ⅳ级病原的流行病学调查, 主持,国家级,2007-08--2010-12
（ 5 ） 杆状病毒-昆虫细胞生物反应器的建设与优化, 主持,部委级,2011-01--2013-12
（ 6 ） 杆状病毒和昆虫细胞间的相互作用, 参与,国家级,2008-01--2012-12
（ 7 ） 我国重要自然宿主及媒介昆虫的病毒病原调查, 主持,国家级,2013-05--2018-12
（ 8 ） 生物遗传资源库, 主持,部委级,2018-06--2018-12
（ 9 ） 重要烈性病毒防控关键技术及产品研发, 参与,部委级,2016-01--2018-12
（ 10 ） 病毒遗传资源库保藏能力建设, 主持,部委级,2017-01--2018-12
（ 11 ） 重要RNA病毒的细胞受体研究, 主持,市地级,2017-01--2018-12
（ 12 ） 欧洲病毒资源库走向全球, 参与,国家级,2016-12--2019-11
（ 13 ） 生防微生物环境适应性与持效性机制, 主持,国家级,2017-07--2020-12
（ 14 ） 湖北省发热伴血小板减少综合症病毒传播途径 和致病机理的研究, 主持,省级,2019-01--2020-12
（ 15 ） 湖北省发热伴血小板减少综合征病毒SFTSV遗传进化与病症相关性研究, 主持,市地级,2018-01--2019-12

参与会议（1）ncorporation of GP64 into Helicoverpa armigera NPV enhances virus infectivity both in vivo and in vitro.2012国际无脊椎病理和微生物防治会议暨45届无脊椎病理年会Shu Shen, Yinyin Gan, Manli Wang, Zhihong Hu, Hualin Wang and Fei Deng. 2012-08-05
（2）HA44 is an Essential Gene for Helicoverpa Armigera Nucleopolyhedrovirus Replication and its Coiled-Coil Domain is Functional Important第44届无脊椎动物病理学年会邓菲2011-08-07
（3）Global View and the phenotype model of the Occlusion-Derived Virus of Helicoverpa armigera Nucleopolyhedrovirus第43届无脊椎动物病理学年会邓菲2010-07-09
（4）Identification of Proteins Associated with Autographa californica Nucleopolyhedrovirus Budded Virions国际无脊椎病理学会第42届年会邓菲2009-08-16


合作情况
项目协作单位

指导学生