基本信息
戴家银男博导中国科学院动物研究所
电子邮件： daijy@ioz.ac.cn
通信地址： 北京市朝阳区北辰西路一号院5号
邮政编码： 100101

研究领域

招生信息
招生专业071010-生物化学与分子生物学
071010-生物化学与分子生物学

招生方向生态毒理
分子毒理


教育背景1996-09--1999-07南京大学博士学位
1993-09--1996-07厦门大学硕士学位
1984-09--1988-07安徽大学学士学位

学历
学位

工作经历
工作简历2005-04~现在,中国科学院动物研究所,研究员
2001-10~2005-04,美国康奈尔大学医学院,博士后
2000-10~2001-10,美国得克萨斯州立大学,博士后
1999-07~2000-10,同济大学,博士后
1996-09~1999-07,南京大学,博士学位
1993-09~1996-07,厦门大学,硕士学位
1984-09~1988-07,安徽大学,学士学位

社会兼职

教授课程

专利与奖励
奖励信息（1） 朱丽月华奖教金, , 其他, 2012

专利成果

出版信息
发表论文（1）Comparative Hepatotoxicity of Novel PFOA Alternatives (Perfluoropolyether Carboxylic Acids) on Male Mice,Environ Sci Technol.,2019,第11作者
（2）Parental exposure to 6:2 chlorinated polyfluorinated ether sulfonate (F-53B) induced transgenerational thyroid hormone disruption in zebrafish,Sci Total Environ,2019,第11作者
（3）Chronic exposure to 6:2 chlorinated polyfluorinated ether sulfonate acid (F-53B) induced hepatotoxic effects in adult zebrafish and disrupted the PPAR signaling pathway in their offspring,Environ Pollut,2019,第11作者
（4）Per- and polyfluoroalkyl substances (PFASs) in the blood of two colobine monkey species from China: Occurrence and exposure pathways,Sci Total Environ.,2019,第11作者
（5）Worldwide Distribution of Novel Perfluoroether Carboxylic and Sulfonic Acids in Surface Water,Environ Sci Technol,2018,第11作者
（6）Corticosteroid-binding globulin, induced in testicular Leydig cells by perfluorooctanoic acid, promotes steroid hormone synthesis,Arch Toxicol,2018,第4作者
（7）Occurrence and Tissue Distribution of Novel Perfluoroether Carboxylic and Sulfonic Acids and Legacy Per/Polyfluoroalkyl Substances in Black-Spotted Frog (Pelophylax nigromaculatus).,Environ Sci Technol,2018,第11作者
（8）6:2 fluorotelomer sulfonamide alkylbetaine (6:2 FTAB), a novel perfluorooctane sulfonate alternative, induced developmental toxicity in zebrafish embryos.,Aquat Toxicol.,2018,第11作者
（9）Nickel(ii) inhibits the oxidation of DNA 5-methylcytosine in mammalian somatic cells and embryonic stem cells.,Metallomics,2018,第3作者
（10）Novel Chlorinated Polyfluorinated Ether Sulfonates and Legacy Per-/Polyfluoroalkyl Substances: Placental Transfer and Relationship with Serum Albumin and Glomerular Filtration Rate.,Environ Sci Technol.,2017,第11作者
（11）High perfluorooctanoic acid exposure induces autophagy blockage and disturbs intracellular vesicle fusion in the liver.,Archives of Toxicology,2017,第11作者
（12）Perfluorooctanoic acid affects endocytosis involving clathrin light chain A and microRNA-133b-3p in mouse testes.,Toxicol Appl Pharmacol.,2017,第11作者
（13）6:2 Chlorinated polyfluorinated ether sulfonate, a PFOS alternative, induces embryotoxicity and disrupts cardiac development in zebrafish embryos.,Aquatic Toxicology,2017,第11作者
（14）Acot1 is a sensitive indicator for PPARα activation after perfluorooctanoic acid exposure in primary hepatocytes of Sprague-Dawley rats.,Toxicol In Vitro,2017,第10作者
（15）RNA-sequencing analysis reveals the hepatotoxic mechanism of perfluoroalkyl alternatives, HFPO2 and HFPO4, following exposure in mice.,J Appl Toxicol.,2017,第11作者
（16）Interaction of perfluoroalkyl acids with human liver fatty acid-binding protein,Archives of Toxicology,2016,第11作者
（17）Comparative hepatotoxicity of 6:2 fluorotelomer carboxylic acid and 6:2 fluorotelomer sulfonic acid, two fluorinated alternatives to long-chain perfluoroalkyl acids, on adult male mice.,Archives of Toxicology,2016,第11作者
（18）Activation of peroxisome proliferator-activated receptor α ameliorates perfluorododecanoic acid-induced production of reactive oxygen species in rat liver.,Archives of Toxicology,2016,第11作者
（19）Perfluorooctanoic acid disrupts the blood-testis barrier and activates the TNFα/p38 MAPK signaling pathway in vivo and in vitro.,Archives of Toxicology,2016,第11作者
（20）High perfluorooctanoic acid exposure induces autophagy blockage and disturbs intracellular vesicle fusion in the liver.,Archives of Toxicology,2016,第11作者
（21）Zebrafish reproductive toxicity induced by chronic perfluorononanoate exposure,Aquatic Toxicology,2016,第11作者
（22）Low dose perfluorooctanoate exposure promotes cell proliferation in a human non-tumor liver cell line.,Journal of Hazard Materials,2016,第11作者
（23）Associations of urinary 5-methyl-2’-deoxycytidine and 5-hydroxymethyl-2’-deoxycytidine with phthalate exposure and semen quality in 562 Chinese adult men,Environment International,2016,第11作者
（24）Integrated proteomic and miRNA transcriptional analysis reveals the hepatotoxicity mechanism of PFNA exposure in mice,J Proteome Res,2015,第11作者
（25）Interaction of perfluoroalkyl acids with human liver fatty acid-binding protein,Arch. Toxicol.,2015,第11作者
（26）Circulating microRNA profiles altered in mice after 28 d exposure to perfluorooctanoic acid,Toxicology Letters,2014,第11作者
（27）Synergistic effects of perfluoroalkyl acids mixtures with J-shaped concentration-responses on viability of a human liver cell line.,Chemosphere,2014,第11作者
（28）Proteomic analysis of mouse testis reveals perfluorooctanoic acid-induced reproductive dysfunction via direct disturbance of testicular steroidogenic machinery,J. Proteome Res,2014,第11作者
（29）Phosphoproteome analysis reveals an important role for glycogen synthase kinase-3 in perfluorododecanoic acid-induced rat liver toxicity,Toxicology Letters,2013,第11作者
（30）Age- and gender-related accumulation of perfluoroalkyl substances in captive Chinese alligators (Alligator sinensis), Environmental Pollution,2013,第11作者
（31）Accumulation pattern of Dechlorane Plus and associated biological effects on rats after 90 d of exposure,Chemosphere,2013,第11作者
（32）Distribution and fate of perfluoroalkyl substances in municipal wastewater treatment plants in economically developed areas of China,Environmental Pollution,2013,第11作者
（33）Phosphoproteome analysis reveals an important role for glycogen synthase kinase-3 in perfluorododecanoic acid-induced rat liver toxicity,Toxicology Letters,2013,第11作者
（34）Sex Differences in Transcriptional Expression of FABPs in Zebrafish Liver after Chronic Perfluorononanoic Acid Exposure,Environmental science technology,2012,第11作者
（35）Association of Perfluorooctanoic Acid with HDL Cholesterol and Circulating miR-26b and miR-199-3p in Workers of a Fluorochemical Plant and Nearby Residents,Environmental science technology,,2012,第11作者
（36）Proteomic analysis of male zebrafish livers chronically exposed to perfluorononanoic acid,Environment International,2012,第11作者

发表著作

科研活动
科研项目（ 1 ） 血脂紊乱影响精子发生的生物标志物的鉴定和临床干预, 主持,国家级,2013-01--2017-12
（ 2 ） 野生动物体内全氟烷基化合物的来源、存在形态及毒性机制研究, 主持,国家级,2014-01--2018-12
（ 3 ） 全氟类化合物与人类肝脏型脂肪酸结合蛋白的相互作用及毒性机制研, 主持,国家级,2014-01--2017-12
（ 4 ） 典型污染物引发机体糖和脂肪代谢紊乱的机制（XDB**）, 主持,部委级,2014-06--2019-06
（ 5 ） 基于系统性毒性研究指导全氟烷基化合物替代品设计与绿色合成, 主持,国家级,2018-01--2022-12
（ 6 ） 食品中典型持久性有机污染物健康危害与毒性机制, 主持,国家级,2017-01--2021-12
（ 7 ） 全氟烷基化合物替代品影响斑马鱼鱼鳔发育的分子机制研究, 主持,国家级,2019-01--2022-12
（ 8 ） 不孕不育人群环境与遗传致病因子鉴定及交互作用研究, 参与,国家级,2018-12--2021-12
（ 9 ） 铬雾抑制剂的研究和产业化, 参与,部委级,2019-01--2020-12

参与会议

合作情况
项目协作单位

指导学生