基本信息
程靓男博导中国科学院化学研究所
电子邮件： chengl@iccas.ac.cn
通信地址： 海淀区中关村北一街2号
邮政编码： 100190

学习工作经历


2000-2004年，北京师范大学化学系，学士
2004-2009年，中国科学院化学研究所，博士
2011-2014年，美国哥伦比亚大学，博士后
2015年-至今，中国科学院化学研究所，研究员，博士生导师




招生信息
招生专业0703Z1-化学生物学
070303-有机化学
071010-生物化学与分子生物学

招生方向RNA的化学生物学
有机合成方法学


教授课程高等有机合成


研究兴趣与方向

RNA的化学生物学研究
RNA修饰的化学调控与干预
化学小分子对RNA的选择性识别



代表论著









































Cheng, H.-P.; Yang, X.-H.; Lan, L.; Xie, L.-J.; Chen, C.; Liu, C.; Chu, J.; Li, Z.-Y.; Zhang, T.-Q.;* Luo, D.-Q.;* Cheng, L.* "Artificial Deprenylation of N⁶‐isopentenyladenosine (i⁶A) RNA", Angew. Chem. Int. Ed. 2020, DOI: 10.1002/anie..


Xie, L.-J.; Liu, L.;Cheng, L.* "Modifying Methionine on Proteins",ChemBioChem,2020, 21, 461-463 (Invited review).



Xie, L.-J.; Liu, L.;Cheng, L.* "Selective Inhibitors of AlkB Family of Nucleic Acid Demethylases",Biochemistry,2020, 59, 230-239 (Invited review,Future of Biochemistry: The Asia-Pacific Issue).



Wang, R. -L.; Lan, L.; Liu, L.;Cheng, L.* "Asymmetric Polymerase Chain Reaction and Loop-mediated Isothermal Amplification (AP-LAMP) for ultrasensitive detection of microRNAs",Chin. Chem. Lett.2020, 31, 159-162.



Wang, R.-L.^#; Jin, X.-Y.^#; Kong, D.-L.; Chen, Z.-G.; Liu, J.; Liu, L.; Cheng, L.* "Visible-Light Facilitated Fluorescence "Switch-On" Labelling of 5-Formylpyrimidine RNA",Adv. Synth. Catal.2019, 361, 5406-5411.



Wang, C.; Zou, P.; Yang, C.; Liu, L.; Cheng, L.; He, X.; Zhang, L.; Zhang, Y.; Jiang, H.*; Chen, P. R.* "Dynamic Modifications of Biomacromolecules: Mechanism and Chemical Interventions", Sci. China Life Sci. 2019, 62, 1459-1471.
Li, X.-D.^#; Gao, Y.-T.^#; Sun, Y.-J.; Jin, X.-Y.; Wang, D.; Liu, L.; Cheng, L.* "A NaI/H₂O₂ Mediated Sulfenylation and Selenylation of Unprotected Uracil and its Derivatives", Org. Lett. 2019, 21, 6643-6647.
Jin, X.-Y.; Wang, R.-L.; Xie, L.-J.; Kong, D.-L.; Liu, L.; Cheng, L.* "A chemical photo-oxidation of 5-methyl cytidines",Adv. Synth. Catal.2019, 361, 4685-4690. (VIP Article)



Lan, L.; Wang, R. L.; Liu , L.; Cheng, L.* "A Label-free Colorimetric Detection of microRNA via G-Quadruplex-based Signal Quenching Strategy",Anal. Chim. Acta. 2019, 1079, 207-211.



程靓，兰玲，刘利，“一种基于G-四链体探针结构解旋的可视化识别microRNA的检测方法”，中国专利，申请号：3.2，申请日：2019年6月14日。
Liu, T.; Zhu, J.; Sun, X.; Cheng, L.; Wu, L.* "I₂/TBHP Mediated Divergent C(sp²)-P Cleavage of Allenylphosphine Oxides: Substituent-Controlled Regioselectivity", Adv. Synth. Catal. 2019, 361, 3532-3537.
程靓，王瑞丽，刘利，“一种基于不对称PCR和LAMP循环扩增反应进行miRNA快速检测的方法”，中国专利，申请号：4X，申请日：2019年3月11日。
程靓，李学东，刘利，“制备5-硫/硒修饰尿嘧啶衍生物的方法”，中国专利，申请号：20**，申请日：2019年1月29日。
Xie, L.-J.^#; Yang, X.-T.^#; Wang, R.-L.; Cheng, H.-P.; Li, Z.-Y.; Liu, L.; Mao, L. Q.; Wang, M.*; Cheng, L.* "Identification of Flavin Mononucleotide as Cell-Active Artificial N⁶-Methyladenosine RNA Demethylase", Angew. Chem. Int. Ed. 2019, 58, 5028-5032.



Liu, J.-J.; Lan, L.; Gao, Y.-T.; Liu, Q.; Cheng, L.*; Wang, D.; Liu, L.* "Visible-Light-Mediated Stereoselective 1,2-Iodoalkylation of Alkynes", Adv. Synth. Catal. 2019, 361, 1283-1288.
Li, X.-D.; Liu, L.; Cheng, L.* "Identification of Thienopyridine Carboxamides as Selective Binders of HIV-1 Trans Activation Response (TAR) and Rev Response Element (RRE) RNAs",Org. Biomol. Chem.2018, 16, 9191-9196.



Gao, Y.-T.; Jin, X.-Y.; Liu, Q.; Liu, A.-D.; Cheng, L.*; Wang, D.; Liu, L.* "Iodide/H₂O₂ Catalyzed Intramolecular Oxidative Amination for the Synthesis of 3,2'-Pyrrolidinyl Spirooxindoles", Molecules, 2018, 23, 2265.
Liu, Q.; Liu, J.-J.; Cheng, L.*, Wang, D.; Liu, L.* "TEMPO Promoted Direct Multi-functionalization of Terminal Alkynes with 2-Oxindoles/Benzofuran-2(3H)-one",Org. Biomol. Chem.2018, 16, 5228-5231.
Zhong, N.-J.; Wang, Y.-Z.; Cheng, L.*; Wang, D.; Liu, L.* "Recent advances in the annulation of Morita-Baylis-Hillman adducts",Org. Biomol. Chem.2018, 16, 5214-5227.
Li, X.-D.; Chen, B.; Lan, L.; Wang, R.-L.; Luo, D.-Q.; Liu, L.; Cheng, L.* "Selective Recognition of HIV RNA by Dinuclear Metallic Ligands", Chin. Chem. Lett. 2018, 29, 1637-1640.



Jin, X.-Y.; Xie, L.-J.; Cheng, H.-P.; Liu, A.-D.; Li, X.-D.; Wang, D.; Cheng, L.*; Liu, L.* "Ruthenium-Catalyzed Decarboxylative C-H Alkenylation in Aqueous Media: A Synthesis of Tetrahydropyridoindoles", J. Org. Chem. 2018, 83, 7514-7522.
Liu, J.-J.^#; Huang, H.-Y.^#; Cheng, L.*; Liu, Q.; Wang, D.; Liu, L.* "Catalyst-Free Intermolecular trans-Iodoalkylation of Alkynes", Org. Biomol. Chem. 2018, 16, 899-903.
Gu, C.-L.*; Li, Y.-X.; Xiao, L.; Fu, H.-B.; Wang, D.; Cheng, L.; Liu, L.* "Tunable Heck-Mizoroki Reaction of Dibromo Naphthalene Diimide with Aryl ethylenes: Design, Synthesis and Characterization of Coplanar NDI-based Conjugated Molecules", J. Org. Chem. 2017, 82, 12806-12812.
Xie, L.-J.; Wang, R.-L.; Wang, D.; Liu, L.; Cheng, L.* "Visible-Light-Mediated Oxidative Demethylation of N⁶-Methyl Adenines", Chem. Commun. 2017, 53, 10734-10737.



程靓，谢丽君，刘利，"N⁶?甲基腺嘌呤的光化学脱甲基方法"，中国专利，授权公告号：CN B，申请日：2017年5月9日（授权日：2019年1月11日）。
Liu, J.-J.; Cheng, L.*; Huang, H.-Y.; Wei, F.; Wang, D.; Liu, L.* "Unprecedented Formation of 3-(Tetrahydrofuran-2-yl)-4H-chromen-4-one in the Reaction between 3,3a-Dihydro-9H-furo[3,4-b]chromen-9-one with Malononitrile", Org. Biomol. Chem. 2017, 15, 5078-5088.
Huang, H.-Y.; Cheng, L.*; Liu, J.-J.; Wang, D.; Liu, L.*; Li, C.-J.* "Transition-Metal-Free Alkynylation of 2-Oxindoles through Radical-Radical Coupling", J. Org. Chem. 2017, 82, 2656-2663.
Wei, F.; Cheng, L.*; Huang, H.-Y.; Liu, J.-J.; Wang, D.; Liu, L.* "Intermolecular Dearomative Oxidative Coupling of Indoles with Ketones and Sulfonylhydrazines Catalyzed by I₂ for the Synthesis of [2,3]-Fused Indoline Tetrahydropyridazines", Sci. China Chem. 2016, 59, 1311-1316.
Kong, D.-L.; Cheng, L.*; Yue, T.; Wu, H.-R.; Feng, W.-C.; Wang, D.; Liu, L.* "Cobalt-Catalyzed Peroxidation of 2-Oxindoles with Hydroperoxides", J. Org. Chem. 2016, 81, 5337-5344.
Wu, H.-R.; Cheng, L.; Kong, D.-L.; Huang, H.-Y.; Gu, C.-L.; Liu, L.*; Wang, D.; Li, C.-J.* "FeCl₃-Mediated Radical Tandem Reactions of 3-Benzyl-2-oxindoles with Styrene Derivatives for the Stereoselective Synthesis of Spirocyclohexene Oxindoles", Org. Lett. 2016, 18, 1382-1385.
Li, X.-D.; Xie, L.-J.; Kong, D.-L.; Liu, L.; Cheng, L.* "Metal-free Allylation of Electron-rich Heteroaryl Boronic Acids with Allylic Alcohols", Tetrahedron 2016, 72, 1873-1880.
Kong, D.-L.; Cheng, L.; Wu, H.; Li, Y.; Wang, D.; Liu, L.* "Metal-free Yne-addition/1,4-aryl migration/decarboxylation Cascade Reaction of Alkynoates with C_sp3-H Centers", Org. Biomol. Chem. 2016, 14, 2210-2217.

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Cheng, L.; Charles, D.*; Breslow, R.* "Evidence for Tunneling in Base-catalyzed Isomerization of Glyceraldehyde to Dihydroxyacetone by Hydride Shift under Formose Conditions", Proc. Natl. Acad. Sci. USA 2015, 112, 4218-4220.
Cheng, L.; Mahendran, A.; Gonzalez, R. L. Jr.*; Breslow, R.* "Deoxypolypeptides Bind and Cleave RNA", Proc. Natl. Acad. Sci. USA 2014, 111, 7920-7924.
Cheng, L.; Abhilash, K. G.; Breslow, R.* "Binding and Biomimetic Cleavage of the RNA Poly(U) by Synthetic Polyimidazoles", Proc. Natl. Acad. Sci. USA 2012, 109, 12884-12887.
Cheng, L.; Liu, L.*; Li, C.; Jia, H.; Wang, D.; Chen, Y. J.* "Nucleophilic Addition of Regioselectively Lithiated Indoline with Aldimines for the Syntheses of 2- and 7-Indolinyl Methanamine Derivatives", Tetrahedron Lett. 2012, 53, 4004-4007.
Zhang, T.; Cheng, L.; Hameed, S.; Liu, L.*; Wang, D.; Chen, Y. J.* "Highly Enantioselective Michael Addition of 2-Oxindoles to Vinyl Selenone in RTILs Catalyzed by a Cinchona Alkaloid-based Thiourea", Chem. Commun. 2011, 47, 6644-6646.
Zhang, T.; Cheng, L.; Liu, L.*; Wang, D.; Chen, Y. J.* "Asymmetric Organocatalytic N-Nitroso-aldol Reaction of Oxindoles", Tetrahedron: Asymmetry 2010, 21, 2800-2806.
Cheng, L.; Liu, L.*; Wang, D.; Chen, Y. J.* "Highly Enantioselective and Organocatalytic alpha-Amination of 2-Oxindoles", Org. Lett. 2009, 11, 3874-3877.
Cheng, L.; Liu, L.*; Jia, H.; Wang, D.; Chen, Y. J.* "Enantioselective Organocatalytic anti-Mannich-type Reaction of N-Unprotected 3-Substituted 2-Oxindoles with Aromatic N-Ts-Aldimines", J. Org. Chem. 2009, 74, 4650-4653.
Cheng, L.; Liu, L.*; Sui, Y.; Wang, D.; Chen, Y. J.* "Highly Diastereoselective Reactions of 2-Lithiated Indoles with Chiral N-Tert-butanesulfinyl Aldimines for the Synthesis of Chiral (2-Indolyl) Methanamine Derivatives", Tetrahedron: Asymmetry 2007, 18, 1833-1843.
校登明，程靓，刘希杰，胡远东，许新合，刘志华，张立鹏，吴伟，王树龙，沈宇，李根，王银，赵胜，李舂龙，唐佳，于洪灏，"作为FAK/Pyk2抑制剂的2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物"，中国专利，授权公告号­：CNB，授权公告日：2016年9月28日。
Xiao, D. M.;Cheng, L.; Liu, X. J.; Hu, Y. D.; Xu, X. H.; Liu, Z. H.; Zhang, L. P.; Wu, W.; Wang, S. L.; Shen, Y.; Li, G.; Wang, Y.; Zhao, S.; Li, C. L.; Tang, J.; Yu, H. H."2,4-Diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine Derivatives as FAK/Pyk2 Inhibitors", US Patent ** B2, Date of Patent: 08/30/2016.
校登明，程靓，刘希杰，胡远东，许新合，刘志华，张立鹏，吴伟，王树龙，沈宇，李根，王银，赵胜，李舂龙，唐佳，于洪灏，"作为FAK/Pyk2抑制剂的2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物"，中国专利，授权公告号：CNA，授权公告日：2015年1月28日。