基本信息
陈笑艳女博导中国科学院上海药物研究所
电子邮件： xychen@mail.shcnc.ac.cn
通信地址： 上海浦东海科路501号
邮政编码： 201210

研究领域

招生信息
招生专业100704-药物分析学

招生方向与药物不良反应相关的药物代谢/转运机制研究
药物代谢新途径化学和生物学基础研究
药物代谢与动力学新方法研究


教育背景1994-09--1999-07沈阳药科大学博士学位
1990-09--1994-07沈阳药科大学学士学位

学历
学位

工作经历
工作简历2005-05~现在,中科院上海药物研究所,研究员，课题组长
1999-08~2005-04,沈阳药科大学,讲师、副教授、教授
1994-09~1999-07,沈阳药科大学,博士学位
1990-09~1994-07,沈阳药科大学,学士学位

社会兼职2016-01-01-2019-01-01,上海市药学会理事会理事,
2015-12-01-今,上海药学会药物分析专业委员会副主任委员,
2015-10-01-今,中国药学会药物分析专业委员会委员,
2014-05-01-今,上海药理学会药物代谢专业委员会副主任委员,
2013-05-01-今,中国药科大学校外兼职导师,


教授课程药物代谢


专利与奖励
奖励信息（1） 2015年上海科技系统“三八红旗集体”, 省级, 2015
（2） 上海药学科技一等奖, 一等奖, 省级, 2014
（3） 几种手性药物的高效液相色谱分析, 三等奖, 省级, 2004
（4） 108种制剂的药物动力学和生物, 二等奖, 省级, 2003

专利成果

出版信息
发表论文（1）Analysis of diacylglycerols by ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry: Double bond location and isomers separation,Analytica Chimica Acta,2016,第11作者
（2）9-Glucathionyl-6,7-dihydroxymethyl-5H- pyrrolizine is the major pyrrolic glutathione conjugate of retronecine-type pyrrolizidine alkaloids in liver microsomes and in rats,Chemical Research in Toxicology,2016,第11作者
（3）Wedelolactone metabolism in rats through regioselective glucuronidation catalyzed by UGT1As,Phytomedicine,2016,第11作者
（4）Metabolism of MRX-I, a novel antibacterial oxazolidinone, in humans: the oxidative ring-opening of 2,3-dihydropyrindin-4-one catalyzed by non-P450 enzymes,Drug Metabolism and Disposition,2015,第11作者
（5）Fasiglifam (TAK-875) inhibits hepatobiliary transporters: a possible factor contributing to fasiglifam-induced liver injury,Drug Metabolism and Disposition,2015,第11作者
（6）Simultaneous determination of capecitabine and its three nucleosidemetabolites in human plasma by high performance liquid chromatography–tandem mass spectrometry,Journal of Chromatography B,2015,第11作者
（7）High-throughput salting-out-assisted liquid–liquid extraction for the simultaneous determination of atorvastatin, ortho-hydroxyatorvastatin, and para-hydroxyatorvastatin in human plasma using ultrafast liquid chromatography with tandem mass spectrometry,Journal of Separation Science,2015,第11作者
（8）Isomer-selective distribution of 3-n-butylphthalide (NBP) hydroxylated metabolites, 3-hydroxy-NBP and 10-hydroxy-NBP, across the rat blood-brain barrier,Acta Pharmacologica Sinica,2015,第11作者
（9）Chemical and Enzymatic Transformations of Nimesulide to GSH Conjugates through Reductive and Oxidative Mechanisms,Chemical Research in Toxicology,2015,第11作者
（10）Effects of renal impairment on the pharmacokinetics of morinidazole: uptake transporter-mediated renal clearance of the conjugated metabolites,Antimicrobial Agents and Chemotherapy,2014,第11作者
（11）Effects of rifampicin and ketoconazole on pharmacokinetics of morinidazole in healthy Chinese subjects.,Antimicrobial Agents and Chemotherapy,2014,第11作者
（12）Identification of amino acid and glutathione N-conjugates of toosendanin: bioactivation of furan ring mediated by CYP3A4,Chemical Research in Toxicology,2014,第11作者
（13）Bioactivation of 3-n-butylphthalide via sulfation of its major metabolite 3-hydroxy-NBP: Mediated mainly by sulfotransferase 1A1,Drug Metabolism and Disposition,2014,第11作者
（14）A chiral high-performance liquid chromatography-tandem mass spectrometry method for the stereospecific determination of morinidazole in human plasma,Journal of Chromatography B,2014,第11作者
（15）A sensitive LC–MS/MS method for quantifying clofarabine triphosphate concentrations in human peripheral blood mononuclear cells,Journal of Chromatography B,2014,第11作者

发表著作

科研活动
科研项目（ 1 ） 醛氧化酶和氰基水解酶介导的创新药物代谢机制研究, 主持,国家级,2016-01--2019-12

参与会议

合作情况
项目协作单位

指导学生