基本信息
Francesco Faiola男博导中国科学院生态环境研究中心
电子邮件： faiola@rcees.ac.cn
通信地址： 北京市海淀区双清路18号 中科院生态环境研究中心
邮政编码：

研究领域

招生信息
招生专业071009-细胞生物学
071010-生物化学与分子生物学
071008-发育生物学

招生方向干细胞毒理学
分子生物学
发育生物学


教育背景2000-08--2006-03University of California，Riverside博士后
1989-09--1998-10University of Rome学士/硕士

学历
学位

工作经历
工作简历2014-03~现在,中国科学院生态环境研究中心,研究员（干细胞毒理学课题组组长）
2010-07~2014-03,Icahn School of Medicine at Mount Sinai, New York,,Postdoctoral Fellow
2006-07~2010-06,University of California, Riverside, CA,Postdoctoral Fellow
2000-08~2006-03,University of California，Riverside,博士后
1989-09~1998-10,University of Rome,学士/硕士

社会兼职

教授课程现代生物学技术在环境健康研究中的应用
干细胞毒理学
环境毒理与健康危害（干细胞毒理基础与进展）


专利与奖励
奖励信息（1） Best Poster Award, 特等奖, 研究所（学校）, 2006
（2） Outstanding Talk Award, 特等奖, 研究所（学校）, 2004
（3） Best Teaching Assistant Award, 特等奖, 研究所（学校）, 2002
（4） Chancellor Prestigious Fellowship, 特等奖, 研究所（学校）, 2000

专利成果（ 1 ） 微孔模具及其制备方法和应用, 2018, 第 2 作者, 专利号: 0.9
（ 2 ） 一种微孔模具, 2018, 第 2 作者, 专利号: 3.X


出版信息
发表论文（1）A human embryonic stem cell-based in vitro model revealed that ultrafine carbon particles may cause skin inflammation and psoriasis,Journal of Environmental Sciences,2020-01,第11作者
（2）The short-chain perfluorinated compounds PFBS, PFHxS, PFBA and PFHxA, disrupt human mesenchymal stem cell self- renewal and adipogenic differentiation,Journal of Environmental Sciences,2020-01,第11作者
（3）Typical halogenated flame retardants affect human neural stem cell gene expression during proliferation and differentiation via glycogen synthase kinase 3 beta and T3 signaling,Ecotoxicology and Environmental Safety,2019-11,第11作者
（4）Toxicogenomic analyses of the effects of BDE-47/209, TBBPA/S and TCBPA on early neural development with a human embryonic stem cell in vitro differentiation system,Toxicology and Applied Pharmacology,2019-09,第11作者
（5）Environmental and human relevant PFOS and PFOA doses alter human mesenchymal stem cell self-renewal, adipogenesis and osteogenesis.,Ecotoxicology and Environmental Safety,2019,第11作者
（6）Establishment of a human embryonic stem cell-based liver differentiation model for hepatotoxicity evaluations.,Ecotoxicology and Environmental Safety,2019,第11作者
（7）5-fluorouracil-induced neurotoxicity in rat cerebellum granule cells involves oxidative stress and activation of caspase-3 pathway.,International Journal of Clinical and Experimental Medicine,2019,第11作者
（8）Embryonic stem cell- and transcriptomics- based in vitro analyses reveal that bisphenols A, F and S have similar and very complex potential developmental toxicities.,Ecotoxicology and Environmental Safety,2019,第11作者
（9）Assessment of the carcinogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin using mouse embryonic stem cells to form teratoma in vivo.,Toxicology Letters,2019,第11作者
（10）Embryoid body-based RNA-seq analyses reveal a potential TBBPA multifaceted developmental toxicity.,Journal of Hazardous Materials,2019,第11作者
（11）Human pluripotent stem cells as tools for predicting developmental neural toxicity of chemicals: strategies, applications and challenges.,Stem Cells and Development,2019,第11作者
（12）Assessment of the developmental neurotoxicity of silver nanoparticles and silver ions with mouse embryonic stem cells in vitro,Journal of Interdisciplinary Nanomedicine,2018,第11作者
（13）干细胞毒理学在大气污染健康风险评估中的应用,中国科学: 化学,2018,第11作者
（14）Non-cytotoxic nanomolar concentrations of bisphenol A induce human mesenchymal stem cell adipogenesis and osteogenesis.,Ecotoxicology and Environmental Safety,2018,第11作者
（15）DEP and DBP induce cytotoxicity in mouse embryonic stem cells and abnormally enhance neural ectoderm development.,Environmental Pollution,2018,第11作者
（16）TBBPA and Its Alternatives Disturb the Early Stages of Neural Development by Interfering with the NOTCH and WNT Pathways,Environmental Science & Technology,2018,第11作者
（17）PFOA and PFOS Disrupt the Generation of Human Pancreatic Progenitor Cells,Environmental Science & Technology Letters,2018,第11作者
（18）Evaluation of the early developmental neural toxicity of F-53B, as compared to PFOS, with an in vitro mouse stem cell differentiation model.,Chemosphere,2018,第11作者
（19）Non-cytotoxic nanomolar concentrations of bisphenol A induce human mesenchymal stem cell adipogenesis and osteogenesis,Ecotoxicology and Environmental Safety,2018,第11作者
（20）NAC1 Regulates Somatic Cell Reprogramming by Controlling Zeb1 and E-cadherin Expression.,Stem Cell Reports,2017,第11作者
（21）Prospects and Frontiers of Stem Cell Toxicology.,Stem Cells Dev.,2017,第11作者
（22）Stem cell toxicology: a powerful tool to assess pollution effects on human health.,National Science Review,2016,第11作者
（23）The rise of stem cell toxicology,Environmental Science & Technology,2015,第11作者
（24）Assessment of Bisphenol A (BPA) neurotoxicity in vitro with mouse embryonic stem cells,Journal of Environmental Sciences,2015,第11作者
（25）Vitamin E attenuates silver nanoparticle-induced effects on body weight and neurotoxicity in rats,Biochemical and Biophysical Research Communications,2015,第11作者
（26）Concise review: pursuing self-renewal and pluripotency with the stem cell factor nanog.,Stem Cells,2013,第2作者
（27）NANOG-dependent function of TET1 and TET2 in establishment of pluripotency.,Nature,2013,第1作者
（28）Zfp281 mediates Nanogautorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming.,Proc Natl Acad Sci U.S.A.,2012,第2作者
（29）Oct4 links multiple epigenetic pathways to the pluripotency network.,Cell Res.,2011,第2作者
（30）Max is acetylated by p300 at several nuclear localization residues.,Biochem J.,2007,第1作者
（31）Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription.,Mol Cell Biol.,2005,第1作者

发表著作

科研活动
科研项目（ 1 ） 中国科学院战略性先导科技专项（典型污染物的环境暴露与健康危害机制 项目三）, 主持,部委级,2014-07--2019-06
（ 2 ） 利用多能干细胞研究环境污染物的健康效应及风险评估, 主持,国家级,2016-01--2019-12
（ 3 ） 环境小分子与表观遗传的交互作用, 参与,部委级,2017-01--2021-12
（ 4 ） 基于人胚胎干细胞胰腺分化模型研究全氟化合物与糖尿病发病的相关性, 主持,国家级,2019-01--2022-12

参与会议（1）The environmental pollutants PFOS and PFOA disrupt the specification and function of pancreatic and endocrine progenitor cells in vitro.2018-12-02
（2）Stem cell toxicology is a powerful system to assess the developmental toxicity of environmental pollution.2018-03-10
（3）Assessment of the developmental toxicity of BPA, BPF and BPS, with a stem cell toxicology system2017年“香港浸会大学-中国科学院生态环境研究中心伙伴国家重点实验室以及环境科学联合研究所”环境科学论坛2017-04-16
（4）Stem cell toxicology: a powerful tool to assess pollution effects on human health国际毒理学学会第56届年会2017-03-12
（5）The rise of stem cell toxicology第13届持久性有毒污染物国际研讨会2016-10-10
（6）Stem Cell Toxicology2016-06-21
（7）Stem cell toxicology: a powerful tool to assess Bisphenol A (BPA) derivatives- toxicity第12届持久性有毒污染物国际研讨会Nuoya Yin, Xinglei Yao, Francesco Faiola2015-11-15


合作情况
项目协作单位

指导学生