基本信息
王琳淇 男 微生物研究所
电话：
电子邮件：wanglq@im.ac.cn
通信地址：北京市朝阳区北辰西路1号院3号F716
邮政编码：100101
研究领域人类病原真菌社会性与毒力
微生物进化出社会性（sociality）用以克服恶劣自然或宿主环境所带来的巨大生存压力。隐球菌是一种重要的医学真菌，其可引发致命的隐球菌肺炎和真菌脑膜炎，导致每年约60万人死亡，超过了全球乳腺癌的死亡人数。本研究组从隐球菌-自然栖居环境-宿主三方的关系着眼，解析其社会性影响毒力与有性生殖的关键生物学机制，并致力发展技术平台将我们的研究转化成以隐球菌诊断、预防和治疗为靶向的临床应用。
我们的研究具体包括以下三个方面：
（1）利用系统生物学手段研究隐球菌致病性和有性生殖相关的细胞亚群形成/转换的时空调控网络，揭示细胞亚群介导的细胞异质性(cell heterogeneity)对隐球菌社会行为和毒力所扮演的生物学角色；
（2）揭示细胞-细胞交流信号转导通路，鉴定其在隐球菌社会性和致病性上的功能和调控机制；
（3）研究由极低隐球菌细胞浓度介导的宿主定植，并揭示其中的转录调控和表观调控机制，以期为隐球菌感染的预防和早期治疗提供理论基础。

招生信息
招生专业071007-遗传学
071005-微生物学

招生方向 人类病原真菌分子致病机制，细胞通讯与有性生殖
微生物社会性，细胞异质性


教育背景 2003-09--2009-07 中国科学院微生物研究所 博士
1998-09--2002-07 山东大学 学士


工作经历
工作简历 2014-12--今 中国科学院微生物研究所 研究员
2010-07--2014-12 德克萨斯A&M大学 博士后
2010-02--2010-07 纽约大学兰贡医学中心 博士后

社会兼职 2013-07--今 Faculty of 1000学术论文评述机构 ，Associate Faculty Member


专利与奖励
奖励信息 （1） EC Outstanding Young Investigator Award，其他级，2011


出版信息代表性论文
1. Wang L^#*, Tian X#, Gyawali R, Upadhyay S, Foyle D, Wang G, Cai J and Lin X* (2014) Morphotype transition and sexual reproduction are genetically associated in a ubiquitous environmental pathogen. PLoS Pathogens. e**. （*co-corresponding author) (Featured research article selected by PLoS Pathogens)
2. Wang L, Tian X, Gyawali R, and Lin X*. （2013）Fungal adhesion protein guides community behaviors and autoinduction in a paracrine manner. PNAS. 110(28):11571-6. (Recommended by Faculty of 1000)
3. Wang L and Lin X. (2012) Morphogenesis in fungal pathogenicity: shape, size, and surface. PLoS Pathogens. 8(12):e**.
4. Wang L, Zhai B, and Lin X. (2012) The link between morphotype transition and virulence in Cryptococcus neoformans. PLoS Pathogens. 8(6):e**
(Featured research article selected by PLoS Pathogens; recommended by Faculty of 1000)
5. Wang L^#, Tian X#, Wang J, Yang H, Fan K, Xu G, Yang K, and Tan H. (2009) Autoregulation of antibiotic biosynthesis by binding of the end product to an atypical response regulator. PNAS106 (21): 8617-22.
(Recommended by Faculty of 1000, Microbiology and Molecular Biology Reviews, Current Biology, Current Opinion in Microbiology)
6. Wang L and Lin X. (2011) Mechanisms of unisexual mating in Cryptococcus neoformans. Fungal Genetics and Biology. 48(7):651-660. (invited review)
7. Yang H^#, Wang L^#, Xie Z, Tian Y, Liu G and Tan H. (2007) The tyrosine degradation gene hppD is transcriptionally activated by HpdA and repressed by HpdR in Streptomyces coelicolor, while hpdA is negatively autoregulated and repressed by HpdR. Molecular Microbiology. 65 (4): 1064-1077 (# co-first author)
8. Zhai B, Wu C, Wang L, Sachs MS and Lin X. (2012) The antidepressant sertraline provides a promising therapeutic option for neurotropic cryptococcal Infections. Antimicrobial Agents Chemotherapy. 56(7):3758-66.
9. Wang J#, Wang W#, Wang L, Zhang G, Fan K, Tan H, Yang K. (2012) A novel role of ’pseudo’γ-butyrolactone receptors in controlling γ-butyrolactone biosynthesis in Streptomyces. Molecular Microbiology. 82(1):236-50.
10. Pan Y, Wang L, He X, Tian Y, Liu G and Tan H. (2011) SabR enhances nikkomycin production via regulating the transcriptional level of sanG, a pathway-specific regulatory gene in Streptomyces ansochromogenes. BMC Microbiology. 20;11:164.
11. Xu G^#, Wang J^#, Wang L, Tian X, Yang H, Fan K, Yang K, and Tan H. (2010) ’Pseudo’ γ-butyrolactone receptors respond to antibiotic signals to coordinate antibiotics biosynthesis. The Journal of Biological Chemistry. 285(35):27440-8.
12. Yang H, An Y, Wang L, Zhang S, Zhang Y, Tian Y, Liu G, and Tan H. (2010) Autoregulation of hpdR and its effect on CDA biosynthesis in Streptomyces coelicolor. Microbiology. 156 (Pt 9):2641-8.
13. Zhang Y, Wang L, Zhang S, Yang H and Tan H. (2008) hmgA, transcriptionally activated by HpdA, influences the biosynthesis of actinorhodin in Streptomyces coelicolor. FEMS Microbiology Letters. 280(2): 219-215.

书籍章节
Wang L and Lin X. (in press) Cryptococcus neoformans and Cryptococcosis. Encyclopedia of Infectious Disease. Greenwood Press.
特邀国际报告
1. Znf2 is the key molecule to link dimorphism and virulence in human pathogen Cryptococcus neoformans. The 26th Fungal Genetics Conference 2011, Asilomar, USA(March, 2011)
2. A Fungal adhesion protein guides community behaviors by autoinduction and paracrine signaling. The 27th Fungal Genetics Conference 2013, Asilomar, USA (March, 2013)
3. Extracellular and intracellular signalings orchestrate morphotype-transition and virulence in Cryptococcus neoformans. The 27th Fungal Genetics Conference 2013, Asilomar, USA (March, 2013)
4. Morphotype transition and unisex are genetically associated through an RNA-binding protein in Cryptococcus neoformans. South/Central Medical Mycology (SCMM) Meeting 2013, Houston, USA（November, 2013）