基本信息
王雁玲女博导中国科学院动物研究所
电子邮件： wangyl@ioz.ac.cn
通信地址： 北京市北辰西路1号院
邮政编码： 100101

研究领域

招生信息
招生专业100104-病理学与病理生理学

招生方向胎盘发育及妊娠相关疾病
生殖免疫调节


教育背景1993-09--1998-07中国科学院动物研究所理学博士
1988-09--1993-07中国科学技术大学理学学士

学历
学位

工作经历
工作简历2004-10~现在,中国科学院动物研究所,研究员
2001-05~2004-09,中国科学院动物研究所,副研究员
1999-05~1999-09,香港大学,访问
1998-07~2001-04,中国科学院动物研究所,助理研究员
1993-09~1998-07,中国科学院动物研究所,理学博士
1988-09~1993-07,中国科学技术大学,理学学士

社会兼职2017-01-01-今,“Biology of Reproduction”杂志编委, 编委
2017-01-01-今,中华预防医学会生命早期发育与疾病防控专业委员会, 副主任委员
2016-01-01-今,妇幼健康研究会母胎医学专业委员会, 副主任委员
2015-01-01-今,中国生理学会生殖生理专业委员会, 理事
2014-01-01-今,《中华围产医学杂志》编委, 编委
2013-12-31-今,中国动物学会生殖生物学专业委员会, 副秘书长
2013-08-01-今,Placenta期刊编委, 编委
2012-06-01-今,CoLab for Pregnancy国际组织执行委员会委员,
2012-01-02-今,PLoS ONE 期刊编委会, Academic Eidtor


教授课程现代生殖医学之病理概论
辅助生殖技术
生殖疾病概论
生殖生物学
生殖生物学seminar


专利与奖励
奖励信息（1） 全国妇幼健康科学技术奖, 二等奖, 国家级, 2017
（2） 子宫内膜异位症的基础与临床研究, 二等奖, 国家级, 2007
（3） 全国人口和计划生育科技工作先进个人, , 部委级, 2006
（4） 子宫内膜异位症的基础与临床研究, 一等奖, 省级, 2005

专利成果（ 1 ） 一株人类胚胎滋养层细胞系的建立及其应用, 2008, 第 1 作者, 专利号: ZL6.X
（ 2 ） 用于预测或早期诊断妊娠高血压疾病的试剂盒, 2014, 第 1 作者, 专利号: PCT/CN2014/074071


出版信息
发表论文（1）Hao Wang, Yangyu Zhao, Rongcan Luo, Xiaotao Bian, Yongqing Wang, Xuan Shao, Yu-xia Li, Ming Liu, Yan-Ling Wang. A positive feedback self-regulatory loop between miR-210 and HIF-1α mediated by CPEB2 is involved in trophoblast syncytiolization: implication of trophoblast malfunction in preeclampsia Self-regulatory loop for trophoblast malfunction.,Biology of Reproduction,2019-12,第11作者
（2）1.Xuan Shao, Yongqing Wang, Yanlei Liu, Xuejiang Guo, Dong Li, Ran Huo, Wentong Jia, Guangming Cao, Yu-Xia Li, Ming Liu, Jiahao Sha, Yangyu Zhao, and Yan-Ling Wang. Association of imbalanced sex hormone production with excessive procoagulation factor SerpinF2 in preeclampsia.,Journal of Hypertension,2019-02,第11作者
（3）Li G#, Ma L, Lin L, Wang YL, Yang H*. The intervention effect of aspirin on a lipopolysaccharide-induced preeclampsia-like mouse model by inhibiting the NF-κB pathway. Biol Reprod. 2018 Aug 1;99(2):422-432.,Biol Reprod,2018,第4作者
（4）Dai J#, Liang K, Zhao S, Jia W, Liu Y, Wu H, Lv J, Cao C, Chen T, Zhuang S, Hou X, Zhou S, Zhang X, Chen XW, Huang Y, Xiao RP, Wang YL, Luo T, Xiao J, Wang C*. Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis. Proc Natl Acad Sci U S A. 2018 Jun 11. pii: .,Proc Natl Acad Sci U S A,2018,第12作者
（5）Wang H#, Zhang L, Guo X, Bai Y, Li YX, Sha J, Peng C, Wang YL*, Liu M. MiR-195 modulates oxidative stress-induced apoptosis and mitochondrial energy production in human trophoblasts via flavin adenine dinucleotide-dependent oxidoreductase domain-containing protein 1 and pyruvate dehydrogenase phosphatase regulatory subunit. J Hypertens. 2018 Feb;36(2):306-318.,J Hypertens,2018,第11作者
（6）Shao X, Wang Y, Liu Y, Guo X, Li D, Huo R, Jia W, Cao G, Li YX, Liu M, Sha J, Zhao Y, Wang YL*. Association of imbalanced sex hormone production with excessive procoagulation factor SerpinF2 in preeclampsia. 2018 Jul 16. doi: 10.1097/HJH.1862. [Epub ahead of print],J Hypertension,2018,第11作者
（7）Shao X#, Tan C, Chen D, Wang YL*. Placental defects are involved in most gene mutations that cause embryonic and fetal death. Biol Reprod. 2018 Sep 1;99(3):476-478,Biol Reprod,2018,第11作者
（8）Liu M#, Wang Y#, Lu H#, Wang H, Shi X, Shao X, Li YX, Zhao Y*, Wang YL*. miR-518b Enhances Human Trophoblast Cell Proliferation Through Targeting Rap1b and Activating Ras-MAPK Signal. Front Endocrinol (Lausanne). 2018 15(9):100,Front Endocrinol (Lausanne),2018,第11作者
（9）Ma L#, Li G#, Cao G#, Zhu Y, Du MR, Zhao Y, Wang H, Liu Y, Yang Y, Li YX, Li DJ, Yang H, Wang YL*. dNK cells facilitate the interaction between trophoblastic and endothelial cells via VEGF-C and HGF. Immunol Cell Biol. 2017, 95(8):695-704,Immunol Cell Biol,2017,第11作者
（10）Shao X#, Liu Y#, Liu M, Wang Y, Yan L, Wang H, Ma L, Lia YX, Zhao Y*, Wang YL*. Testosterone represses estrogen signaling via upregulating mir-22: mechanism for imbalanced steroid hormone production in preeclampsia. Hypertension, 2017, 69:721-730 (Editorial highlight),Hypertension,2017,第11作者
（11）Luo R#, Wang Y#, Xu P#, Cao G, Zhao Y, Shao X, Li YX, Chang C, Peng C, Wang YL*. Hypoxia-inducible miR-210 contributes to preeclampsia via targeting thrombospondin type I domain containing 7A. Sci Rep, 2016, 6:19588.,Scientific Reports,2016,第11作者
（12）Liu M, Cao G, Zhang Y, Qu J, Li W, Wan X, Li YX, Zhang Z, Wang YL, Gao F. Changes in the morphology and protein expression of germ cells and Sertoli cells in plateau pikas testes during non-breeding season. Sci Rep. 2016 Mar 4;6:22697.,Scientific Reports,2016,第11作者
（13）Wu H#, Wang H#, Liu M, Bai Y, Li YX, Ji L, Peng C, Yu Y*, Wang YL*. MiR-195 participates in the placental disorder of preeclampsia via targeting activin receptor type-2B in trophoblastic cells. J Hypertens. 2016,34(7):1371-9,J Hypertens,2016,第11作者
（14）Variations of micrornas in human placentas and plasma from preeclamptic pregnancy. ,Hypertension,2014,第11作者
（15）MicroRNA-210 contributes to preeclampsia by down-regulating KCMF1,Hypertension,2014,第11作者
（16）Maturation of GDF15 in human placental trophoblast cells depends on the interaction with matrix metalloproteinase-26 (MMP-26).,J Clin Endo Metab,2014,第11作者
（17）Optimising sample collection for placental research.,Placenta,2014,第11作者
（18）Placental trophoblast cell differentiation: physiological regulation and pathological relevance to preeclampsia.,Molecular Aspects of Medicine,2013,第11作者
（19）The imprinted H19 gene regulates human placental trophoblast cell proliferation via encoding miR-675 that targets Nodal Modulator 1 (NOMO1).,RNA Biol,,2012,第11作者
（20）Downregulated miR-195 detected in preeclamptic placenta affects trophoblast cell invasion via modulating ActRIIA expression. ,PLoS ONE,2012,第11作者
（21）Self-control of HGF regulation on human trophoblast cell invasion via enhancing c-Met receptor shedding by ADAM10 and ADAM17.,J Clin Endo Metab, ,2012,第11作者
（22）High levels of ActivinA detected in preeclamptic placenta induce trophoblast cell apoptosis by promoting Nodal signaling.,J Clin Endo Metab,,2012,第11作者
（23）Detection of global DNA methylation and paternally imprinted H19 gene methylation in preeclamptic placentas.,Hypertension Research,2011,第11作者
（24）GnRH I and II up-regulate MMP-26 expression through the JNK pathway in human cytotrophoblasts.,Reprod Biol Endocrinol,2010,第11作者
（25）Prostasin Regulates Human Placental Trophoblast Cell Proliferation via the EGFR Signaling Pathway.,Human Reproduction,2010,第11作者
（26）Promotion of Human Trophoblasts Invasion by Gonadotropin-Releasing Hormone (GnRH) I and GnRH II via Distinct Signaling Pathways.,Mol Endocrinol,2009,第11作者
（27）Plasma level of soluble Met is tightly associated with the clinical risk of preeclampsia. ,Am J Obstet Gyn,2009,第11作者
（28）Prostasin Inhibits Cell Invasion in Human Choriocarcinomal JEG-3 Cells.,Histochem Cell Biol,2009,第11作者
（29）Hormonal and paracrine Regulation of embryonic implantation: A workshop report. ,Placenta,2007,第11作者
（30）Dual effect of TGF？1 on cell adhesion and invasion in human normal placenta trophoblast cells. ,Reproduction,2006,第11作者
（31）An immortalized normal human cytotrophoblast cell line generated by exogenous expression of telomeric reverse transcriptase. ,Mol Hum Reprod,2006,第1作者
（32）Dynamic expression of matrix metalloproteinases (MMP-2, -9 and -14) and the tissue inhibitors of MMPs (TIMP-1, -2 and -3) at the implantation site during tubal pregnancy. ,Reproduction,2005,第11作者
（33）Differential regulation of ERa and ERb in primate mammary gland. ,J Clin Endocrinol Metab,2005,第4作者
（34）Spatio-temporal expression of matrix metalloproteinase-26 in human placental trophoblasts and fetal red cells during normal placentation. ,Biol Reprod,2005,第11作者
（35）Determination of genes involved in the early process of embryonic implantation in rhesus monkey (Macaca mulatta) by suppression subtractive hybridization. ,Biol Reprod,2004,第11作者
（36）Temporal and spatial expression of integrins and their extracellular matrix ligands at the maternal-fetal interface in the rhesus monkey during pregnancy. ,Biol Reprod,2003,第11作者

发表著作（ 1 ） 子宫生物学转化研究, Effect of matrix metalloproteinase-26 on cell invasion and its modulation by gonadotropin releasing hormones in human trophoblast cells. In Translational research in Uterine Biology,Elsevier,2008-07,第1作者
（ 2 ） 子宫内膜疾病的新进展,Progress of Endometrial Disease,清华同方电子光盘出版社,2010-10,第5作者


科研活动
科研项目（ 1 ） 母胎互作调控紊乱致复发流产和子痫前期等妊娠疾病的分子机制, 主持,国家级,2015-01--2019-12
（ 2 ） 胎盘类固醇激素调节机体凝血-纤溶平衡和妊娠结局的机制, 主持,国家级,2016-01--2019-12
（ 3 ） 中国人群辅助生殖人口与子代队列建立与应用基础研究, 参与,国家级,2016-07--2021-06
（ 4 ） 妊娠过程中类固醇激素合成和代谢紊乱导致子痫前期发生发展的机制, 主持,国家级,2018-01--2022-12
（ 5 ） 胎盘形成的分子机制, 主持,国家级,2018-12--2021-12

参与会议

合作情况
项目协作单位

指导学生