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中国科学院大学研究生导师简介-陈国强

中国科学院大学 免费考研网/2016-05-09

1、招生信息2、教育背景3、工作经历4、教授课程5、专利与奖励6、出版信息7、科研活动8、合作情况9、指导学生
基本信息
陈国强 男 博导 上海交通大学
电子邮件: gqchen@sibs.ac.cn
通信地址: 上海市重庆南路280号西二栋905室
邮政编码: 200025
研究领域
招生信息

招生专业100104


招生方向肿瘤(白血病)细胞分化与凋亡生物学及其治疗学基础研究

教育背景1993-09--1996-07 上海第二医科大学(现上海交通大学医学院) 博士
1985-09--1988-07 上海第二医科大学(现上海交通大学医学院) 硕士
1980-09--1985-07 湖南衡阳医学院(现南华大学) 学士


学历

学位
工作经历

工作简历2010-11~现在, 上海交通大学副校长,医学院院长, 院长
2006-10~2010-10,上海交通大学医学院, 副院长
2002-05~现在, 上海交通大学医学院, 教授、主任
2001-08~现在, 中科院上海生命科学研究院-健康所, “百人计划”课题组长
1999-09~2001-08,美国Mount-Saint医学中心, visiting assistant professor
1997-05~1997-12,法国巴黎Saint Louis医院, 访问学者
1996-07~2002-08,上海第二医科大学附属瑞金医院, 副研究员、研究员
1993-09~1996-07,上海第二医科大学(现上海交通大学医学院), 博士
1988-07~1993-08,湖南衡阳医学院, 助教、讲师
1985-09~1988-07,上海第二医科大学(现上海交通大学医学院), 硕士
1980-09~1985-07,湖南衡阳医学院(现南华大学), 学士


社会兼职
教授课程
专利与奖励

奖励信息(1)白血病细胞分化与凋亡的新机制,部委级,2010
(2)白血病细胞生命活动规律的新发现,国家级,2008
(3)白血病细胞分化和凋亡相关的若干问题,国家级,2008
(4)白血病细胞分化与凋亡新机制的提出与发展,国家级,2005
(5)上海市自然科学牡丹奖,,2005
(6)上海市青年科技英才,,2004
(7)三氧化二砷单用或联合全反式维甲酸治疗急性早幼粒细胞白血病作用机制及临床研究,国家级,2004
(8)中国青年科技奖,,2004
(9)全反式维甲酸和三氧化二砷治疗恶性血液疾病的分子机制研究,部委级,2001
(10)血液系统恶性肿瘤基因产物靶向治疗的机制研究,,2000


专利成果( 1 )川藏香茶菜甲素在防治急性淋巴细胞白血病及宫颈癌中的应用,2009,第 1 作者,专利号: **8.5

出版信息

发表论文(1) Pathologically decreased miR-26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer, Carcinogenesis, 2011, 第 5 作者
(2) Ikaros is degraded by proteasome-dependent mechanism in the early phase of apoptosis induction, Biochemical and Biophysical Research Communications, 2011, 第 5 作者
(3) Pharicin B stabilizes retinoic acid receptor-α and presents synergistic differentiation induction with ATRA in myeloid leukemic cells., Blood, 2010, 第 5 作者
(4) Molecular mechanisms of leukemia-associated protein degradation, Front. Med. China, 2010, 第 5 作者
(5) Current advences in the application of proteomics in apoptosis research, Scientia Sinica Vitae, 2010, 第 5 作者
(6) Induction of SENP1 in Endothelial Cells Contributes to Hypoxia-driven VEGF Expression and Angiogenesis, THE JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 第 5 作者
(7) Hypoxia inducible factor-1 mediates expression of galectin-1: the potential role in migration/invasion of colorectal cancer cells, Carcinogenesis, 2010, 第 5 作者
(8) The downregulation of onzin expression by PKCe-ERK2 signaling and its potential role in AML cell differentiation, Leukemia, 2010, 第 5 作者
(9) Downregulation of ANP32B, a novel substrate of caspase-3, enhances caspase-3 activation and apoptosis induction in myeloid leukemic cells, Carcinogenesis, 2010, 第 5 作者
(10) Synergistic mitosis-arresting effects of arsenic trioxide and paclitaxel on human malignant lymphocytes, Chemico-Biological Interactions, 2010, 第 5 作者
(11) Proteomics-based identification of two novel direct targets of hypoxia-inducible factor-1 and their potential roles in migration/invasion of cancer cells, Proteomics, 2009, 第 5 作者
(12) Protein kinase Cdelta stimulates proteasome-dependent degradation of C/EBPalpha during apoptosis induction of leukemic cells., PLoS One., 2009, 第 5 作者
(13) Hypoxia-HIF-1alpha-C/EBPalpha/Runx1 signaling in leukemic cell differentiation., Pathophysiology, 2009, 第 5 作者
(14) Nuclear translocation of dihydrofolate reductase is not a pre-requisite for DNA damage induced apoptosis, Apoptosis, 2009, 第 5 作者
(15) PU.1, a novel capase-3 substrate, partially contributes to chemotherapeutic agents-induced apoptosis in leukemic cells, Biochemical and Biophysical Research Communications, 2009, 第 5 作者
(16) NDRG1 is down-regulated in the early apoptotic event induced by camptothecin analogs: the potential role in proteolytic activation of PKC delta and apoptosis., Proteomics, 2009, 第 5 作者
(17) NSC606985 induces apoptosis, exerts synergistic effects with cisplatin, and inhibits hypoxia-stabilized HIF-1alpha protein in human ovarian cancer cells., Cancer Lett. , 2009, 第 5 作者
(18) Protein Kinase C-δ mediates down-regulation of heterogeneous nuclear ribonucleoprotein K protein: involvement in apoptosis induction, E X P E R I M E N T A L C E L L R E S E A R C H, 2009, 第 5 作者
(19) Accumulation of hypoxia-inducible factor-1a protein and its role in the differentiation of myeloid leukemic cells induced by all-trans retinoic acid, haematologica, 2008, 第 5 作者
(20) Multi-sites cleavage of leukemogenic AML1-ETO fusion protein by caspase-3 and its contribution to increased apoptotic sensitivity, Leukemia, 2008, 第 5 作者
(21) Physical and functional interaction of Runt-related protein 1 with hypoxia-inducible factor-1a, Oncogene, 2008, 第 5 作者
(22) Hypoxia-inducible factor-1a-induced differentiation of myeloid leukemic, Oncogene, 2008, 第 5 作者
(23) Arsenic trioxide and proteasome inhibitor bortezomib synergistically induce apoptosis in leukemic cells: the role of protein kinase Cd, Leukemia, 2007, 第 5 作者
(24) Subcellular Proteome Analysis of Camptothecin Analogue NSC606985-Treated Acute Myeloid Leukemic Cells, Journal of Proteome Research, 2007, 第 5 作者
(25) Antileukemic roles of human phospholipid scramblase 1 gene, evidence from inducible PLSCR1-expressing leukemic cells, Oncogene, 2006, 第 5 作者
(26) Inducible expression of AML1-ETO fusion protein endows leukemic cells with susceptibility to extrinsic and intrinsic apoptosis, Leukemia, 2006, 第 5 作者
(27) Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia, Blood, 2006, 第 5 作者
(28) Hypoxia-simulating agents and selective stimulation of arsenic trioxide-induced growth arrest and cell differentiation in acute promyelocytic leukemic cells, haematologica, 2005, 第 5 作者
(29) Nanomolar concentration of NSC606985, a camptothecin analog, induces leukemic-cell apoptosis through protein kinase Cd–dependent mechanisms, BLOOD, 2005, 第 5 作者
(30) Protein kinase Cd mediates retinoic acid and phorbol myristate acetate–induced phospholipid scramblase 1 gene expression:its role in leukemic cell differentiation, Blood, 2005, 第 5 作者
(31) Cobalt chloride and low oxygen tension trigger differentiation of acute myeloid leukemic cells: possible mediation of hypoxia-inducible factor-1a, Leukemia, 2003, 第 5 作者
(32) Arsenic trioxide-induced mitotic arrest and apoptosis in acute promyelocytic leukemia cells, Leukemia, 2003, 第 5 作者
(33) Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia, Leukemia, 2000, 第 5 作者


发表著作
科研活动

科研项目( 1 )影响蛋白质修饰的活性小分子化合物的发现和活性机制研究, 主持, 国家级, 2009-01--2013-08
( 2 )白血病细胞分化与凋亡信息基础的化学生物学研究, 主持, 国家级, 2009-01--2012-12
( 3 )肿瘤病理生理学创新团队, 主持, 省级, 2009-01--2011-12


参与会议
合作情况

项目协作单位
指导学生

相关话题/医学院 上海交通大学 细胞 信息 奖励