1、招生信息2、教育背景3、工作经历4、教授课程5、专利与奖励6、出版信息7、科研活动8、合作情况9、指导学生
基本信息
丁文军 男 博导 生命科学学院
电子邮件:dingwj@ucas.ac.cn
通信地址:北京市石景山区玉泉路19号(甲)
邮政编码:
研究领域生物化学与分子生物学、细胞生物学(Biochemistry and Molecular Biology, Cell Biology)
招生信息
招生专业071010-生物化学与分子生物学
071009-细胞生物学
招生方向环境与健康/糖尿病
教育背景
学历-- 研究生
学位-- 博士
出国学习工作
教授课程生物化学研究方法
细胞生物学技术及应用
细胞生物学实验
出版信息
发表论文 (1) Cellular metabolism and macrophage functional polarization,International Reviews of Immunology,2015,通讯作者
(2) PM2.5-induced oxidative stress increases adhesion molecules expression in human endothelial cells through ERK/AKT/NF-κB-dependent pathway,Journal of Applied Toxicology,2015,通讯作者
(3) Macrophages treated with particulate matter PM2.5 induce selective neurotoxicity through glutaminase-mediated glutamate generation,J Neurochem,2015,通讯作者
(4) Oxidovanadium(IV) Sulfate-induced glucose uptake in HepG2 cells through IR/Akt pathway and hydroxyl radicals,Journal of Inorganic Biochemistry,2015,通讯作者
(5) Inhibitory effect of ursolic acid on differentiation and adipogenesis of 3T3-L1 adipocytes,Evidence-Based Complementary and Alternative Medicine,2015,通讯作者
(6) Nrf2抵抗胰岛β细胞氧化损伤的作用机制,中国科学院大学学报,2015,通讯作者
(7) Polymorphisms in the interleukin 18 receptor 1 gene and Tuberculosis susceptibility among Chinese,PLoS One,2014,通讯作者
(8) Water-insoluble fraction of airborne particulate matter (PM10) induces oxidative stress in human lung epithelial A549 cells,Environmental Toxicology,2014,通讯作者
(9) Effects of vanadium(III, IV, V)-chlorodipicolinate on glycolysis and antioxidant status in the liver of STZ-induced diabetic rats,J Inorg Biochem,2014,通讯作者
(10) Airborne fine particulate matter induces multiple cell death pathways in human lung epithelial cells,Apoptosis,2014,通讯作者
(11) ZnO nanoparticles-induced oxidative stress triggers apoptosis by activating JNK signaling pathway in cultured primary astrocytes,Nanoscale Res Lett,2014,通讯作者
(12) Tetrabromobisphenol A (TBBPA) induced oxidative stress in hepatoma HepG2 cells,International Journal of Applied Environmental Sciences,2014,第4作者
(13) PM2.5诱导肺上皮MLE-12细胞的氧化应激和自噬,PM2.5 induces autophagy in lung epithelial A549 and MLE-12 cells,中国药理与毒理学杂志,2013,第2作者
(14) 可吸入颗粒物与血管内皮细胞功能紊乱的关系,环境与健康杂志,2013,通讯作者
(15) 可吸入颗粒物与血管内皮细胞功能紊乱的关系,The Relationship between Inhaled Particulate Matter and Dysfunction of Vascular Endothelial Cells,环境与健康杂志,2013,通讯作者
(16) PM2.5-induced oxidative stress triggers autophagy in human lung epithelial A549 cells,Toxicology in Vitro,2013,通讯作者
(17) 纳米金属化合物的神经毒性效应研究进展,神经药理学报,2013,通讯作者
(18) V5dipic-Cl改善高脂诱导的肥胖C57BL/6J小鼠脂代谢紊乱的研究,中国科学院研究生院学报,2013,通讯作者
(19) PM2.5 induces nrf2-mediated defense mechanisms against oxidative stress by activating pik3/akt signaling pathway in human lung alveolar epithelial A549 cells,Cell Biology and Toxicology,2013,通讯作者
(20) Effect of VIVO(dipic-Cl)(H2O)2 on lipid metabolism disorders in the liver of STZ-induced diabetic rats,Journal of Diabetes Research,2013,通讯作者
(21) CXCL12 enhances human neural progenitor cell survival through a CXCR7- and CXCR4-mediated endocytotic signaling pathway,Stem Cells,2012,第5作者
(22) Alterations of peripheral CD4+CD25+Foxp3+ T regulatory cells in mice with STZ-induced diabetes,Cellular Molecular Immunology,2012,通讯作者
(23) The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: relationship with metabolic factors and complications,Journal of Molecular Medicine,2012,通讯作者
(24) 冬季和夏季PM10和PM2.5对人肺上皮细胞A549毒性的比较,中国科学院研究生院学报,2012,第2作者
(25) The phenotype and functional alterations of macrophages in mice with hyperglycemia for long term,Journal of Cellular Physiology,2012,通讯作者
(26) Anti-diabetic effects of a series of vanadium dipicolinate complexes in rats with streptozotocin-induced diabetes,Coordination Chemistry Reviews,2011,第5作者
(27) Oxidative stress induced by urban fine particles in cultured EA.hy926 cells,Human and Experimental Toxicology,2011,通讯作者
(28) 全氟辛烷磺酸对SD大鼠肝毒性及其肝脏细胞色素P450 mRNA表达的影响,Hepatotoxicity of PFOS in SD rats and its effect on the expression of CYP450 mRNAin liver,毒理学杂志,2010,通讯作者
(29) Evaluation of inhibition of fatty acid synthase by ursolic acid: Positive cooperation mechanism,Biochemical and Biophysical Research Communications,2010
(30) PM2.5对肺泡II型上皮细胞MLE-12的毒性研究,毒理学杂志,2010
(31) 血管紧张素原基因CD235Met-Thr变异与高血压脑梗塞发病的相关性,中科院研究生院学报,2010
(32) Acute Toxicity of Ferric Oxide and Zinc Oxide Nanoparticles in Rats,Journal of Nanoscience and Nanotechnology,2010
(33) 血管紧张素转化酶基因I/D多态性与高血压脑梗塞发病的相关性,中科院研究生院学报,2010
(34) 生物降解介导的表面变化的聚合物分子及其对细胞生长的影响,Biodegradation-induced surface change of polymer microspheres and its influence on cell growth,Polymer Degradation and Stability,2010,第5作者
(35) 姜黄素激活PPAR对降低高脂膳食糖尿病小鼠血糖的作用,Anti-diabetic effects of emodin involved in the activation of PPARgamma on high-fat diet-fed and low dose of streptozotocin-induced diabetic mice,Fitoterapia,2010,通讯作者
(36) Anti-diabetic effects of sodium 4-amino-2,6-dipicolinatodioxovanadium(V) dihydrate in streptozotocin-induced diabetic rats,Journal of Inorganic Biochemistry,2009
(37) Biodegradable Polymeric Microcarriers with Controllable Porous Structure for Tissue Engineering,Macromol. Biosci,2009
(38) Chloro-substituted dipicolinate vanadium complexes: Synthesis, solution, solid-state, and insulin-enhancing properties,Journal of Inorganic Biochemistry,2009
(39) 基于代谢组学方法研究纳米二氧化钛对大鼠肾功能的影响,毒理学杂志,2009
(40) Anti-diabetic effects of sodium 4-amino-2,6-dipicolinatodioxovanadium(V) dihydrate in streptozotocin-induced diabetic rats,Journal of Inorganic Biochemistry,2009
(41) Efficient fabrication of transparent antimicrobial poly(vinyl alcohol) thin films,J Nanopart Res,2009
(42) Anti-diabetic effects of vanadium(III, IV, V)–chlorodipicolinate complexes in streptozotocin-induced diabetic rats,Biometals,2009
(43) 钒化合物抗糖尿病作用的研究进展,化学进展,2009
(44) 纳米氧化锌对人肺腺癌细胞A549的毒性,中国科学院研究生院学报,2009
(45) 钒对遗传性Ⅱ型糖尿病KK小鼠降糖作用的实验研究,中国科学院研究生院学报,2008
(46) Diabetes-induced alteration of F4/80+ macrophages: a study in mice with streptozotocin-induced diabetes for a long term,J Mol Med,2008
(47) Reversal of Osteoporotic Changes of Mineral Composition in Femurs of DiabeticRats by Insulin ,Biol Trace Elem Res,2008
(48) Anti-diabetic Effects of Cesium Aqua (N,N′-ethylene (salicylideneiminato)-5-sulfonato) Oxovanadium (IV) Dihydrate in Streptozotocin-induced Diabetic Rats,Biol Trace Elem Res,2008
(49) The association of psychological symptoms with unintentional injuries among retired employees of a university in China,International Journal of Injury Control and Safety Promotion,2008
(50) Inhibition of protein tyrosine phosphatase 1B and alkaline phosphatase by bis(maltolato)oxovanadium (IV),Journal of Inorganic Biochemistry,2008
(51) 纳米毒理研究进展,中国药理学与毒理学杂志,2007
(52) 4-氯-2, 6-双吡啶双氧钒化合物降低1型糖尿病大鼠血糖的生物学作用,中国科学院研究生院学报,2007
(53) Element analysis in femur of diabetic osteoporosis model by SRXRF microprobe ,Micron,2007
(54) STZ诱导的糖尿病对骨密度和血清睾酮的影响(英文),中国科学院研究生院学报,2007
(55) Effect of vanadate on gene expression of the insulin signaling pathway in skeletal muscle of streptozotocin-induced diabetic rats,J Biol Inorg Chem,2007
(56) 口服富铬啤酒酵母对链脲佐霉素诱导糖尿病大鼠的生物效应,中国科学院研究生院学报,2007
发表著作 (1) 国家污染物环境健康风险名录(生物分册),Directory of National Environment and Heath: Biological Pollutant,中国环境科学出版社,2013-12,第1作者
(2) 国家污染物环境健康风险名录(化学第二分册),Directory of National Environment and Heath: Chemical Pollutant II,中国环境科学出版社,2011-08,第1作者
(3) 国内外化学污染物环境与健康风险排序比较研究,Overview of Risk Assessment for Chemcial Pollution and Human Health in the World ,科学出版社,2010-09,第2作者
(4) Comprhensive Handbook of Iodine,Oxford: Academic Press,2009-11
(5) 国家污染物环境健康风险名录-化学第一分册,Directory of National Environment and Health: Chemical Pollutant Part I,中国环境科学出版社,2009-02,第1作者
科研活动
科研项目 (1) 同步辐射技术研究PM2.5迁移转化及其诱导细胞氧化损伤的分子作用机制,主持,国家级,2015-01--2018-12
(2) PM2.5暴露诱发胰岛素抵抗的分子作用机制,主持,国家级,2014-01--2017-12
(3) 海外创新团队,主持,部委级,2013-02--2017-01
(4) 《健康风险名录》生物分册,主持,部委级,2011-01--2012-12
(5) 国内外POPs优控名录比较研究,主持,国家级,2010-01--2012-09
(6) 机动车污染健康影响评价方法,主持,部委级,2010-01--2013-09
(7) 除草剂抗体的制备纯化与筛选,主持,部委级,2009-01--2012-08
(8) 铍及其化合物检测排放,主持,专项级,2009-01--2014-12
(9) 钒诱导的氧化应激效应,主持,国家级,2009-01--2011-12
(10) POPs的机体负荷与健康效应评价,主持,国家级,2008-01--2012-09
(11) 纳米颗粒的跨膜分子机制研究,主持,国家级,2007-01--2011-12
参与会议Wenjun Ding, Dan Wei, Ming Li, Fang Zhang. The effect of vanadate on insulin signaling pathway in rat L6 myoblast cells. The 7th International Symposium on the Chemistry and Biological Chemistry of Vanadium. October 6-9, 2010. Toyama, Japan. (Oral)
Yang Liu, Wenjun Ding*. Inhibitory effects of ursolic acid on lipid accumulation in 3T3-L1 cells: association with fatty acid synthase. The 6th International Student Forum. September 23-26, 2010. Beijing, China. (Oral)
Yang Liu, Wei Zhang, Wenjun Ding*. Triterpenic acids decreases lipid droplets via Inhibition of fatty acid synthase activity. BIT's 8th International Drug Discovery Science and Technology. October 23-26, 2010. Beijing, China.
Jieting Wang, Fang Zhang, Wenjun Ding. Oxidative stress and cytotoxicity induced by zinc oxide nanoparticles in primary culture glia cells. BIT's 1th Annual World Congress of NanoMedicine. October 23-26, 2010. Beijing, China.
1. Wenjun Ding, Fang Zhang, Lin Wang, Lijuan Wang. Toxic effect of ZnO nanopartiles on lung in rats. National Conference on Environment and Health, Guangzhou 2009. October 9-11, 2009. (Oral).
2. Wenjun Ding, Xiaoyong Cui. Comparison study of Chemical Pollutant on Environment and Health. The 4th Forum for Environment and Health, China 2009. Sept. 16-17, 2009. Guangzhou, China (Oral)
3. Wenjun Ding, Dan Wei, Ming Li. The insulin-mimetic properties of vanadium with its effects on the gene expression profiling of the insulin signaling pathway in diabetic mellitus. The 6th International Vanadium Symposium - Vanadium Chemistry and Biochemistry. July 17-19. 2008. Lisbon, Portugal (Oral)
4. Wenjun Ding, Lijuan Wang, Lin Wang, Fang Zhang. Cytotoxicity of nano-ZnO in hippocampal neurons. The International Conference on Nano Toxicology, Zhenzhou 2008, Sept. 19-20, 2008. (Oral)
5. Lijuan Wang, Lin Wang, Fang Zhang, Wenjun Ding*. Cytotoxicity of nano-ZnO particles in hippocampal neurons cells. The International Conference on Nano Toxicology, Zhenzhou, Sept. 19-20, 2008. (Poster)
6. Han Wei, Dan Wei, Shuo Yi, Fan Qu, Fang Zhang*, Wenjun Ding*. PM2.5 particular matters induce apoptosis in H9c2 cells. The International Conference on Nano Toxicology, Zhenzhou, 2008, Sept. 19-20. (Poster)
7. Ming Li, Wenjun Ding*. The inhibitory effects of BMOV on GST-PTP1B and ALP activities in vitro. The 9th Conference on Biological Inorganic Chemistry of Chinese Chemical Society. Oct. 19-22. 2007. Guilin, China. (Oral)
8. Wenjun Ding, Fang Zhang, Shuo Yi, Fang Qu. Biological Effects of Transition Metals in Airborne Particulate Matter. 2007 International Workshop on Environmental Security and Health. Sept. 7-12, 2007. Wuhan, China (Oral)
9. Wenjun Ding, Junhui He, Lianghong Guo, Shuo Yi. Atmospheric Process, Interface Reaction and Health Effects of Inhaled Particles. CAS-AIST-NEDO workshop 2006. Dec. 11-13, 2006. Beijing, China (Oral)
10. Wenjun Ding, Min Zhang. Study on Chemical Specie of Chromium in Brewer’s Yeast Cells and Biological Effect of Chromium-rich Yeast in Diabetes Mellitus. YABEC 2006. 12th Symposium of Young Asian Biochemical Engineer’s Community. Nov. 25-27, 2006. Kaohsiung, Taiwan (Oral)
11. Wenjun Ding, Xiaoyong Cui, Ju Zhou, Shuo Yi. Health Effects of Inhaled Particulate Matters (IPM) in the Personal Exposure and Its Biometric Identification Technology. Forum for Environment and Health, China 2006. Sept. 25-27, 2006. Shenyang, China (Oral)
12. Wenjun Ding, Debbie C. Crans. Chemical Species of Vanadium: Evidence of Different Biological Activity. The 5th International Symposium on the Chemistry and Biological Chemistry of Vanadium. Sept. 10-14, 2006. San Francisco, USA. (Oral)
13. Subalita Baruah, Jason J. Smee, Jason A. Epps, Wenjun Ding, Debbie C Crans. Synthesis of chlorodipicolinate and its coordination complexes of vanadium in oxidation state III, IV and V. The 5th International Symposium on the Chemistry and Biological Chemistry of Vanadium. Sept. 10-14, 2006. San Francisco, USA. (Poster)
14. Ming Li, Wenjun Ding, Debbie C. Crans. Effect Effects of [VVO2dipic]- complex on STZ-induced diabetic rats. The 3rd Asian Biological Inorganic Chemistry Conference. Oct. 31-Nov. 3. 2006. Nanjing, China. (Poster)
15. Xiaolin Zhang, Dan Wei, Ming Li, Yurong Fei, Jianhong Yang, Wenjun Ding. Effect of Insulin Treatment on the Distribution of Elements in the Femur of STZ-induced Diabetic Rats. The 3rd Asian Biological Inorganic Chemistry Conference. Oct. 31-Nov. 3. 2006. Nanjing, China. (Poster)
16. Min Zhang, Xi Li, Wenjun Ding. Preparation of Chromium-rich Yeast. The 3rd Asian Biological Inorganic Chemistry Conference. Oct. 31-Nov. 3. 2006. Nanjing, China. (Poster)
17. Lijuan Wang, Lin Wang, Wenjun Ding. Acute Toxicity of Oxide Nanoparticles in Healthy Adult Rats. The 3rd Asian Biological Inorganic Chemistry Conference. Oct. 31-Nov. 3. 2006. Nanjing, China. (Poster)
合作情况
项目协作单位中国科学院理化技术研究所、中国科学院生态环境研究中心、中国科学院动物所、中国环境科学研究院、中国疾病控制与预防中心、中国医科院基础医学研究所、中国科学院高能物理研究所、中国科学院化学所、美国科罗拉多州立大学、日本理化学研究所、日本山梨县环境科学研究所、美国内布拉斯加大学医学中心
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中国科学院大学研究生导师简介-丁文军
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