1、招生信息2、教育背景3、工作经历4、专利与奖励5、出版信息6、科研活动
基本信息
日本山梨大学主任教授
城市环境研究所兼职博士生导师

电子邮件：sjdong@iue.ac.cn
日本国山梨县中央市下河东1110山梨大学大学院医学工学総合研究部

主要从事高脂血症，糖尿病，肥胖，动脉硬化及炎症等研究，特别是在遗传因素及环境因素与心血管病的关系方面的研究领域，世界上首次开发研制转基因家兔模型，应用先进分子生物学技术，发现脂蛋白脂酶，C反应蛋白，细胞外基质蛋白酶12 (MMP-12)等蛋白与心血管病发生的关系。已发表SCI文章120篇，其中含IF>10的论文有6篇（包括2篇Proceeding of National Academy of Sciences, USA, 1篇Journal of Clinical Investigation, 2篇Circulation, 1篇Circulation Research）IF>5的论文有33篇。日本专利授权2项。

研究领域分子病理学
招生信息

招生专业083001-环境科学

招生方向环境性疾病
环境性疾病
教育背景1978年9月～1983年8月 延边大学医学院毕业获学士学位
1983年9月～1986年8月 中国医科大学(病理解剖学)硕士学位
1987年1月～1992年3月 日本佐贺医科大学医学博士

学历 研究生


学位博士

工作经历

工作简历1986年9月～1986年12月 中国医科大学病理解剖教研室助教
1992年4月～1995年5月 美国加州大学旧金山分校Gladstone研究所博士后
1995年6月～2002年12月 日本筑波大学基础医学系Assistant Professor
2001年5月～2006年２月 日本筑波大学基础医学系心血管病研究室，主任
2002年1月～2006年２月 日本筑波大学基础医学系Associate Professor
2003年3月～2006年２月 日本筑波大学先端学际领域研究中心，課題責任人
2006年3月至今 日本山梨大学大学院医学工学総合研究部 分子病理学講座、主任教授


社会兼职学术任职：
日本病理学会评议员
日本动脉硬化学会评议员
日本循环器学会会员
日本实验动物学会会员
美国分子生物学学会会员
美国病理学会会员
美国心脏学会（AHA） fellow(院士)
中国自然科学基金海外评审员
中国国家优秀自费留学生奖学金（日本）评审委员
中国动脉硬化杂志特邀编委
中国長江学者教授評選委員会委員
日中国人医師会会長
日中医学会评议员(Japan China Medical Association)

国际权威杂志编委及审稿:
Atherosclerosis
Arteriosclerosis, Thrombosis, and Vascular Biology
American Journal of Pathology
Biochemistry Biophysics Research Communication
Circulation
Circulation Research
Clinica Chimica Acta
Experimental Animals
Histology and Histopathology
Journal of Atherosclerosis and Thrombosis
Journal of Biological Chemistry
Journal of Clinical Investigation
Journal of Lipid Research
Laboratory Investigation
Pathology International
Pharmacology Research
Pharmacology Therapeutics
Thrombosis Research
Transgenic Research

专利与奖励

奖励信息The Clinical Research Meeting Trainee Investigator Award, Baltimore, MD, USA美国临床研究学会青年奖；
The Best Research Award for Young Investigators, the Japan Atherosclerosis Society日本动脉硬化学会青年学者最优秀奖；
Young Investigator Award, the Japan Vascular Biology Society日本血管生物学会青年学者奖；
International Fellow of the council on Arteriosclerosis, Thrombosis, and Vascular Biology, AHA美国心脏学会动脉硬化，血栓，血管生物学分会国际院士；
Irvine H. Page Arteriosclerosis Research Award for Young Investigators of the American Heart Association美国心脏学会陪基科学奖；
Scientific Research Award of the Japan Pathology Society日本病理学会科学研究奖；
The Award of Goto Yuichirou of the Japan Atherosclerosis Society日本动脉硬化学会五岛雄一郎科学奖。
出版信息

发表论文
1. Ding Y, Wang Y, Zhu H, Fan J, Yu L, Liu G, Liu E. Hypertriglyceridemia and delayed clearance of fat load in transgenic rabbits expressing human apolipoprotein CIII. Transgenic Res. 2011;in press Epubahead of print.
2. Pravenec M, Kajiya T, Zidek V, Landa V, Mlejnek P, Simakova M, Silhavy J, Malinska H, Oliyarnyk O, Kazdova L, Fan J, Wang J, Kurtz TW. Effects of Human C-Reactive Protein on Pathogenesis of Features of the Metabolic Syndrome. Hypertension. 2011;in press, Epubahead of print.
3. Matsuda S, Yamashita A, Sato Y, Kitajima S, Koike T, Sugita C, Moriguchi-Goto S, Hatakeyama K, Takahashi M, Koshimoto C, Matsuura Y, Iwakiri T, Chen YE, Fan J, Asada Y. Human C-reactive protein enhances thrombus formation after neointimal balloon injury in transgenic rabbits. J Thromb Haemost. 2011;9:201-208.
4. Waqar AB, Koike T, Yu Y, Inoue T, Aoki T, Liu E, Fan J. High-fat diet without excess calories induces metabolic disorders and enhances atherosclerosis in rabbits. Atherosclerosis. 2010;213:148-155.
5. Zhang C, Zheng H, Yu Q, Yang P, Li Y, Cheng F, Fan J, Liu E. A practical method for quantifying atherosclerotic lesions in rabbits. J Comp Pathol. 2010;142:122-128.
6. Reifenberg K, Lehr HA, Fan J, Koike T, Wiese E, Kupper I, Sagban TA, Schaefer SC, Zahringer U, Torzewski M, Lackner KJ, Bhakdi S. Endotoxin accelerates atherosclerosis independent of complement activation. Thromb Res. 2009;123:653-658.
7. Koike T, Kitajima S, Yu Y, Li Y, Nishijima K, Liu E, Sun H, Waqar AB, Shibata N, Inoue T, Wang Y, Zhang B, Kobayashi J, Morimoto M, Saku K, Watanabe T, Fan J. Expression of human apoAII in transgenic rabbits leads to dyslipidemia: a new model for combined hyperlipidemia. Arterioscler Thromb Vasc Biol. 2009;29:2047-2053.
8. Zheng H, Zhang C, Yang W, Wang Y, Lin Y, Yang P, Yu Q, Fan J, Liu E. Fat and cholesterol diet induced lipid metabolic disorders and insulin resistance in rabbit. Exp Clin Endocrinol Diabetes. 2009;117:400-405.
9. Koike T, Kitajima S, Yu Y, Nishijima K, Zhang J, Ozaki Y, Morimoto M, Watanabe T, Bhakdi S, Asada Y, Chen YE, Fan J. Human C-reactive protein does not promote atherosclerosis in transgenic rabbits. Circulation. 2009;120:2088-2094.
10. Houdebine L, Fan J. Rabbit Biotechnology: Rabbit genomics, transgenesis, cloning and models: Springer; 2009.
11. Kitazato K, Fan J. Principles of Gene Therapy. In: Lin Y, Li S, eds. A text book of Fundamental Medical Pharmacology. Changchun: Jilin Science and Technology Publishing House; 2004:45-53.
12. Zhao S, Chu Y, Zhang C, Lin Y, Xu K, Yang P, Fan J, Liu E. Diet-induced central obesity and insulin resistance in rabbits. J Anim Physiol Anim Nutr (Berl). 2008;92:105-111.
13. Zhao S, Zhang C, Lin Y, Yang P, Yu Q, Chu Y, Yang P, Fan J, Liu E. The effects of rosiglitazone on aortic atherosclerosis of cholesterol-fed rabbits. Thromb Res. 2008;123:281-287.
14. Yamada S, Wang KY, Tanimoto A, Fan J, Shimajiri S, Kitajima S, Morimoto M, Tsutsui M, Watanabe T, Yasumoto K, Sasaguri Y. Matrix metalloproteinase 12 accelerates the initiation of atherosclerosis and stimulates the progression of fatty streaks to fibrous plaques in transgenic rabbits. Am J Pathol. 2008;172:1419-1429.
15. Zhang X, Qi R, Xian X, Yang F, Blackstein M, Deng X, Fan J, Ross C, Karasinska J, Hayden MR, Liu G. Spontaneous atherosclerosis in aged lipoprotein lipase-deficient mice with severe hypertriglyceridemia on a normal chow diet. Circ Res. 2008;102:250-256.
16. Yu Y, Koike T, Kitajima S, Liu E, Morimoto M, Shiomi M, Hatakeyama K, Asada Y, Wang KY, Sasaguri Y, Watanabe T, Fan J. Temporal and quantitative analysis of expression of metalloproteinases (MMPs) and their endogenous inhibitors in atherosclerotic lesions. Histol Histopathol. 2008;23:1503-1516.
17. Shiomi M, Fan J. Unstable coronary plaques and cardiac events in myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits: questions and quandaries. Curr Opin Lipidol. 2008;19:631-636.
18. Wang J, Xian X, Huang W, Chen L, Wu L, Zhu Y, Fan J, Ross C, Hayden MR, Liu G. Expression of LPL in endothelial-intact artery results in lipid deposition and vascular cell adhesion molecule-1 upregulation in both LPL and ApoE-deficient mice. Arterioscler Thromb Vasc Biol. 2007;27:197-203.
19. Yang X, Dong Y, Zhao J, Sun H, Deng Y, Fan J, Yan Q. Increased expression of human macrophage metalloelastase (MMP-12) is associated with the invasion of endometrial adenocarcinoma. Pathol Res Pract. 2007;203:499-505.
20. Liu E, Morimoto M, Kitajima S, Koike T, Yu Y, Shiiki H, Nagata M, Watanabe T, Fan J. Increased expression of vascular endothelial growth factor in kidney leads to progressive impairment of glomerular functions. J Am Soc Nephrol. 2007;18:2094-2104.
21. Kitajima S, Jin Y, Koike T, Yu Y, Liu E, Shiomi M, Marcovina SM, Morimoto M, Watanabe T, Fan J. Lp(a) enhances coronary atherosclerosis in transgenic Watanabe heritable hyperlipidemic rabbits. Atherosclerosis. 2007;193:269-276.
22. Liu E, Kitajima S, Wiese E, Reifenberg K, Morimoto M, Watanabe T, Fan J. Re-establishment of complement C6-deficient rabbit colony by cryopreserved sperm transported from abroad. Exp Anim. 2007;56:167-171.
23. Wu X, Wang J, Fan J, Chen M, Chen L, Huang W, Liu G. Localized vessel expression of lipoprotein lipase in rabbits leads to rapid lipid deposition in the balloon-injured arterial wall. Atherosclerosis. 2006;187:65-73.
24. Liang J, Liu E, Yu Y, Kitajima S, Koike T, Jin Y, Morimoto M, Hatakeyama K, Asada Y, Watanabe T, Sasaguri Y, Watanabe S, Fan J. Macrophage metalloelastase accelerates the progression of atherosclerosis in transgenic rabbits. Circulation. 2006;113:1993-2001.
25. Fan J, Chen YE. Source(s) of CRP in atherosclerotic lesions. Am J Pathol. 2006;168:1054-1056.
26. Sun H, Koike T, Ichikawa T, Hatakeyama K, Shiomi M, Zhang B, Kitajima S, Morimoto M, Watanabe T, Asada Y, Chen YE, Fan J. C-reactive protein in atherosclerotic lesions: its origin and pathophysiological significance. Am J Pathol. 2005;167:1139-1148.
27. Koike T, Liang J, Wang X, Ichikawa T, Shiomi M, Sun H, Watanabe T, Liu G, Fan J. Enhanced aortic atherosclerosis in transgenic Watanabe heritable hyperlipidemic rabbits expressing lipoprotein lipase. Cardiovasc Res. 2005;65:524-534.
28. Watanabe N, Nakagawa H, Kitajima S, Liu E, Morimoto M, Watanabe T, Fan J. Establishment of a SPF colony of human apo(a) transgenic rabbits by frozen-thawed embryo transfer. Exp Anim. 2005;54:353-357.
29. Liu E, Kitajima S, Higaki Y, Morimoto M, Sun H, Watanabe T, Yamada N, Fan J. High lipoprotein lipase activity increases insulin sensitivity in transgenic rabbits. Metabolism. 2005;54:132-138.
30. Ichikawa T, Liang J, Kitajima S, Koike T, Wang X, Sun H, Morimoto M, Shikama H, Watanabe T, Yamada N, Fan J. Macrophage-derived lipoprotein lipase increases aortic atherosclerosis in cholesterol-fed Tg rabbits. Atherosclerosis. 2005;179:87-95.
31. Kitajima S, Liu E, Morimoto M, Koike T, Yu Y, Watanabe T, Imagawa S, Fan J. Transgenic rabbits with increased VEGF expression develop hemangiomas in the liver: a new model for Kasabach-Merritt syndrome. Lab Invest. 2005;85:1517-1527.
32. Liu M, Sun H, Wang X, Koike T, Mishima H, Ikeda K, Watanabe T, Ochiai N, Fan J. Association of increased expression of macrophage elastase (matrix metalloproteinase 12) with rheumatoid arthritis. Arthritis Rheum. 2004;50:3112-3117.
33. Xiong S, Wang Y-F, Zhang M-Y, Liu X-Y, Zhang C-H, Liu S-S, Li J-X, Lu J-H, Wan Z-Y, Zheng H-Y, Yan X-G, Fan J. Immunogenicity of SARS inactivated vaccine in BALB/c mice. Immunol Lett. 2004;95:139-143.
34. Zhang A-H, Gao S, Fan J, Huang W, Zhao T-Q, Liu G. Increased plasma HDL cholesterol levels and biliary cholesterol excretion in hamster by LCAT overexpression. FEBS Lett. 2004;570:25-29.
35. Fan J, Watanabe T. Lipoprotein(a) and atherosclerosis: a study from transgenic rabbits. In: Matsuzawa Y, Kita T, Nagai R, et al., eds. International Congress Series, Atherosclerosis XIII. Vol 1262. Amsterdam: Elsevier B.V.; 2004:550-553.
36. Fan J, Wang X, Wu L, Matsumoto S, Liang J, Koike T, Ichikawa T, Sun H, Shikama H, Sasaguri Y, Watanabe T. Macrophage-specific overexpression of human matrix metalloproteinase-12 in transgenic rabbits. Transgenic Res. 2004;13:261-269.
37. Xi S, Yin W, Wang Z, Lian X, Koike T, Fan J, Zhang Q. A minipig model of high-fat/high-sucrose diet-induced diabetes and atherosclerosis. Int J Exp Pathol. 2004;85:223-231.
38. Yin W, Liao D, Kusunoki M, Xi S, Tsutsumi K, Wang Z, Lian X, Koike T, Fan J, Yang Y, Tang C. NO-1886 decreases ectopic lipid deposition and protects pancreatic beta cells in diet-induced diabetic swine. J Endocrinol. 2004;180:399-408.
39. Yin W, Liao D, Wang Z, Xi S, Tsutsumi K, Koike T, Fan J, Yi G, Zhang Q, Yuan Z, Tang K. NO-1886 inhibits size of adipocytes, suppresses plasma levels of tumor necrosis factor-alpha and free fatty acids, improves glucose metabolism in high-fat/high-sucrose-fed miniature pigs. Pharmacol Res. 2004;49:199-206.
40. Wang X, Liang J, Koike T, Sun H, Ichikawa T, Kitajima S, Morimoto M, Shikama H, Watanabe T, Sasaguri Y, Fan J. Overexpression of human matrix metalloproteinase-12 enhances the development of inflammatory arthritis in transgenic rabbits. Am J Pathol. 2004;165:1375-1383.
41. Kitajima S, Morimoto M, Liu E, Koike T, Higaki Y, Taura Y, Mamba K, Itamoto K, Watanabe T, Tsutsumi K, Yamada N, Fan J. Overexpression of lipoprotein lipase improves insulin resistance induced by a high-fat diet in transgenic rabbits. Diabetologia. 2004;47:1202-1209.
42. Ichikawa T, Kitajima S, Liang J, Koike T, Wang X, Sun H, Okazaki M, Morimoto M, Shikama H, Watanabe T, Yamada N, Fan J. Overexpression of lipoprotein lipase in transgenic rabbits leads to increased small dense LDL in plasma and promotes atherosclerosis. Lab Invest. 2004;84:715-726.
43. Koike T, Liang J, Wang X, Ichikawa T, Shiomi M, Liu G, Sun H, Kitajima S, Morimoto M, Watanabe T, Yamada N, Fan J. Overexpression of lipoprotein lipase in transgenic Watanabe heritable hyperlipidemic rabbits improves hyperlipidemia and obesity. J Biol Chem. 2004;279:7521-7529.
44. Shiomi M, Ito T, Yamada S, Kawashima S, Fan J. Correlation of vulnerable coronary plaques to sudden cardiac events. Lessons from a myocardial infarction-prone animal model (the WHHLMI rabbit). J Atheroscl Thromb. 2004;11:184-189.
45. Shiomi M, Ito T, Yamada S, Kawashima S, Fan J. Development of an animal model for spontaneous myocardial infarction (WHHLMI rabbits). Arterioscler Thromb Vasc Biol. 2003;23:1239-1244.
46. Fan J, Watanabe T. Inflammatory reactions in the pathogenesis of atherosclerosis. J Atheroscler Thromb. 2003;10:63-71.
47. Fan J, Watanabe T. Lipoprotein lipase transgenic rabbits. Mol. Cardiovas. Med. 2003;4:197-201.
48. Wu L, Tanimoto A, Murata Y, Sasaguri T, Fan J, Sasaguri Y, Watanabe T. Matrix metalloproteinase-12 gene expression in human vascular smooth muscle cells. Genes Cells. 2003;8:225-234.
49. Fan J, Watanabe T. Transgenic rabbits as therapeutic protein bioreactors and human disease models. Pharmacol Ther. 2003;99:261-282.
50. Kitajima S, Morimoto M, Watanabe T, Fan J. Transgenic rabbits: Production and applications for human disease models. Recent Res. Dev. Biophy. Biochem. 2003;3:179-194.
51. Fan J, Ichikawa T, Unoki H, Liang J, Koike T, Wang X, Watanabe T. Atherogenicity of lipoprotein lipase in transgenic rabbits. In: Kostner GM, Kostner KM, Kostner B, eds. Atherosclerosis: Risk factors, diagnosis, and treatment. Bologna, Italy: Monduzzi Editore; 2002.
52. Fan J. Cardiovascular pathology. In: Watanabe T, ed. Essential Pathology. Tokyo: Hirokawa Publishing Co.; 2002:127-145.
53. Koike T, Wang X, Unoki H, Liang J, Ichikawa T, Kitajima S, Watanabe T, Fan J. Increased expression of lipoprotein lipase in transgenic rabbits does not lead to abnormalities in skeletal and heart muscles. Muscle Nerve. 2002;26:823-827.
54. Sun H, Unoki H, Wang X, Liang J, Ichikawa T, Arai Y, Shiomi M, Marcovina S, Watanabe T, Fan J. Lipoprotein(a) enhances advanced atherosclerosis and vascular calcification in WHHL transgenic rabbits expressing human apolipoprotein(a). J Biol Chem. 2002;277:47486-47492.
55. Ichikawa T, Unoki H, Sun H, Shimoyamada H, Marcovina S, Shikama H, Watanabe T, Fan J. Lipoprotein(a) promotes smooth muscle cell proliferation and dedifferentiation in atherosclerotic lesions of human apo(a) transgenic rabbits. Am J Pathol. 2002;160:227-236.
56. Sun H, Usui S, Shiomi M, Watanabe T, Fan J. A rapid PCR method of genotyping LDL receptor mutations in WHHL rabbits. J. Atheroscl. Thromb. 2002;9:145-148.
57. Shimoyamada H, Fan J, Watanabe T, Nagata M. Renal atherosclerosis in transplantation. Clin Transplant. 2002;16(Suppl. 8):35-39.
58. Iwasa S, Fan J, Miyauchi T, Watanabe T. Blockade of endothelin receptors reduces diet-induced hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice. Pathobiology. 2001;69:1-10.
59. Fan J, Sun H, Unoki H, Shiomi M, Watanabe T. Enhanced atherosclerosis in Lp(a) WHHL transgenic rabbits. Ann N Y Acad Sci. 2001;947:362-365.
60. Wu L, Tanimoto A, Murata Y, Fan J, Sasaguri Y, Watanabe T. Induction of human matrix metalloproteinase-12 gene transcriptional activity by GM-CSF requires the AP-1 binding site in human U937 monocytic cells. Biochem Biophys Res Commun. 2001;285:300-307.
61. Fan J, Unoki H, Kojima N, Sun H, Shimoyamada H, Deng H, Okazaki M, Shikama H, Yamada N, Watanabe T. Overexpression of lipoprotein lipase in transgenic rabbits inhibits diet-induced hypercholesterolemia and atherosclerosis. J Biol Chem. 2001;276:40071-40079.
62. Fan J, Shimoyamada H, Sun H, Marcovina S, Honda K, Watanabe T. Transgenic rabbits expressing human apolipoprotein(a) develop more extensive atherosclerotic lesions in response to a cholesterol-rich diet. Arterioscler Thromb Vasc Biol. 2001;21:88-94.
63. Fan J, Watanabe T. Cholesterol-fed and transgenic rabbits for the study of atherosclerosis. J Atheroscler Thromb. 2000;7:26-32.
64. Kobayashi T, Miyauchi T, Iwasa S, Sakai S, Fan J, Nagata M, Goto K, Watanabe T. Corresponding distributions of increased endothelin-B receptor expression and increased endothelin-1 expression in the aorta of apolipoprotein E-deficient mice with advanced atherosclerosis. Pathol Int. 2000;50:929-936.
65. Fan J, Challah M, Shimoyamada H, Shiomi M, Marcovina S, Watanabe T. Defects of the LDL receptor in WHHL transgenic rabbits lead to a marked accumulation of plasma lipoprotein[a]. J Lipid Res. 2000;41:1004-1012.
66. Fan J, Watanabe T. Development of transgenic rabbit models. Anitechs. 2000;12:147-152.
67. Wu L, Fan J, Matsumoto S, Watanabe T. Induction and regulation of matrix metalloproteinase-12 by cytokines and CD40 signaling in monocyte/macrophages. Biochem Biophys Res Commun. 2000;269:808-815.
68. Fan J, Unoki H, Iwasa S, Watanabe T. Role of endothelin-1 in atherosclerosis. Ann N Y Acad Sci. 2000;902:84-94.
69. Fan J, Watanabe T. Transgenic rabbit model and its applications in medical science. J Clin Exp Med (Igaku no Ayumi). 2000;193:474-478.
70. Fan J, Watanabe T. Transgenic rabbits expressing human apolipoprotein(a). J Atheroscler Thromb. 2000;7:8-13.
71. Fan J, Challah M, Shimoyamada H, Watanabe T. Transgenic rabbits expressing human apolipoprotein(a) as a useful model for the study of lipoprotein(a). Ann N Y Acad Sci. 2000;902:347-351.
72. Araki M, Fan J, Challah M, Bensadoun A, Yamada N, Honda K, Watanabe T. Transgenic rabbits expressing human lipoprotein lipase. Cytotechnology. 2000;33:93-99.
73. Fan J, Araki M, Wu L, Challah M, Shimoyamada H, Lawn RM, Kakuta H, Shikama H, Watanabe T. Assembly of lipoprotein (a) in transgenic rabbits expressing human apolipoprotein (a). Biochem Biophys Res Commun. 1999;255:639-644.
74. Araki M, Fan J, Haraoka S, Moritake T, Yoshii Y, Watanabe T. Extracranial metastasis of anaplastic ganglioglioma through a ventriculoperitoneal shunt: a case report. Pathol Int. 1999;49:258-263.
75. Iwasa S, Fan J, Shimokama T, Nagata M, Watanabe T. Increased immunoreactivity of endothelin-1 and endothelin B receptor in human atherosclerotic lesions. A possible role in atherogenesis. Atherosclerosis. 1999;146:93-100.
76. Unoki H, Fan J, Watanabe T. Low-density lipoproteins modulate endothelial cells to secrete endothelin-1 in a polarized pattern: a study using a culture model system simulating arterial intima. Cell Tissue Res. 1999;295:89-99.
77. Barbagallo CM, Fan J, Blanche PJ, Rizzo M, Taylor JM, Krauss RM. Overexpression of human hepatic lipase and ApoE in transgenic rabbits attenuates response to dietary cholesterol and alters lipoprotein subclass distributions. Arterioscler Thromb Vasc Biol. 1999;19:625-632.
78. Fan J, Challah M, Watanabe T. Transgenic rabbit models for biomedical research: current status, basic methods and future perspectives. Pathol Int. 1999;49:583-594.
79. Watanabe T, Fan J. Atherosclerosis and inflammation mononuclear cell recruitment and adhesion molecules with reference to the implication of ICAM-1/LFA-1 pathway in atherogenesis. Int J Cardiol. 1998;66 (Suppl 1):S45-55.
80. Fan J, Watanabe T. Hepatic lipase. J Atheroscler Thromb. 1998;5:41-45.
81. Araki M, Fan J, Watanabe T. Immunohistochemical localization of lipoprotein lipase and apolipoprotein E in human atherosclerotic lesions. Acta Histochem Cytochem. 1998;31:485-492.
82. Fan J, Ji ZS, Huang Y, de Silva H, Sanan D, Mahley RW, Innerarity TL, Taylor JM. Increased expression of apolipoprotein E in transgenic rabbits results in reduced levels of very low density lipoproteins and an accumulation of low density lipoproteins in plasma. J Clin Invest. 1998;101:2151-2164.
83. Watanabe T, Fan J, Matsumoto S, Kobayashi T. Macrophage and lymphocytes in atherogenesis. J. Atheroscl. Thromb. 1998;26:173-177.
84. Dichek HL, Brecht W, Fan J, Ji ZS, McCormick SP, Akeefe H, Conzo L, Sanan DA, Weisgraber KH, Young SG, Taylor JM, Mahley RW. Overexpression of hepatic lipase in transgenic mice decreases apolipoprotein B-containing and high density lipoproteins. Evidence that hepatic lipase acts as a ligand for lipoprotein uptake. J Biol Chem. 1998;273:1896-1903.
85. Sanan DA, Fan J, Bensadoun A, Taylor JM. Hepatic lipase is abundant on both hepatocyte and endothelial cell surfaces in the liver. J Lipid Res. 1997;38:1002-1013.
86. Nie Q, Fan J, Haraoka S, Shimokama T, Watanabe T. Inhibition of mononuclear cell recruitment in aortic intima by treatment with anti-ICAM-1 and anti-LFA-1 monoclonal antibodies in hypercholesterolemic rats: implications of the ICAM-1 and LFA-1 pathway in atherogenesis. Lab Invest. 1997;77:469-482 (Commentary).
87. Taylor JM, Fan J. Transgenic rabbit models for the study of atherosclerosis. Front Biosci. 1997;2:298-308.
88. Fan J. Transgenic rabbit models for the study of athrosclerosis. Pathol Clin Med. 1997;15 (suppl):236.
89. Watanabe T, Fan J. Development of a novel animal model by genetic manipulation: Transgenic rabbits. Farmaw. 1996;32:51-54.
90. Fan J. Hepatic triglyceride lipase: recent insights from transgenic rabbit study. Therapeutic Res. 1996;17:341-346.
91. Sanan DA, Murata JI, Fan J, Bensadoun A, Newland DL, Taylor JM. Localization of hepatic lipase in the liver of transgenic rabbits. Mol Biol Cell. 1996;7(Suppl):1560.
92. Fan J. Transgenic rabbit models: Recent insights into the roles of hepatic lipase and apolipoprotein E in atherosclerosis. Therapeutic Res. 1996;17:11-19.
93. Yamanaka S, Balestra ME, Ferrell LD, Fan J, Arnold KS, Taylor S, Taylor JM, Innerarity TL. Apolipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals. Proc Natl Acad Sci U S A. 1995;92:8483-8487.
94. Fan J, Mahley Rw, Taylor JM. Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma HDL and IDL. In: Woodford FP, ed. Atherosclerosis X. Amsterdam, the Netherlands: Elsevier Science Publishers; 1995:666-669.
95. Fan J, McCormick SP, Krauss RM, Taylor S, Quan R, Taylor JM, Young SG. Overexpression of human apolipoprotein B-100 in transgenic rabbits results in increased levels of LDL and decreased levels of HDL. Arterioscler Thromb Vasc Biol. 1995;15:1889-1899.
96. Dang Q, Walker D, Taylor S, Allan C, Chin P, Fan J, Taylor JM. Structure of the hepatic control region of the human apolipoprotein E/C- I gene locus. J Biol Chem. 1995;270:22577-22585.
97. Fan J, Shimokama T, Tokunaga O, Watanabe T. Activation and cholesterol accumulation of macrophages induced by hypercholesterolemia. A study using a rat peritoneal macrophage model for extravascular in vivo generation of foam cells. Pathobiology. 1994;62:1-7.
98. Fan J, Wang J, Bensadoun A, Lauer SJ, Dang Q, Mahley RW, Taylor JM. Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins. Proc Natl Acad Sci U S A. 1994;91:8724-8728.
99. Fan J, Shimokama T, Haraoka S, Tokunaga O, Watanabe T. Monocyte-endothelial cell interactions in vitro, with reference to the influence of interleukin-1 and tumor necrosis factor. Biol Cell. 1993;79:17-26.
100. Takeda H, Yano T, Kishikawa H, Miyata T, Shinohara M, Yamaguchi E, Kobori S, Fan J, Tokunaga O, Shichiri M. Abnormalities in platelets and vascular endothelial cells induced by glycated lipoproteins. Intern Med. 1992;31:746-751.
101. Uemura Y, Okamoto K, Fan J, watanabe T. Chemotaxis of monocytes toward hexapeptides of elastin. In: Yanaihara N, ed. Peptide Chemistry. Tokyo: Escom Science Publishers; 1992:396-398.
102. Fan J, Kubota E, Imamura H, Shimokama T, Tokunaga O, Katsuki T, Watanabe T. Clear cell odontogenic carcinoma. A case report with massive invasion of neighboring organs and lymph node metastasis. Oral Surg Oral Med Oral Pathol. 1992;74:768-775.
103. Tokunaga O, Fan J, Watanabe T, Kobayashi M, Kumazaki T, Mitsui Y. Endothelin. Immunohistologic localization in aorta and biosynthesis by cultured human aortic endothelial cells. Lab Invest. 1992;67:210-217.
104. Fan J, Yamada T, Tokunaga O, Watanabe T. Functions of macrophages and hypercholesterolemia. J. Jpn. Atheroscl. Soc. 1992;20:1-6.
105. Yamada T, Fan J, Shimokama T, Tokunaga O, Watanabe T. Induction of fatty streak-like lesions in vitro using a culture model system simulating arterial intima. Am J Pathol. 1992;141:1435-1444.
106. Kondo M, Miyazaki M, Fan J, Watanabe T. Studies of dimiric fMLF with high chemotactic activity. In: Smith JA, Rivier JE, eds. Peptides: Chemistry and Biology. Leiden: ESCOM Science publishers B.V.; 1992:425-426.
107. Tokunaga O, Yamada T, Fan J, Watanabe T. Age-related decline in prostacyclin synthesis by human aortic endothelial cells. Qualitative and quantitative analysis. Am J Pathol. 1991;138:941-949.
108. Fan J, Yamada T, Tokunaga O, Watanabe T. Alterations in the functional characteristics of macrophages induced by hypercholesterolemia. Virchows Arch B Cell Pathol and Mol Pathol. 1991;61:19-27.
109. Imamura H, Kubota E, Fan J, Watanabe T. Clinicopathological study of a huge clear cell odontogenic carcinoma with partial transformation into squamous cells. Jpn. J. Oral Maxillofaci Surg. 1991;37:2026-2034.
110. Miyazaki M, Aramomi Y, Kodama H, Kondo M, Fan J, Watanabe T. Synthesis and biological activity of fMLP dimeric homologues. In: Shimonishi Y, ed. Peptide Chemistry. Osaka: Protein Research Foundation; 1991:273-276.
111. Tokunaga O, Fan J, Watanabe T. Atherosclerosis- and age-related multinucleated variant endothelial cells in primary culture from human aorta. Am J Pathol. 1989;135:967-976.
112. Tokunaga O, Fan J, Watanabe T. Atherosclerosis and endothelium. Part II. Properties of aortic endothelial and smooth muscle cells cultured at various ambient pressures. Acta Pathol Jpn. 1989;39:356-362.
113. Watanabe T, Tokunaga O, Fan J, Shimokama T. Atherosclerosis and macrophages. Acta Pathol Jpn. 1989;39:473-486.



科研活动

科研项目厚生労働科学研究費補助金（創薬基盤推進研究事業）
日本学術振興会科学研究費（基盤研究Ｂ）：CRPの動脈硬化？心筋梗塞への作用の解明とトランスレーショナルリサーチへの展開
日本学術振興会科学研究費（挑戦的萌芽研究）：核移植によるノックアウトウサギ病態モデルの作製及び動脈硬化への応用
Elucidation of human endothelial lipase in HDL metabolism and atherosclerosis: AstraZeneca research grant
日本学術振興会科学研究費：二国间共同研究
武田科学振兴财团科研助成金