1、招生信息2、教育背景3、工作经历4、发表论文5、指导学生6、课题组成员7、招生招聘8、国际合作9、科研项目10、教授课程
基本信息
鞠建华 男 汉族 博导 南海海洋研究所
电子邮件：jju@scsio.ac.cn
联系电话：**
手机号码：
通信地址：广州市新港西路164号，标本楼405室
邮政编码：510301


个人简介 鞠建华，男，1972年生，理学博士，研究员，博士生导师，中国科学院大学岗位教授。广东省海洋药物重点实验室主任（2010-），中国科学院热带海洋生物资源与生态重点实验室副主任（2010-）。2008年入选中科院“引进国外杰出人才”百人计划，2014年获得国家杰出青年科学基金、入选科技部“创新人才推进计划”中青年科技创新领军人才。主要从事海洋微生物活性次级代谢产物的发现、生物合成和抗感染、抗肿瘤创新药物研发工作。主持国家科技部863计划重点课题、973计划子课题、国家自然科学基金项目、国家海洋经济创新发展区域示范专项课题、广东省科技计划项目、中科院科技创新交叉团队项目等20余项。获得第五届施维雅青年药物化学奖(2002)、第七届药明康德生命化学研究奖(2013)。中国药学会海洋药物专业委员会委员，中国微生物学会海洋微生物专业委员会委员，热带海洋学报副主编，中国海洋药物编委。在国内外重要学术刊物Angew. Chem. Int. Ed.(IF=11.3)、J. Am. Chem. Soc (IF=11.4)、Org. lett.(IF=6.3)、Antimicrob. Agents Chemother.(IF=4.5)、J. Nat. Prod.(IF=3.9)、ChemBioChem (IF=3.1)、Nature Chem. Biol.、PNAS等发表论文105篇（其中SCI论文75篇），多篇论文被Nature Chemical Biology, Faculty of 1000, Science-Perspectives和Global Medical Discovery等作为研究亮点评述，获授权专利12项，参与撰写专著3部。

研究领域 本学科组以海洋微生物为研究对象，以海洋微生物活性次级代谢产物的生物合成机制为拟解决的关键科学问题。主要从特殊海洋环境（深海沉积物、珊瑚礁生态系统、不同深度的海水层等）中分离、培养海洋放线菌、真菌和细菌，综合运用微生物学、天然产物化学、细菌遗传学、分子生物学、生物信息学、生物化学和药理学等多学科专业技能，从中筛选结构新颖的生物活性物质，发掘新的生物合成途径、新型酶催化反应机理，利用代谢工程、组合生物合成和合成生物学技术手段构建新结构衍生物，具体包括以下内容：

(1) 海洋微生物活性次级代谢产物的发现（Marine Bioactive Natural Products Discovery）。利用化学生态学原理和多种发酵培养技术，从海洋微生物中筛选、分离和鉴定结构新颖、活性显著的生物活性物质。研究海洋微生物产生的活性物质在特定海洋生态系统中的化学防御机理；发现生理活性显著药物先导化合物，为开发具有我国独立知识产权的创新药物提供物质基础。

(2) 海洋微生物复杂活性天然产物的代谢工程、组合生物合成和合成生物学技术改造(Metabolic Engineering, Combinatorial Biosynthesis and Synthetic Biology of Complex Bioactive Natural Products)。包括：抗生素生物合成基因簇的克隆、序列测定和生物信息学分析；重要活性化合物产生菌全基因组的序列测定及其功能基因研究；新的生物合成途径的发现及其调控机制；基因阻断、置换、重组或异源表达构建工程菌，产生“非天然”的天然产物或提高目标天然产物的产量；利用基因克隆、蛋白表达、纯化手段，对酶促反应机理和动力学进行表征，发掘新型酶促反应催化剂；利用合成生物学技术体内构建新的生物合成途径，定向生产目标活性分子；重要活性天然产物的体外全生物合成(in vitro total biosynthesis)，体外构建重要天然产物的生物合成途径，用生物酶快速合成天然产物衍生物库。

(3) 抗感染、抗肿瘤海洋药物的成药性评价和药物研发。对通过发现和生物合成技术改造获得的化合物进行构效关系研究，筛选出结构新颖、活性显著、具有自主知识产权的化合物进行体内药效、毒理和药代等临床前研究，获得抗肿瘤海洋药物。

招生信息

招生专业 海洋生物学



招生方向 海洋微生物活性代谢产物
海洋微生物代谢产物生物合成

教育背景 1995-09--2000-07 北京协和医学院/中国医学科学院 研究生/博士，天然药物化学
1991-09--1995-07 山东大学 药学院 本科/学士，药学


出国学习工作2003年3月—2008年3月，美国威斯康星–麦迪逊大学 (University of Wisconsin-Madison) 药学院天然产物及其生物合成实验室，Research Associate、Assistant Researcher.
工作经历

工作简历 2008-03--今 中国科学院南海海洋研究所 研究员
2003-03--2008-02 University of Wisconsin- Madison.Research Associate/Assistant Researcher
2000-09--2003-03 中国医学科学院/北京协和医学院药用植物研究所 助理研究员、副研究员


行政职务广东省海洋药物重点实验室 主任
中国科学院海洋生物资源可持续利用重点实验室 副主任
发表论文2015:
29. Liu, J.; Wang, B.; Li, H.; Xie, Y.; Li, Q.; Qin, X.; Zhang, X.; Ju, J.* Biosynthesis of the anti-infective marformycins featuring pre-NRPS assembly line N-formylation and O-methylation and post-assembly line C-hydroxylation chemistries. Org. Lett. 2015, 17, 1509-1512.

28. Gui, C.; Li, Q.; Mo, X.; Qin, X.; Ma, J; Ju, J.* Discovery of a new family of Dieckmann cyclases essential to tetramic acid and pyridone-based natural products biosynthesis. Org. Lett. 2015, 17, 628-631.

27. Li, Q,; Song, X.; Qin, X,; Zhang, X.; Sun, A.; Ju, J.* Identification of the biosynthetic gene cluster for the anti-infective desotamides and production of a new analogue in a heterologous host. J. Nat. Prod., 2015, 78, 944-948.

26. Song, Y.; Liu, G.; Li, J.; Huang, H.; Zhang, X.; Zhang, H.,* Ju, J.* Cytotoxic and antibacterial angucycline- and prodigiosin- analogues from the deep-sea derived Streptomyces sp. SCSIO 11594. Mar. Drugs 2015,13, 1304-1316 (In special issue: Marine Compounds and Cancer).

2014：
25. Song,Y.; Li, Q.; Liu, X.; Chen, Y.; Zhang, Y.; Sun, A.; Zhang, W.; Zhang, J.; Ju, J.* Cyclic hexapeptides from the deep South China Sea-derived Streptomyces scopuliridis SCSIO ZJ46 active against pathogenic Gram-positive bacteria. J. Nat. Prod. 2014, 77, 1937-1941.

24. Ji C., Chen Q., Li Q., Huang H., Song Y., Ma J., Ju J.* Chemoenzymatic synthesis of new β-carboline derivatives using McbA, an ATP-dependent amide synthetase. Tetrahedron Lett. 2014, 55, 4901-4904.

23. Mo X., Li Q., Ju J.* Naturally occurring tetramic acid products: isolation, structure elucidation and biological activity. RSC Advances, 2014, 4, 50566-50593.

22. Xie, Y.; Li, Q.; Song, Y.; Ma, J.; Ju, J.* Involvement of SgvP in carbon–sulfur bond formation during griseoviridin biosynthesis. ChemBioChem, 2014, 15, 1183-1189 (recommended by Faculty of 1000).

21. Zhou X., Huang H., Li J., Song Y., Jiang R., Liu J., Zhang S., Hua Y.,* Ju J.* New anti-infective cycloheptadepsipeptide congeners and absolute stereo-chemistry from the deep sea-derived Streptomyces drozdowiczii SCSIO 10141. Tetrehedron, 2014, 70, 7795-7801 (in Symposia-in-print:Peptide Macrocycles).

2013:
20. Chen, Q.; Ji, C.; Song, Y.; Huang, H.; Ma, J.; Tian, Xi.; Ju, J* Discovery of McbB, a novel enzyme catalyzing the β-Carboline skeleton construction in the marinacarboline biosynthetic pathway. Angew. Chem. Int. Ed. 2013, 52, 9980-9984 (recommended by Faculty 1000).

19. Zhang, Y.; Huang, H.; Chen, Q.; Luo, M.; Sun, A.; Song, Y.; Ma, J.; Ju, J.* Identification of the grincamycin gene cluster unveils divergent roles for GcnQ in different hosts, tailoring the L-rhodinose moiety. Org. Lett., 2013, 15, 3254-3257.

18. Wang, B.; Song, Y.; Luo, M.; Chen, Q.; Ma, J.; Huang, H.; Ju, J.* Biosynthesis of 9-methylstreptimidone involves a new decarboxylative step for polyketide terminal diene formation. Org. Lett., 2013, 15, 1278-1281.

17. Song, Y.; Huang, H.; Chen, Y.; Ding, J.; Zhang, Y.; Sun, A.; Zhang, W.; Ju, J.* Cytotoxic and antibacterial marfuraquinocins from the deep South China Sea-derived Streptomyces niveus SCSIO 3406. J. Nat. Prod. 2013, 76, 2263-2268.

16. Zhang, Y.; Zhou, X.; Huang, H.; Tian, X.; Song, Y.; Zhang, S.; Ju, J.* 03219A, a new Δ8,9-pregnene isolated from Streptomyces sp. SCSIO 03219 obtained from a South China Sea sediment. J. Antibiot., 2013, 66, 327-331.

15. Zhang, H.; Chen, J.; Wang, H.; Xie, Y.; Ju, J.; Yan, Y.;* Zhang, H.* Structural analysis of HmtT and HmtN involved in the tailoring steps of himastatin biosynthesis. FEBS Lett., 2013, 587, 1675-1680.

2012:
14. Mo, X.; Ma, J.; Huang, H.; Wang, B.; Song, Y.; Zhang, S.; Zhang, C.; Ju, J.* Δ11,12 double bond formation in tirandamycin biosynthesis is atypically catalyzed by TrdE, a glycoside hydrolase family enzyme. J. Am. Chem. Soc. 2012, 134, 2844-2847 (highlighted in Nat. Chem. Biol. 2012, 8, 320).

13. Zhu,Q.; Li, J.; Ma, J.;Luo, M.;Wang, B.; Huang, H.; Tian, X.; Li, W.; Zhang, S.; Zhang, C.; Ju, J.* Discovery and engineered overproduction of antimicrobial nucleoside antibiotic A201A from deep sea marine actinomycete Marinactinospora thermotolerans SCSIO 00652. Antimicrob. Agents Chemother. 2012, 56, 110-114.

12. Xie, Y.; Wang, B.; Liu, J.; Zhou, J.; Ma, J.; Huang, H.; Ju, J.* Identification of the biosynthetic gene cluster and regulatory cascade for the synergistic antibacterial antibiotics griseoviridin and viridogrisein in Streptomyces griseoviridis. ChemBioChem, 2012, 13, 2745-2757 (highlighted in ChemBioChem as inside cover).

11. Ma, J.; Zuo, D.; Song, Y.; Huang, H.; Yao, Y.; Li, W.; Zhang, C.; Ju, J.* Characterization of a single gene cluster responsible for methylpendolmycin and pendolmycin biosynthesis in the deep sea bacterium Marinactinospora thermotolerans. ChemBioChem, 2012, 13, 547-552.

10. Zhou, X.; Huang, H.; Chen, Y.; Tan, J.; Song, Y.; Zou, J.; Tian, X.; Hua, Y.; Ju, J.* Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60-L scale fermentation of the deep sea-derived marinactinospora thermotolerans SCSIO 00652. J. Nat Prod. 2012, 75, 2251-2255.

9. Huang, H.; Yang, T.; Ren, X.; Liu, J.; Song,Y.; Sun, A.; Ma, J.; Zhang, Y.; Huang, C.; Zhang, C.; Ju, J.* Cytotoxic angucycline class glycosides from the deep sea actinomycete Streptomyces lusitanus SCSIO LR32. J. Nat. Prod. 2012, 75, 202-208.

8. Chen, Z.; Song, Y.; Chen, Y.; Huang, H.; Zhang, W.; Ju, J.* Cyclic heptapeptides, codyheptapeptides C–E, from marine-derived fungus Acremonium persicinum SCSIO 115. J. Nat. Prod., 2012, 75, 1215-1219.

7. Huang, H.; Wang, F.; Luo, M.; Chen, Y.; Song, Y.; Wang, B.; Ma, J.; Zhang, W.; Zhang, S.; Ju, J.* Halogenated anthranquinones from the deep sea-derived fungus Aspergillus sp. SCSIO F063. 2012, J. Nat Prod. 75,1346-1352.

6. Chen, Z.; Zheng, Z.; Huang, H.; Song, Y.; Zhang, X.; Ma, J.; Wang, B.; Zhang C.; Ju, J.* Penicacids A-C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp. SOF07. Bioorg. Med. Chem. Lett., 2012, 22, 3332-3335.

2011:
5. Ma, J.; Wang, Z.; Huang, H.; Zuo, D.; Luo, M.; Wang, B.; Sun, A.; Cheng, Y.; Zhang, C.; Ju, J.* Biosynthesis of himastatin: Assembly line and characterization of three cytochrome P450 enzymes involved in the post-tailoring oxidative steps. Angew. Chem. Int. Ed. 2011, 50, 7797-7802 (recommended by Faculty 1000).

4. Mo, X.; Huang, H.; Ma, J.; Wang, Z.; Wang, B.; Zhang, S.; Zhang, C.; Ju J.* Characterization of TrdL as a 10-hydroxy dehydrogenase and generation of new analogues from a tirandamycin biosynthetic pathway. Org. Lett. 2011, 13, 2212-2215.

3. Huang, H.; Yao, Y.; He, Z.; Yang, T.; Ma, J.; Tian, X.; Li, Y.; Huang, C.; Chen, X.; Li, W.; Zhang, S.; Zhang, C.; Ju, J.* Antimalarial b-carboline and indolactam alkaloids from Marinactinospora thermotolerans, a deep sea isolate. J. Nat. Prod. 2011, 74, 2122-2127 (key scientific article highlighted by Global Medical Discovery).

2. Mo, X.; Wang, Z.; Wang, B.; Ma, J.; Huang, H.; Tian, X.; Zhang, S.; Zhang, C.; Ju, J.* Cloning and characterization of the biosynthetic gene cluster of the bacterial RNA polymerase inhibitor tirandamycin from marine-derived Streptomyces sp. SCSIO1666. Biochem. Biophys. Res. Commun., 2011, 406, 341-347.

1. Chen, Z.; Huang, H; Chen, Y.; Wang, Z.; Ma, J.; Wang, B.; Zhang, W.; Zhang, C.; Ju, J.* New cytochalasins from the marine-derived fungus Xylaria sp. SCSIO 156. Helv. Chim. Acta. 2011, 94, 1671-1676.

Other publications:
29. Ma, M.; Kwong, T.; Lim, S.-K.; Ju, J.; Lohman, J. R.; Shen, B.* Post-polyketide synthase steps in iso-migrastatin biosynthesis, featuring tailoring enzymes with broad substrate specificity. J. Am. Chem. Soc., 2013, 135, 2489-2492.

30. Huang, Y.; Huang, S. X.; Ju, J.; Tang, G.; Liu, T.; Shen, B.* Characterization of the lnmKLM genes unveiling key intermediates for b-alkylation in leinamycin biosynthesis. Org. Lett.; 2011, 13, 498-501.

31. Schneider-Poetsch, T.; Ju, J.; Eyler, D. E.; Dang, Y.; Bhat, S.; Merrick, W. C.; Green, R.; Shen, B.; Liu, J. O*. Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin. Nat. Chem. Biol. 2010, 6, 209-217.

32. Ju, J.; Rajski, S. R.; Lim, S. K.; Seo, J. W.; Peters, N. R.; Hoffmann, F. M.; Shen, B.* Lactimidomycin, iso-migrastatin and related glutarimide-containing 12-membered macrolides are extremely potent inhibitors of cell migration. J. Am. Chem. Soc. 2009, 131, 1370-1371.

33. Ju, J.; Li, W.; Yuan, Q.; Peters, N. R.; Hoffmann, F. M.; Rajski, S. R.; Osada, H.; Shen, B.* Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity. Org. Lett., 2009, 11, 1639-1642.

34. Ju, J.; Lim, S.K.; Jiang, H.; Seo, J.W.; Shen, B.* Isomigrastatin congeners from Streptomyces platensis and generation of a glutarimide polyketide library featuring the dorrigocin, lactimidomycin, migrastatin, and NK30424 scaffolds. J. Am. Chem Soc. 2005, 127, 11930-11931

35. Ju, J.; Lim, S.K.; Jiang, H.; Shen, B.* Migrastatin and dorrigocins are shunt metabolites of iso-migrastatin. J. Am. Chem. Soc. 2005, 127, 1622-1623.

36. Ju, J.; Seo, J.-W.; Her, Y.; Lim, S.-K; Shen, B*. New lactimidomycin congeners shed insight into lactimidomycin biosynthesis in Streptomyces amphibiosporus. Org. Lett., 2007, 9, 5183-5186.

37. Ju, J.; Lim, S.-K; Jiang, H.; Seo, J.-W.; Her, Y.; Shen, B*. Thermolysis of isomigrastatin and its congeners via [3,3]-sigmatropic rearrangement: a new route to the synthesis of migrastatin and its analogues. Org. Lett., 2006, 8, 5865-5868.

38. Ju, J.; Ozanick, S.G.; Shen, B.; Thomas, M.G.* Conversion of (2S)-arginine to (2S, 3R)-capreomycidine by VioC and VioD from the viomycin biosynthetic pathway of Streptomyces sp. strain ATCC11861. ChemBioChem, 2004, 5:1281-1285.

39. Kennedy, D.R.; Ju, J.; Shen, B.; Beerman, T.A.* Designer enediynes generate DNA breaks, interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses. Proc. Natl. Acad. Sci. U.S.A., 2007, 104, 17632-17637.

40. Zhang, J.; Lanen, S.G.V.; Ju, J.; Liu, W.; Dorrestein, P.C.; Li, W.; Kelleher, N.; Shen, B.* A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis. Proc. Natl. Acad. Sci. U.S.A., 2008, 105, 1460-1465.

41. Luo, Y.; Li, W.; Ju, J.; Yuan, Q., Peters, N.R.; Hoffmann, F.M.; Huang, S.; Bugni, T. S.; Rajski, S.; Osada, H.; Shen, B.* Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis. J. Am. Chem. Soc. 2010, 132, 6663-6671.

42. Zhao, C.; Coughlin, J. M.; Ju, J.; Zhu, D.; Wendt-Pienkowski, E.; Zhou, X.; Wang, Z.; Shen, B.*; Deng, Z.* Oxazolomycin biosynthesis in Streptomyces albus JA3453 featuring an “acyltransferase-less” type I polyketide synthase that incorporates two distinct extender units. J. Biol. Chem. 2010, 285, 20097-20108.

43. Chen, Y.; Wendt-Pienkowski, E.; Ju, J.; Lin, S.; Rajski, S.R.; Shen, B.* Characterization of FdmV as an amide synthetase for fredericamycin A biosynthesis in Streptomyces griseus ATCC 43944. J. Biol. Chem. 2010, 285, 38853-38860.

44. Lim, S.K.; Ju, J.; Zazopoulos, E.; Jiang, H.; Seo, J.-W., Chen, Y.; Feng, Z.; Rajski, S.R.; Farnet, C. M.; Shen, B*. iso-Migrastatin, migrastatin, and dorrigocin production in Streptomyces platensis NRRL 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase. J. Biol. Chem. 2009, 284, 29746-29756.

45. Li, W.; Ju, J.; Rajski, S. R.; Osada, H.; Shen, B*. Characterization of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus unveiling new insights into dialkylmaleic anhydride and polyketide biosynthesis. J. Biol. Chem. 2008, 283, 28607-28617.

46. Li, W.; Ju, J.; Osada, H.; Shen B.* Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus. J. Bacteriol., 2006, 188, 4148-4152.

47. Zhao, C.; Ju, J., Christenson, S.D.; Smith, W.C.; Song, D.; Zhou, X.; Shen, B.;* Deng, Z.* Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning the oxazolomycin biosynthetic gene cluster from Streptomyces albus JA3453. J. Bacteriol., 2006, 188, 4142-4147.

48. Ju, J.; Rajski, S. R.; Lim, S. K.; Seo, J. W.; Peters, N. R.; Hoffmann, F. M.; Shen, B.* Evaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency. Bioorg. Med. Chem. Lett. 2008, 18, 5951-5954.

49. Guan, C.; Ju, J.; Borlee, B.R.; Williamson, L.L.; Shen, B.; Raffa, K.F.; Handelsman, J.* Signal mimics derived from a metagenomic analysis of the gypsy moth gut microbiota. Appl. Environ. Microbiol., 2007, 73, 3669-3676.

50. Lanen, S.G.V.; Dorrestein, P.C.; Christenson, S.D.; Liu, W.; Ju J.; Kelleher, N.L.; Shen, B.* Biosynthesis of the beta-amino acid moiety of the enediyne antitumor antibiotic C-1027 featuring beta-amino acyl-S-carrier protein intermediates. J. Am. Chem. Soc. 2005, 127, 11594-11595.

51. Kennedy, D.R.; Gawron, L.S.; Ju, J.; Liu, W.; Shen, B.; Beerman, T. A.* Single chemical modifications of the C-1027 enediyne core, a radiomimetic antitumor drug, affect both drug potency and the role of ataxia-telangiectasia mutated in cellular responses to DNA double-strand breaks. Cancer Res., 2007, 67, 773-781.

52. Galm, U.; Hager, M.H.; Lanen, S.G.V.; Ju J.; Thorson, J.S.*, Shen, B.* Antitumor antibiotics: bleomycin, enediynes, and mitomycin. Chem. Rev. 2005, 105:739-758.

53. Li, W.; Luo Y.; Ju, J.; Rajski, S. R.; Osada, H.; Shen, B*. Characterization of the tautomycetin biosynthetic gene cluster from Streptomyces griseochromogenes provides new insight into dialkylmaleic anhydride biosynthesis. J. Nat. Prod., 2009, 72, 450-459.

54. Chen, Y.; Luo, Y.; Ju, J.; Wendt-Pienkowski, E.; Rajski, S. R.; Shen, B*. Identification of fredericamycin E from Streptomyces griseus: Insights into fredericamycin A biosynthesis highlighting carbaspirocycle formation. J. Nat. Prod., 2008, 71, 431–437.

55. Adler, J.T.; Cook, M.; Luo, Y.; Pitt, S. C.; Ju, J.; Li, W.; Shen, B.; Kunnimalaiyaan, M.; Chen, H. Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3beta. Mol. Cancer Ther. 2009, 8, 914-920.

56. Pinchot, S. N.; Adler, J. T.; Luo, Y.; Ju, J.; Li, W.; Shen, B.; Kunnimalaiyaan, M.; Chen, H*. Tautomycin suppresses growth and neuroendocrine hormone markers in carcinoid cells through activation of the Raf-1 pathway. Am. J. Surg. 2009, 197, 313-319.

57. Song, D., Coughlin, J., Ju, J., Zhou, X., Shen, B., Zhao, C.*, Deng, Z*. Alternative method for site-directed mutagenesis of complex polyketide synthase in Streptomyces albus JA3453. Acta Biochim. Biophys. Sin., 2008, 40, 319-326.

58. Ju, J.*; Liu, D.; Lin, G.; Xu, X.; Han, B.; Yang, J*. Tu, G.; Ma, L.; Beesiosides A-F, Six new cycloartane triterpene glycosides from Beesia calthaefolia. J. Nat. Prod., 2002, 65, 42-47.

59. Ju, J.*; Liu, D.; Lin, G.; Zhang, Y.; Yang, J.*; Lu, Y.; Gong N.; Zheng, Q. Beesiosides G, H, and J-N, Seven new cycloartane triterpene glycosides from Beesia calthifolia. J. Nat. Prod., 2002, 65, 147-152.

60. Ju, J.; Liu, D.; Lin, G.; Xu, X.; Yang, J*. New oleanane-type glycosides from Beesia calthaefolia. Acta Botanica Sinica 2001, 43, 983-987.

61. Ju, J.; Yang, J.*; Li, J.; Xiao, P. Cypripediquinone A, a new phenanthraquinone from Cypripedium macranthum. Chin. Chem. lett. 2000, 11, 37-38.

课题组成员课题组成员
马俊英：博士，副研究员，分子生物学（华南农业大学）
黄洪波：博士，副研究员，天然产物化学（中山大学）
宋永相：博士，副研究员，天然产物化学（中山大学）
李青连：博士，副研究员，分子生物学（北京协和医学院/清华大学医学部）
谢运昌：博士，助理研究员，分子生物学（中国科学院大学）
秦湘静：博士，助理研究员，分子生物学（中山大学）

博士生8名（已毕业4人），硕士生13名（已毕业8人）

联合培养硕士生4名（已毕业）
招生招聘1. 招收硕士/博士研究生。招生专业：海洋生物学（方向一：海洋微生物活性代谢产物；方向二：海洋微生物活性代谢产物的生物合成）。每年9月份接受985、211工程院校生物科学、生物技术、生物工程、化学和药学等相关专业推荐免试直博生1名、推荐免试硕士生1名，接受联合培养硕士/博士研究生。
2. 招收博士后、创新岗位助理研究员/副研究员。欢迎天然药物化学、分子生物学/微生物学/生物化学、药学或相关领域的博士学位获得者或博士后出站人员发信联系。


国际合作与美国University of Wisconsin-Madison, Johns Hopkins University, Indiana University, University of Medicine & Dentistry of New Jersey药学院、医学院有关教授开展长期合作，研究（a）微生物活性天然产物的筛选、生物合成机理；（b）利用天然产物小分子化学探针阐明信号转导、血管生成、细胞增殖等重要生命过程的调控机制，以天然小分子发现蛋白靶点筛选小分子抑制剂；（c）从微生物天然产物中寻找蛋白激酶（特别是酪氨酸激酶）抑制剂，利用小分子探针阐明信号通路机制；和（d）抗肿瘤药物的作用机理及其TOR信号传递机制。


科研项目1. NSFC-广东联合基金重点项目：南海海洋放线菌中抗感染环肽药物先导化合物的发现、优化与评价，2016.01-2019.12，主持、在研；
2. 国家杰出青年科学基金项目：天然药物化学(**)，2015.01-2019.12，主持、在研；
3. 广东省海洋渔业科技推广专项：抗白血病药物GCN-B的规模化制备与成药性评价(A201403)，2015.01-2017.12，主持、在研；
4. 863计划重点课题：深海微生物活性物质的挖掘及其利用技术(2012AA092104)；2012.01-2015.12，课题负责人；主持、结题；
5. 中国科学院“科技创新交叉与合作”团队项目：海洋微生物药物先导化合物的发现及其遗传改造交叉团队(2013.01-2015.12)，团队负责人； 主持、结题；
6. 广东省海洋经济创新发展区域示范专项项目：海洋生物天然产物化合物库，GD2012-D01-001，2012.12.01-2015.12.31，课题负责人，主持、结题。
教授课程 生物有机化学