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中国科学院大学研究生导师简介-李川

中国科学院大学 免费考研网/2016-05-09

1、招生信息2、教育背景3、工作经历4、教授课程5、专利与奖励6、出版信息7、科研活动8、合作情况9、指导学生
基本信息
李川 男 博导 中国科学院上海药物研究所
电子邮件: chli@mail.shcnc.ac.cn
通信地址: 上海市张江高科技园区海科路501号1-502
邮政编码: 201203
研究领域
招生信息

招生专业100706


招生方向中药药代动力学,药代动力学

教育背景1995-04--1998-04 日本 - 东京药科大学 博士学位


学历

学位
工作经历

工作简历2000-12~现在, 中国科学院上海药物研究所, 课题组长
1998-05~2000-11,美国 - 新泽西州立大学 , 博士后
1995-04~1998-04,日本 - 东京药科大学, 博士学位


社会兼职
教授课程药代动力学概论及新药研发中的药

专利与奖励

奖励信息(1)治疗代谢性疾病的中药新药发现与评价关键技术研究及应用,国家级,2010
(2)药明康德生命化学研究奖,国家级,2008
(3)液相色谱电解质效应的发现及液-质联用技术分析中药多成分复杂样品方法学研究,省级,2007
(4)政府特殊津贴,院级,2004
(5)首批“新世纪百千万人才工程”国家级人选,院级,2004


专利成果( 1 )一种测定人或动物全血中喜明替康和吉咪替康含量的方法,2010,第 3 作者,专利号: **8.0

出版信息

发表论文(1) Intestinal absorption and presystemic elimination of various chemical constituents present in GBE50 extract, a standardized extract of Ginkgo biloba leaves. , Curr. Drug Metab., 2011, 第 5 作者
(2) Oral bioavailability and brain penetration of (?)-stepholidine, a tetrahydroprotoberberine agonist at dopamine D1 and antagonist at D2 receptors, in rats., Br. J. Pharmacol., 2009, 第 5 作者
(3) Absorption and disposition of ginsenosides after oral administration of Panax notoginseng extract to rats., Drug Metab. Dispos., 2009, 第 5 作者
(4) Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu-tang across human intestinal Caco-2 cell monolayers., Acta Pharmacol. Sin., 2008, 第 5 作者
(5) Plasma and urinary tanshinol from Salvia Miltiorrhiza (Danshen), can be used as pharmacokinetic markers for Cardiotonic pills, a cardiovascular herbal medicine., Drug Metab. Dispos., 2008, 第 5 作者
(6) Pulse gradient, large-volume injection, high-throughput ultra-performance liquid chromatographic/tandem mass spectrometry bioanalysis for measurement of plasma amrubicin and its metabolite amrubicinol. , J. Chromatogr. A, 2008, 第 5 作者
(7) Simultaneous determination of ginkgo flavonoids and terpenoids in plasma: ammonium formate in LC mobile phase enhancing electrospray ionization efficiency and capacity. , J. Am. Soc. Mass Spectrom. , 2008, 第 5 作者
(8) ‘LC-electrolyte effects’ improve the bioanalytical performance of liquid chromatography/tandem mass spectrometric assays in supporting drug discovery pharmacokinetic study. , Rapid Commun. Mass Spectrom. , 2007, 第 5 作者
(9) Comparative metabolic capabilities and inhibitor profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17. , Drug Metab. Dispos., 2007, 第 5 作者
(10) A sensitive method for the detection and quantification of ginkgo flavonols from plasma. , Rapid Commun. Mass Spectrom. , 2007, 第 5 作者
(11) Simultaneous quantification of multiple licorice flavonoids in rat plasma. , J. Am. Soc. Mass Spectrom. , 2007, 第 5 作者
(12) Characterization and quantification of eight water-soluble constituents in tubers of Pinellia ternata and in tea granules from the Chinese multiherb remedy Xiaochaihu-tang. , J. Chromatogr. B, 2006, 第 5 作者
(13) Rapid and direct measurement of free concentrations of highly protein-bound fluoxetine and its metabolite norfluoxetine in plasma. , Rapid Commun. Mass Spectrom., 2006, 第 5 作者
(14) A new method for measurement of (–)-sophocarpine, a candidate therapeutic for viral myocarditis, in plasma: application to a toxicokinetic study in beagle dogs. , Rapid Commun. Mass Spectrom. , 2005, 第 5 作者
(15) Determination of saikosaponin derivatives in Radix bupleuri and in pharmaceuticals of the Chinese multiherb remedy Xiaochaihu-tang using liquid chromatographic tandem mass spectrometry. , Anal. Chem. , 2004, 第 5 作者
(16) Liquid chromatography-nuclear magnetic resonance spectroscopy and its applications in drug metabolism studies. , Asian J. Drug Metab. Pharmacokinet., 2004, 第 5 作者
(17) A sensitive method for the determination of the novel cholinesterase inhibitor ZT-1 and its active metabolite huperzine A in rat blood using liquid chromatography/tandem mass spectrometry. , Rapid Commun. Mass Spectrom., 2004, 第 1 作者
(18) Liquid chromatography/tandem mass spectrometry for the determination of fluoxetine and its main active metabolite norfluoxetine in human plasma with deuterated fluoxetine as internal standard. , Rapid Commun. Mass Spectrom. , 2002, 第 1 作者


发表著作
科研活动

科研项目( 1 )国家杰出青年科学基金, 主持, 国家级, 2010-01--2013-12
( 2 )银杏酮酯(GBE50)及其制剂活性成分代谢及体内变化过程动力学研究, 主持, 省级, 2007-10--2011-10


参与会议
合作情况

项目协作单位
指导学生

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