1、招生信息2、教育背景3、工作经历4、教授课程5、专利与奖励6、出版信息7、科研活动8、合作情况9、指导学生
基本信息
李富花 女 博导 中国科学院海洋研究所
电子邮件： fhli@qdio.ac.cn
通信地址： 青岛市南海路7号
邮政编码： 266071
研究领域
招生信息

招生专业070703


招生方向实验海洋生物学，海洋生物技术

教育背景1993-09--1999-07 中国科学院海洋研究所 博士
1987-09--1990-10 厦门大学 硕士
1983-09--1987-07 厦门大学 学士


学历

学位
工作经历

工作简历2009-02~2009-03,澳大利亚CSIRO动物研究所, 高访
2005-01~2005-04,法国蒙彼利埃第二大学, 高访
2001-10~现在, 中国科学院海洋研究所, 研究员
1998-01~1999-05,美国康州大学, 访问学者
1996-02~2001-10,中国科学院海洋研究所, 副研究员
1993-09~1999-07,中国科学院海洋研究所, 博士
1993-02~1996-02,中国科学院海洋研究所, 助理研究员
1990-10~1993-02,中国科学院海洋研究所, 研究实习员
1987-09~1990-10,厦门大学, 硕士
1983-09~1987-07,厦门大学, 学士


社会兼职
教授课程
专利与奖励

奖励信息（1）对虾抗逆、生长等性状的分子生物学基础及其应用研究,部委级,2012
（2）经济虾贝类功能基因组学研究,部委级,2007
（3）海洋水产动物的遗传学基础和免疫学分子机制,部委级,2007


专利成果（ 1 ）一种对虾性别探针及其获取方法 ,2012,第 1 作者,专利号:ZL 2009 1 **.7
（ 2 ）不同种类对虾三倍体的制备方法,2009,第 2 作者,专利号: WO2006/042445A1
（ 3 ）一种中国明对虾抗菌蛋白基因及其表达和应用,2009,第 3 作者,专利号:ZL2005 1 004 7228.7
（ 4 ）一种累代选育对虾新品种的鉴定方法,2014,第 4 作者,专利号: ZL 2012 1 **.2
（ 5 ）一种明显提高脊尾白虾人工育苗存活率的方法,2014,第 3 作者,专利号: ZL2012 1 **.7
（ 6 ）进行凡纳滨对虾家系鉴定的多重微卫星鉴定体系及其应用,2015,第 2 作者,专利号: ZL 2013 1 **.1
（ 7 ）一种中华绒螯蟹三倍体诱导新方法,2015,第 2 作者,专利号: ZL2013 1 **.7
（ 8 ）一种稳定提高中华绒螯蟹多倍体诱导效率的便利设施,2013,第 2 作者,专利号: ZL2013 2 **.7

出版信息

发表论文（1） One type of VEGFR is involved in WSSV infection to the Pacific whiteleg shrimp Litopenaeus vannamei, Developmental and Comparative Immunology, 2015, 第 5 作者
（2） Molecular markers for identifying a new selected variety of Pacific white shrimp Litopenaeus vannamei, Chinese Journal of Oceanology and Limnology, 2015, 第 5 作者
（3） Functional diversity of anti-lipopolysaccharide factor isoforms in shrimp and their characters related to antiviral activity, Marine Drugs, 2015, 第 5 作者
（4） Analysis on the expression and function of syndecan in the Pacific white shrimp Litopenaeus vannamei, Developmental and Comparative Immunology, 2015, 第 5 作者
（5） Acute effects of cadmium and copper on survival, oxygen consumption, ammonia-N excretion, and metal accumulation in juvenile Exopalaemon carinicauda, Ecotoxicology and Environmental Safety, 2014, 第 2 作者
（6） Effect of starvation on survival, growth, and development of Exopalaemon carinicauda larvae, Aquaculture Research, 2014, 第 2 作者
（7） Comparison of protein expression profiles of the hepatopancreas in Fenneropenaeus chinensis with heat-inactivated Vibrio anguillarum and white spot syndrome virus, Marine Biotechnology, 2014, 第 2 作者
（8） Functional analysis on immune deficiency (IMD) homolog gene in Chinese shrimp Fenneropenaeus chinensis., Molecular Biology Reports, 2014, 第 5 作者
（9） SNP discovery in the transcriptome of White Pacific Shrimp Litopenaeus vannamei by next generation sequencing, PLoS ONE, 2014, 第 5 作者
（10） Prediction on the invasion route of WSSV infection to shrimp by bioinformatics analysis, BioMed Research International, 2014, 第 5 作者
（11） A new anti-lipopolysaccharide factor (ALF) gene with its SNP polymorphisms related to WSSV resistance of L. vannamei, Fish and shellfish immunology, 2014, 第 5 作者
（12） Cloning and expression analysis on a homolog of spermatogonial stem-cell renewal factor in Fenneropenaeus chinensis, Invertebrate Reproduction and Development, 2014, 第 5 作者
（13） Function of Shrimp STAT during WSSV Infection, Fish and Shellfish Immunology , 2014, 第 5 作者
（14） Modification of a synthetic LPS-binding domain of anti-lipopolysaccharide factor from shrimp reveals strong structure-activity relationship in their antimicrobial characteristics, Developmental and Comparative Immunology, 2014, 第 5 作者
（15） Transcriptome analysis of the initial stage of acute WSSV infection caused by temperature change, PLoS ONE , 2014, 第 5 作者
（16） A new ALF from Litopenaeus vannamei and its SNPs related to WSSV resistance, Chinese Journal of Oceanology and Limnology, 2014, 第 5 作者
（17） Characterization and function analysis of an anti-lipopolysaccharide factor (ALF) from the Chinese shrimp Fenneropenaeus chinensis, Developmental and Comparative Immunology, 2014, 第 5 作者
（18） A new shrimp peritrophin-like gene from Exopalaemon carinicauda involved in white spot syndrome virus (WSSV) infection, Fish and Shellfish Immunology , 2013, 第 2 作者
（19） Screening of genes regulated by Relish in Chinese shrimp Fenneropenaeus chinensis, Developmental and Comparative Immunology, 2013, 第 5 作者
（20） Expression and function analysis of Rac1 homolog in Chinese shrimp Fenneropenaeus chinensis, Fish and Shellfish Immunology, 2013, 第 5 作者
（21） Recent advances in researches on the innate immunity of shrimp in China, Developmental and Comparative Immunology, 2013, 第 1 作者
（22） Signaling pathways regulating innate immune responses in shrimp, Fish and Shellfish Immunology, 2013, 第 1 作者
（23） Analysis on the dynamic changes of the amount of WSSV in Chinese shrimp Fenneropenaeus chinensis, Aquaculture , 2013, 第 5 作者
（24） Shrimp MyD88 Responsive to Bacteria and White Spot Syndrome Virus, Fish and Shellfish Immunology, 2013, 第 5 作者
（25） An IκB homologue (FcCactus) in Chinese shrimp Fenneropenaeus chinensis, Developmental and Comparative Immunology , 2013, 第 5 作者
（26） Transcriptome analysis on Chinese shrimp Fenneropenaeus chinensis during WSSV acute infection, PLoS ONE, 2013, 第 5 作者
（27） A Homolog of Cell Apoptosis Susceptibility Gene Involved in the Ovary Development of Chinese Shrimp Fenneropenaeus chinensis, Biology of Reproduction, 2012, 第 5 作者
（28） Expression profiles of antimicrobial peptides (AMPs) and their regulation by Relish, Chinese Journal of Oceanology and Limnology, 2012, 第 5 作者
（29） Functional relationship among the major antioxidant enzymes in eliminating hydrogen peroxide in penaeid shrimp, Cell Stress and Chaperone, 2012, 第 5 作者
（30） Two spliced variants of insulin-like androgenic gland hormone gene in the Chinese shrimp, Fenneropenaeus chinensis, General and Comparative Endocrinology , 2012, 第 5 作者
（31） Identification and characterization of the sex-determiner transformer-2 homologue in Chinese shrimp, Fenneropenaeus chinensis, Sexual Development , 2012, 第 5 作者
（32） Structure and partial protein profiles of the peritrophic membrane (PM) from the gut of the shrimp Litopenaeus vannamei, Fish and Shellfish Immunology, 2012, 第 2 作者
（33） A Dorsal homolog (FcDorsal) in the Chinese shrimp Fenneropenaeus chinensis is responsive to both bacteria and WSSV challenge, Developmental and Comparative Immunology, 2010, 第 1 作者
（34） Cloning and expression profiles of two isoforms of a CHH-like gene specifically expressed in male Chinese shrimp, Fenneropenaeus chinensis, General and Comparative Endocrinology, 2010, 第 5 作者
（35） Proteomic analysis of differentially expressed proteins in lymphoid organ of Fenneropenaeus chinensis response to Vibrio anguillarum stimulation, Fish and Shellfish Immunology, 2010, 第 5 作者
（36） Screening of genes related to ovary development in Chinese shrimp Fenneropenaeus chinensis by suppression subtractive hybridization, Comparative Biochemistry and Physiology, Part D, 2010, 第 5 作者
（37） Three tetraspanins from Chinese shrimp, Fenneropenaeus chinensis, may play important roles in WSSV infection, Journal of Fish Diseases, 2010, 第 1 作者
（38） Penaeid shrimp polyploidy: Global status and future direction, aquaculture, 2010, 第 2 作者
（39） Identification of a novel inducible cytosolic Hsp70 gene in Chinese shrimp Fenneropenaeus chinensis and comparison of its expression with the cognate Hsc70 under different stresse, Cell Stress and Chaperone , 2010, 第 5 作者
（40） Molecular characterization and effect of RNA interference of retinoid X receptor (RXR) on E75 and chitinase gene expression in Chinese shrimp Fenneropenaeus chinensis, Comparative Biochemistry and Physiology, Part B, 2009, 第 2 作者
（41） Molecular cloning and characterisation of a pattern recognition protein, lipopolysaccharide and β-1,3-glucan binding protein (LGBP) from the Chinese shrimp Fenneropenaeus chinensis, Moecular Biology Reprots, 2009, 第 2 作者
（42） Molecular cloning and characterisation of prophenoloxidase (ProPO) cDNA from Fenneropenaeus chinensis and its transcription injected by Vibrio anguillarum, Molecular Biology Reportes, 2009, 第 2 作者
（43） Identification of a novel relish homolog in Chinese shrimp Fenneropenaeus chinensis and its function in regulating the transcription of antimicrobial peptides, Developmental and Comparative Immunology, 2009, 第 1 作者
（44） Cloning of cytoplasmic heat shock protein 90 (FcHSP90) from Fenneropenaeus chinensis and its expression response to heat shock and hypoxia, Cell Stress and Chaperones, 2009, 第 1 作者
（45） Comparative proteomic profiles of the hepatopancreas in Fenneropenaeus chinensis response to hypoxic stress, Proteomics, 2009, 第 1 作者
（46） A serpin from Chinese shrimp Fenneropenaeus chinensis is responsive to bacteria and WSSV challenge, Fish and Shellfish Immunology , 2009, 第 1 作者
（47） Cloning and expression of glucose regulated protein 78 (GRP78) in Fenneropenaeus chinensis, Molecular Biology Report, 2009, 第 5 作者
（48） Comparison of gene expression profiles of Fenneropenaeus chinensis challenged with WSSV and Vibrio, Marine Biotechnology, 2008, 第 1 作者
（49） Molecular Cloning and Characterization of Proliferating Cell Nuclear Antigen (PCNA) from Chinese Shrimp Fenneropenaeus chinensis, Comparative Biochemistry and Physiology, Part B, 2008, 第 5 作者
（50） cDNA cloning, characterization and expression analysis of the antioxidant enzyme gene, catalase of Chinese shrimp Fenneropenaeus chinensis, Fish and Shellfish Immunology, 2008, 第 2 作者
（51） Synaptonemal Complex Analysis in Spermatocytes of Diploid and Triploid Chinese Shrimp Fenneropenaeus chinensis, Tissue and Cell, 2008, 第 5 作者
（52） Microsatellite -centromere distances and microsatellite diversity in different ploidy classes of Chinese shrimp (Fenneropenaeus chinensis), Genetica, 2008, 第 2 作者
（53） Molecular cloning, characterization and expression analysis of a putative C-type lectin (Fclectin) gene in Chinese shrimp Fenneropenaeus chinensis., Molecular Immunology, 2007, 第 2 作者
（54） Molecular cloning, expression of a peroxiredoxin gene in Chinese shrimp Fenneropenaeus chinensis and the antioxidant activity of its recombinant protein, Molecular Immunology, 2007, 第 2 作者
（55） The mitochondrial manganese superoxide dismutase gene in Chinese shrimp Fenneropenaeus chinensis: Molecular cloning, characterization and expression, Developmental and Comparative Immunology, 2007, 第 2 作者
（56） A transglutaminase from Chinese shrimp (Fenneropenaeus chinensis), full length cDNA cloning, tissue localization and expression profile after challenge, Fish and Shellfish Immunology, 2007, 第 2 作者
（57） Cloning and recombinant expression of a crustin-like gene from Chinese shrimp, Fenneropenaeus chinensis, Journal of Biotechnology, 2007, 第 2 作者
（58） Molecular characteristics and expression analysis of calreticulin in Chinese shrimp Fenneropenaeus chinensis., Comparative Biochemistry and Physiology B, 2007, 第 2 作者
（59） Expression, purification, and characterization of recombinant Chinese shrimp crustin-like protein (CruFc) in Pichia pastoris., Biotechnology Letters, 2007, 第 2 作者
（60） Larval metamorphosis and morphological characteristic analysis of triploid shrimp Fenneropenaeus chinensis, Aquaculture Research , 2006, 第 1 作者
（61） Discovery of the genes in response to white spot syndrome virus (WSSV) infection in Fenneropenaeus chinensis through cDNA microarray, Marine Biotechnology, 2006, 第 2 作者
（62） Cloning, Expression and Identification of Ferritin from Chinese Shrimp, Fenneropenaeus chinensis, Journal of Biotechnology, 2006, 第 2 作者
（63） Evaluation of induced triploid shrimp Penaeus (Fenneropenaeus) chinensis cultured under laboratory conditions, Aquaculture, 2006, 第 2 作者


发表著作
科研活动

科研项目（ 1 ）三倍体对虾卵巢发育调控关键基因的克隆与表达, 主持, 国家级, 2009-01--2011-12
（ 2 ）对虾对病原识别应答的核因子NF-κB信号转导通路研究, 主持, 国家级, 2011-01--2013-12
（ 3 ）对虾产业体系岗位科学家, 主持, 国家级, 2011-01--2015-12
（ 4 ）养殖虾类病毒快速诊断与生物防控技术的研究与示范, 主持, 国家级, 2011-01--2015-12
（ 5 ）VEGF信号通路在对虾抗病毒免疫中的功能研究, 主持, 国家级, 2013-01--2016-12
（ 6 ）甲壳动物神经肽在调控性别特异性的胰岛素样雄激素介导的性别分化中的作用研究, 主持, 国家级, 2014-10--2017-09


参与会议
合作情况

项目协作单位
指导学生