1、招生信息2、教育背景3、工作经历4、教授课程5、专利与奖励6、出版信息7、科研活动8、合作情况9、指导学生
基本信息
刘青松 男 硕导 中国科学院合肥物质科学研究院
电子邮件： Qsliu97@hmfl.ac.cn
通信地址： 安徽省合肥是蜀山湖路350号
邮政编码： 230031
研究领域
招生信息

招生专业071011


招生方向激酶抑制剂的系统开发，肿瘤的抗药性机理

教育背景2004-08--2006-08 Vanderbilt University/美国 访问博士研究生
2002-01--2006-12 Texas A&M University/美国 博士学位
2001-08--2001-12 Brandeis University/美国 博士研究生
1997-09--2001-06 南开大学 学士学位


学历

学位
工作经历

工作简历2011-02~2012-02,Dana Farber Cancer Institute/HMS, Research Scientist
2007-11~2011-01,Dana Farber Cancer Institute/HMS, Research Fellow
2006-09~2007-10,Harvard Medical School, Postdoc fellow
2004-08~2006-08,Vanderbilt University/美国, 访问博士研究生
2002-01~2006-12,Texas A&M University/美国, 博士学位
2001-08~2001-12,Brandeis University/美国, 博士研究生
1997-09~2001-06,南开大学, 学士学位


社会兼职
教授课程
专利与奖励

奖励信息

专利成果（ 1 ）soluble mTOR complexes and modulators thereof,2010,第 5 作者,专利号: WO**
（ 2 ）Host targeted irreversible inhibitors of dengue virus and other biodefense viruses,2013,第 3 作者,专利号: WO ** A1
（ 3 ）Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof,2014,第 3 作者,专利号: WO/2014/063054 A1

出版信息

发表论文（1） Identification of Wee1 as a novel therapeutic target for mutant RAS-driven acute leukemia and other malignancies, Leukemia, 2014, 第 5 作者
（2） Exploration of Type II Binding Mode a Privileged Approach for Kinase Inhibitor Focused Drug Discovery, ACS Chem Biol, 2014, 第 5 作者
（3） Interleukin-6 secretion by astrocytes is dynamically regulated by PI3K-mTOR-calcium signaling, PloS One, 2014, 第 5 作者
（4） Discovery of a Potent, Covalent BTK Inhibitor for B-Cell Lymphoma, ACS Chem Biol, 2014, 第 5 作者
（5） Combined inhibition of mTORC1 and mTORC2 signaling pathways is a promising therapeutic option in inhibiting pheochromocytoma tumor growth: in vitro and in vivo studies in female athymic nude mice, Endocrinology, 2013, 第 5 作者
（6） Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR., Cancer Res., 2013, 第 1 作者
（7） Selective Akt inhibitors synergize with tyrosine kinase inhibitors and effectively override stroma-associated cytoprotection of mutant FLT3-positive AML cells., PLoS One, 2013, 第 1 作者
（8） Developing irreversible inhibitors of the protein kinase cysteinome., Chem Biol, 2013, 第 1 作者
（9） Discovery of a Selective Irreversible BMX Inhibitor for Prostate Cancer., ACS Chem Biol. , 2013, 第 5 作者
（10） Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a target in LKB1 Mutant Lung Cancer., Cancer Discov., 2013, 第 5 作者
（11） The influence of hypoxia on CML trafficking through modulation of CXCR4 and E-cadherin expression., Leukemia, 2013, 第 5 作者
（12） Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor, ACS Chem Biol, 2013, 第 5 作者
（13） Chaperones as thermodynamic sensors of drug::target interactions in living cells, Nature Biotechnology, 2013, 第 5 作者
（14） A simple, highly visual in vivo screen for anaplastic lymphoma kinase inhibitors., ACS Chem Biol, 2012, 第 5 作者
（15） Kinase inhibitors targeting angiogenesis as anti-cancer therapies, Current Angiogenesis, 2012, 第 5 作者
（16） Development of ATP-competitive mTOR inhibitors., Methods Mol Biol, 2012, 第 1 作者
（17） Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics, J Biol Chem, 2012, 第 1 作者
（18） Natural products as kinase inhibitors., Nat Prod Rep, 2012, 第 5 作者
（19） Systematic identification of genomic markers of drug sensitivity in cancer cells., Nature, 2012, 第 5 作者
（20） Selective ATP-Competitive Inhibitors of TOR Suppress Rapamycin-Insensitive Function of TORC2 in Saccharomyces cerevisiae, ACS Chem Biol. , 2012, 第 1 作者
（21） Functional Characterization of an Isoform-Selective Inhibitor of PI3K-p110β as a Potential Anticancer Agent., Cancer Discovery, 2012, 第 1 作者
（22） Using combination therapy to override stromal-mediated chemoresistance in mutant FLT3-positive AML: synergism between FLT3 inhibitors, dasatinib/multi-targeted inhibitors, and JAK inhibitors., Leukemia, 2012, 第 1 作者
（23） The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma., Cancer Cell, 2012, 第 5 作者
（24） Discovery and optimization of potent and selective benzonaphthyridinone analogs as small molecule mTOR inhibitors with improved mouse microsome stability., Bioorg Med Chem Lett., 2011, 第 1 作者
（25） Systemic inhibition of the mammalian target of rapamycin (mTOR) pathway reduces neuropathic pain in mice., Pain, 2011, 第 5 作者
（26） The controversial links among calorie restriction, SIRT1, and resveratrol., Free Radic Biol Med, 2011, 第 5 作者
（27） Anti-HCV drugs in the pipeline., Curr Opin Virol., 2011, 第 4 作者
（28） Characterization of a selective inhibitor of the Parkinsons disease kinase LRRK2, Nat Chem Biol, 2011, 第 5 作者
（29） Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer., J Med Chem., 2011, 第 1 作者
（30） Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer., J Med Chem., 2010, 第 1 作者
（31） mTOR Mediated Anti-Cancer Drug Discovery., Drug Discov Today Ther Strateg. , 2009, 第 1 作者
（32） Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors., Bioorg Med Chem Lett. , 2009, 第 5 作者
（33） FLT3 inhibition and mechanisms of drug resistance in mutant FLT3-positive AML., Drug Resist Updat., 2009, 第 3 作者
（34） An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1., J Biol Chem., 2009, 第 4 作者
（35） Synthesis and evaluation of the cytotoxicity of apoptolidinones A and D., J Org Chem., 2008, 第 4 作者
（36） Studies on the Synthesis of Apoptolidin: Progress on the Stereocontrolled Assembly of the Pseudo Aglycone of Apoptolidin, E. J. Org. Chem, 2006, 第 2 作者
（37） Development of an End-Game Strategy Towards Apoptolidin: a Sequential Suzuki Coupling Approach, Tetrahedron , 2005, 第 2 作者
（38） Total synthesis of apoptolidinone., Angew Chem Int Ed Engl, 2004, 第 2 作者


发表著作（ 1 ）mTOR : Methods and Protocols: Development of ATP-competitive mTOR inhibitors, mTOR : Methods and Protocols: Development of ATP-competitive mTOR inhibitors, Humana Press, 2012-05, 第 1 作者
（ 2 ）The Emerging Mechanism of Limited Therapeutic Efficacy of Rapamycin for Cancer, The Emerging Mechanism of Limited Therapeutic Efficacy of Rapamycin for Cancer, Nova Science Publishers, 2012-06, 第 5 作者
（ 3 ）Applications of fluorescent molecular probes in cell biology, Applications of fluorescent molecular probes in cell biology, Nova Science Publishers, 2013-09, 第 5 作者

科研活动

科研项目

参与会议（1）Rational Design, Synthesis and Characterization of Synthetic Kinase Inhibitors ---A Chemical Biology Link Between Synthetic Materials and Life Science qingsong Liu 2011-07-01
（2）Discovery and optimization of potent and selective benzonaphthyridinone analogs as dual mTOR/ATR small molecular inhibitors for treatment of cancer Qingsong Liu, Danny Zhou, Bunsho Shiotani, Nathanael S. Gray, Stephen J. Elledge, Lee Zou 2011-04-02
（3）2.Discovery of Torin1 as a highly potent, selective Mammalian Target of Rapamycin (mTOR) inhibitor for the treatment of cancer Qingsong Liu, Jae Won Chang, Jinhua Wang, Seong A. Kang , Carson C. Thoreen , Andrew Markhard, Wooyoung Hur , Jianming Zhang , Taebo Sim, David M. Sabatini , Nathanael S. Gray 2010-11-02
（4）Synthesis of pseudoapoptolidinone and structural corroboration of apoptolidin. Wu, Bin; Jin, Bohan; Qu, Tao; Liu, Qingsong; Sulikowski, Gary A 2003-03-27

合作情况

项目协作单位
指导学生