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中国科学院大学研究生导师简介-刘永宏

中国科学院大学 免费考研网/2016-05-09

1、招生信息2、教育背景3、工作经历4、教授课程5、科研活动6、合作情况7、指导学生8、招聘9、发表论文10、奖励11、课题组成员12、专利与奖励13、出版信息
基本信息
刘永宏 男 博导 南海海洋研究所
电子邮件:yonghongliu@scsio.ac.cn
通信地址:广州市新港西路164号
邮政编码:510301


研究领域主要研究领域为海洋生物活性物质的研究,以海洋天然产物化学研究为基础,以海洋生物中防治重要疾病创新药物先导结构的发现与优化为主要研究方向。主要研究内容包括:综合运用现代分离、分析技术与活性追踪相结合的方法,研究发现海洋生物中用于防治严重危害人类健康的重要疾病创新药物先导结构或目标分子;对发现的重要活性先导化合物进行系统的结构修饰或合成研究,探讨相关衍生物的结构与活性的关系,发现结构简单、活性强、毒性小的新药研究目标分子。

近年来,开展了一些海洋化学生态学研究,旨在通过海洋生物学,生态学和海洋天然产物化学等多学科的配合,从仿生学的观点,以抗污损生物附着活性筛选为导向,结合现代色谱学,现代波谱学,现代色谱-波谱联机技术,快速分离并结构确定海洋生物中的抗藤壶幼虫附着靶向化学防御物质,改构活性成分,发现生产新的抗附着先导结构,研究抗附着活性与结构关系,总结出显效基团,在此基础上进行抗其它污损生物附着活性的研究,探讨海洋生物抗附着化合物与环境竞争适应机制,揭示海洋生物的抗附着活性化合物的化学生态学作用,为研制海洋生物来源的新型无毒绿色防污剂奠定基础。


招生信息招收推免生硕士生,联合培养相关专业博士生,硕士生若干名 。
招生博士毕业工作人员及博士后人员

招生专业 海洋化学
有机化学
海洋生物学

招生方向 海洋天然产物化学
海洋化学生态学
海洋药物学
教育背景 1999-09--2002-08 韩国釜山大学 海洋天然药物化学专业博士
1996-09--1999-08 长春中医药大学 天然药物化学专业硕士
1992-09--1996-08 长春中医药大学 中药学学士


学历博士研究生


学位博士


出国学习工作2002年9月-2003年3月 韩国釜山大学 药学大学 博士后
2003年4月-2004年3月 日本大阪大学 药学大学 博士后
2004年4月-2005年12月 葡萄牙里斯本新大学 科技学院 化学系 博士后

工作经历2002年9月-2003年3月 韩国釜山大学 药学大学 博士后
2003年4月-2004年3月 日本大阪大学 药学大学 博士后
2004年4月-2005年12月 葡萄牙里斯本新大学 科技学院 化学系 博士后
2006年1月至今 中国科学院南海海洋研究所 研究员 博士生导师


工作简历 2006-01--2011-07 中国科学院南海海洋研究所 研究员
2004-04--2006-01 葡萄牙里斯本新大学 博士后
2003-04--2004-03 日本大阪大学 博士后
2002-09--2003-03 韩国釜山大学 博士后


社会兼职 2012-10--2014-12 natural product research,编委
2011-01--2014-12 Journal of Arthritis编委,编委
2011-01--2014-12 Journal of Medicinal Chemistry 编委

教授课程 海洋天然药物化学
科研活动

科研项目 (1) 重要生理功能和重大疾病相关蛋白质研究公共资源库建设,参与,国家级,2011-01--2015-12
(2) 南海掘海绵Dysidea sp.靶向抗PA生物膜活性物质及其作用机制研究,主持,国家级,2010-01--2012-12
(3) 海洋微生物次生代谢的生理与生态效应及其生物合成机制,参与,国家级,2010-01--2014-12


参与会议 (1) Bioactive Metabolites from the South China Sea Invertebrates,第六届韩国海洋生物技术国际研讨会,2010-11, yonghong liu

合作情况出站博士后:李云秋博士,柴兴云博士,林秀萍博士, 彭燕博士
在站博士后:M. Fredimoses博士(印度)

项目协作单位
指导学生已指导学生

董光 硕士研究生 070703-海洋生物学

黄日明 博士研究生 070702-海洋化学

杨斌 博士研究生 070702-海洋化学

胡静 硕士研究生 070702-海洋化学

孙见凡 博士研究生 070702-海洋化学

连喜平 博士研究生 070703-海洋生物学

白志强 硕士研究生 070702-海洋化学

现指导学生

李盈蕾 博士研究生 070702-海洋化学

钟志龙 硕士研究生 070702-海洋化学

冼嘉韵 硕士研究生 070702-海洋化学

艾文 博士研究生 070702-海洋化学

李晋昇 硕士研究生 070702-海洋化学

汤勇 硕士研究生 070702-海洋化学

田永奇 博士研究生 070702-海洋化学

招聘中国科学院南海海洋研究所刘永宏研究员课题组2014年诚聘,微生物药物化学,药物化学,有机合成相关专业固定研究人员2名,药物化学/微生物学专业博士后2名,以及联合培养相关专业博士生,硕士生若干名。

本课题组隶属中国科学院南海海洋研究所,依托广东省海洋药物重点实验室和中国科学院热带海洋生物资源可持续利用重点实验室作为研究平台。主要开展海洋生物及其共附生微生物活性成分的天然产物化学和化学生态学研究。

固定人员及博士后应聘条件:

1. 拥有有机合成,天然产物化学或微生物学及其相关专业的博士学位;在所属学科领域发表过有影响的SCI论文。

2. 能够较独立地开展科研工作,中英文基础良好,能够撰写流畅的科研论文。

3. 工作勤奋,认真负责,有较强的团队协作精神。

应聘者请准备个人简历,直接与刘永宏研究员联系。

电话:(020) **

地址:广州市新港西路164号

欢迎通过E-mail:yonghongliu@scsio.ac.cn 咨询。

http://lmb.scsio.ac.cn/teamshow.asp?action=74

http://sourcedb.scsio.cas.cn/cn/rck/brjh/200907/t**_**.html

发表论文2013论文
1. Wang L, Yang B, Lin X, Zhou X, Liu Y*, Sesterterpenoids, Natural Product Report 2013, 30, 455-473.
2. Sun J, Han Z, Zhou X, Yang Y, Lin X, Liu J, Peng Y, Yang X, Liu Y*, Antifouling briarane type diterpenoids from South China Sea gorgonians Dichotella gemmacea, Tetrahedron 2013,69, 971-880.
3. Zhou X, Liu J, Yang B, Lin X, Yang X, Liu Y*, Marine Natural Products with Anti-HIV Activities in the Last Decade, Current Medicinal Chemistry 2013, 20(7), 953-973.
4. Peng Y, Xie E, Zheng K, Fredimoses M, Yang Y, Zhou X, Wang Y, Yang B, Lin X, Liu J, Liu Y*. Nutritional and Chemical Composition and Antiviral Activity of Cultivated Seaweed Sargassum naozhouense Tseng et Lu. Marine Drugs 2013, 11, 20-32.
5. Yang X, Zhang G, Ying J, Yang B, Zhou X, Steinmetz A, Liu Y*, Wang N. Isolation, characterization, and bioactivity evaluation of 3-((6-methylpyrazin-2-yl) methyl) - 1H-indole, a new alkaloid from a deep-sea-derivated actinomycete Serinicoccus profundi sp. nov. Marine Drugs 2013, 11, 33-39.
6. Zhou X, Lin X, Guo X, Yang Y, Yang X, Liu Y*, Chemical Constituents of the Sponge Mycale Species from South China Sea, Records of Natural Products 2013, 7, 119-123.
7. Yang B, Tao H, Zhou X, Lin X, Liu Y*. Two new alkaloids from marine sponge Callyspongia sp. Natural Product Research 2013, 27(4-5), 433-437.
8. Huang RM, Peng Y, Zhou XF, Fu MQ, Tian S, Liu Y*. A new pyrimidinedione derivative from the gorgonian coral Verrucella umbraculum. Natural Product Research 2013, 27(4-5), 319-322.
9. Guo Z, Chai X, Yang B, Zhou X, Liu Y*, Tu P. Sesquiterpenoids from a South China Sea gorgonian Menella sp. Journal of Chinese Pharmaceutical Science 2013, 22 (3), 282–285.
2012论文
10. Yang B, Zhou X, Huang H, Yang X, Liu J, Lin X, Li X, Peng Y, Liu Y*. New Cembrane Diterpenoids from a Hainan Soft Coral Sinularia sp. Marine Drugs 2012, 10, 2023-2032.
11. Lin X, Zhou X, Wang F, Liu K, Yang B, Yang X, Peng P, Liu L, Ren Z, Liu Y*. A new cytotoxic sesquiterpene quinone produced by Penicillium sp. F00120 isolated from a deep sea sediment sample. Marine Drugs 2012, 10, 106-115.
12. Chen J, Lan X, Liu Y*, Jia A. In vitro effects of natural diketopiperazines on release of cytokines and chemokines in J774A.1 macrophages. Bioorganic Medicinal Chemistry Letter 2012, 16, 3177-3180.
13. Liao X, Tang L, Liang Y, Jian S, Xu S, Liu Y*. New pentahydroxylated steroids from the South China Sea gorgonian Subergorgia suberosa Chemistry & Biodiversity 2012, 9, 370-375.
14. Kim E, Li J, Dang H, Hong J, Lee C, Kim D, Yoon W, Kim E, Liu Y, Jung J. Cytotoxic cytochalasins from the endozoic fungus Phoma sp. of the giant jellyfish Nemopilema nomurai. Bioorganic & Medicinal Chemistry Letters 2012, 22, 3126–3129.
15. Yang B, Zhou X, Lin X, Liu J, Peng Y, Yang X, Liu Y*. Cembrane diterpenes chemistry and biological properties. Current Organic Chemistry 2012, 16(12), 1512-1539.
16. Liu Y*. Renaissance of Marine Natural Product Drug Discovery and Development. Journal of Marine Science Research & Development 2012, 2:2 http://dx.doi.org/10.4172/2155-9910.1000e106.
17. Yang B, Hu J, Lei H, Chen XC, Zhou XF, Liu Y*. Chemical constituents of marine sponge Callyspongia sp. from the South China Sea. Chemistry of Natural Compounds 2012, 48(2), 350-351.
18. He WH, Lin L, Xu T, Jung JH, Yin H, Yang B, Liu Y*. A new norsesterterpenoid from the sponge species Sarcotragus. Chemistry of Natural Compounds 2012, 48(2), 208-210.
19. Li W, Wang L, Zhao D, Liu Y*. Steroidal alkaloids from Veratrum nigrum L. Chemistry of Natural Compounds 2012, 48(5), 919-920.
20. Huang R, Wang B, Liu Y*. Briarane-type diterpenoids from the gorgonian coral Verrucella umbraculum. Chemistry of Natural Compounds 2012, 48(3), 516-517.
2011年
21. Yang X, Dong G, Zhou X, Chai X, Li Y, Yang B, Zhang W, Liu Y*. Antitumor steroids from the starfish Archaster typicus. Food Chemistry 2011, 124, 1634-1638.
22. Sun J, Huang H, Chai X, Yang X, Meng L, Huang C, Zhou X, Yang B, Hu J, Chen X, Lei H, Wang L, Liu Y*. Dichotellides A-E, five new iodine-containing briarane type diterpenoids from Dichotella gemmacea. Tetrahedron 2011, 67, 1245-1250.
23. Wang L, Zhao D, Di L, Cheng D, Zhou X, Yang X, Liu Y*. The anti-hyperplasia of mammary gland effect of Thladiantha dubia root ethanol extract in rats reduced by estrogen and progestogen. Journal of Ethnopharmacology 2011, 134, 136-140.
24. Dong G, Yang X, Zhou X. Liu Y*. Chemical constituents and bioactivities of starfish. Chemistry & Biodiversity 2011, 8(5), 740-791.
25. Liu Y*, Jung J, Xu T, Long LJ, Lin XP, Yin H., Yang B, Zhou XF, Yang XW. New cyclitol derivative from a sponge Sarcotragus species. Natural Products Research 2011, 25(6), 648-652.
26. Hu J, Yang B, Lin X, Zhou X, Yang X, Long L, Liu Y*. Chemical and Biological Studies of Soft Corals Nephtheidae Family. Chemistry & Biodiversity 2011, 8, 1011-1032.
27. Liu Y*, Yan H, Wen K, Zhang J, Xu T, Wang L, Zhou X, Yang X. Identification of epidioxysterol from South China Sea urchin Tripneustes gratilla Linnaeus and its cytotoxic activity. Journal of Food Biochemistry 2011, 35, 932-938.
28. Huang R, Zhou X, Peng Y, Yang X, Xu T, Liu Y*. Nucleosides from the marine sponge Callyspongia sp. Chemistry of Natural Compounds 2011, 46, 1010-1011.
29. Wang L, Zhao D, Di L, Xu T, Lin X, Yang B, Zhou X, Yang X, Liu Y*. The analgesic and anti-rheumatic effects of Thladiantha dubia fruit crude polysaccharide fraction in mice and rats. Journal of Ethnopharmacology 2011, 137, 1381-1387.
30. Zhou X, Lu Y, Lin X, Yang Y, Yang X, Liu Y. Brominated aliphatic hydrocarbons and sterols from the sponge Xestospongia testudinaria with their bioactivities Chemistry and Physics of lipids 2011, 164, 703-706.
31. Yang X, Li Y, Li S, Shen Y, Tian J, Zhu Z, Feng L, Wu, L, Lin, S, Wang, N, Liu Y, Zhang W. Mono- and sesquiterpenoids, flavonoids, lignans, and other miscellaneous compounds of Abies georgei. Planta Medica 2011, 77(7), 742-748.
2010年
32. Huang R, Zhou X, Xu T, Yang X, Liu Y*. Diketopiperazines from marine organisms. Chemistry & Biodiversity 2010, 7, 2809-2829.
33. Chai X, Sun J, Tang L, Yang X, Li Y, Huang H, Zhou X, Yang B, Liu Y*. A novel cyclopentene derivative and a polyhydroxylated steroid from a South China Sea gorgonian Menella sp. Cheimcal & Pharmaceutical Bulletin 2010, 58(10), 1391-1394.
34. Peng Y, Zheng J, Huang R, Wang Y, Xu T, Zhou X, Liu Q, Zeng F, Ju H, Yang X, Liu Y*. Polyhydroxysteroids and saponins from the China Sea starfish Asterina sp. and their biological activities. Chemical & Pharmaceutical Bulletin 2010, 58(6), 856-858.
35. Zhou X, Xu T, Wen K, Yang X, Xu S, Liu Y*. A new N-acyl taurine from the sea urchin Glyptocidaris crenularis. Bioscience, Biotechnology and Biochemistry 2010, 74(5), 1089-1091.
36. Zhou X, Liu Y, Tang L, Zhang P, Wu J. Chemical constituents from the roots of Actinidia chinensis. Chemistry of Natural Compounds 2010, 46(2), 308-309.
37. Zhou X, Wen K, Yang X, Huang R, Dong G, Yang B, Sun J, Liu Y*. Chemical constituents from the sea urchin Glyptocidaris crenularis. Biochemical Systematics and Ecology 2010, 38, 103-105.
38. Huang L, Wen K, Gao X, Liu Y*. Hypolipidemic effect of fucoidan from Laminaria japonica in hyperlipidemic rats. Pharmaceutical Biology 2010, 48(4), 422-426.
39. Liu J, Wang L, Zhao D, Cheng D, Xu T, Zhou X, Yang X, Liu Y*. A new lignan from Saururus chinensis. Chemistry of Natural Compounds 2010, 46(4), 631-632.
40. Wang L, Zhou X, Xu T, Yang X, Liu Y*. Lignans from Saururus chinensis. Chemistry of Natural Compounds 2010, 46(3), 451-452.
41. Xu Y, Liu Y, Xu T, Xie S, Si Y, Liu Y, Zhou H, Liu T, Xu D. A new furostanol glycoside from Tribulus terrestris. Molecules 2010, 15, 613-618.
42. Xu Y, Bai L, Liu Y, Xu T, Liu Y, Xie S, Si Y, Zhou H, Liu T, Xu D. A new triterpenoid saponin from Pulsatilla cernua. Molecules 2010, 15, 1891-1897.
43. Huang R, Ma W, Dong J, Zhou X, Xu T, Lee K, Yang X, Xu S, Liu Y*. A new 1,4-diazepine from South China Sea marine sponge Callyspongia species. Molecules 2010, 15, 871-877.
44. Ren S, Ma W, Xu T, Lin X, Yin H, Yang B, Zhou X, Yang X, Long L, Lee K, Gao Q, Liu Y*. Two novel alkaloids from the South China Sea marine sponge Dysidea sp. Journal of Antibiotics 2010, 63, 699-701.
45. Lei H, Zhou X, Yang Y, Xu T, Yang X, Sun J, Yang Y, Hu J, Lin X, Long L, Liu Y*. Bryostatins from South China Sea bryozoan Bugula neritina L. Biochemical Systematics and Ecology 2010, 38, 1231-1233.
46. Yang X, Li S, Li Y, Xia J, Wu L, Shen Y, Tian J, Wang N, Liu Y, Zhang W. Abiespiroside A, an Unprecedented Sesquiterpenoid Spirolactone with a 6/6/5 Ring System from Abies delavayi. European Journal of Organic Chemistry 2010, 34, 6531-6534.
47. Yang X, Li S, Wu L, Li Y, Feng L, Shen Y, Tian J, Tang J, Wang N, Liu Y, Zhang W. Abiesatrines A-J: anti-inflammatory and anti-tumor triterpenoids from Abies georgei Orr. Organic & Biomolecular Chemistry 2010, 8, 2609-2616.
48. Yang X, Feng L, Li S, Liu X, Li Y, Wu L, Shen Y, Tian J, Zhang X, Liu X, Wang N, Liu Y, Zhang, W. Isolation, structure, and bioactivities of abiesadines A–Y, twenty-five new diterpenes from Abies georgei Orr. Bioorganic Medicinal Chemistry 2010, 18, 744-754.
49. Zhou X, Xu T, Yang X, Xu S, Liu Y*. Chemical and biological aspects of marine sponge of the genus Xestospongia. Chemistry & Biodiversity 2010, 7, 2201-2227.
2009年
50. Zhou X, Tang L, Zhang P, Zhao X, Pi H, Zhang Y, Ruan H, Liu Y, Wu J. The interleukin-18 inhibitory activities of echinocystic acid and its saponins from Impatiens pritzellii var. hupehensis. Zeitschrift Fur Naturforschung 2009, 64c, 369-372.
51. Zhou X, Tang L, Liu Y. An isomeric mixture of novel cerebrosides isolated from Impatiens pritzellii reduces lipopolysaccharide-induced release of IL-18 from human peripheral blood mononuclear cells. Lipids 2009, 44(8), 759-763.
52. Wang L, Zhao D, Xu T, Zhou X, Yang X, Liu Y*. A new triterpene hexaglycoside from the bark of Kalopanax septemlobus (Thunb.) Koidz. Molecules 2009, 14, 4497-4504.
53. Wang L, Cheng D, Wang H, Di L, Zhou X, Xu T, Yang X, Liu Y*. The hepatoprotective and antifibrotic effects of Saururus chinensis against carbon tetrachloride induced hepatic fibrosis in rats. Journal of Ethnopharmacology 2009, 126, 487-491.
54. Yang B, Dong J, Zhou X, Yang X, Lee K, Wang L, Zhang S, Liu Y*. Proline-containing dipeptides from the marine sponge a Callyspongia species. Helvetica Chimica Acta 2009, 92, 1112-1117.
55. Wang B, Dong J, Zhou X, Lee KJ, Huang R, Zhang S, Liu Y*. Nucleosides from marine sponges including known ones from Haliclona sp. Zeitschrift Fur Naturforschung 2009, 64c, 143-148.
56. Wang B, Lee K, Zhang S, Jung J, Liu Y*. 2-Palmitamidoethanesulfonic acid, new aminoethylsulfonic acid derivative from marine sponge Haliclona sp. Chemistry of Natural Compounds 2009, 45(1), 137-138.
57. Wang L, Zhao D, Liu Y*. GC-MS analysis of the supercritical CO2 fluid extraction of Ephedra sinica roots and its antisudorific activity. Chemistry of Natural Compounds 2009, 45(3), 434-436.
2008年
58. Wang L, Zhao D, Cheng D, Liu Y*. ent-Sauchinone from Saururus chinensis. Heterocycles 2008, 75(5), 1241-1246.
59. Yin H, Zhang S, Luo X, Liu Y*. Preparative isolation and purification of two benzoxazinoid glucosides from Acanthus ilicifolius L. by high-speed counter-current chromatography. Journal of Chromatography A 2008, 1205, 177-181.
60. Jiang S, Li X, Zhang L, Sun W, Dai S, Xie L, Liu Y, Lee K. Culturable actinobacteria isolated from marine sponge Iotrochota sp. Marine Biology 2008, 153(5), 945-952.
61. Liu Y*, Murakami N, Wang L, Zhang S. Preparative high-performance liquid chromatography for the purification of natural acylated anthocyanins from red radish (Raphanus sativus L). Journal of Chromatographic Science 2008, 46(8), 743-746.
62. Liu Y*, Ji H, Zhang S, Jung J, Xu T. Trisoxazole macrolides from the sponge Sarcotragus species. Chemistry of Natural Compounds 2008, 44(1), 140-141.
63. Liu Y*, Ji H, Dong J, Zhang S. Lee K, Matthew S. Antioxidant alkaloid from South China Sea marine sponge Iotrochota sp. Zeitschrift Fur Naturforschung 2008, 63c, 636-638.
64. Wang L, Zhao D, Liu Y*. Quality assessment of Veratrum nigrum L. by LC-ELSD fingerprints and LC quantitative analysis. Chromatographia 2008, 68, 961-967.
65. Tao H, Wang L, Cui Z, Zhao D, Liu Y*. Dimeric proanthocyanidins from roots of Ephedra sinica Stapf. Planta Medica 2008, 74, 1823-1825.
66. Wang L, Li W, Liu Y*. Hypotensive effect and toxicology of total alkaloids and veratramine from roots and rhizomes of Veratrum nigrum L. in spontaneously hypertensive rats. Pharmazie 2008, 63(8), 606-610.
2007年
67. Liu Y*, Wang L, Jung J, Zhang S. Sesterterpenoids. Natural Product Reports 2007, 24(6), 1401-1429.
68. Liu Y*, Zhang S, Jung J, Xu T. Variabilin, a chemotaxonomic marker for the familly Irciniidae. Zeitschrift Fur Naturforschung 2007, 62c, 473-476.
69. Liu Y*, Ji H, Zhang S, Murakami N, Xu T. Structure-activity relationships of 1’- acetoxychavicol acetate homologues as new nuclear export signal inhibitors. Pharmazie 2007, 62(9), 659-662.
70. Liu Y*, Murakami N, Abreu P, Ji H, Zhang S. Antimalarial flavonol glycosides from Euphorbia hirta. Pharmaceutical Biology 2007, 45(4), 278-281.
71. Jiang S, Sun W, Chen M, Dai S, Zhang L, Liu Y, Lee K, Li X. Diversity of culturable actinobacteria isolated from marine sponge Haliclona sp. Antonie Van Leeuwenhoek International Journal of General and Molecular Microbiology 2007, 92(4), 405-416.
72. Abreu P. Liu Y, Ozoroalide, a new macrolide from Ozoroa insignis. Fitoterapia 2007, 78, 388-389.
73. Jung J, Shinde P, Hong J, Liu Y, Sim C. Secondary metabolites from a marine sponge Discodermia calys. Biochemical Systematics and Ecology 2007, 35, 48-51.
2006年
74. Liu Y*, Zhang S, Abreu P. Heterocyclic terpenes: linear furano-and pyrroloterpenoids. Natural Product Reports 2006, 23(4), 630-651.
75. Liu Y, Abreu P. Tirucallane triterpenes from the roots of Ozoroa insignis. Phytochemistry 2006, 67, 1309-1315.
76. Liu Y, Abreu P. Long chain alkyl and alkenyl phenols from Ozoroa insignis. Journal of the Brazilian Chemical Society 2006, 17(3), 527-536.
77. Liu Y*, Jung J, Zhang S. Linear pyrrolosesterterpenes from a sponge Sarcotragus species. Biochemical Systematics and Ecology 2006, 34, 774-776.
78. Liu Y*, Jung J, Zhang S. Indole alkaloids from a sponge Sarcotragus species. Biochemical Systematics and Ecology 2006, 34(5), 453-456.
79. Liu Y*, Jung J, Ji H, Zhang S. Glycerolipids from a Sarcotragus species sponge. Molecules 2006, 11, 714-719.
80. Liu Y*, Jung J, Zhang S. An unsaturated ω-hydroxy methyl ester from a sponge Sarcotragus species. Chemistry of Natural Compounds 2006, 42(4), 487-488.
81. Lee Y, Liu Y, Jung J, Im D. Effect of sarcotride A on membrane potential in C6 glioma cells. Korean Society of Applied Pharmacology 2006, 14(2), 110-113.
其余论文
82. Liu Y, Shinde P, Hong J, Lee C, Im K, Jung J. Trisoxazole macrolide from a marine sponge Sarctragus species. Natural Product Sciences 2005, 11(1), 50-53.
83. Liu Y, Mansoor T, Hong J, Lee C, Sim C, Im K, Jung J. New cytotoxic sesterterpenoids and norsesterterpenoids from two sponges of the genus Sarcotragus. Journal of Natural Products 2003, 66(11), 1451-1456.
84. Park Y, Liu Y, Hong J, Lee C, Cho H, Kim D, Im K, Jung J. New bromotyrosine derivatives from an association of two sponges, Jaspis wondoensis and Poecillastra wondoensis. Journal of Natural Products 2003, 66(11), 1495-1498.
85. Zhao Q, Liu Y, Hong J, Lee C, Park J, Lee D, Jung J. A new cyclitol derivatives from a sponge Stelletta species. Natural Product Sciences 2003, 9(1), 18-21.
86. Liu Y, Hong J, Lee C, Im KS, Kim N, Choi J, Jung J. New cytotoxic furano- and pyrroloterpenoids from the sponge Sarcotragus species. Journal of Natural Products 2002, 65(9), 1307-1314.
87. Liu Y, Lee C, Hong, J, Jung J. Cyclitol derivatives from the sponge Sarcotragus species. Bulletin of the Korean Chemical Society 2002, 23(10), 1467-1469.
88. Wang W, Li F, Alam N, Liu Y, Hong J, Lee C, Jung J. New saponins from the starfish Certonardoa semiregularis. Journal of Natural Products 2002, 65(11), 1649-1656.
89. Liu Y, Bae B, Alam N, Hong J, Sim C, Lee C, Im K, Jung J. New cytotoxic sesterterpenes from the sponge Sarcotragus species. Journal of Natural Products 2001, 64(10), 1301-1304.


奖励(1) 海南省科技进步奖,一等奖,省级,2010,第15名
(2) 热带海洋生物活性物质的利用技术,二等奖,国家级,2007 第11名

(3) 吉林省科技进步奖,二等奖,省级,2011,第3名

课题组成员杨献文副研究员
周雪峰副研究员
林秀萍助理研究员
杨斌助理研究员
刘娟助理研究员
廖升荣助理研究员
王俊峰助理研究员

专利与奖励

奖励信息 (1) 三白草等5种药材药效活性物质基础及制剂"消肝纤胶囊"的研究,二等奖,省级,2011
(2) 海南省科技进步奖,一等奖,省级,2010
(3) 热带海洋生物活性物质的利用技术,二等奖,国家级,2007


专利成果 (1) 一种海胆提取物及其制备方法和抗癌应用,发明,2010,第1作者,专利号:ZL**4.4
(2) 一种二聚黄酮化合物及其制备方法和抗癌应用,发明,2010,第1作者,专利号:ZL**6.3
(3) 一种治疗高血压的海洋药物及其制备方法和分散片 ,发明,2009,第1作者,专利号:ZL**6.0
(4) 1.西松烷型二萜flexibilide或其可药用盐在制备PGC-1α抑制剂中的应用,发明,2012,第5作者,专利号:2012

出版信息

发表论文 (1) Peng Y, Xie E, Zheng K, Fredimoses M, Yang Y, Zhou X, Wang Y, Yang B, Lin X, Liu J, Liu Y. Nutritional and Chemical Composition and Antiviral Activity of Cultivated Seaweed Sargassum naozhouense Tseng et Lu.,Marine Drugs ,2013,通讯作者
(2)Isolation, characterization, and bioactivity evaluation of, Marine Drugs,2013,通讯作者
(3) Sesterterpenoids,Natural product Reports,2013,通讯作者
(4) Two new alkaloids from marine sponge Callyspongia sp. ,Natural product research ,2013,通讯作者
(5) Marine Natural Products with Anti-HIV Activities in the Last Decade ,CURRENT MEDICINAL CHEMISTRY,2013,通讯作者
(6) Antifouling briarane type diterpenoids from South China Sea gorgonians Dichotella gemmacea.,Tetrahedron,2013,通讯作者
(7) Nucleosides from the marine sponge Callyspongia sp. ,Chemistry of Natural Compounds,2011,通讯作者
(8) Dichotellides A-E, five new iodine-containing briarane type diterpenoids from Dichotella gemmacea.,Tetrahedron,2011,通讯作者
(9) The anti-hyperplasia of mammary gland effect of Thladiantha dubia root ethanol extract in rats reduced by estrogen and progestogen., Journal of Ethnopharmacology,2011,通讯作者
(10) Chemical constituents and bioactivities of starfish. ,Chemistry Biodiversity,2011,通讯作者
(11) New cyclitol derivative from a sponge Sarcotragus species. ,Natural Products Research,2011,通讯作者
(12) Chemical and Biological Studies of Soft Corals Nephtheidae Family. ,Chemistry Biodiversity,2011,通讯作者
(13) Identification of epidioxysterol from South China Sea urchin Tripneustes gratilla Linnaeus and its cytotoxic activity. ,Journal of Food Biochemistry,2011,通讯作者
(14) Antitumor steroids from the starfish Archaster typicus,Food Chemistry ,2011,通讯作者
(15) A new 1,4-diazepine from South China Sea marine sponge Callyspongia species. ,Molecules,2010,通讯作者
(16) Lignans from Saururus chinensis. ,Chemistry of Natural Compounds,2010,通讯作者
(17) A new lignan from Saururus chinensis. ,Chemistry of Natural Compounds,2010,通讯作者
(18) Hypolipidemic effect of fucoidan from Laminaria japonica in hyperlipidemic rats. ,Pharmaceutical Biology,2010,通讯作者
(19) Chemical constituents from the sea urchin Glyptocidaris crenularis. ,Biochemical Systematics and Ecology,2010,通讯作者
(20) A new N-acyl taurine from the sea urchin Glyptocidaris crenularis. ,Bioscience, Biotechnology and Biochemistry ,2010,通讯作者
(21) Polyhydroxysteroids and saponins from the China Sea starfish Asterina sp. and their biological activities. ,Chemical Pharmaceutical Bulletin,2010,通讯作者
(22) A novel cyclopentene derivative and a polyhydroxylated steroid from a South China Sea gorgonian Menella sp. ,Cheimcal Pharmaceutical Bulletin,2010,通讯作者
(23) Bryostatins from South China Sea bryozoan Bugula neritina L.,Biochemical Systematics and Ecology,2010,通讯作者
(24) Chemical and biological aspects of marine sponge of the genus Xestospongia. ,Chemistry Biodiversity,2010,通讯作者
(25) Two novel alkaloids from the South China Sea marine sponge Dysidea sp. ,Journal of Antibiotics,2010,通讯作者
(26) 2-Palmitamidoethanesulfonic acid, new aminoethylsulfonic acid derivative from marine sponge Haliclona sp. ,Chemistry of Natural Compounds,2009,通讯作者
(27) Nucleosides from marine sponges including known ones from Haliclona sp. ,Zeitschrift Fur Naturforschung,2009,通讯作者
(28) Proline-containing dipeptides from the marine sponge a Callyspongia species. ,Helvetica Chimica Acta,2009,通讯作者
(29) he hepatoprotective and antifibrotic effects of Saururus chinensis against carbon tetrachloride induced hepatic fibrosis in rats. ,Journal of Ethnopharmacology ,2009,通讯作者
(30) A new triterpene hexaglycoside from the bark of Kalopanax septemlobus (Thunb.) Koidz. ,Molecules,2009,通讯作者
(31) GC-MS analysis of the supercritical CO2 fluid extraction of Ephedra sinica roots and its antisudorific activity. ,Chemistry of Natural Compounds,2009,通讯作者


发表著作 (1) 海洋药妆品的化学性质,Chemical Properties of Marine Cosmeoceuticals,TaylorFrancis CRC Press,2011-11,第1作者
(2) 藻类活性产物,Bioactive metabolites from seaweeds,Wiley-Blackwell publisher,2011-10,第5作者
(3) 传统利尿药-泽泻,Alisma orientale (Sam.) Juzep., a Common Traditional Chinese Medicine Plant as a Diuretic Agent, Stadium Pree LLC, U.S.A.,2009-01,第3作者
(4) 活性海绵呋喃二倍半萜,Bioactive furanosesterterpenoids from marine sponge,Springer-Verlag Berlin Heidelberg Press,2007-02,第1作者


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