基本信息
马旅雁 女 博导 微生物研究所
电子邮件：luyanma27@im.ac.cn
联系电话：
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通信地址：北京市海淀区北四环西路10号
邮政编码： 100190


研究领域Biofilm(生物被膜) 是附着于载体表面的微生物膜性聚合物(surface-associated communities ), 是微生物在自然界的普遍存在方式。据估计，60%以上的细菌感
染都是由生物被膜形成而造成的。由细菌生物被膜所引发的感染是造成难治疗的感染性疾病的重要原因之一。目前开展以下几方面的研究：

1. 细菌生物被膜形成的分子机理；

2. 生物被膜形成直接相关的关键多糖的合成与代谢调控；

3. 细胞程序性死亡与细菌生物被膜形成与发育；

4. 细菌生物被膜的防治及其应用。


招生信息2012年拟招硕士生1名、博士生2名。

招生专业微生物学
生物化学与分子生物学



招生方向微生物生理
环境微生物


教育背景1991 学士 北京农业大学生物学院
1996 理学博士 中国农业大学生物学院微生物系

工作经历1996-1998 讲师 中国农业大学农业生物技术国家重点实验室
1998-1999 博士后 法国巴斯德研究所
1999-2002 副教授 中国农业大学生物学院微生物系
2000-2004 访问学者 美国康涅狄克大学(University of Connecticut)医学院
2005-2008 访问学者 美国北卡罗来纳州WAKE FOREST大学
2008-2010 助理教授 俄亥俄州立大学(the Ohio State University)
2010年5月至今 研究员 中国科学院微生物研究所资源前期开发国家重点实验

指导学生
发表文章1. Byrd, M.S., Sadovskaya, I., Vinogradov, E., Lu, H., Sprinkle, A., Richardson, S., Ma, L-Y., Ralston, B., Parsek, M.R., Lam, J. and Wozniak, D.J. (2009) Genetic and Biochemical Analyses of the Pseudomonas aeruginosa Psl Exopolysaccharide Reveals Overlapping Roles for Polysaccharide Synthesis Enzymes in Psl and LPS Production. Mol. Microbiol. 73(4) 622-638.
2. Starkey, M., Hickman, J.H., Ma, L-Y., Zhang, N., Long, S.D., Hinz, A., Palacios, S., Maoil, C., Kirisits, M., Starner, T., Wozniak, D.J., Hardwood, C.S. and Parsek, M.R. (2009) Pseudomonas aeruginosa rugose small colony variants have adtaptions that likely promote persistence in the cystic fibrosis lung. J. Bacteriol. 191:3492-3503.
3. Ma, L-Y., Conover, M., Lu, H., Parsek, M. R., Bayles, K. and Wozniak, D.J. (2009) Assembly and development of the Pseudomonas aeruginosa biofilm matrix. Plos Pathogens 5: e**.
4. Huigens, R. W., Ma, L-Y., Gambino, C. D., Moeller, P.D., Basso, A., Cavanagh, J. D., Wozniak, J., and Melander, C. (2008) Control of bacterial Biofilms with marine alkaloid derivatives. Molecular Biosystems. 4(6):614-621.
5. Ma, L-Y., Parsek, M. R. and Wozniak, D.J. (2007) Pseudomonas aeruginosa Psl is a galactose- and mannose-rich exopolysaccharide. J. Bacteriol. 189:8353-8356.
6. Ma, L-Y., Jackson, K., Parsek, M. R. and Wozniak, D.J. (2006) Analysis of Pseudomonas aeruginosa conditional Psl variants reveals roles for the Psl as an adhesin and in maintaining biofilm structure post-attachment. J. Bacteriol. 188:8213-8221.
7. Taghbalout, A., Ma, L-Y., Rothfield, L. (2006) Role of MinD-membrane association in Min protein interaction. J. Bacteriol. 188:2993-3001.
8. Cui, Y., Tu, R., Guan, Y., Ma, L-Y., Chen, S. (2006) Cloning, sequencing, and characrization of the Azospirillum brasilense flue Gene. Curr. Microbiol. 52(3):169-177.
9. Ma, L-Y., King, G., Rothfield, L. (2004) Positioning of MinE and MinC binding sites on the MinD surface provides a mechanism for activation of the E. coli MinD ATPase during division site selection. Mol. Microbiol. 54(1):99-108.
10. Schimanski, B., Ma, L-Y., Gunzl, A.(2004) Failure to detect binding of Trypanosoma brucei SNAPc to U2 and U6 snRNA genes by in vitro transcription competition and pull-down assays. Molecular & Biochemical Parasitology. 137:293-296.
11. Ma, L-Y., King, G., Rothfield, L. (2003) Mapping the MinE Site involved in interaction with the MinD division site selection protein of Escherichia coli. J. Bacteriol. 185:4948-4955.
12. Desnoues, N., Li, M., Guo, X., Ma, L-Y., Carreno-Lopez, R., Elmerich, C.(2003) Nitrogen fixation genetics and regulation in Pseudomonas stutzeri strain associated with rice. Microbiology. 149:2251-2262.
13. Wang, J , Chen, S-F., Ma, L-Y., , Li, J-L.(2001) Cloning , sequencing and expression pattern, functional analysis of nifA in Azospirillum brasilense Yu62. Acta Microbiologia Sinica. 41:655-661(in Chinese ).
14. Ma, L-Y., Wu, Y. Wang, J., Zhao, Y-S., Li, J-L.(1999) Site-directed mutagenesis analysis of draTG genes and their downstream region from Azospirillum brasilense Yu62. Chinese J. of Biotechnology 15:281-287 (in Chinese ).
15. Ma, L-Y. and Li, J-L.(1998) Advance in genetics researches of nitrogen fixation(a review). In Engineering of Agriculural Biology. Man, K-Q., Chen, S-Y., Li, J-L., Zhu, Y-D.(eds.). Chemical Industry Publisher. p15-48. (in Chinese )
16. Ma, L-Y. and Li, J-L.(1997) Advance in genetics of Azospirillum and plant-root interactions (a review). High Technology letters 11:56-59. (in Chinese )
17. Ma, L-Y. and Li, J-L.(1997) Sequencing and analysis of function of the upstream region of draTG genes from Azospirillum brasilense Yu62. Chinese J. of Biotechnology 13(4):343-349 (in Chinese and English).
18. Ma, L-Y. and Li, J-L.(1997) Cloning and sequencing of draTG genes and downstream region from Azospirillum brasilense Yu62. Chinese J. of Biotechnology 13(3):227-235 (in Chinese and English).
19. Yan, D-L., He, L-H., Ma, L-Y., Li, J-L.(1995) Effect of Klebsiella pneumoniae nifA on the regulation of nif gene expression by ammonia in Azospirillum brasilense. Chinese J. of Biotechnology 11(4):385-388. (in Chinese )
20. Yan, D-L., He, L-H., Ma, L-Y., Li, J-L.(1995) Transcriptional activation of Azospirillum brasilense nifH promoter by NifA of Klebsiella pneumoniae. Chinese J. of Biotechnology 11(3):205-210. (in Chinese)
21. Ma, L-Y., Yan, D-L., He, L-H., Li, J-L.(1994) Insertion mutagensis used in nitrogen-fixing bacteria (a review). Microbiology 21:101-105 . (in Chinese )
22. Nan, Q-X., Ren, F-ZH., Yang, Z-B., Zhang, X-J., Ma, L-Y.(1992) Studies on the forming process of milk fan in Yun nan province. Chinese J. of Animal Science 28(2):25-27.