基本信息
聂广军 男 博导 国家纳米科学中心
电子邮件：niegj@nanoctr.cn
通信地址：中关村北一条11号
邮政编码：100190

聂广军，博士生导师。2002年于中国科学院生物物理所获博士学位，之后在加拿大McGill大学从事博士后研究。2008年中科院“百人计划”回国，建立了“纳米-生物界面化学”实验室，开展纳米结构和生物体相互作用的界面化学和调控机制等方面的研究。目前工作主要结合化学、纳米和生物技术、生物材料和生物化学等手段，研究纳米和生物界面相互作用的基本化学规律，以及新型纳米结构在生物医学领域的应用。05年来在Blood，JACS, Angew Chem, JBC, Small, Biomaterials, British Journal of Haematology, Antioxidants Redox Signaling等专业期刊发表30余篇文章。获中国科学院“百人计划”海外杰出人才择优支持；主持科技部重大研究计划（973）项目；The Methodist Hospital Research Institute（美国休斯敦）和华东理工大学（中国上海）兼职教授。

研究领域研究领域主要包括肿瘤纳米生物学、纳米生物技术和纳米生物效应与安全性。目前主要从事的研究方向包括：1）纳米药物调控肿瘤微环境、纳米药物输运和膜囊泡系统在纳米材料机体代谢中的作用机制；2）生物分子指导的功能性纳米材料设计、构筑和多层次组装机制以及在生物医学上的应用；3）机体铁代谢的表观遗传学机制和铁代谢相关疾病病生理机制研究。
招生信息招收纳米生物和纳米医学交叉领域的博士和硕士；
招生专业包括：生物学、医学、化学、生物材料、物理化学和生物物理学等方向；

招生方向 纳米生物学，纳米肿瘤学，化学生物学，
血液学，细胞生物学
纳米毒理学
教授课程 纳米生物学和纳米技术
科研活动

科研项目 （1） 973基于肿瘤微环境调控的纳米材料设计和抗肿瘤机制研究，主持，国家级，2012-01--2016-12
（2） 细胞铁代谢的调控机制，主持，国家级，2010-01--2012-12
（3） 973 水污染检测和治理的纳米技术研究，参与，国家级，2010-01--2014-12

指导学生已指导学生

张英慧 博士研究生 070304-物理化学

现指导学生

宁波 博士研究生 070304-物理化学

魏文博 博士研究生 070304-物理化学

张文娣 硕士研究生 070304-物理化学

王海 博士研究生 070304-物理化学

饶子渔 硕士研究生 085238-生物工程

季天骄 硕士研究生 071011-生物物理学

宋晓 博士研究生 070304-物理化学

刘罡 博士研究生 070304-物理化学

林耀新 硕士研究生 071011-生物物理学

郭珊珊 硕士研究生 071011-生物物理学

近期发表文章29. Xin Tian, Motao Zhu, Yanhua Tian, Ramm A. Grant, Yuliang Zhao*, Guangjun Nie*, A membrane vesicle-based dual vaccine against melanoma and Lewis lung carcinoma, Biomaterials, in press.

28. Motao Zhu, Xin Tian, Xiao Song, Yanhua Tian, Yuliang Zhao, and Guangjun Nie*, Nanoparticle-Induced Exosomes Target Antigen-Presenting Cells to Initiate Th1-Type Immune Activation, Small, in press.

27. Gang Liu, Shiwen Niu, Ailian Dong, Hao Cai, Gregory J Anderson, Bing Han* and Guangjun Nie*, A Chinese family carrying novel mutations in the SEC23B and HFE2 genes, British Journal of Haematology, published online: 2012 Mar 20, DOI: 10.1111/j.1365-2141.2012.09102.x.

26. Li Wan, Guangjun Nie, Jie Zhang, Baolu Zhao*, Overexpression of human wild-type amyloid precursor protein decreases the iron content and increases the oxidative stress of neuroblastoma SH-SY5Y cells, Journal of Alzheimer’s Disease, published online: 2012 Mar 26. DOI: 10.3233/JAD-2012-111169.

25. Motao Zhu, Yiye Li, Jian Shi, Weiyue Feng, Guangjun Nie*, and Yuliang Zhao*, Cellular responses to nanomaterials: exosomes as extrapulmonary signaling conveyors for nanoparticle-induced systemic immune activation, Small, 2012, 8, 404-412. (*corresponding authors) (Full paper published as the front cover and highlighted by MaterialsView entitled “Trojan horse causes nanoparticle allergy”).

24. Xuemei Zhou, Jinyao Lan, Gang Liu*, Ke Deng, Yanlian Yang, Guangjun Nie, Jiaguo Yu*, and Linjie Zhi*, Facet-mediated photodegradation of organic dye over hematite architectures by visible light, Angew Chem Int Ed, 2012, 51, 178-182.

23. Zhenlin Fan, Xiao Yang, Yiye Li, Suping Li, Shiwen Niu, Xiaochun Wu, Jingyan Wei*, Guangjun Nie*, Deciphering an underlying mechanism of differential cellular effects of nanoparticles: an example of Bach-1 dependent induction of HO-1 expression by gold nanorod, Biointerphases, 2012, 7, 10. (*corresponding authors)

22. Hao Chen, Ying Zhao, Hai Wang, Guangjun Nie* and Kaihui Nan*, Co-delivery strategies based on multifunctional nanocarriers for cancer therapy, Current Drug Metabolism, 2012 in press. (*corresponding authors)

21. Jinyao Lan, Xuemei Zhou, Gang Liu*, Jiaguo Yu, Jingchang Zhang, Linjie Zhi* and Guangjun Nie*, Enhancing photocatalytic activity of one-dimensional KNbO3 nanowires by Au nanoparticles under Ultraviolet and Visible-light, Nanoscale 2011 3, 5161-5167. (*corresponding authors)

20. Bo Ning, Gang Liu, Yuanyuan Liu, Xiufen Su, Gregory J Anderson, Xin Zheng, Yanzhong Chang, Mingzhou Guo, Yuanfang Liu, Yuliang Zhao and Guangjun Nie*, 5-aza-2'-deoxycytidine activates iron uptake and heme biosynthesis by increasing c-Myc nuclear localization and binding to the E-boxes of TfR1 and ferrochelatase genes, Journal of Biological Chemistry, 2011, 286, 37196-37206. (*corresponding author)

19. Hai Wang, Ying Zhao, Yan Wu, Kaihui Nan, Guangjun Nie* and Hao Chen*, Enhanced antitumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxyPEG-PLGA copolymer nanoparticles, Biomaterials, 2011, 32, 32, 8281-8290. (*corresponding authors)

18. Yiye Li, Yunlong Zhou, Hai-Yan Wang, Sarah Perrett, Yuliang Zhao*, Zhiyong Tang*, Guangjun Nie*, Chirality of glutathione surface coating affects the toxicity of quantum dots, Angew Chem Int Ed, 2011, 50, 5860-5864. (*corresponding authors) (Highlighted by Nature Materials).

17. Cuiji Sun, Hui Yang,Yi Yuan, Xin Tian, Liming Wang, Yi Guo, Li Xu*, Jianlin Lei, Ning Gao, Gregory J. Anderson, Xing-jie Liang, Chunying Chen, Yuliang Zhao*, Guangjun Nie*, Controlling assembly of paired gold clusters within apoferritin nanoreactor for in vivo kidney targeting and biomedical imaging, J Am Chem Soc, 2011, 133 (22), 8617–8624 (article) (*corresponding authors).

16. Zhuzhen Zhang, Fan Zhang, Peng An, Xin Guo, Yuanyuan Shen, Yunlong Tao, Qian Wu, Yuchao Zhang, Yu Yu, Bo Ning, Guangjun Nie, Mitchell D. Knutson, Gregory J Anderson, and Fudi Wang, Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses, Blood, 2011, 118, 1912-1922.

15. Gang Liu, Xiaoqing Li, Huijun Shu, Yu-lin Hu, Greg Anderson, Jiaming Qian* and Guangjun Nie*, Identification of two novel PBGD mutations in acute intermittent porphyria patients accompanying anemia in mainland China, Blood Cells, Molecules, & Diseases, 2011, 47, 2, 138-9.. (*corresponding authors).

14. Wendy Zhang, Baoyun Sun, Longze Zhang, Baolu Zhao, Guangjun Nie* and Yuliang Zhao*, Biosafety assessment of Gd@C82(OH)22 nanoparticles on Caenorhabditis elegans, Nanoscale，2011, 3, 2636–2641. (*corresponding authors).

13. Jia Fan, Jun-Jie Yin, Bo Ning, Xiaochun Wu, Ye Hu, Mauro Ferrari, Gregory J. Anderson, Jingyan Wei*, Yuliang Zhao* and Guangjun Nie*, Direct evidence for catalase and peroxidase activities of ferritin-platinum nanoparticles, Biomaterials, 2011, 32, 6, 1611-1618. (*corresponding authors)

12. Li Wan, Guangjun Nie, Jie Zhang, Yunfeng Luo, Peng Zhange, Zhiyong Zhang and Baolu Zhao, β-amyloid peptide increases levels of iron content and oxidative stress in human cell and C. elegans models of Alzheimer's disease, Free Radical Biology & Medicine, 2011, 50, 1, 122-129.

11. Qinghua Miao, Dongxue Xu, Zhi Wang, Li Xu, Tiewei Wang, Yan Wu*, David B. Lovejoy, Danuta S. Kalinowski, Des R. Richardson*, Guangjun Nie*, Yuliang Zhao, Amphiphilic hyper-branched co-polymer nanoparticles for the controlled delivery of anti-tumor agents, Biomaterials, 2010, 31, 7364-7375.

10. Wang, Y., LV, J., Ma, X., Wang, D., Ma, H., Chang, Y., Guangjun Nie, Jia, L., Duan, X. and Liang, X.J*. Specific hemosiderin deposition in spleen induced by a low dose of cisplatin: altered iron metabolism and its implication as an acute hemosiderin formation model. Current Drug Metabolism, 2010,11, 507-515.

9. Yinghui Zhang, Marc Mikhael, Dongxue Xu, Yiye Li, Shan Soe-Lin, Bo Ning, Wei Li, Guangjun Nie*, Yuliang Zhao, and Prem Ponka, Lysosomal Proteolysis Is the Primary Degradation Pathway for Cytosolic Ferritin and Cytosolic Ferritin Degradation Is Necessary for Iron Exit, Antioxidants & Redox Signaling, 2010, 13:7, 999-1009 (*corresponding author).

8. Soe-Lin, S, Mikhael, M, Apte, S, Kayembe, L, Guangjun Nie, Ponka, P. Both Nramp1 and DMT1 are necessary for efficient macrophage iron recycling, Experimental Hematology, 2010;38:609–617.

7. Shi Z*, Guangjun Nie,* Duan, X, Rouault, T, Wu, W, Ning, B, Zhang, N, Chang, Y, Zhao, B. Neuroprotective mechanism of mitochondrial ferritin on 6-hydroxydopamine induced dopaminergic cell damage: implication for neuroprotection in Parkinson’s disease. Antioxidants & Redox Signaling, 2010, 13:6, 783-796 (*co-first authors).

6. Xu J, Song J, Su J, Wei J*, Yu Y, Lv S, Li W, Guangjun Nie*. A new human catalytic antibody Se-scFv-2D8 and its selenium-containing single domains with high GPX activity. Journal of Molecular Recognition, 2010; 23: 352–359 (*corresponding authors).

5. Lu, Z*, Guangjun Nie*, Li, Y, Soe-Lin, S, Tao, Y, Cao, Y, Zhang, Z, Liu, N, Ponka, P, Zhao, B. Overexpression of mitochondrial ferritin sensitizes cells to oxidative stress via an iron-mediated mechanism. Antioxidant Redox Signaling 2009, 11: 8, 1791-803 (*co-first authors).

4. Guangjun Nie, Guohua Chen, Alex D. Sheftel, Kostas Pantopoulos and Prem Ponka. In Vivo Tumor Growth is Inhibited by Cytosolic Iron Deprivation Caused by the Expression of Mitochondrial Ferritin, Blood, 2006, 108:2428-34.

3. Zhongbi Lu, Guangjun Nie, Peter Belton, Huiru Tang and Baolu Zhao. Structure-activity relationship analysis of antioxidant ability and neuroprotective effect of gallic acid derivatives Neurochemistry International, 2006, 48:4, 263-74.

2. M. Priwitzerova, Guangjun Nie, A. Sheftel, D. Pospisilova, V. Divoky, P. Ponka. Functional Consequences of the Human DMT1 Mutation on Protein Expression and Iron Uptake. Blood, 2005, 106(12):3985-7.

1. Guangjun Nie, Alex Sheftel, Songwon Kim, Prem Ponka. Overexpression of Mitochondrial Ferritin Causes Cytosolic Iron Depletion and Changes Cellular Iron Homeostasis. Blood, 2005, 105:2161-7.

课题组简介课题组2008年成立，在纳米中心的支持下建立了“纳米-生物界面化学”实验室，主持了多项国家级科研项目，包括科技部重大科学计划纳米专项 2002CB934000、科技部863新材料领域专项 2009AA03Z335、基金委生命科学、化学、医学和数理学部等多项面上和青年项目、中科院百人计划项目以及横向合作项目等。

目前实验室有副研究员一名，助理研究员多名，助理工程师一名，纳米中心在学学生9名，联合培养学生4名，博士后多名，多名访问学者和学生。和美国、澳大利亚和加拿大等多个纳米医学和生命科学的多个著名实验室建立了良好的合作关系。目前实验室有5位中科院特聘访问教授，共同开展学科互补的科研合作。