申河清 男 博导 城市环境研究所
电子邮件：hqshen@iue.ac.cn
通信地址：福建厦门集美大道1799号
邮政编码：


研究领域暴露科学和环境污染与健康：人群暴露环境污染物及其健康效应研究，即环境监测，人群暴露检测，暴露标志物和效标志物，环境污染物的系统生物学效应，环境和表观基因相互作用等。
招生信息分析化学，生物化学，公共卫生学，环境毒理学研究方向的学士和硕士研究生/同等学历考生。

招生专业083001-环境科学
-
-
083001-环境科学
-
-
招生方向污染物暴露科学
暴露与健康效应

教育背景1991年6月，本科毕业于太原理工大学应用化学系；

1997年7月，硕士毕业于中科院大连化学物理研究所；

2005年3月，博士毕业于德国慕尼黑技术大学(Technical University Munich)。

学历-- 研究生


学位-- 博士


出国学习工作2001年12月-2005年03月: 德国慕尼黑技术大学(Technical University Munich)博士研究生；

2005年3月-2006年3月，慕尼黑赫姆霍茨中心-德国环境健康研究中心的生态化学研究所(Institute of Ecology Chemistry, Helmholtz Zentrum München - German Research Center for Environmental Health)博士后；

2006年4月-2009年3月在丹麦哥本哈根大学医院作研究学者(Senior Staff Cand. Sci., Dept. Growth and Reproduction, Copenhagen University, Rigshospitalets)。

工作经历

工作简历

社会兼职 2010-12--今 厦门大学兼职教授

教授课程
专利与奖励2010年中国科学院“百人计划”入选者


奖励信息

专利成果
出版信息发表论文：
2015
1. Mohmand J, Eqani SAMAS*, Fasola M, Alamdar A, Mustafa I, Ali N, Liu L, Peng S, Shen H*. Human exposure to toxic metals via contaminated dust: Bio-accumulation trends and their potential risk estimation. Chemosphere 2015, 132, 142-151.
2. Huang Q, Zhang J, Luo L, Wang X, Wang X, Alamdar A, Peng S, Liu L, Tian M, Shen H*. Metabolomics reveals disturbed metabolic pathways in human lung epithelial cells exposed to airborne fine particulate matter. Toxicol Res 2015 DOI: 10.1039/c5tx00003c
3. Peng S, Zhang J, Liu L, Zhang X, Huang Q, Alamdar A, Tian M, Shen H*. Newborn Meconium and Urinary Metabolome Response to Maternal Gestational Diabetes Mellitus: A Preliminary Case-Control Study. J Proteome Res. 02/2015; DOI: 10.1021/pr**
4. Wang X, Mu X, Zhang J*, Huang Q, Alamdar A, Tian M, Liu L, Shen H*. Serum metabolomics reveals that arsenic exposure disrupted lipid and amino acid metabolism in rats: a step forward in understanding chronic arsenic toxicity. Metallomics 2015 DOI: 10.1039/c5mt00002e
5. Subhani M, Mustafa I, Alamdar A, Katsoyiannis IA, Ali N, Huang Q, Peng S, Shen H*, Eqani SAMAS*. Arsenic levels from different land-use settings in Pakistan: bio-accumulation and estimation of potential human health risk via dust exposure. Ecotoxicol. Environ. Safety 2015, 115, 187-194
6. Peng S, Liu L, Zhang X, Heinrich J, Zhang J, Schramm K-W, Huang Q, Tian M, Eqani SAMAS, Shen H*. A Nested Case-Control Study Indicating Heavy Metal Residues in Meconium Associate with Maternal Gestational Diabetes Mellitus Risk. Environ. Health 2015, 14:19 DOI: 10.1186/s12940-015-0004-0
7. Gong M, Weschler CJ*, Liu L, Shen H, Huang L, Sundell J, Zhang Y. Phthalate metabolites in urine samples from Beijing children and correlations with phthalate levels in their handwipes. Indoor Air 2015. doi:10.1111/ina.12179
8. Wang X, Zhang J*, Huang Q, Alamdar A, Tian M, Liu L, Shen H*. Serum metabolomics analysis reveals impaired lipid metabolism in rats after oral exposure to benzo(a)pyrene. Mol. BioSyst. 2015, DOI: 10.1039/C4MB00565A
9. Liu L, She J, Zhang X, Zhang J, Tian M, Huang Q, Eqani SAMAS, Shen H*. Online background cleanup followed by high-performance liquid chromatography with tandem mass spectrometry for the analysis of perfluorinated compounds in human blood. J. Sep. Sci. 2015 DOI 10.1002/jssc.**
2014
10. Zafar A, Eqani SAMAS, Bostan N, Cincinelli A, Tahir F, Shah STA, Hussain A, Alamdar A, Huang Q, Peng S, Shen H*. Toxic metals signature in the human seminal plasma of Pakistani population and their potential role in male infertility. Environ. Geochem. Health 2014, DOI 10.1007/s10653-014-9666-8
11. Zhang J, Shen H*, Xu W, Xia Y, Barr DB, Mu X, Wang X, Liu L, Huang Q, Tian M. Urinary metabolomics revealed arsenic internal dose-related metabolic alterations: a proof-of-concept study in a Chinese male cohort. Environ. Sci. Technol. 2014; 48(20):12265-74. doi: 10.1021/es503659w
12. Tian M, Bao H, Martin FL, Zhang J, Liu L, Huang Q, and Shen H*. Association of DNA Methylation and Mitochondrial DNA Copy Number with Human Semen Quality. Biol. Reprod. 2014, doi:10.1095/biolreprod.114.122465
13. Zhang J, Mu X, Xu W, Martin FL, Alamdar A, Liu L, Tian M, Huang Q, Shen H*. Exposure to arsenic via drinking water induces 5-hydroxymethylcytosine alteration in rat. Sci. Total Environ. 2014, (497-498) 618-625.
14. Liu L, Xia T, Zhang X, Barr DB, Alamdar A, Zhang J, Tian M, Huang Q, Shen H*. Biomonitoring of infant exposure to phenolic endocrine disruptors using urine expressed from disposable gel diapers. Anal. Bioanal. Chem., 2014, Doi:10.1007/s00216-014-7908-3.
15. Zhang J, Mu X, Xia Y, Martin, FL, Hang W, Liu L, Tian M, Huang Q, Shen H*. Metabolomic Analysis Reveals a Unique Urinary Pattern in Normozoospermic Infertile Men. J. Proteome. Res. 2014 (doi:10.1021/pr**)
16. Ye T, Kang M, Huang Q, Fang C, Chen Y, Shen H, Dong S. Exposure to DEHP and MEHP from hatching to adulthood causes reproductive dysfunction and endocrine disruption in marine medaka (Oryzias melastigma). Aquatic Toxicol. 2014, 146, 115-126, 10.1016/j.aquatox.2013.10.025
17. Zhang J, Huang Z, Chen M, Xia Y, Martin FL, Hang W, Shen H*. Urinary metabolome identifies signatures of oligozoospermic infertile men. Fertil. Steril. 2014, 102(1) 44–53.e12. doi: 10.1016/j.fertnstert.2014.03.033.
18. Shen H*, Xu W, Peng S, Scherb H, She J, Voigt K, Alamdar A, Schramm K*. Pooling samples for "top-down" molecular exposomics research: the methodology. Environ. Health 2014, 13 :8 (DOI: 10.1186/1476-069X-13-8)
19. Xu W, Shen H*. Arsenic exposure induced male reproductive effects: a brief review. Ch. Sci. Bulletin, 2014, 59(3), 238-244
20. Shen H*, Martin FL, Su Y. Environmental chemical stressors as epigenome modifiers: A new horizon in assessment of toxicological effects. Ch. Sci. Bulletin, 2014, 59(4), 349-355
21. Huang Q, Zhang J*, Peng S, Tian M, Chen J, Shen H*. Effects of water soluble PM2.5 extracts exposure on human lung epithelial cells (A549): A proteomic study. J. Appl. Toxicol. 2014, 34(6), 675-687
2013
22. Peng S, Yan L, Zhang J*, Wang Z, Tian M, Shen H*. An integrated metabonomics and transcriptomics approach to understanding metabolic pathway disturbance induced by perfluorooctanoic acid. J. Pharm. Biomed. Anal. 2013, 86, 56-64
23. Huang Q, Zhang J, Martin FL, Peng S, Tian M, Mu X, Shen H*. Perfluorooctanoic acid induces apoptosis through the p53-dependent mitochondrial pathway in human hepatic cells: A proteomic study. Toxicol. Letters, 223 (2013) 211-220.
24. Shen H, Xu W, Zhang J, Chen M, Martin FL, Xia Y*, Liu L, Dong S, Zhu Y-G*. Urinary Metabolic biomarkers link oxidative stress indicators associated with general arsenic exposure to male infertility in a Han Chinese population. Environ. Sci. Technol., 2013, 47, 8843-8851
25. Xia T, Liu L, Zhang W*, Shen H*. Determination of phenolic endocrine disrupting chemicals in human urine by high performance liquid chromatography tandem electrospray ionization mass spectrometry. J. Inst. Anal., 2013, 32 (2), 211-217
26. Fang C, Huang Q, Ye T, Chen Y, Kang M, Liu L, Lin Y, Shen H, Dong S*. Embryonic exposure to PFOS induces immunosuppression in the fish larvae of marine medaka. Ecotoxicol. Environ. Safety, 2013, 92, 104-111
27. Lin Y, Sun X, Qiu L, Wei J, Huang Q, Fang C, Ye T, Kang M, Shen H, Dong S*. Exposure to bisphenol A induces dysfunction of insulin secretion and apoptosis through the damage of mitochondria in rat insulinoma (INS-1) cells. Cell Death Disease, 2013, 4, e460;doi:10.1038/cddis.2012.206
28. Liao Y, Dong S*, Kiyama R, Cai P, Liu L, Shen H. Flos Lonicerae Extracts and Chlorogenic Acid Protect Human Umbilical Vein Endothelial Cells from the Toxic Damage of Perfluorooctane Sulphonate. Inflammation. 2013, 36(3), 767-779
29. Gu J, Zhang P, Zhang F*, Shen H, Yang B*, Liang X and Chu X. Determination of aristolochic acids in rat serum by high performance liquid chromatography-Q-TOF tandem mass spectrometry. Anal. Methods 2013, 5(3), 718-721
2012
30. Zhang J, Yan L, Pan C, Lin L, Zhang X, Shen H*, Simultaneous analysis of 19 antibiotics in dairy products using ultra-performance liquid chromatography coupled with high resolution time-of-flight mass spectrometry. Ch. J. Chromatogr. 2012, 30(10), 1031-1036
31. Zhang J, Liu F, Chen R, Feng T, Dong S, Shen H*, Levels of Polychlorinated Biphenyls and Organochlorine Pesticides in Edible Shellfish from Xiamen (China) and Estimation of Human Dietary Intake. Food Chem. Toxicol. 2012, 50, 4285–4291 32. Xu W, Bao H, Liu F, Liu L, Zhu Y-G, She J, Dong S, Cai M, Li L, Li C, Shen H*. Environmental exposure to arsenic may reduce human semen quality: associations derived from a Chinese cross-sectional study. Environ. Health 2012, 11:46
33. Peng S, Zhang J*, Tian M, Wang Z, Shen H*. Determination of Global DNA Methylation in Biological Samples by Liquid Chromatography-Tandem Mass Spectrometer. Ch. J. Anal. Chem. 2012, 40 (8), 1201-1206
34. Zhang J, Yan L, Tian M, Huang Q, Peng S, Dong S, Shen H*. The metabonomics of combined dietary exposure to phthalates and polychlorinated biphenyls in mice. J. Pharm. Biomed. Anal. 2012, 66, 287-297
35. Krysiak-Baltyn K, Skakkeb?k NE, Toppari J, Jensen T, Virtanen H, Schramm K-W, Shen H, Vartiainen T, Kiviranta H, Taboureau O, Brunak S, Main K. Association between chemical pattern in breast milk and congenital cryptorchidism: modeling of complex human exposure. Int. J. Androl. 2012, 35 (3), 294-302
36. Liu L, Xia T, Guo L, Cao L, Zhao B, Zhang J, Dong S, Shen H*. Expressing urine from a gel disposable diaper for biomonitoring using phthalates as an example. J. Expo. Sci. Environ. Epidemiol., 2012, 22, 625-631
37. Peng S, Yan L, Zhang* J, Shen H*. Hepatotoxicity of perfluorooctanoic acid in human hepatocytes using metabonomics. Ch. J. Chromatogr. 2012, 30 (02): 123-127
38. Tian M, Peng S, Martin FL, Zhang J, Liu L, Wang Z, Dong S, Shen H*. Perfluorooctanoic acid induces gene promoter hypermethylation of glutathione-S-transferase Pi in human liver L02 cells. Toxicology. 2012, 296 (1-3) 48-55
39. Liao Y, Wang J, Huang Q, Fang C, Kiyama R, Shen H*, Dong S*. Evaluation of cellular response to perfluorooctane sulfonate in human umbilical vein endothelial cells. Toxicol. in Vitro 2012, 26(3): 421-428
40. Shen H, Henkelmann B, Rambeck WA, Mayer R, Wehr U, Schramm K-W. Physiologically based persistent organic pollutant accumulation in pig tissues and their edible safety differences: An in vivo study. Food Chem. 2012,132 (4)1830-1835
41. Shen H, Henkelmann B, Rambeck WA, Mayer R, Wehr U, Schramm K-W. The predictive power of the elimination of dioxin-like pollutants from pigs: An in vivo study. Environ. Int. 2012, 38 73-78
42. Liu F, Ni H-G, Chen F, Luo Z-X, Shen H*, Liu L, Wu P. Metal accumulation in the tissues of grass carps (Ctenopharyngodon idellus) from fresh water around a copper mine in Southeast China. Environ. Monit. Assess. 2012, 184(7), 4289-4299
43. Zhao B, Shen H*, Liu F, Liu S, Niu J, Guo F, Sun X. Exposure to organochlorine pesticides is independent risk factor of hepatocellular carcinoma: A case-control study, J. Expo. Sci. Environ. Epidemiol. 2012, 22, 541-548
44. Liu L, Bao H, Liu F, Zhang J, Shen H*. Phthalates exposure of the Chinese reproductive age couples and their effect on male semen quality, a primary study. Environ. Int. 2012, 42,78-83
2011
45. Fang C, Wu X, Huang Q, Liao Y, Liu L, Qiu L, Shen H*, Dong S*. PFOS elicits transcriptional responses of the ER, AHR and PPAR pathways in Oryzias melastigma in a stage-specific manner. Aquatic Toxicol. 2011, 106-107, 9-19
46. Wang X, Suo Y, Yin R, Shen H*, Wang H*. Ultra-performance liquid chromatography/tandem mass spectrometry for accurate quantification of global DNA methylation in human sperms. J. Chromatogr. B. 2011, 879, 1647-1652
47. Zhao B, Liu F, Liu S, Niu J, Guo F, Sun X, Shen H*. A case-control study of the association between human exposure to selected chlorinated pesticides and primary hepatocellular carcinoma. Epidemiology 2011, 22, S145
Before 2010
48. Voigt K, Brueggemann R, Scherb H, Shen H, Schramm K-W. Evaluating the relationship between chemical exposure and cryptorchidism by discrete mathematical method using PyHasse software. Environ. Model. Softw. 2010, 25:1801-1812.
49. ?ok ？, Donmez MK, Uner M, Demirkaya E, Henkelmann B, Shen H, Kotalik J, Schramm K-W. Polychlorinated dibenzo-p-dioxins, dibenzofurans and polychlorinated biphenyls levels in human breast milk from different regions of Turkey. Chemosphere 2009, 76: 1563-1571.
50. Krysiak-Baltyn K, Skakkeb?k NE, Toppari J, Jensen T, Virtanen H, Schramm K-W, Shen H, Vartiainen T, Kiviranta H, Taboureau O, Brunak S, Main K. Country-specific chemical signatures of persistent environmental compounds in breast milk. Int. J. Androl. 2009, 32:1-9.
51. Shen H, Henkelmann B, Levy W, Zsolnay A, Weiss P, Jakobi G, Kirchner M, Moche W, Braun K and K-W Schramm. Altitudinal and chiral signature of persistent organochlorine pesticides in air, soil, and spruce needles (Picea abies) of the Alps. Environ. Sci. Technol. 2009, 43:2450-2455.
52. ?ok ？, Donmez MK, Sat？ro？lu MH, Ayd？nuraz B, Henkelmann B, Shen H, Kotalik J, Schramm K-W. Concentrations of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like PCBs in adipose tissue of infertile men. Arch. Environ. Contam. Toxicol. 2008, 55:143-152.
53. Shen H, Main KM, Andersson A-M, Damgaard IN, Virtanen HE, Skakkebaek NE, Toppari J, and Schramm K-W. Concentrations of persistent organochlorine compounds in human milk and placenta are higher in Denmark than in Finland. Hum. Reprod. 2008, 23:201-210.
54. Shen H, Main KM, Virtanen HE, Damggard IN, Haavisto A-M, Kaleva M, Boisen KA, Schmidt IM, Chellakooty M, Skakkebaek NE, Toppari J, Schramm K-W. From mother to child: Investigation of prenatal and postnatal exposure to persistent bioaccumulating toxicants using breast milk and placenta biomonitoring. Chemosphere 2007, 67:256-262.
55. Simm M, Roots O, Kotta J, Lankov A, Henkelmann B, Shen H, K-W Schramm. PCDD/Fs in sprat (Sprattus sprattus balticus) from the gulf of Finland, the Baltic Sea. Chemosphere 2006, 65:1570-1575.
56. Damgaard IN, Skakkeb?k NE, Toppari J, Virtanen HE, Shen H, Schramm K-W, Petersen JH, Jensen TK, Main KM and the Nordic Cryptorchidism. Study group, Persistent pesticides in human breast milk and Cryptorchidism. Environ. Health Persp. 2006, 114:1133-1138.
57. Shen H, Virtanen HE, Main KM, Kaleva M, Andersson AM, Skakkeb?k NE, Toppari J and Schramm K-W. Enantiomeric ratios as an indicator of exposure processes for persistent pollutants in human placentas. Chemosphere 2006, 62:390-395.
58. Shen H, Main KM, Kaleva M, Virtanen H, Haavisto A-M, Skakkebaek NE, Toppari J and Schramm K-W. Prenatal organochlorine pesticides in placentas from Finland: Exposure of male infants born during 1997–2001. Placenta 2005, 26:512-514.
59. Zhou L, Nie M, Wang Q, Zhu D, Shen H. Enthalpy-entropy compensation effect in gas chromatographic enantiomeric separation. Ch. J. Chem. 1999, 17:363-376.
60. Shen H, Wang Q, Zhu D, Zhou L. A study of a molecular mechanics field used in simulating enantiorecognition. Ch. Chem. Letters 1999, 10:415-418.
61. Zhang D, Lu Z, Shen H, Zhou L, Guo W. The asymmetrical reduction of 1-4’-hydroxyphenyl-1-butanone complexed with solid l-cedrol, Ch. J. Synthetic Chem, 1997, A5:559.
62. Shen H, Wang Q, Zhu D, Zhou L. Study of four pentylated α-, β-cyclodextrin chiral stationary phases on capillary gas chromatography. Ch. J. Anal. Chem. 1998, 26:211-214.
63. Shen H, Wang Q, Zhu D, Zhou L. Study on 2,6-Dipentyl-β-cyclodextrin as a stationary phase in capillary gas chromatographic separation of enantiomers. J. Inst. Anal. 1998, 17:45-46.
64. Shen H, Wang Q, Zhu D, Zhou L. Molecular modeling method and its applications in chiral recognition mechanism. Ch. J. Anal. Chem. 1997, 25:110-114.


发表著作
科研活动承担科研项目情况：
1.育龄男性全氟烷烃类化合物暴露和精子DNA甲基化关系研究,自然科学基金面上项目,2012.1-2015.12,负责人
2.用胶质纸尿片采集尿液作为婴幼儿易代谢内分泌干扰物测定的可行性研究,教育部回国人员科研启动基金,2010.11-2012.11,负责人
3.环境污染物的人群暴露与健康,中国科学院百人计划项目,2009.04-2012.04,负责人

参与会议

合作单位
指导学生现指导学生

彭思远 硕士研究生 083001-环境科学

刘良坡 博士研究生 083001-环境科学

徐伟攀 博士研究生 083001-环境科学

合作情况

项目协作单位