1、招生信息2、教育背景3、工作经历4、教授课程5、专利与奖励6、出版信息7、科研活动8、合作情况9、指导学生
基本信息
宋凤瑞女博导
电子邮件：songfr@ciac.jl.cn
联系电话：**
手机号码：
通信地址：长春市人民大街5625号
邮政编码：130022


研究领域质谱及其它分析技术的应用研究。包括：
1、中药材及其相关产品的质量控制与评价
2、中药及天然产物的分离分析
3、中药及其保健品的研究与开发
4、遗传代谢性疾病筛查方法

招生信息

招生专业物理化学

招生方向天然产物质谱
中药质量控制及分离分析
代谢及代谢组学研究

教育背景

学历1984年7月：大连轻工业学院，工学学士

1998年7月： 中科院长春应化所，理学硕士

2005年1月： 中科院长春应化所，理学博士
学位中国科学院长春应用化学研究所 理学博士


出国学习工作2001-2002年：香港浸会大学化学系，访问学者。
工作经历

工作简历1987年—：中国科学院长春应用化学研究所

社会兼职
教授课程物化前沿（专题）

专利与奖励

奖励信息吉林省科技进步一等奖（2项，2001，2006）
吉林省科技进步二等奖（2002）
吉林省科技进步三等奖（2006）

专利成果ZL**.X 一种刺五加叶中的黄酮的检测方法 发明 中药学
**5.0 一种中药龙胆的质量检测方法 发明中药学
**9一种中药五味子的炮制方法发明 中药学
**2一种人参保健品冲剂的制备方法发明中药学
**5.4 一种增加人参总皂苷提取物中稀有皂苷的方法 发明 中药学
**2一种乌头类水解单酯型生物碱的制备方法发明中药学
**3一种以乌头属中药材为原料制备单酯型生物碱的方法发明中药学

出版信息

发表论文 1. Fengrui Song，Meng Cui，Zhiqiang L iu，Biao Yu，Shuying Liu Multiple-stage tandem mass spectrometry For differentiation of isomeric saponins. Rapid Commun. Mass Spectrom.,2004；18:2241-2248

2. Fengrui Song, Zhiqiang Liu, Shuying Liu, Zongwei Cai. Differentiation and identification of ginsenoside isomers by electrospray ionization tandem mass spectrometry, Anal. Chim. Acta , 2005，531：69-77

3. Song FR, Liu Ning, Yan CY,Liu ZQ, Liu SY, Non-covalent Interaction Between Oligodeoxynucleotide and Alkaloid Compounds via Negative Ion Electrospray Ionization Mass Spectrometry（I）, Chem. J. Chinese U., 2004, 25（10）：2830－1832

4. Song FR, Yan CY,Liu Ningh, Liu ZQ, Liu SY. Studies on the Non-covalent Complexes between Oligodeoxynucleotide and Compounds from Some Chinese Herbs,Chinese J. Anal. Chem.2005,33（12）:1743-1746

5. Liu SY, Song FR,The Application of Mass Spectrometry on the Analysis of Chinese Medicine, Modern Methoology in Chinese Medicine Study, Chemical Industry Press.,2004, 76－84

6. Chen ML, Song FR, Guo MQ, Liu ZQ, Liu SY. Analysis of Flavonoid Constituents from Leaves of Acanthopanax Senticosus Harms by Electrospray Tandem Mass Spectrometry, Rapid Commun. Mass Spectrom., 2002, 16: 264~ 271

7. Cai ZW, Song FR, Yang MS, Capillary liquid chromatographic –high -resolution mass spectrometric analysis of ribonucleotides .J. Chromatography A., 2002, 976, 135-143

8. Guo MQ, Song FR, Bai Y, Liu ZQ, Liu SY Rapid Analysis of A Triterpenoid Saponin Mixture from Plant Extracts by Electrospray Lonization Tandem Mass Spectrometry. Anal. Sci., 2002, 18(4) 481-484

9. Yong Wang, Fengrui Song. Qingxuan Xu, Zhiqiang Liu and Shuying Liu Characterization of aconitine-type alkaloids in the flowers of Aconitum kusnezoffii by electrosprayionization tandem mass spectrometry. J.Mass Spectrom. 2003;38:962-970

10. Mingquan Guo, Fengrui Song, Zhiqiang Liu. and Shuying Liu, Characterization of non-covalent complexes of rutin with cyclodextrins by electrospray ionization tandemmass spectrometry, J. Mass Spectrom. 2004; 39: 594–599

11. Yu Bai, Fengrui Song, Maolian Chen, Junpeng Xing, Zhiqiang Liu and Shuying Liu, Application of Multistage Tandem Electrospray Ionisation Mass Spectrometry (ESI-MSn) to characterisation of Rutin-Met al Complex, Anal.Sci., 2004,20, 1147 - 1151.

12. Wei Wu, Fengrui Song, Cunyu Yan, Zhiqang Liu Shuying Liu.，Structursal analyses of protoberberine alkaloids in medicine herbs by using ESI-FT-ICR-MS and HPLC-ESI-MS， J. pharm. Biomed. Anal.，2005, 378: 437-446，

13. Guo, MQ; Song, FR; Liu, ZQ; Liu, SY，Characterization of triterpenoidic saponin mixture in crude extracts from leaves of Acanthopanax senticosus Harms by saponin structural correlation and mass spectrometry，Anal. Chim. Acta ,2006，557 (1-2): 198-203

14. Xu Zhang, Fengrui Song, Zhiqiang Liu, Shuying Liu. Investigation of the hydrolysis of ginsenosides by high performance liquid chromatography –electrospray ionization mass spectrometry. Planta Medica ,2007,73,1225-1229

15. Xin Huang, Fengrui Song, Zhiqiang Liu, Shuying Liu. Studies on lignan constituents from Schisandra Chinensis(Turcz.) Bail. Fruits using high-performance liquid chromatography/electrospray ionization multiple-stage tandem mass spectrometry. J.Mass Spectrom., 2007;42:1148-1161

16. Xin Huang, Fengrui Song, Zhiqiang Liu, Shuying Liu, Structural characterization and identification of dibenzocyclooctadiene lignans in Fructus Schisandrae using electrospray ionization ion trap multiple-stage tandem mass spectrometry and electrospray ionization Fourier transform ion cyclotron resonance multiple-stage tandem mass spectrometry. Anal. Chim. Acta, 2008,19:141-147

17. Wei Li, Fengrui Song, Shuying Liu, Zhiqiang Liu. Qualitative and semi-quantitative analysis of quaternary alkaloids in the coptis-scute herb couple by using electrospray mass spectrometry Chem. Res. Chinese U. 2008, 24(2), 162-166

18. Zhaofu Wang, Meng Cui, Fengrui Song, Lin Lu, Zhiqiang Liu, Shuying Liu Evaluation of Flavonoids Binding to DNA Duplexes by Electrospray Ionization Mass Spectrometry . J Am Soc Mass Spectrom, 2008,43(3):327-335

19. Mingquan Guo, Suoqing Zhang, Fengrui Song, Daowu Wang, Zhiqiang Liu and Shuying Liu Studies on the non-covalent complexes between noleanolic acid and cyclodextrins using electrospray ionization tandem mass spectrometry. J. Mass Spectrom. 2003;38: 723-731

20. Wu Wei, Liu ZQ, Song FR, Liu SY. Structural analysis of selected characteristic flavones by electrospray tandem mass spectrometry. Anal. Sci. 2004; 20: 1103-1105.

21. Hongjuan Dong , Zhiqiang Liu , Fengrui Song , Zhan Yu , Huilin Li, Shuying Liu. Structural analysis of monoterpene glycosides extracted from Paeonia lactiflora Pall. using electrospray ionization fourier transform ion cyclotron resonance mass spectrometry and high performance liquid chromatography – electrospray ionization tandem mass spectrometry. Rapid Commun. Mass Spectrom..2007,21(19),3193-3199


发表著作 《中药研究现代方法学》,10. 质谱技术及其在中药分析研究中的应用,化学出版社，2004年

科研活动

科研项目国家科技支撑计划子课题，吉林省重点科技发展项目，长春市科技发展项目，吉林省中医药管理局科研项目，中科院长春应化所创新项目
参与会议
合作情况

项目协作单位
指导学生