基本信息
王秀杰 女 博导 遗传与发育生物学研究所
电子邮件：xjwang@genetics.ac.cn
通信地址：北京朝阳区北辰西路1号院2号中科院遗传发育所
邮政编码：100101


研究领域1. 非编码RNA与表观遗传修饰在哺乳动物胚胎干细胞多能性调控中的功能与机制研究。

利用新一代高通量测序技术，发现对哺乳动物胚胎干细胞多能性的获得与维持具有重要调控作用的microRNA、lncRNA等非编码RNA并研究部分非编码RNA的作用机制，研究RNA甲基化等表观遗传修饰对哺乳动物胚胎干细胞多能性的影响与机理。

2. 细胞分化与组织器官形成的调控机制研究。

整合各种高通量测序数据，解析哺乳动物细胞分化与主要组织器官形成的调控网络，挖掘调控哺乳动物细胞分化与主要组织器官形成的关键因子。

3. 生物信息学算法和软件的开发。
招生信息

招生专业 生物信息学



招生方向 基因组学
系统生物学和生物信息学

教育背景 2000-08--2004-06 The Rockefeller University 博士
1998-08--2000-06 香港科技大学 硕士
1994-06--1998-06 南开大学 学士


学历-- 研究生


学位-- 博士

工作经历

工作简历 2005-01--今 中科院遗传与发育研究所 研究员
2004-06--2004-12 The Rockefeller University 博士后


社会兼职
教授课程 干细胞研究进展系列讲座、 生物信息学应用、 生物信息学、 人类基因组学研究-进展与应用、 遗传发育学系列讲座
专利与奖励2007年获得国家自然科学基金委杰出青年科学基金和美国杜邦公司青年科学家奖。2012年获得“中央国家机关五四青年奖章标兵”和“全国青年岗位能手”荣誉称号。2013年获得“中国青年五四奖章”荣誉称号，作为共同完成人获得“中国科学院杰出科技成就奖集体奖”。2014年作为第二完成人，获得国家自然科学奖二等奖。2015年获得“全国五一巾帼标兵”荣誉称号，入选科技部“中青年科技创新领军人才”。

现任国家重大科学研究计划项目首席科学家。担任 RNA Biology, BMC Genomics, Journal of Genetics and Genomics 等杂志编委。

奖励信息 （1） 中国科学院京区“巾帼建功”先进集体，院级级，2014
（2） “中国科学院杰出科技成就奖”集体奖，院级级，2013
（3） 第十七届“中国青年五四奖章”荣誉称号，国家级，2013
（4） 第二届“中央国家机关青年五四奖章标兵”荣誉称号，国家级，2012
（5） 杜邦青年科学奖，其他级，2007
（6） 国家杰出青年基金，国家级，2007


专利成果 （1） 启动子AFB4及其应用，发明，2012，第1作者，专利号：ZL **7.1
（2） 启动子miR172c及其应用，发明，2012，第1作者，专利号：ZL **7.6
（3） 启动子miR390及其应用，发明，2013，第1作者，专利号：ZL **2.0
（4） ath-eTM160在抑制microRNA160功能中的应用，发明，2014，第1作者，专利号：ZL **2.6
（5） miR-24 用于治疗或诊断心衰或患心衰倾向或，发明，2014，第1作者，专利号：ZL **7.2

出版信息2015

1.Chen T, Hao YJ, Zhang Y, Li MM, Wang M, Han W, Wu Y, Lv Y, Hao J, Wang L, Li A, Yang Y, Jin KX, Zhao X, Li Y, Ping XL, Lai WY, Wu LG, Jiang G, Wang HL, Sang L, Wang XJ*, Yang YG* and Zhou Q*. (2015) m6A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency. Cell Stem Cell (Cover Story) 16:289-301. (*co-corresponding author)



2014

2. Luo GZ, Yang W, Ma YK and Wang XJ*. (2014) ISRNA: an integrative online toolkit for short reads from high-throughput sequencing data. Bioinformatics 30: 434-436.


3. Liu YX, Wang M and Wang XJ*. (2014) Endogenous small RNA clusters in plants. Genomics Proteomics Bioinformatics 12: 64-71.


4. Gao W, Sun HX, Xiao HB, Cui GH, Hillwig ML, Jackson A, Wang X, Shen Y, Zhao N, Zhang LX, Wang XJ*, Peters R.J* and Huang LQ*. (2014) Combining metabolomics and transcriptomics to characterize tanshinone biosynthesis in Salvia miltiorrhiza. BMC Genomics 15: 73.


5. Li W, Li X, Li T, Jiang MG, Wan H, Luo GZ, Feng C, Cui X, Teng F, Yuan Y, Zhou Q, Gu Q, Shuai L, Sha J, Xiao Y, Wang L, Liu Z, Wang XJ, Zhao XY and Zhou Q. (2014) Genetic modification and screening in rat using haploid embryonic stem cells. Cell Stem Cell 14: 404-414.


6. Cui Y, Xiao Z, Chen T, Wei J, Chen L, Liu L, Chen B, Wang XJ, Li X and Dai JW. (2014) The miR-7 identified from collagen biomaterial-based three-dimensional cultured cells regulates neural stem cell differentiation. Stem Cells and Development 23: 393-405.



2013

7. Wu HJ, Wang ZM, Wang M and Wang XJ*. (2013) Wide-spread long non-coding RNAs (lncRNAs) as endogenous target mimics (eTMs) for microRNAs in plants. Plant Physiology 161:1875-84.


8. Zhang Y, Teng F, Luo GZ, Wang M, Tong M, Zhao X, Wang L, Wang XJ* and Zhou Q*. (2013) MicroRNA-323-3p Regulates the Activity of Polycomb Repressive Complex 2 (PRC2) via Targeting the mRNA of Embryonic Ectoderm Development (Eed) Gene in Mouse Embryonic Stem Cells. Journal of Biological Chemistry 288:23659-23665 (*co-corresponding author).


9. Liu X, Zhang Y, Tong M, Liu XY, Luo GZ, Xie DF, Ren SF, Bai DH, Wang L, Zhou Q and Wang XJ*. (2013) Identification of a small molecule 1,4-bis-[4-(3-phenoxy-ropoxy)-but-2-ynyl]-piperazine as a novel inhibitor of the transcription factor p53. Acta Pharmacologica Sinica 34: 805–810.


10. Li W, Yang W and Wang XJ*. (2013) Pseudogenes: Pseudo or real functional elements? Journal of Genetics and Genomics 40:171-177.


11. Zhang X, Ma Y, Liu X, Zhou Q* and Wang XJ*. (2013) Evolutionary and Functional Analysis of the Key Pluripotency Factor Oct4 and Its Family Proteins Journal of Genetics and Genomics 40:399-412.


12. Ling HQ, Zhao S, Liu D, Wang J, Sun H, Zhang C, Fan H, Li D, Dong L, Tao Y, GaoC, Wu H, Li Y, Cui Y, Guo X, Zheng S, Wang B, Yu K, Liang Q, Yang W, Lou X, Chen J, Feng M, Jian J, Zhang X, Luo G, Jiang Y, Liu J, Wang Z, Sha Y, Zhang B, Wu H, Tang D, Shen Q, Xue P, Zou S, Wang X, Liu X, Wang F, Yang Y, An X, Dong Z, Zhang K, Zhang X, Luo MC, Dvorak J, Tong Y, Wang J, Yang H, Li Z, Wang D, Zhang A, Wang J. (2013) Draft genome of the wheat A-genome Triticum urartu. Nature 496:87-90.


13. Zhu H, Zhou Y, Castillo-Gonzales, Lu A, Ge C, Zhao YT, Duan L, Li Z, Axtell MJ, Wang XJ and Zhang X* (2013). Bidirectional processing of pri-miRNAs with branched terminal loops by Arabidopsis Dicer-like1. Nature Structureal & Molecular Biology 20: 1106-1115. (Cover story)


14. Li RC, Tao J, Guo YB, WU HD, Liu RF, Bai Y, Lv ZZ, Luo GZ, Li LL, Wang M, Yang HQ, Gao W, Han QD, Zhang YY, Wang XJ, Xu M* and Wang SQ*. (2013) In vivo suppression of microRNA-24 prevents the transition toward decompensated hypertrophy in aortic-constricted mice. Circulation Research 112: 601-605.


15. Zhang B#, Lv Z#, Pang J#, Liu Y, Guo X, Fu S, Li J, Dong Q, Wu HJ, Gao Z, Wang XJ* and Han F*. (2013) Formation of a Functional Maize Centromere after Loss of Centromeric Sequences and Gain of Ectopic Sequences. Plant Cell doi/10.1105/tpc.113.110015.


16. Fu S, Lv Z, Gao Z, Wu H, Pang J, Zhang B, Dong Q, Guo X, Wang XJ, Birchler JA and Han F*. (2013)De novo centromere formation on a chromosome fragment in maize. Proc. Natl. Acad. Sci. USA 110:6033-6036.


17. Zheng G, Dahl JA, Niu Y, Fedorcsak P, Huang CM, Li CJ, Vagbo CB, Shi Y, Wang WL, Song SH, Lu Z, Bosmans RP, Dai Q, Hao YJ, Yang X, Zhao WM, Tong WM, Wang XJ, Bogdan F, Furu K, Fu Y, Jia G, Zhao X, Liu J, Krokan HE, Klungland A, Yang YG* and He C*. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Molecular Cell 10: 18-29.


18. Shi Z, Luo G, Fu L, Fang Z, Wang XJ and Li X. (2013) miR-9 and miR-140-5p target FoxP2 and are regulated by the social context of song behavior in zebra finches. Journal of Neuroscience 16:16510-16521.


19. Niu Y, Zhao X, wu YS, Li MM, Wang XJ and Yang YG*. (2013) N6-methyl-adenosine (m6A) in RNA: An old modification with a novel epigenetic function. Genomics Proteomics Bioinformatics 11: 8-17.



2012

20. Li W, Shuai L, Wan H, Dong M, Wang M, Sang L, Feng C, Luo GZ, Li T, Li X, Wang L, Zheng QY, Sheng C, Wu HJ, Liu Z, Liu L, Wang L, Wang XJ, Zhao XY* and Zhou Q*. (2012) Androgenetic haploid embryonic stem cells produce live transgenic mice. Nature 490:407-411.


21. Xu M, Wu HD, Li RC, Zhang HB, Wang M, Tao J, Feng XH, Guo YB, Li SF, Lai ST,Zhou P, Li LL, Yang HQ, Luo GZ, Bai Y,XiJ, Gao W, Han QD, Zhang YY, Wang XJ*, Meng X and Wang SQ*. (2012) Mir-24 regulates Junctophilin-2 expression in cardiomyocytes. Circulation Research 111:837-841. (*co-corresponding author)


22. Wu HJ, Zhang Z, Wang J, Oh DH, Dassanayake M, Liu B, Huang Q, Sun HX, Xia R,Wu Y, Wang Y, Yang Z, Liu Y, Zhang W, Zhang H, Chu J, Yan C, Fang S, Zhang J, Wang Y, Zhang F, Wang G, Lee SY, Cheeseman JM, Yang B, Li B, Ming J, Yang L, Wang J, Chu C*, Chen S*, Bohert HJ, Zhu JK*, Wang XJ* and Xie Q*. (2012) Insights into salt tolerance from the genome of Thellungislla salsuginea.Proc. Natl. Acad. Sci. USA 109: 12219-12224. (*co-corresponding author)


23. Wu HJ, Ma YK, Chen T, Wang M and Wang XJ*. (2012) PsRobot: a web-based plant small RNA meta-analysis toolbox. Nucleic Acids Research 40:W22-W28.


24. Zhao YT, Wang M, Fu SX, Yang WC, Qi CK and Wang XJ*. (2012) Small RNA profiling in two Brassica napus cultivars identifies microRNAs with oil production and developmental correlated expressions and new small RNA classes. Plant Physiology 158:813-823.


25. Luo GZ, Hafner M, Shi Z, Brown M, Feng GH, Tuschl T, Wang XJ* and Li X*. (2012) Genome-wide annotation and analysis of zebra finch microRNA repertoire reveal sex-biased expression. BMC Genomics 13:727. (*co-corresponding author)


26. Du Y, Gao C, Liu Z, Wang L, Liu B, He F, Zhang T, Wang Y, Wang X, Xu M, Zhu Y, Xu Q, Wang X, and Kong W. (2012) Up-regulation of ADAMTS-7 by miR-29 expression mediates vascular smooth muscle calcification. Arteriosclerosis, Thrombosis, and Vascular Biology 32:2580-2588.


27. Zhang C, Xu Y, Guo S, Zhu J, Huan Q, Liu H, Wang L, Guo G, Wang X and Chong K. (2012) Dynamics of brassinosteroid response modulated by negative regulator LIC in rice. PLoS Genetics 8: e**.


28. Woo J, MacPherson CR, Liu J, Wang H, Kiba T, Hannah M, Wang XJ, Bajic VB and Chua NH. (2012) The response and recovery of the Arabidopsis thaliana transcriptome to phosphate starvation. BMC Plant Biology 12:62.


29. Song XM, Li PC, Zhai JX, Zhou M, Ma LJ, Liu B, Jeong DH, Nakano M, Cao SY, Liu CY, Chu CC, Wang XJ, Green PJ, Meyers BC and Cao XF. (2012) Roles of DCL4 and DCL3b in rice phased small RNA biogenesis. The Plant Journal 69:462-474


30. Xu N, Li Y, Zhao YT, Guo L, Fang YY, Zhao JH, Wang XJ, Huang L and Guo HS. (2012) Identification and characterization of small RNAs in the hyperthermophilic archaeon Sulfolobus solfataricus. PLoS One 7: e35306.


31. Sheng C, Zheng QY, Wu JY, Xu Z, Wang LB, Li W, Zhang HJ, Zhao XY, Liu L, Wang ZW, Guo CL, Wu HJ, Liu ZH, Wang L, He SG, Wang XJ, Chen ZG and Zhou Q. (2012) Direct reprogramming of sertoli cells into multipotent neural stem cells by defiend factors. Cell Research 22:208-218.



2011

32. Wang H, Zhang X, Liu J, Kiba T, Woo J, Ojo T, Hafner M, Tuschl T, Chua NH* and Wang XJ*. (2011) Deep sequencing of small RNAs specifically associated with Arabidopsis AGO1 and AGO4 uncovers new AGO functions. The Plant Journal 67:292-304.


33. Cui H, Zhang ST, Yang HJ, Ji H and Wang XJ. (2011) Gene expression profileanalysis of tobacco leaf trichomes. BMC Plant Biology 11:76.


34. Lei M, Liu Y, Zhang B, Zhao Y, Wang X, Zhou Y, Raghothama KG and Liu D. (2011) Genetic and genomic evidence that sucrose is a global regulator of plant responses to phosphate starvation in Arabidopsis. Plant Physiology 156:1116-1130.


35. Liang H, Zhao YT, Zhang JQ, Wang XJ, Fang RX and Jia YT. (2011) Identification and functional characterization of small non-coding RNAs in Xanthomonas oryzae pathovar oryzae. BMC Genomics 12:87.


36. Wong CE, Zhao YT, Wang XJ, Croft L, Wang ZH, Haerizadeh F, Mattick JS, Singh MB, Carroll BJ, Bhalla PL. (2011) MicroRNAs in the shoot apical meristem of soybean. Journal of Experimental Botany62:2495-2506.


37. Wang JL, Liu DC, Guo XL, Yang WL, Wang XJ, Zhan KH and Zhang AM.(2011) Variability of gene expression afterpolyhaploidization in wheat (Triticum aestivum L.) Genes Genomics Genetics 1:27-33.


38. Li W, Zhao XY, Wan HF, Zhang Y, Liu L, Zhuo L, Wang XJ, Wang L and Zhou Q. (2011)iPS cells generated without c-Myc have active Dlk1-Dio3 region and are capable of producing full-term mice through tetraploid complementation. Cell Research 21:550-553.


39. Tong M, Lv Z, Liu L, Zhu H, Zheng QY, Zhao XY, Li W, Wu YB, Zhang HJ, Wu HJ, Li ZK, Zeng FY, Wang L, Wang XJ, Sha JH and Zhou Q. (2011) Mice generated from tetraploid complementation competent iPS cells show similar developmental features as those from ES cells but are prone to tumorigenesis. Cell Research 21: 1634-1637.



2010

40. Liu L, Luo GZ, Yang W, Zhao X, Zheng Q, Lv Z, Li W, Wu HJ, Wang L, Wang XJ* and Zhou Q*. (2010) Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells. Journal of Biological Chemistry (Cover story) 285:19483-19490 (*co-corresponding author).


41. Zhang Y, Liu J, Jia C, Li T, Wu R, Wang J, Chen Y, Zou X, Chen R, Wang XJ* and Zhu D*. (2010) Systematic identification and evolutionary features of rhesus monkey small nucleolar RNAs. BMC Genomics 11:61 (*co-corresponding author).　　


42. Yang W, Zhou Q and Wang XJ*. (2010) Regulation beyond genome sequences: DNA and histone methylation in embryonic stem cells. Frontier of Biology 5:41-47.


43. Li Y, Liu X, Huang L, Guo H and Wang XJ*. (2010) Potential coexistence of both bacterial and eukaryotic small RNA biogenesis and functional related protein homologs in Archaea. Journal of Genetics and Genomics 37: 493-503.


44. Xiong X, Lu Y, Zhang L, Wang B, Zhao Y, Wang XJ, Huo X, Shen Y, Liang Z and Chen M. (2010) Discovery of novel cell proliferation-enhancing gene by random siRNA library based combinatorial screening. Combinatorial Chemistry & High Throughput Screening 13:798-806.


45. Jian X, Zhang L, Li G, Zhang L, Wang X, Cao X, Fang X and Chen F. (2010)Identification of novel stress-regulated microRNAs from Oryza sativa L. Genomics 95:47-55.


2009

46. Zheng Q, Zhang Y, Chen Y, Yang N, Wang XJ* and Zhu D*. (2009) Systematic identification of genes involved in divergent skeletal muscle growth rates of broiler and layer chickens. BMC Genomics 10: 87 (*co-corresponding author).


47. Liu X, Luo G, Bai X and Wang XJ*. (2009) Bioinformatic analysis of microRNA biogenesis and function related proteins in eleven animal genomes. Journal of Genetics and Genomics 36: 591-601.


48. Ha M, Lu J, Tian L, Ramachandran V, Kasschau KD, Chapman EJ, Carrington JC, Chen X, Wang XJ and Chen ZJ. (2009) Small RNAs serve as a genetic buffer against genomic shock in Arabidopsis interspecific hybrids and allopolyploids. Proc. Natl. Acad. Sci. USA 106: 17835–17840.


49. Wuriyanghan H, Zhang B, Cao WH, Ma B, Lei G, Liu YF, Wei W, Wu HJ, Chen LJ, Chen HW, Cao YR, He SJ, Zhang WK, Wang XJ, Chen SY and Zhang JS. (2009) The ethylene receptor ETR2 delays floral transition and affects starch accumulation in Rice. Plant Cell 21: 1473-1494.


50. Besecker MI, Harden ME, Li G, Wang XJ, and Griffiths A. (2009) Discovery of herpes B virus-encoded microRNAs. Journal of Virology 83: 3413-3416.


51. Zhou Y, Li S, Qian Q, Zeng D, Zhang M, Guo L, Liu XL, Zhang B, Deng L, Liu XF, Luo G, Wang X and Li J. (2009) BC10, a DUF266-containing and golgi-located type II membrane protein, is required for cell wall biosynthesis in rice (Oryzasativa L.) The Plant Journal 57: 446-462.


52. Huang Y, Huang X, Liu H, Gong J, Ouyang Z, Cui H, Cao J, Zhao Y, Wang X, Jiang Y, and Qin Q. (2009) Complete sequence determination of a novel reptile iridovirus isolated from soft-shelled turtle and evolutionary analysis of iridoviridae. BMC Genomics 10: 224.


53. Zhang Y, Wang J, Huang S, Zhu X, Liu J, Yang N, Song D, Wu R, Deng W, Skogerb? G, Wang XJ, Chen R and Zhu D. (2009) Systematic identification and characterization of chicken (Gallus gallus) ncRNAs. Nucleic Acids Research 37: 6562-6574.


54. Ruan MB, Zhao YT, Meng ZH, Wang XJ and Yang WC. (2009) Conserved miRNA analysis in Gossypium hirsutum through small RNA sequencing. Genomics 94: 263-268.


55. Wang Y, Li P, Cao X, Wang X, Zhang A and Li X. (2009) Identification and expression analysis of miRNAs from nitrogen-fixing soybean nodules. Biochemical Biophysical Research Communications 378:799-803.



2008

56. Zheng Q and Wang XJ*. (2008) GOEAST: a web-based software toolkit for Gene Ontology enrichment analysis. Nucleic Acids Res.36: W358-W363.　


57. Mu J, Tan H, Zheng Q, Fu F, Liang Y, Zhang J, Yang X, Wang T, Chong K, Wang XJ and Zuo J. (2008) LEAFY COTYLEDON1 is a key regulator of fatty acid biosynthesis in Arabidopsis thaliana. Plant Physiology 148: 1042-1054.


58. Lu F, Li G, Cui X, Liu C, Wang XJ and Cao X. (2008) Comparative analysis of JmjC domain-containing proteins in higher plants and human reveals potential histone demethylases in Arabidopsis and rice. Journal of Integrative Plant Biology 50: 886-896.



2007

59. Zhao T, Li G, Mi S, Li S, Hannon GJ, Wang XJ* and Qi Y*. (2007) A complex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii. Genes & Development 21: 1190-1203 (*co-corresponding Author).　


60. Li X*, Wang XJ*, Tannenhauser J, Podell S, Mukherjee P, Hertel, M, Biane J, Masuda S, Nottebohm F and Gaasterland T. (2007) Genomic resources for songbird research and their use in characterizing gene expression during brain development. Proc. Natl. Acad. Sci. USA 104: 6834-6839 (*co-first author).


61. Liu B, Chen Z, Song X, Liu C, Cui X, Zhao X, Fang J, Xu W, Zhang H, Wang X, Chu C, Deng X, Xue Y and Cao X. (2007) Oryza sativa Dicer-like4 reveals a key role for small interfering RNA silencing in plant development. Plant Cell 19:2705-2718.


62. Li P, Wang Y, Qian Q, Fu Z, Wang M, Zeng D, Li B, Wang X and Li J. (2007) LAZY1 controls rice shoot gravitropism through regulating polar auxin transport. Cell Research 15:402-410.


63. Liu X, Bai X, Wang X and Chu C. (2007) OsWRKY71, a rice transcription factor, is involved in rice defense response. Journal of Plant Physiology 164: 969-979.



2006

64. Wang H, Chua NH and Wang XJ*. (2006) Prediction of trans-antisense transcripts in Arabidopsis thaliana. Genome Biology 7:R92.


65. Qi Y, He X, Wang XJ, Kohany O, Jurka J and Hannon GJ. (2006) Distinct Catalytic and Non-Catalytic Roles of ARGONAUTE4 in RNA-Directed DNA Methylation. Nature 443: 1008-1012.


66. Cui C, Griffiths A, Li G, Silva LM, Kramer MF, Gaasterland T, Wang XJ* and Coen DM*. (2006) Prediction and Identification of Herpes Simplex Virus 1-Encoded MicroRNAs. Journal of Virology 80: 5499-5508 (* co-corresponding author).


67. Li G, Tao S and Wang XJ*. (2006) Sequence and epitope analysis of surface proteins of avian influenza H5N1 viruses from Asian patients. Chinese Science Bulletin 51: 472-2481.　


68. Liu J and Wang XJ*. (2006) An integrative analysis of the effects of auxin on jasmonic acid biosynthesis in Arabidopsis thaliana. Journal of Integrative Plant Biology 48: 110-114.　


69. Luo A, Qian Q, Yin H, Liu X, Yin C, Lan Y, Tang J, Tang Z, Cao S, Wang X, Xia K, Fu X, Luo D and Chu C. (2006) EUI1, encoding a putative cytochrome P450 monooxygenase, regulates the internodes elongation by modulating GA responses in rice. Plant Cell Physiology 47: 181-191.



2005 and before

70. Wang XJ, Gaasterland T and Chua NH. (2005) Genome-wide prediction and identification of cis-natural antisense transcripts in Arabidopsis thaliana. Genome Biology 6:R30.


71. Liu XQ, Bai XQ, Qian Q, Wang XJ, Chen MS and Chu CC. (2005) OsWRKY03, a rice transcriptional activator that functions in defense signaling pathway upstream of OsNPR1. Cell Research 15: 593-603.


72. Wang XJ, Reyes JL, Chua NH and Gaasterland T. (2004) Prediction and identification of Arabidopsis thaliana microRNA genes and their mRNA targets. Genome Biology 5:R65.


73. Hoth S, Ikeda Y, Morganteb M, Wang X, Zuo J, Hanafey MK, Gaasterland T, Tingey SV and Chua NH. (2003) Monitoring genome-wide changes in gene expression in response to endogenous cytokinin reveals targets in Arabidopsis thaliana. FEBS Letters 554: 373-380.


74. Wang X, Ching YP, Lam WH, Qi Z, Zhang M and Wang JH. (2000) Identification of a common protein association region in the neuronal Cdk5 activator. Journal of Biological Chemistry 275: 31763-31769.

发表论文 （1） ISRNA:an integrative online toolkit for short reads from high-throughput sequencing data，Bioinformatics，2014，通讯作者
（2） Genetic Modification and Screening in Rat Using Haploid Embryonic Stem Cells，Cell Stem Cell，2014，第5作者
（3） Draft genome of the wheat A-genome Triticum urartu，Nature，2013，第5作者
（4） Identification of a small molecule 1,4-bis-[4-(3-phenoxy-ropoxy)-but-2-ynyl]-piperazine as a novel inhibitor of the transcription factor p53，Acta Pharmacologica Sinica ，2013，通讯作者
（5）MicroRNA-323-3p Regulates the Activity of Polycomb Repressive Complex 2 (PRC2) via Targeting the mRNA of Embryonic Ectoderm Development (Eed) Gene in Mouse Embryonic Stem Cells，Journal of Biological Chemistry ，2013，通讯作者
（6） Formation of a Functional Maize Centromere after Loss of Centromeric Sequences and Gain of Ectopic Sequences，Plant Cell，2013，通讯作者
（7） Wide-spread long non-codingRNAs (lncRNAs) as endogenous target mimics (eTMs) for microRNAs in plants，Plant Physiology ，2013，通讯作者
（8） Genetic and genomic evidence that sucrose is a global regulator of plant responses to phosphate starvation in Arabidopsis，Plant Physiol.，2011，通讯作者
（9） Identification and functional characterization of small non-coding RNAs in Xanthomonas oryzae pathovar oryzae，BMC Genomics ，2011，通讯作者
（10） Small RNA profiling in two Brassica napus cultivars identifies microRNAs with oil production and developmental correlated expressions and new small RNA classes，Plant Physiol，2011，通讯作者
（11）iPS cells generated without c-Myc have active Dlk1-Dio3 region and are capable of producing full-term mice through tetraploid complementation，Cell Res.，2011，通讯作者
（12） Deep sequencing of small RNAs specifically associated with Arabidopsis AGO1 and AGO4 uncovers new AGO functions，Plant Journal ，2011，通讯作者


发表著作
科研活动

科研项目 （1） 细胞命运维持与转化的表观遗传调控作用与机制研究，主持，国家级，2014-01--2018-12
（2） 真核生物基因保守性的系统分析与功能研究，主持，国家级，2013-01--2016-12
（3） 非编码RNA和系统生物学网络分析算法研究，参与，院级级，2011-01--2012-12
（4） RNA介导的体细胞重编程技术，主持，院级级，2011-01--2016-12
（5） microRNA或microRNA基因簇在干细胞多能性维持与分化过程中的作用与调控机制，参与，国家级，2011-01--2015-12
（6） 影响水稻幼苗生长的激素互作网络研究和职务激素相关数据整合平台的建立，主持，国家级，2010-01--2012-12
（7） 遗传学，主持，国家级，2008-01--2011-12
（8） 非编码RNA研究的新理论、新技术的发展及神经和肌肉早期发育过程中非编码RNA的系统发现，参与，国家级，2007-07--2011-08


参与会议 （1） 无，第十届世界生物技术工业国际年会，2013-06，无
（2） 无，国际干细胞协会第十一届年会，2013-06，无
（3） 无，国际干细胞协会第十届年会，2012-06，无
（4） 无，国际干细胞协会第九届年会，2011-06，无

合作情况

项目协作单位
指导学生已指导学生

吴旭东 博士研究生 071021-生物信息学

郑淇 博士研究生 071021-生物信息学

刘君 博士研究生 071021-生物信息学

王欢 博士研究生 071021-生物信息学

骆观正 博士研究生 071021-生物信息学

赵营涛 博士研究生 071021-生物信息学

王亦男 博士研究生 071021-生物信息学

刘修营 博士研究生 071021-生物信息学

吴华君 博士研究生 071021-生物信息学

李玲玲 硕士研究生 430139-生物工程

冯桂海 博士研究生 071021-生物信息学

马英克 博士研究生 071021-生物信息学

杨维 博士研究生 071021-生物信息学

孙海汐 博士研究生 071021-生物信息学

刘永鑫 博士研究生 071021-生物信息学

陈同 博士研究生 071021-生物信息学

徐阳 硕士研究生 085238-生物工程

庞军玲 博士研究生 0710J3-生物信息学

现指导学生

李稳 博士研究生 071021-生物信息学

王志敏 博士研究生 071021-生物信息学

苑宝文 硕士研究生 0710J3-生物信息学

王运浩 博士研究生 0710J3-生物信息学

陈斌 硕士研究生 085238-生物工程

张泽宇 硕士研究生 0710J3-生物信息学

黄增辉 博士研究生 0710J3-生物信息学

刘勇杰 博士研究生 071009-细胞生物学

李长昊 博士研究生 0710J3-生物信息学