基本信息
吴皓 女 博导 其它
电子邮件：wu@crystal.harvard.edu
通信地址：北京市朝阳区大屯路15号
邮政编码：


研究领域天然免疫相关蛋白的结构与功能
教育背景

学历1982-1985 北京大学，生物学医预相等学士

1985-1988 北京协和医科大学，主攻医学

1988-1992 美国普渡大学，生物化学博士　

学位博士
工作经历1992-1997 美国哥伦比亚大学，生物化学博士后

1997-2012 美国康奈尔大学威尔医学院，助理教授、副教授、教授

2012-至今 美国哈佛大学医学院，生物化学及分子药理学教授， 美国波士顿儿童医院, 高级研究员

2014-至今 中国科学院生物物理研究所，研究员

工作简历

社会兼职
教授课程
专利与奖励

奖励信息

专利成果
出版信息Lu A, Li Y, Qian Y, Ruan J, Yu X, Egelman E, Wu H. (2015). Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2. Cell Discovery. published online

Onizawa M, Oshima S, Schulze-Topphoff U, Oses-Prieto JA, Lu T, Tavares R, Prodhomme T, Duong B, Whang MI, Advincula R, Agelidis A, Barrera J, Wu H, Burlingame A, Malynn BA, Zamvil SS, Ma A. (2015). The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIP3 and protects cells from necroptosis. Nature Immunology. 16:618-627

Wei S, Kozono S, Kats L, Nechama M, Li W, Guarnerio J, Luo M, You MH, Yao Y, Kondo A, Hu H, Bozkurt G, Moerke NJ, Cao S, Reschke M, Chen CH, Rego EM, Lo-Coco F, Cantley LC, Lee TH, Wu H, Zhang Y, Pandolfi PP, Zhou XZ, Lu KP. (2015). Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer. Nat Med. 21:457-466

Hauenstein A, Zhang L, Wu H. (2015). The hierarchical structural architecture of inflammasomes, supramolecular inflammatory machines. Curr Opin Struct Biol. 31:75-83

Yin Q, Fu TM, Li J, Wu H. (2015). Structural Biology of Innate Immnuity. Annu. Rev. Immunol. 33:393-416

Li L, Yin Q, Kuss P, Maliga Z, Millán JL, Wu H, Mitchison T. (2014). Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs. Nat Chem Biol. 10:1043-8

Jang TH, Zheng C, Li J, Richards C, Hsiao YS, Walz T, Wu H, Park HH. (2014). Structural Study of the RIPosptosome core reveals a helical assembly for kinase recruitment. Biochemistry. 53:5424-31

Kagan JC, Magupalli V, Wu H. (2014). Supramolecular Organizing Centres (SMOCs): Site-Specific Higher Order Signalling Complexes that Control Innate Immunity. Nature Rev Immunol. 14:821-6

Ferrao R, Zhou H, Shan Y, Liu Q, Li Q, Shaw DE, Li X, Wu H. (2014). IRAK4 Dimerization and the Trans-autophosphorylation are Induced by Myddosome Assembly. Mol Cell. 55:891-903

Ru H, Zhang P, Wu H. (2014). Promiscuity is not Always Bad. Mol Cell. 2:208-9

Lu A, Magupalli VG, Ruan J, Yin Q, Atianand MK, Vos MR, Schr?der GF, Fitgerald KA, Wu H, Egelman EH. (2014). Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes. Cell. 6:1193-206

Furman RR, Cheng S, Lu P, Setty M, Perez AR, Guo A, Racchumi J, Xu G, Wu H, Ma J, Steggerda SM, Coleman M, Leslie C, Wang YL. (2014). Ibrutinib Resistance in Chronic Lymphocytic Leukemia. N Engl J Med. 24:2352-4

Lu A, Kavaleeswaran V, Fu T, Magupalli VG, Wu H. (2014). Crystal Structure of the F27G AIM2 PYD Mutant and Similarities of Its Self-Association to DED/DED Interactions. J Mol Biol. 7:1420-7

Yang C, David L, Qiao Q, Damko E, Wu H. (2013). The CBM Signalosome: Potential Therapeutic Target for Aggressive Lymphoma? Cytokine Growth Factor Rev. 2:175-183

Qiao Q, Yang C, Zheng C, Fontan L, David L, Yu X, Bracken C, Rosen M, Melnick A, Egelman E, Wu H. (2013). Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly. Mol Cell. 51:766-779

Kim S, Li L, Maliga Z, Yin Q, Wu H, Mitchison T. (2013). Anticancer Flavonoids Are Mouse-Selective STING Agonists. ACS Chemical Biology. 8:1396-1401

Li J, Yin Q, Wu H. (2013). Structural Basis of Signal Transduction in the TNF Receptor Superfamily. Advanced Immunology. 119:135-53

Yin Q, Sester DP, Tian Y, Hsiao YS, Lu A, Cridlan JA, Sagulenko V, Thygesen SJ, Chouhey D, Hornung V, Walz T, Stacey KJ, Wu H. (2013). Molecular Mechanism for p202-mediated Specific Inhibition of AIM2 Inflammasome Activation. Cell Reports. 4:327-39

Lee JH, Yi L, Li J, Schweitzer K, Borgmann M, Naumann M, Wu H. (2013). Crystal Structure and Versatile Functional Roles of the COP9 Signalsome Subunit 1. Proceedings of the National Academy of Sciences. 110:11845-50

Kim S, Li L, Maliga Z, Yin Q, Wu H, Mitchison T. (2013). Anti-Cancer Flavonoids are Mouse Selective STING agonists. ACS Chemical Biology. 8:1396-1401

Napteschnig J, Wu H. (2013). Molecular Basis of NF-kB signaling. Annual Reviews in Biophysics. 42:443-68

Lu TT, Onizawa M, Hammer GE, Turer EE, Yin Q, Damko E, Agelidis A, Shifrin N, Advincula R, Barrera J, Malynn BA, Wu H, Ma A. (2013). Dimerization and Ubiquitin Mediated Recruitment of A20, a Complex Deubiquitinating Enzyme. Immunity. 38:1-10

Wu H. (2013). Higher-Order Assemblies in a New Paradigm of Signal Transduction. Cell. 153:287-292

Fontan L, Yang C, Kabaleeswaran V, Volpon L, Osborne MJ, Beltran E, Garcia M, Cerchietti L, Shaknovich R, Yang SN, Fang F, Gascoyne RD, Martinez-Climent JA, Glickman JF, Borden K, Wu H, Melnick A. (2012). MALT1 Small Molecule Inhibitors Specifically Suppress ABC-DLBCL In Vitro and In Vivo. Cancer Cell. 22:812-24

Ferrao R, Li J, Bergamin E, Wu H. (2012). Structural insights into the assembly of large oligomeric signalosomes in the Toll-like receptor-interleukin-1 receptor superfamily. Sci Signal. 5:re3

Yin Q, Tian Y, Kabaleeswaran V, Jiang X, Tu D, Eck MJ, Chen ZJ, Wu H. (2012). Cyclic di-GMP sensing via the innate immune signaling protein STING. Mol Cell. 46:735-45

Li J, McQuade T, Siemer AB, Napetschnig J, Moriwaki K, Hsiao YS, Damko E, Moquin D, Walz T, McDermott A, Chan FK, Wu H. (2012). The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell. 150:339-50

Ferrao R, Wu H. (2012). Helical assembly in the death domain (DD) superfamily. Curr Opin Struct Biol. 22:241-7

Feldman T, Kabaleeswaran V, Jang SB, Antczak C, Djaballah H, Wu H, Jiang X. (2012). A class of allosteric caspase inhibitors identified by high-throughput screening. Mol Cell. 47:585-95

Xu G, Lo YC, Li Q, Napolitano G, Wu X, Jiang X, Dreano M, Karin M, Wu H. (2011). Crystal structure of inhibitor of kappaB kinase beta. Nature. 472:325-330

Wu H, Siegel RM. Medicine. (2011). Progranulin resolves inflammation. Science. 332:427-8

Zheng C, Yin Q, Wu H. (2011). Structural studies of NF-kB signaling. Cell Research. 21:183-959

H Wu, YC Lo, Q Yin. (2011). Structural studies of NEMO and TRAF6: implications in NF-kB activation. Adv Exp Med Biol. 691: 89-91

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